SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TYD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 12 PRO A 278
HIS A 292
GLY A 294
GLY A  12
VAL A 317
 TYD  A 401 (-4.2A)
TYD  A 401 (-3.9A)
TYD  A 401 (-3.5A)
TYD  A 401 ( 3.7A)
None
 1.22A 1ffyA-4g2tA:
2.0		 1ffyA-4g2tA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 ASN A 103
GLY A  99
GLN A  98
VAL A  95
LEU A 151
 None
None
TYD  A 401 (-3.0A)
None
None
 1.35A 1nhzA-3hjnA:
undetectable		 1nhzA-3hjnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		4 / 6 TYR A  97
GLY A  38
SER A  67
ARG A  47
 TYD  A 401 (-3.8A)
None
None
TYD  A 401 (-2.9A)
 1.35A 2a3cB-3hjnA:
undetectable		 2a3cB-3hjnA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A 131
SER A  53
ARG A  61
HIS A  64
 None
None
TYD  A2187 (-3.7A)
TYD  A2187 (-4.3A)
 0.89A 2f78A-1epzA:
undetectable		 2f78A-1epzA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 VAL A 131
SER A  53
ARG A  61
HIS A  64
 None
None
TYD  A2187 (-3.7A)
TYD  A2187 (-4.3A)
 0.82A 2f8dA-1epzA:
0.0		 2f8dA-1epzA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 12 ILE A 282
LEU A 279
GLY A 197
ALA A 255
VAL A 254
 None
TYD  A 401 (-3.8A)
None
TYD  A 401 (-3.3A)
None
 1.01A 2oc8A-4g2tA:
undetectable		 2oc8A-4g2tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ILE A  52
ASP A 108
LEU A 106
GLY A 107
 None
TYD  A3001 ( 2.9A)
TYD  A3001 (-3.4A)
TYD  A3001 (-4.1A)
 0.92A 2tsrB-1lvwA:
undetectable		 2tsrB-1lvwA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  43
GLY A  39
GLU A  44
ARG A  47
GLU A  36
 None
None
None
TYD  A 401 (-2.9A)
None
 1.17A 2vdvE-3hjnA:
undetectable		 2vdvE-3hjnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 11 GLY A  43
GLY A  39
GLU A  44
ARG A  47
GLU A  36
 None
None
None
TYD  A 401 (-2.9A)
None
 1.16A 2vdvF-3hjnA:
undetectable		 2vdvF-3hjnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 SER A 232
PHE A 321
GLY A 296
HIS A 295
THR A 301
 CLJ  A 394 ( 4.2A)
None
None
TYD  A 393 (-3.9A)
None
 1.50A 3a25A-3othA:
4.4		 3a25A-3othA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		4 / 7 ILE A 113
GLY A 110
VAL A  72
ARG A 156
 None
None
TYD  A 215 (-4.1A)
None
 0.91A 3elzA-3lv8A:
undetectable		 3elzA-3lv8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GF2_A_SALA147_1
(146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		4 / 4 TYR A  97
LEU A 151
ARG A 155
TYR A 158
 TYD  A 401 (-3.8A)
None
None
None
 1.17A 3gf2A-3hjnA:
0.0		 3gf2A-3hjnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 5 TYR A 225
ILE A 202
LEU A 301
PHE A 284
 None
None
TYD  A 406 (-4.6A)
None
 1.16A 3ls4L-1pn3A:
undetectable		 3ls4L-1pn3A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		3 / 3 SER A 149
ASP A 278
ASN A 213
 None
None
TYD  A 901 ( 4.8A)
 0.83A 3lslA-1r66A:
undetectable
3lslD-1r66A:
undetectable		 3lslA-1r66A:
21.01
3lslD-1r66A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 GLY A  62
ASP A 172
ARG A  61
GLN A  66
 None
TYD  A2187 ( 4.4A)
TYD  A2187 (-3.7A)
None
 1.29A 3qx3A-1epzA:
undetectable		 3qx3A-1epzA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 GLY A  62
ASP A 172
ARG A  61
GLN A  66
 None
TYD  A2187 ( 4.4A)
TYD  A2187 (-3.7A)
None
 1.32A 3qx3B-1epzA:
0.0		 3qx3B-1epzA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 107
LEU A   6
GLN A  24
ASP A  57
SER A  53
