SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TYI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A 305
ILE A 330
THR A  94
MET A 322
 TYI  A 308 ( 4.6A)
EDO  A 505 ( 4.9A)
None
None
 1.25A 1kglA-4ikmA:
undetectable		 1kglA-4ikmA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4tvc DEXTRANSUCRASE
(Leuconostoc
mesenteroides) 		4 / 5 ALA A1802
PHE A1816
ILE A1809
ASP A2073
 None
None
None
TYI  A2075 (-3.9A)
 1.15A 1yc2D-4tvcA:
undetectable		 1yc2D-4tvcA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 193
THR A 194
ALA A 347
THR A 346
ILE A 349
 None
None
None
TYI  A 342 ( 4.0A)
None
 1.20A 3a35A-4ikmA:
undetectable		 3a35A-4ikmA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 193
THR A 194
ALA A 347
THR A 346
ILE A 349
 None
None
None
TYI  A 342 ( 4.0A)
None
 1.21A 3a35B-4ikmA:
undetectable		 3a35B-4ikmA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 193
THR A 194
ALA A 347
THR A 346
ILE A 349
 None
None
None
TYI  A 342 ( 4.0A)
None
 1.23A 3a3bA-4ikmA:
undetectable		 3a3bA-4ikmA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
TYI  A 308 ( 4.9A)
MAL  A 501 (-2.9A)
TYI  A 211 ( 3.8A)
 0.83A 3tbgB-4ikmA:
undetectable		 3tbgB-4ikmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
TYI  A 308 ( 4.9A)
MAL  A 501 (-2.9A)
TYI  A 211 ( 3.8A)
 0.82A 3tbgD-4ikmA:
undetectable		 3tbgD-4ikmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4tvc DEXTRANSUCRASE
(Leuconostoc
mesenteroides) 		4 / 5 THR A1798
THR A1797
THR A1979
HIS A2818
 None
TYI  A2075 ( 4.8A)
None
None
 1.29A 4pgfB-4tvcA:
undetectable		 4pgfB-4tvcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2vlw MUSCARINIC M1-TOXIN1
(Dendroaspis
angusticeps) 		3 / 3 SER A  32
TYR A  36
TYR A  30
 None
None
TYI  A  51 ( 4.6A)
 0.91A 5lakA-2vlwA:
undetectable
5lakI-2vlwA:
undetectable		 5lakA-2vlwA:
13.91
5lakI-2vlwA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 TYI  A 342 ( 3.7A)
None
None
None
None
None
 1.39A 5w4zA-4ikmA:
undetectable		 5w4zA-4ikmA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 TYI  A 342 ( 3.7A)
None
None
None
None
None
 1.43A 5w4zB-4ikmA:
undetectable		 5w4zB-4ikmA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gh8 IODOTYROSINE
DEHALOGENASE 1
(Mus
musculus) 		3 / 3 LEU A 258
THR A 174
ASN A 175
 None
TYI  A 302 ( 3.7A)
None
 0.66A 6baaE-3gh8A:
undetectable		 6baaE-3gh8A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gh8 IODOTYROSINE
DEHALOGENASE 1
(Mus
musculus) 		3 / 3 LEU A 258
THR A 174
ASN A 175
 None
TYI  A 302 ( 3.7A)
None
 0.66A 6baaF-3gh8A:
undetectable		 6baaF-3gh8A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gh8 IODOTYROSINE
DEHALOGENASE 1
(Mus
musculus) 		3 / 3 LEU A 258
THR A 174
ASN A 175
 None
TYI  A 302 ( 3.7A)
None
 0.66A 6baaG-3gh8A:
undetectable		 6baaG-3gh8A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3gh8 IODOTYROSINE
DEHALOGENASE 1
(Mus
musculus) 		3 / 3 LEU A 258
THR A 174
ASN A 175
 None
TYI  A 302 ( 3.7A)
None
 0.67A 6baaH-3gh8A:
undetectable		 6baaH-3gh8A:
10.38