SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TTP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Sulfurisphaera
tokodaii) 		4 / 5 ALA A   8
ALA A  82
LYS A  78
GLU A 181
 TTP  A 500 (-3.5A)
None
None
TTP  A 500 (-3.0A)
 1.21A 1e7cA-2ggqA:
undetectable		 1e7cA-2ggqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		5 / 12 TRP A  57
TYR A  70
GLN A  81
ALA A 110
GLU A 172
 None
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.6A)
 0.90A 1ki7A-2jcsA:
14.8		 1ki7A-2jcsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		5 / 12 TRP A  57
GLN A  81
ARG A 105
ALA A 110
GLU A 172
 None
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.6A)
 0.88A 1ki7B-2jcsA:
15.1		 1ki7B-2jcsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1xbt THYMIDINE KINASE,
CYTOSOLIC
(Homo
sapiens) 		4 / 8 ASP A  58
ASP A  97
GLY A  99
THR A 163
 TTP  A1195 (-3.2A)
MG  A1194 ( 4.3A)
None
TTP  A1195 ( 3.8A)
 0.82A 1m4iA-1xbtA:
undetectable		 1m4iA-1xbtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		4 / 5 PHE A 114
ARG A 105
ILE A 164
GLU A 172
 TTP  A1210 (-3.5A)
TTP  A1210 (-3.7A)
None
TTP  A1210 (-3.6A)
 1.42A 1oniG-2jcsA:
undetectable
1oniH-2jcsA:
undetectable		 1oniG-2jcsA:
17.67
1oniH-2jcsA:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		6 / 12 ILE A  29
VAL A  54
TRP A  57
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.93A 1p5zB-2jcsA:
27.3		 1p5zB-2jcsA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		8 / 12 ILE A  29
VAL A  54
TRP A  57
LEU A  66
MET A  69
TYR A  70
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.76A 1p5zB-2jcsA:
27.3		 1p5zB-2jcsA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		8 / 12 ILE A  29
VAL A  54
TRP A  57
LEU A  66
TYR A  70
GLN A  81
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.66A 1p5zB-2jcsA:
27.3		 1p5zB-2jcsA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P62_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		7 / 11 ILE A  29
TRP A  57
MET A  69
TYR A  70
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.98A 1p62B-2jcsA:
27.0		 1p62B-2jcsA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P62_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		8 / 11 ILE A  29
VAL A  54
TRP A  57
MET A  69
TYR A  70
GLN A  81
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.83A 1p62B-2jcsA:
27.0		 1p62B-2jcsA:
31.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Sulfurisphaera
tokodaii) 		3 / 3 SER A  10
GLY A   9
ARG A 179
 TTP  A 500 (-2.6A)
TTP  A 500 (-3.0A)
TTP  A 500 (-3.3A)
 0.39A 1t9wA-2ggqA:
undetectable		 1t9wA-2ggqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A 256
SER A 373
TYR A 371
 TTP  A1601 (-3.2A)
None
None
 0.68A 1x70A-5tusA:
undetectable		 1x70A-5tusA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A7Q_A_CFBA328_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		8 / 12 VAL A  54
TRP A  57
MET A  69
PHE A  80
GLN A  81
ARG A 105
PHE A 114
TYR A 179
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
None
 0.87A 2a7qA-2jcsA:
26.2		 2a7qA-2jcsA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A7Q_A_CFBA328_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 VAL A  54
TRP A  57
MET A  69
TYR A  70
PHE A  80
GLN A  81
PHE A 114
GLU A 172
TYR A 179
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
None
 0.69A 2a7qA-2jcsA:
26.2		 2a7qA-2jcsA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A7Q_A_CFBA328_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		5 / 12 VAL A  54
TRP A  57
PHE A  80
GLN A  81
GLU A 171
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