 TYD  A3001 (-4.1A)
TYD  A3001 (-3.5A)
TYD  A3001 (-3.5A)
None
None
 1.07A 3tbgA-1lvwA:
undetectable		 3tbgA-1lvwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 107
LEU A   6
GLN A  24
ASP A  57
SER A  53
 TYD  A3001 (-4.1A)
TYD  A3001 (-3.5A)
TYD  A3001 (-3.5A)
None
None
 1.04A 3tbgB-1lvwA:
0.0		 3tbgB-1lvwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 107
LEU A   6
GLN A  24
ASP A  57
SER A  53
 TYD  A3001 (-4.1A)
TYD  A3001 (-3.5A)
TYD  A3001 (-3.5A)
None
None
 1.05A 3tbgC-1lvwA:
0.0		 3tbgC-1lvwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		5 / 12 GLY A  10
LEU A  11
GLU A  12
SER A 102
PHE A 165
 None
None
TYD  A 215 (-2.8A)
TMP  A 214 ( 4.2A)
None
 1.29A 3tbgC-3lv8A:
undetectable		 3tbgC-3lv8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3oth CALG1
(Micromonospora
echinospora) 		5 / 12 GLY A 296
GLY A 297
THR A 231
GLY A 318
ASP A 319
 None
TYD  A 393 (-3.6A)
TYD  A 393 (-3.1A)
CLJ  A 394 (-3.8A)
None
 0.95A 3uboA-3othA:
6.9		 3uboA-3othA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 SER A  94
TYR A  97
ALA A 135
PHE A 150
LEU A 151
 TYD  A 401 (-2.7A)
TYD  A 401 (-3.8A)
None
None
None
 1.34A 3vw1B-3hjnA:
undetectable		 3vw1B-3hjnA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 8 GLN A 282
PHE A 182
ILE A 370
VAL A 366
 TYD  A 393 (-3.5A)
None
None
None
 0.90A 4dx7B-3othA:
undetectable		 4dx7B-3othA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE
(Campylobacter
jejuni) 		4 / 8 PHE A  56
ILE A  93
PHE A  58
GLY A  47
 None
None
None
TYD  A 201 (-3.5A)
 0.96A 4fgjA-5tpvA:
undetectable
4fgjB-5tpvA:
undetectable		 4fgjA-5tpvA:
20.43
4fgjB-5tpvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 VAL A 259
HIS A 120
ALA A 255
MET A 336
ASP A 323
 TYD  A 501 (-4.3A)
None
TYD  A 501 ( 3.8A)
None
None
 1.27A 4qckA-4zyjA:
undetectable		 4qckA-4zyjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		4 / 4 GLU A 115
GLY A  12
HIS A 295
ARG A 138
 None
TYD  A 401 ( 3.7A)
None
None
 1.08A 4r82A-4g2tA:
undetectable
4r82B-4g2tA:
undetectable		 4r82A-4g2tA:
19.65
4r82B-4g2tA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3oth CALG1
(Micromonospora
echinospora) 		4 / 5 GLY A 230
THR A 231
HIS A 295
GLY A 299
 TYD  A 393 ( 3.7A)
TYD  A 393 (-3.1A)
TYD  A 393 (-3.9A)
TYD  A 393 (-3.6A)
 1.03A 4v20A-3othA:
undetectable		 4v20A-3othA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 12 GLU A 115
GLY A  12
GLU A  11
LEU A  63
ALA A 315
 None
TYD  A 401 ( 3.7A)
None
None
None
 1.10A 4wcxC-4g2tA:
undetectable		 4wcxC-4g2tA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 3m9v FAD-DEPENDENT
OXIDOREDUCTASE
(Actinomadura
kijaniata) 		5 / 10 GLY A 253
ALA A 316
ASP A 317
SER A 320
ALA A 321
 TYD  A 901 (-3.3A)
None
None
None
None
 0.85A 4wnuD-3m9vA:
undetectable		 4wnuD-3m9vA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 12 PHE A 245
GLY A 303
LEU A 307
VAL A 333
VAL A 297
 None
TYD  A 397 (-3.4A)
None
None
None
 1.18A 4wnwA-3rscA:
undetectable		 4wnwA-3rscA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 12 PHE A 245
GLY A 303
LEU A 307
VAL A 333
VAL A 297
 None
TYD  A 397 (-3.4A)
None
None
None
 1.06A 4wnwB-3rscA:
undetectable		 4wnwB-3rscA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3m9v FAD-DEPENDENT
OXIDOREDUCTASE
(Actinomadura
kijaniata) 		5 / 12 MET A 327
GLU A 113
LEU A  79
