SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TYL'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E06_B_IPBB600_0 (ODORANT-BINDING PROTEIN)	4yji	ARYL ACYLAMIDASE (bacterium CSBL00001)	4 / 4	ILE A 428 MET A 325 VAL A 381 GLY A 185	None None None TYL A 502 (-3.6A)	1.02A	1e06B-4yjiA: undetectable	1e06B-4yjiA: 13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WG8_B_SAMB3141_0 (PREDICTED S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	4yji	ARYL ACYLAMIDASE (bacterium CSBL00001)	5 / 12	GLY A 181 GLY A 180 ASP A 183 PHE A 87 SER A 164	None None TYL A 502 ( 4.8A) None None	1.17A	1wg8B-4yjiA: undetectable	1wg8B-4yjiA: 22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MTE_A_SAMA220_0 (16S RRNA METHYLASE)	4yji	ARYL ACYLAMIDASE (bacterium CSBL00001)	5 / 12	GLY A 140 PRO A 191 ALA A 168 ALA A 169 THR A 131	TYL A 502 ( 4.9A) None None None None	1.02A	3mteA-4yjiA: undetectable	3mteA-4yjiA: 18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_A_SAMA6735_0 (16S RRNA METHYLASE)	4yji	ARYL ACYLAMIDASE (bacterium CSBL00001)	5 / 12	GLY A 140 PRO A 191 ALA A 168 ALA A 169 THR A 131	TYL A 502 ( 4.9A) None None None None	1.05A	3p2kA-4yjiA: undetectable	3p2kA-4yjiA: 16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N09_C_ADNC401_1 (ADENOSINE KINASE)	4yji	ARYL ACYLAMIDASE (bacterium CSBL00001)	5 / 12	ASP A 183 GLY A 184 GLY A 185 LEU A 435 GLY A 162	TYL A 502 ( 4.8A) TYL A 502 (-3.4A) TYL A 502 (-3.6A) None None	0.94A	4n09C-4yjiA: undetectable	4n09C-4yjiA: 23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YMG_A_SAMA1001_0 (PUTATIVE SAM-DEPENDENT O-METHYLTRANFERASE)	4yji	ARYL ACYLAMIDASE (bacterium CSBL00001)	5 / 12	MET A 83 GLY A 166 SER A 163 ALA A 160 ALA A 168	None None TYL A 502 (-3.4A) None None	1.08A	4ymgA-4yjiA: undetectable	4ymgA-4yjiA: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YMG_B_SAMB1001_0 (PUTATIVE SAM-DEPENDENT O-METHYLTRANFERASE)	4yji	ARYL ACYLAMIDASE (bacterium CSBL00001)	5 / 12	MET A 83 GLY A 166 SER A 163 ALA A 160 ALA A 168	None None TYL A 502 (-3.4A) None None	1.14A	4ymgB-4yjiA: undetectable	4ymgB-4yjiA: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GQB_A_GCSA603_1 (CHITINASE)	4yji	ARYL ACYLAMIDASE (bacterium CSBL00001)	4 / 8	GLY A 219 TRP A 322 ASP A 183 ARG A 189	None None TYL A 502 ( 4.8A) None	1.06A	5gqbA-4yjiA: undetectable	5gqbA-4yjiA: 24.58

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E06_B_IPBB600_0","ODORANT-BINDING PROTEIN","4yji","ARYL ACYLAMIDASE","bacterium CSBL00001",4,"ILE A 428;MET A 325;VAL A 381;GLY A 185","None;None;None;TYL A 502 (-3.6A)","1.02A","1e06B-4yjiA:undetectable",null],["1WG8_B_SAMB3141_0","PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","4yji","ARYL ACYLAMIDASE","bacterium CSBL00001",5,"GLY A 181;GLY A 180;ASP A 183;PHE A  87;SER A 164","None;None;TYL A 502 ( 4.8A);None;None","1.17A","1wg8B-4yjiA:undetectable","1e06B-4yjiA:13.46"],["3MTE_A_SAMA220_0","16S RRNA METHYLASE","4yji","ARYL ACYLAMIDASE","bacterium CSBL00001",5,"GLY A 140;PRO A 191;ALA A 168;ALA A 169;THR A 131","TYL A 502 ( 4.9A);None;None;None;None","1.02A","3mteA-4yjiA:undetectable","1wg8B-4yjiA:22.36"],["3P2K_A_SAMA6735_0","16S RRNA METHYLASE","4yji","ARYL ACYLAMIDASE","bacterium CSBL00001",5,"GLY A 140;PRO A 191;ALA A 168;ALA A 169;THR A 131","TYL A 502 ( 4.9A);None;None;None;None","1.05A","3p2kA-4yjiA:undetectable","3mteA-4yjiA:18.43"],["4N09_C_ADNC401_1","ADENOSINE KINASE","4yji","ARYL ACYLAMIDASE","bacterium CSBL00001",5,"ASP A 183;GLY A 184;GLY A 185;LEU A 435;GLY A 162","TYL A 502 ( 4.8A);TYL A 502 (-3.4A);TYL A 502 (-3.6A);None;None","0.94A","4n09C-4yjiA:undetectable","3p2kA-4yjiA:16.16"],["4YMG_A_SAMA1001_0","PUTATIVE SAM-DEPENDENT O-METHYLTRANFERASE","4yji","ARYL ACYLAMIDASE","bacterium CSBL00001",5,"MET A  83;GLY A 166;SER A 163;ALA A 160;ALA A 168","None;None;TYL A 502 (-3.4A);None;None","1.08A","4ymgA-4yjiA:undetectable","4n09C-4yjiA:23.01"],["4YMG_B_SAMB1001_0","PUTATIVE SAM-DEPENDENT O-METHYLTRANFERASE","4yji","ARYL ACYLAMIDASE","bacterium CSBL00001",5,"MET A  83;GLY A 166;SER A 163;ALA A 160;ALA A 168","None;None;TYL A 502 (-3.4A);None;None","1.14A","4ymgB-4yjiA:undetectable","4ymgA-4yjiA:21.24"],["5GQB_A_GCSA603_1","CHITINASE","4yji","ARYL ACYLAMIDASE","bacterium CSBL00001",4,"GLY A 219;TRP A 322;ASP A 183;ARG A 189","None;None;TYL A 502 ( 4.8A);None","1.06A","5gqbA-4yjiA:undetectable","4ymgB-4yjiA:21.24"]]