None
 1.33A 2a7qA-2jcsA:
26.2		 2a7qA-2jcsA:
31.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 2ja1 THYMIDINE KINASE
(Bacillus
cereus) 		4 / 6 ASP A  88
SER A  22
LEU A 116
GLY A 115
 TTP  A1193 (-3.4A)
TTP  A1193 (-2.7A)
MPD  A1194 (-4.6A)
None
 1.03A 2j2pA-2ja1A:
undetectable
2j2pC-2ja1A:
undetectable		 2j2pA-2ja1A:
20.69
2j2pC-2ja1A:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 10 VAL A  54
TRP A  57
PHE A  80
GLN A  81
VAL A  84
MET A  88
ARG A 105
ALA A 110
PHE A 114
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-4.8A)
None
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
 0.55A 2jj8A-2jcsA:
30.4		 2jj8A-2jcsA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		11 / 12 TRP A  57
LEU A  66
TYR A  70
PHE A  80
GLN A  81
VAL A  84
MET A  88
ARG A 105
ALA A 110
PHE A 114
MET A 118
 None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-4.8A)
None
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
None
 0.61A 2jj8B-2jcsA:
30.6		 2jj8B-2jcsA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		10 / 12 ILE A  29
TRP A  57
LEU A  66
MET A  69
PHE A  80
GLN A  81
ARG A 105
ALA A 110
PHE A 114
MET A 118
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
None
 0.72A 2jj8C-2jcsA:
29.9		 2jj8C-2jcsA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		10 / 12 VAL A  54
TRP A  57
LEU A  66
MET A  69
PHE A  80
GLN A  81
ARG A 105
ALA A 110
PHE A 114
MET A 118
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
None
 0.58A 2jj8C-2jcsA:
29.9		 2jj8C-2jcsA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 10 ILE A  29
TRP A  57
PHE A  80
GLN A  81
VAL A  84
MET A  88
ARG A 105
ALA A 110
PHE A 114
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-4.8A)
None
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
 0.68A 2jj8D-2jcsA:
30.7		 2jj8D-2jcsA:
99.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
VAL A  54
TRP A  57
LEU A  66
MET A  69
TYR A  70
PHE A  80
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.69A 2no0A-2jcsA:
26.1		 2no0A-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
VAL A  54
TRP A  57
LEU A  66
TYR A  70
PHE A  80
GLN A  81
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.56A 2no0A-2jcsA:
26.1		 2no0A-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		7 / 12 ILE A  29
VAL A  54
TRP A  57
PHE A  80
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.87A 2no0A-2jcsA:
26.1		 2no0A-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		5 / 12 VAL A  54
TRP A  57
MET A  69
PHE A  80
GLU A 171
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.2A)
None
 1.41A 2no0A-2jcsA:
26.1		 2no0A-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
VAL A  54
TRP A  57
LEU A  66
MET A  69
TYR A  70
PHE A  80
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.77A 2no0B-2jcsA:
26.9		 2no0B-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
VAL A  54
TRP A  57
LEU A  66
TYR A  70
PHE A  80
GLN A  81
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.68A 2no0B-2jcsA:
26.9		 2no0B-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		7 / 12 ILE A  29
VAL A  54
TRP A  57
PHE A  80
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.97A 2no0B-2jcsA:
26.9		 2no0B-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		5 / 12 VAL A  54
TRP A  57
MET A  69
PHE A  80
GLU A 171
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.2A)
None
 1.47A 2no0B-2jcsA:
26.9		 2no0B-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_A_ETVA302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
TRP A  57
LEU A  66
MET A  69