THR A  66
GLY A 107
 None
TYD  A 901 (-3.8A)
None
None
None
 1.33A 4zjlA-3m9vA:
undetectable		 4zjlA-3m9vA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 LEU A  63
GLY A  38
ASP A   9
ASN A 143
PHE A 145
 None
None
TYD  A 401 (-2.9A)
TYD  A 401 (-3.2A)
TYD  A 401 (-4.0A)
 1.28A 5d0yA-3hjnA:
undetectable		 5d0yA-3hjnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 ARG A 205
TYR A 291
TYR A 260
ALA A 282
SER A 283
 TYD  A 402 (-3.6A)
None
None
None
None
 1.11A 5ikrA-4mzuA:
undetectable		 5ikrA-4mzuA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.22A 5jhnB-3hjnA:
undetectable		 5jhnB-3hjnA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.18A 5jinA-3hjnA:
undetectable		 5jinA-3hjnA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.20A 5jj0A-3hjnA:
undetectable		 5jj0A-3hjnA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ARG A  78
LEU A  50
ILE A 197
GLY A  85
ILE A   4
 None
None
None
TYD  A3001 (-3.5A)
None
 1.04A 5kr1A-1lvwA:
undetectable		 5kr1A-1lvwA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		4 / 6 GLU A  12
ALA A  14
LEU A  11
TYR A 106
 TYD  A 215 (-2.8A)
ADP  A 213 (-4.2A)
None
TYD  A 215 ( 3.8A)
 1.11A 5phhA-3lv8A:
undetectable		 5phhA-3lv8A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.20A 5t0kA-3hjnA:
undetectable		 5t0kA-3hjnA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.21A 5t0mB-3hjnA:
undetectable		 5t0mB-3hjnA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.10A 5tuyA-3hjnA:
undetectable		 5tuyA-3hjnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.11A 5tuyB-3hjnA:
undetectable		 5tuyB-3hjnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 7 GLY A 172
LEU A 106
LEU A  50
ILE A  86
ILE A  97
 None
TYD  A3001 (-3.4A)
None
None
None
 1.17A 5vkqA-1lvwA:
undetectable
5vkqB-1lvwA:
undetectable		 5vkqA-1lvwA:
9.76
5vkqB-1lvwA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 7 GLY A 172
LEU A 106
LEU A  50
ILE A 197
ILE A  97
 None
TYD  A3001 (-3.4A)
None
None
None
 1.24A 5vkqA-1lvwA:
undetectable
5vkqB-1lvwA:
undetectable		 5vkqA-1lvwA:
9.76
5vkqB-1lvwA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 GLY A 172
LEU A 106
LEU A  50
ILE A  86
ILE A  97
 None
TYD  A3001 (-3.4A)
None
None
None
 1.18A 5vkqB-1lvwA:
undetectable
5vkqC-1lvwA:
undetectable		 5vkqB-1lvwA:
9.76
5vkqC-1lvwA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 GLY A 172
LEU A 106
LEU A  50
ILE A 197
ILE A  97
 None
TYD  A3001 (-3.4A)
None
None
None
 1.21A 5vkqB-1lvwA:
undetectable
5vkqC-1lvwA:
undetectable		 5vkqB-1lvwA:
9.76
5vkqC-1lvwA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3lv8 THYMIDYLATE KINASE
(Vibrio
cholerae) 		4 / 8 ILE A 157
ARG A 156
VAL A  72
ASP A  65
 TMP  A 214 (-3.3A)
None
TYD  A 215 (-4.1A)
CL  A 222 ( 4.7A)
 1.10A 5vlmF-3lv8A:
1.4		 5vlmF-3lv8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.12A 5vscA-3hjnA:
undetectable		 5vscA-3hjnA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A  85
ASP A  84
ASP A 172
LEU A 166
LEU A 125
 None
None
TYD  A2187 ( 4.4A)
None
None
 1.20A 6ew0F-1epzA:
undetectable		 6ew0F-1epzA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 3m9v FAD-DEPENDENT
OXIDOREDUCTASE
(Actinomadura
kijaniata) 		4 / 5 LEU A 104
THR A  66
THR A 109
GLY A 107
 None
None
TYD  A 901 (-4.0A)
None
 1.25A 6gtqA-3m9vA:
undetectable		 6gtqA-3m9vA:
17.99