SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TWN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5hgg CAMELID DERIVED
ANTIBODY FRAGMENT,
NB4
(Vicugna
pacos) 		5 / 12 GLU S 115
GLY S 102
THR S 105
ARG S 111
SER S 108
 TWN  S 202 (-3.5A)
TWN  S 202 ( 4.5A)
None
None
None
 1.05A 3r75A-5hggS:
undetectable		 3r75A-5hggS:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5hgg CAMELID DERIVED
ANTIBODY FRAGMENT,
NB4
(Vicugna
pacos) 		5 / 12 GLU S 115
GLY S 102
THR S 105
ARG S 111
SER S 108
 TWN  S 202 (-3.5A)
TWN  S 202 ( 4.5A)
None
None
None
 1.06A 3r75B-5hggS:
undetectable		 3r75B-5hggS:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 5hgg CAMELID DERIVED
ANTIBODY FRAGMENT,
NB4
(Vicugna
pacos) 		4 / 5 GLU S 107
GLY S 102
TYR S 113
ASP S  99
 None
TWN  S 202 ( 4.5A)
None
None
 1.32A 3w9tD-5hggS:
undetectable		 3w9tD-5hggS:
16.47