TYR A  70
GLN A  81
ARG A 105
PHE A 114
TYR A 179
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
None
 0.74A 2no6A-2jcsA:
25.8		 2no6A-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		8 / 11 ILE A  29
TRP A  57
LEU A  66
MET A  69
TYR A  70
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.74A 2no6B-2jcsA:
26.8		 2no6B-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
TRP A  57
LEU A  66
MET A  69
TYR A  70
PHE A  80
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.69A 2noaA-2jcsA:
25.9		 2noaA-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		7 / 11 ILE A  29
TRP A  57
LEU A  66
TYR A  70
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.79A 2noaB-2jcsA:
26.6		 2noaB-2jcsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		5 / 12 SER A  31
LEU A 180
VAL A 175
HIS A 187
TYR A 152
 TTP  A1210 (-3.3A)
None
None
None
None
 1.31A 2prgB-2jcsA:
0.0		 2prgB-2jcsA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 167
PHE A 168
ALA A  87
ILE A  77
LEU A   6
 None
None
None
None
TTP  A 500 (-4.0A)
 1.07A 2rlcA-2ggqA:
undetectable		 2rlcA-2ggqA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		8 / 12 ILE A  29
TRP A  57
MET A  69
PHE A  80
GLN A  81
ARG A 105
ALA A 110
PHE A 114
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
 0.76A 2vppA-2jcsA:
31.2		 2vppA-2jcsA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
TRP A  57
MET A  69
TYR A  70
PHE A  80
GLN A  81
ALA A 110
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.58A 2vppA-2jcsA:
31.2		 2vppA-2jcsA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		8 / 12 VAL A  54
TRP A  57
MET A  69
PHE A  80
GLN A  81
ARG A 105
ALA A 110
PHE A 114
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
 0.73A 2vppA-2jcsA:
31.2		 2vppA-2jcsA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 VAL A  54
TRP A  57
MET A  69
TYR A  70
PHE A  80
GLN A  81
ALA A 110
PHE A 114
GLU A 172
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.57A 2vppA-2jcsA:
31.2		 2vppA-2jcsA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
VAL A  54
TRP A  57
MET A  69
PHE A  80
GLN A  81
ARG A 105
ALA A 110
PHE A 114
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
 0.77A 2vppB-2jcsA:
29.9		 2vppB-2jcsA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		10 / 12 ILE A  29
VAL A  54
TRP A  57
MET A  69
TYR A  70
PHE A  80
GLN A  81
ALA A 110
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.66A 2vppB-2jcsA:
29.9		 2vppB-2jcsA:
99.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4xjc DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Bacillus
halodurans) 		4 / 9 ILE A 122
ALA A 111
VAL A  95
GLU A  96
 TTP  A 201 (-4.1A)
None
TTP  A 201 ( 4.6A)
None
 0.73A 2vufA-4xjcA:
undetectable		 2vufA-4xjcA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		4 / 6 ALA A 110
ALA A 113
THR A 116
PHE A 129
 TTP  A1586 ( 3.9A)
None
None
None
 1.01A 2xfhA-1h79A:
undetectable		 2xfhA-1h79A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A   8
LEU A 171
LEU A 184
LEU A   6
LEU A 163
 TTP  A 500 (-3.5A)
None
None
TTP  A 500 (-4.0A)
None
 1.10A 2xn5A-2ggqA:
undetectable		 2xn5A-2ggqA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
TRP A  57
MET A  69
TYR A  70
PHE A  80
GLN A  81
ARG A 169
GLU A 172
TYR A 179
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.3A)
TTP  A1210 (-3.6A)
None
 0.71A 2zi9A-2jcsA:
26.2		 2zi9A-2jcsA:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		6 / 12 ILE A  29
TRP A  57
PHE A  80
GLN A  81
ARG A 105
TYR A 179
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
None
