SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TYE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		6 / 11 GLY A  43
HIS A  52
HIS A  55
GLY A 194
ASP A 196
GLN A 197
 TYE  A1434 ( 3.5A)
ATP  A1433 (-4.3A)
ATP  A1433 (-4.2A)
ATP  A1433 (-3.2A)
ATP  A1433 ( 4.2A)
TYE  A1434 ( 3.5A)
 0.71A 1jzsA-1h3eA:
1.1		 1jzsA-1h3eA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A  54
HIS A  55
GLY A 194
ASP A 196
GLN A 197
 ATP  A1433 (-3.4A)
ATP  A1433 (-4.2A)
ATP  A1433 (-3.2A)
ATP  A1433 ( 4.2A)
TYE  A1434 ( 3.5A)
 0.70A 1qu2A-1h3eA:
5.0		 1qu2A-1h3eA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 SER A  87
GLN A 197
VAL A  23
CYH A 218
 None
TYE  A1434 ( 3.5A)
None
None
 1.20A 3b9lA-1h3eA:
0.0		 3b9lA-1h3eA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 ASN A 128
TRP A 131
ASP A  45
 TYE  A1434 ( 4.8A)
None
TYE  A1434 ( 3.8A)
 0.80A 4a7tA-1h3eA:
0.1
4a7tF-1h3eA:
0.2		 4a7tA-1h3eA:
16.03
4a7tF-1h3eA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 ALA A 112
TYR A 108
ALA A  44
ILE A  75
ILE A  76
 None
None
ATP  A1433 (-3.8A)
TYE  A1434 ( 3.9A)
None
 1.15A 4eatB-1h3eA:
undetectable		 4eatB-1h3eA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 SER A 129
ASP A  78
ILE A  75
GLN A 216
ILE A 186
 None
None
TYE  A1434 ( 3.9A)
None
None
 1.30A 4uroA-1h3eA:
undetectable		 4uroA-1h3eA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 ARG A 155
GLY A  88
ASP A 157
ASP A  85
 None
None
None
TYE  A1434 (-3.8A)
 1.32A 5hp1A-1h3eA:
0.4		 5hp1A-1h3eA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 ILE A  76
ALA A  44
GLY A  43
GLY A  84
TYR A 175
 None
ATP  A1433 (-3.8A)
TYE  A1434 ( 3.5A)
None
TYE  A1434 (-4.3A)
 1.28A 6nm4B-1h3eA:
undetectable		 6nm4B-1h3eA:
18.50