SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TXP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ASN A  98
GLY A  99
GLN A 103
LEU A 107
ILE A 123
 TXP  A 302 (-3.3A)
None
None
None
TXP  A 302 (-4.3A)
 1.50A 1p93B-5ojlA:
undetectable		 1p93B-5ojlA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		4 / 5 LEU A 107
GLN A  79
LEU A  81
GLU A  78
 None
TXP  A 302 (-3.9A)
None
None
 1.13A 3h5gA-5ojlA:
undetectable
3h5gB-5ojlA:
undetectable		 3h5gA-5ojlA:
undetectable
3h5gB-5ojlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Rhodospirillum
rubrum) 		5 / 12 GLY C 129
THR C 134
ILE C 163
ASP C 190
ALA C 191
 TXP  C 400 (-3.9A)
None
None
TXP  C 400 (-3.7A)
TXP  C 400 (-3.5A)
 1.10A 3nvkI-2oorC:
3.7		 3nvkI-2oorC:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ALA A  43
GLY A  16
GLY A  14
LEU A  72
LEU A  71
 None
TXP  A 302 (-3.3A)
TXP  A 302 (-3.6A)
TXP  A 302 (-4.1A)
TXP  A 302 (-4.2A)
 0.99A 4lg1A-5ojlA:
4.5		 4lg1A-5ojlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ALA A  43
GLY A  16
GLY A  14
LEU A  72
LEU A  71
 None
TXP  A 302 (-3.3A)
TXP  A 302 (-3.6A)
TXP  A 302 (-4.1A)
TXP  A 302 (-4.2A)
 0.98A 4lg1B-5ojlA:
4.7		 4lg1B-5ojlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		6 / 12 LEU A 158
LEU A  66
ILE A  68
LEU A  10
ILE A 123
PHE A  26
 None
None
None
None
TXP  A 302 (-4.3A)
None
 1.50A 4odrA-5ojlA:
undetectable
4odrB-5ojlA:
undetectable		 4odrA-5ojlA:
19.23
4odrB-5ojlA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ASN A  98
GLY A  99
GLN A 103
LEU A 107
ILE A 123
 TXP  A 302 (-3.3A)
None
None
None
TXP  A 302 (-4.3A)
 1.46A 4p6xA-5ojlA:
undetectable		 4p6xA-5ojlA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ASN A  98
GLY A  99
GLN A 103
LEU A 107
ILE A 123
 TXP  A 302 (-3.3A)
None
None
None
TXP  A 302 (-4.3A)
 1.50A 4p6xE-5ojlA:
undetectable		 4p6xE-5ojlA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ASN A  98
GLY A  99
GLN A 103
LEU A 107
ILE A 123
 TXP  A 302 (-3.3A)
None
None
None
TXP  A 302 (-4.3A)
 1.48A 4p6xI-5ojlA:
undetectable		 4p6xI-5ojlA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Rhodospirillum
rubrum) 		5 / 12 GLY C  56
TYR C 171
ILE C 163
ALA C  62
ASP C 190
 TXP  C 400 (-3.4A)
TXP  C 400 (-3.9A)
None
None
TXP  C 400 (-3.7A)
 0.97A 5kvaA-2oorC:
undetectable		 5kvaA-2oorC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Rhodospirillum
rubrum) 		5 / 12 GLY C  56
TYR C 171
ILE C 163
ALA C  62
ASP C 190
 TXP  C 400 (-3.4A)
TXP  C 400 (-3.9A)
None
None
TXP  C 400 (-3.7A)
 0.95A 5kvaB-2oorC:
undetectable		 5kvaB-2oorC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ALA A  60
ILE A  68
ALA A  63
CYH A  70
LEU A  71
 None
None
None
None
TXP  A 302 (-4.2A)
 1.02A 6a5zD-5ojlA:
undetectable		 6a5zD-5ojlA:
23.53