 0.97A 2zi9A-2jcsA:
26.2		 2zi9A-2jcsA:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
TRP A  57
MET A  69
TYR A  70
PHE A  80
PHE A 114
ARG A 167
GLU A 172
TYR A 179
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.6A)
None
 0.73A 2zi9B-2jcsA:
25.9		 2zi9B-2jcsA:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
TRP A  57
TYR A  70
PHE A  80
GLN A  81
PHE A 114
ARG A 167
GLU A 172
TYR A 179
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.6A)
None
 0.65A 2zi9B-2jcsA:
25.9		 2zi9B-2jcsA:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		7 / 12 ILE A  29
TRP A  57
GLN A  81
ARG A 105
PHE A 114
GLU A 172
TYR A 179
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
None
 0.82A 2ziaA-2jcsA:
26.6		 2ziaA-2jcsA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 ILE A  29
TRP A  57
LEU A  66
MET A  69
TYR A  70
GLN A  81
PHE A 114
GLU A 172
TYR A 179
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
None
 0.72A 2ziaA-2jcsA:
26.6		 2ziaA-2jcsA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		10 / 12 ILE A  29
VAL A  54
TRP A  57
LEU A  66
MET A  69
TYR A  70
GLN A  81
PHE A 114
GLU A 172
TYR A 179
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
None
 0.75A 2ziaB-2jcsA:
26.6		 2ziaB-2jcsA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Salmonella
enterica) 		5 / 12 ASP A 111
ILE A  52
ASN A 112
LEU A 107
THR A  43
 TTP  A 501 (-3.2A)
None
None
None
None
 1.11A 3eeyA-1mp3A:
undetectable		 3eeyA-1mp3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Salmonella
enterica) 		5 / 12 ASP A 111
ILE A  52
ASN A 112
LEU A 107
THR A  43
 TTP  A 501 (-3.2A)
None
None
None
None
 1.12A 3eeyE-1mp3A:
undetectable		 3eeyE-1mp3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Salmonella
enterica) 		5 / 12 ASP A 111
ILE A  52
ASN A 112
LEU A 107
THR A  43
 TTP  A 501 (-3.2A)
None
None
None
None
 1.13A 3eeyF-1mp3A:
undetectable		 3eeyF-1mp3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Salmonella
enterica) 		5 / 12 ASP A 111
ILE A  52
ASN A 112
LEU A 107
THR A  43
 TTP  A 501 (-3.2A)
None
None
None
None
 1.17A 3eeyI-1mp3A:
undetectable		 3eeyI-1mp3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		5 / 12 SER A  31
LEU A 180
VAL A 175
HIS A 187
TYR A 152
 TTP  A1210 (-3.3A)
None
None
None
None
 1.29A 3g9eA-2jcsA:
undetectable		 3g9eA-2jcsA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4xjc DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Bacillus
halodurans) 		4 / 4 LEU A  17
ALA A  93
VAL A 114
PRO A 116
 None
None
TTP  A 201 ( 4.0A)
None
 0.94A 3gv1B-4xjcA:
undetectable		 3gv1B-4xjcA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		8 / 12 TRP A  57
MET A  69
TYR A  70
PHE A  80
MET A  88
ARG A 105
ALA A 110
PHE A 114
 None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
None
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
 1.07A 3hp1A-2jcsA:
26.4		 3hp1A-2jcsA:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		8 / 12 TRP A  57
TYR A  70
PHE A  80
GLN A  81
MET A  88
ARG A 105
ALA A 110
PHE A 114
 None
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
None
TTP  A1210 (-3.7A)
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
 1.04A 3hp1A-2jcsA:
26.4		 3hp1A-2jcsA:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		5 / 12 VAL A  54
TRP A  57
MET A  69
PHE A  80
GLU A 171
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.2A)
None
 1.27A 3hp1A-2jcsA:
26.4		 3hp1A-2jcsA:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 VAL A  54
TRP A  57
MET A  69
TYR A  70
PHE A  80
MET A  88
ALA A 110
PHE A 114
GLU A 172
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
None
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.86A 3hp1A-2jcsA:
26.4		 3hp1A-2jcsA:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		9 / 12 VAL A  54
TRP A  57
TYR A  70
PHE A  80
GLN A  81
MET A  88
ALA A 110
PHE A 114
GLU A 172
 TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
None
TTP  A1210 (-3.4A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.85A 3hp1A-2jcsA:
26.4		 3hp1A-2jcsA:
29.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 5 ASP A 411
LEU A 415
ARG A 482
LYS A 560
ASP A 623
 CA  A 897 (-2.4A)
TTP  A 896 (-4.3A)
TTP  A 896 (-2.9A)
TTP  A 896 (-2.8A)
CA  A 897 (-2.9A)
 0.67A 3kd5E-3sunA:
49.1		 3kd5E-3sunA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		6 / 9 ILE A  29
GLN A  81
ARG A 105
PHE A 114
TYR A 179
LEU A 183
 TTP  A1210 (-3.9A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
None
None
 0.88A 3mjrA-2jcsA:
23.7		 3mjrA-2jcsA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_B_AC2B401_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		5 / 9 ILE A  29
PHE A  80
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.74A 3mjrB-2jcsA:
23.3		 3mjrB-2jcsA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		4 / 8 PHE A  80
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 1.19A 3mjrD-2jcsA:
21.7		 3mjrD-2jcsA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		4 / 8 TYR A  70
PHE A  80
GLN A  81
ARG A 105
 TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
 0.92A 3mjrD-2jcsA:
21.7		 3mjrD-2jcsA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 2j87 THYMIDINE KINASE
(Vaccinia
virus) 		5 / 9 GLY A  84
ASP A  82
ILE A 105
ILE A  10
ILE A   6
 None
TTP  A 300 (-3.0A)
None
None
None
 0.90A 3s53A-2j87A:
undetectable		 3s53A-2j87A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 125
SER A  83
THR A 127
ASP A  23
 None
None
TTP  A 201 (-4.1A)
None
 1.42A 3tm4B-2qxxA:
undetectable		 3tm4B-2qxxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		3 / 3 PRO A 444
THR A 443
LEU A 448
 TTP  A1589 ( 4.0A)
TTP  A1589 (-4.3A)
TTP  A1589 (-4.0A)
 0.77A 3ttrA-1h79A:
undetectable		 3ttrA-1h79A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 ARG A 256
ARG A 381
GLU A 355
HIS A 305
 TTP  A1601 (-3.2A)
None
None
None
 1.50A 3zmdA-5tusA:
undetectable
3zmdB-5tusA:
undetectable		 3zmdA-5tusA:
14.65
3zmdB-5tusA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		3 / 3 LYS A 103
TYR A 139
ARG A 142
 TTP  A1586 (-4.6A)
None
None
 1.15A 4gc9A-1h79A:
undetectable		 4gc9A-1h79A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Salmonella
enterica) 		4 / 7 ASP A 111
GLN A  26
ASN A 112
ILE A   8
 TTP  A 501 (-3.2A)
TTP  A 501 (-4.0A)
None
None
 1.17A 4ii8A-1mp3A:
undetectable		 4ii8A-1mp3A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 2j87 THYMIDINE KINASE
(Vaccinia
virus) 		5 / 12 GLY A 162
ASN A 163
MET A 165
ILE A 160
LEU A 109
 None
None
None
TTP  A 300 (-4.2A)
TTP  A 300 (-4.8A)
 1.36A 4kovA-2j87A:
undetectable		 4kovA-2j87A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 2j87 THYMIDINE KINASE
(Vaccinia
virus) 		5 / 11 GLY A 162
ASN A 163
MET A 165
ILE A 160
LEU A 109
 None
None
None
TTP  A 300 (-4.2A)
TTP  A 300 (-4.8A)
 1.40A 4koyA-2j87A:
undetectable		 4koyA-2j87A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2j87 THYMIDINE KINASE
(Vaccinia
virus) 		4 / 5 TYR A 166
GLY A 111
ASP A 110
GLU A  83
 TTP  A 300 (-4.0A)
None
None
TTP  A 300 (-3.9A)
 1.01A 4nkvD-2j87A:
undetectable		 4nkvD-2j87A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		5 / 12 SER A  31
LEU A 180
VAL A 175
PHE A 114
HIS A 187
 TTP  A1210 (-3.3A)
None
None
TTP  A1210 (-3.5A)
None
 0.88A 4o8fB-2jcsA:
undetectable		 4o8fB-2jcsA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 124
PHE A  88
PHE A 122
MET A 151
GLY A  18
 None
None
TTP  A 201 ( 3.7A)
None
None
 1.36A 4qa0A-2qxxA:
undetectable		 4qa0A-2qxxA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 6 LYS A 560
ARG A 482
ASP A 623
ASP A 411
 TTP  A 896 (-2.8A)
TTP  A 896 (-2.9A)
CA  A 897 (-2.9A)
CA  A 897 (-2.4A)
 1.30A 5hp1C-3sunA:
3.0		 5hp1C-3sunA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		6 / 12 ILE A  29
PRO A  73
GLN A  81
ARG A 105
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.96A 5mqtA-2jcsA:
23.5		 5mqtA-2jcsA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 2jcs DEOXYNUCLEOSIDE
KINASE
(Drosophila
melanogaster) 		6 / 12 ILE A  29
PRO A  73
GLN A  81
ARG A 105
GLU A 172
TYR A 179
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.6A)
None
 0.79A 5mqtC-2jcsA:
24.2		 5mqtC-2jcsA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		5 / 12 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.02A 5n0oA-1h79A:
1.6		 5n0oA-1h79A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		5 / 12 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.02A 5n0oB-1h79A:
2.3		 5n0oB-1h79A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		5 / 12 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 0.99A 5n0sA-1h79A:
2.3		 5n0sA-1h79A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		5 / 12 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.08A 5n0tA-1h79A:
0.8		 5n0tA-1h79A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		5 / 12 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.04A 5n0wA-1h79A:
2.1		 5n0wA-1h79A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		5 / 12 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.03A 5n0wB-1h79A:
undetectable		 5n0wB-1h79A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		5 / 12 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.04A 5n0xA-1h79A:
undetectable		 5n0xA-1h79A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		5 / 12 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.02A 5n0xB-1h79A:
2.4		 5n0xB-1h79A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN
(Escherichia
virus
T4) 		5 / 12 ILE A 402
GLY A 403
HIS A 405
VAL A 466
ALA A 445
 None
None
None
None
TTP  A1589 (-4.8A)
 1.01A 5n4iA-1h79A:
0.7		 5n4iA-1h79A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Salmonella
enterica) 		5 / 8 GLY A 175
LEU A 109
LEU A  53
ILE A 200
ILE A 100
 None
TTP  A 501 ( 3.9A)
None
None
None
 1.16A 5vkqB-1mp3A:
undetectable
5vkqC-1mp3A:
undetectable		 5vkqB-1mp3A:
10.67
5vkqC-1mp3A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Salmonella
enterica) 		5 / 9 GLN A  91
GLN A  83
ASP A 111
GLY A 196
SER A 193
 None
TTP  A 501 (-2.9A)
TTP  A 501 (-3.2A)
None
None
 1.33A 5x7pA-1mp3A:
0.3		 5x7pA-1mp3A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Salmonella
enterica) 		4 / 6 VAL A 289
TYR A 284
GLU A 256
ARG A 260
 None
None
TTP  A 504 (-3.5A)
None
 0.99A 5z3jA-1mp3A:
undetectable		 5z3jA-1mp3A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Salmonella
enterica) 		4 / 6 GLN A  83
GLU A 197
ALA A  90
GLN A  91
 TTP  A 501 (-2.9A)
TTP  A 501 ( 4.9A)
None
None
 1.45A 6f6jC-1mp3A:
0.0
6f6jD-1mp3A:
0.0		 6f6jC-1mp3A:
20.75
6f6jD-1mp3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		3 / 3 ASP A 714
ASP A 411
ASN A 564
 None
CA  A 897 (-2.4A)
TTP  A 896 (-3.2A)
 0.79A 6gngB-3sunA:
undetectable		 6gngB-3sunA:
21.04