SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TTB'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XDK_B_9CRB600_1 (RETINOIC ACIDRECEPTOR, BETA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 10 / 12 | PHE A 221ALA A 225CYH A 228LEU A 259LEU A 262ILE A 263ILE A 266ARG A 269SER A 280PHE A 295 | TTB A 1 (-4.7A)TTB A 1 (-4.0A)TTB A 1 ( 3.8A)TTB A 1 ( 4.9A)TTB A 1 (-3.9A)TTB A 1 ( 4.9A)TTB A 1 ( 4.0A)TTB A 1 (-3.3A)TTB A 1 (-3.1A)TTB A 1 ( 4.1A) | 0.46A | 1xdkB-1xapA:37.1 | 1xdkB-1xapA:92.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XDK_B_9CRB600_2 (RETINOIC ACIDRECEPTOR, BETA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 3 / 3 | LEU A 224PHE A 279ARG A 387 | TTB A 1 (-4.4A)TTB A 1 (-4.6A)None | 0.19A | 1xdkB-1xapA:37.1 | 1xdkB-1xapA:92.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XDK_F_9CRF1600_1 (RETINOIC ACIDRECEPTOR, BETA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 6 / 12 | PHE A 221ALA A 225ARG A 269SER A 280PHE A 295LEU A 298 | TTB A 1 (-4.7A)TTB A 1 (-4.0A)TTB A 1 (-3.3A)TTB A 1 (-3.1A)TTB A 1 ( 4.1A)None | 0.63A | 1xdkF-1xapA:37.1 | 1xdkF-1xapA:92.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XDK_F_9CRF1600_1 (RETINOIC ACIDRECEPTOR, BETA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 10 / 12 | PHE A 221ALA A 225CYH A 228LEU A 259LEU A 262ILE A 263ILE A 266ARG A 269SER A 280PHE A 295 | TTB A 1 (-4.7A)TTB A 1 (-4.0A)TTB A 1 ( 3.8A)TTB A 1 ( 4.9A)TTB A 1 (-3.9A)TTB A 1 ( 4.9A)TTB A 1 ( 4.0A)TTB A 1 (-3.3A)TTB A 1 (-3.1A)TTB A 1 ( 4.1A) | 0.46A | 1xdkF-1xapA:37.1 | 1xdkF-1xapA:92.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XDK_F_9CRF1600_2 (RETINOIC ACIDRECEPTOR, BETA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 3 / 3 | LEU A 224PHE A 279ARG A 387 | TTB A 1 (-4.4A)TTB A 1 (-4.6A)None | 0.21A | 1xdkF-1xapA:37.1 | 1xdkF-1xapA:92.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AVV_E_MK1E902_4 (POL POLYPROTEIN) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 3 / 3 | ARG A 269VAL A 302GLY A 294 | TTB A 1 (-3.3A)NoneNone | 0.61A | 2avvE-1xapA:undetectable | 2avvE-1xapA:17.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2LBD_A_REAA500_1 (RETINOIC ACIDRECEPTOR GAMMA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 10 / 12 | PHE A 221LYS A 227CYH A 228LEU A 262ARG A 265ILE A 266ARG A 269PHE A 279SER A 280LEU A 391 | TTB A 1 (-4.7A)NoneTTB A 1 ( 3.8A)TTB A 1 (-3.9A)NoneTTB A 1 ( 4.0A)TTB A 1 (-3.3A)TTB A 1 (-4.6A)TTB A 1 (-3.1A)None | 0.53A | 2lbdA-1xapA:38.3 | 2lbdA-1xapA:87.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2LBD_A_REAA500_1 (RETINOIC ACIDRECEPTOR GAMMA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 9 / 12 | PHE A 221LYS A 227CYH A 228LEU A 262ARG A 265PHE A 279SER A 280GLY A 384LEU A 391 | TTB A 1 (-4.7A)NoneTTB A 1 ( 3.8A)TTB A 1 (-3.9A)NoneTTB A 1 (-4.6A)TTB A 1 (-3.1A)TTB A 1 ( 4.0A)None | 0.65A | 2lbdA-1xapA:38.3 | 2lbdA-1xapA:87.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3A9E_B_REAB1_1 (RETINOIC ACIDRECEPTOR ALPHA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 5 / 11 | ILE A 266ARG A 269PHE A 279SER A 280LEU A 213 | TTB A 1 ( 4.0A)TTB A 1 (-3.3A)TTB A 1 (-4.6A)TTB A 1 (-3.1A)None | 1.30A | 3a9eB-1xapA:37.2 | 3a9eB-1xapA:81.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3A9E_B_REAB1_1 (RETINOIC ACIDRECEPTOR ALPHA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 10 / 11 | PHE A 221CYH A 228LEU A 262ILE A 266ARG A 269PHE A 279SER A 280PHE A 295VAL A 388LEU A 391 | TTB A 1 (-4.7A)TTB A 1 ( 3.8A)TTB A 1 (-3.9A)TTB A 1 ( 4.0A)TTB A 1 (-3.3A)TTB A 1 (-4.6A)TTB A 1 (-3.1A)TTB A 1 ( 4.1A)TTB A 1 (-4.3A)None | 0.49A | 3a9eB-1xapA:37.2 | 3a9eB-1xapA:81.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3LBD_A_9CRA424_1 (RETINOIC ACIDRECEPTOR GAMMA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 9 / 12 | PHE A 221ALA A 225LEU A 259LEU A 262ILE A 266ARG A 269SER A 280PHE A 295ILE A 403 | TTB A 1 (-4.7A)TTB A 1 (-4.0A)TTB A 1 ( 4.9A)TTB A 1 (-3.9A)TTB A 1 ( 4.0A)TTB A 1 (-3.3A)TTB A 1 (-3.1A)TTB A 1 ( 4.1A)TTB A 1 ( 4.8A) | 0.34A | 3lbdA-1xapA:38.2 | 3lbdA-1xapA:87.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3LBD_A_9CRA424_1 (RETINOIC ACIDRECEPTOR GAMMA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 7 / 12 | PHE A 221ALA A 225LEU A 259LEU A 262SER A 280GLY A 384ILE A 403 | TTB A 1 (-4.7A)TTB A 1 (-4.0A)TTB A 1 ( 4.9A)TTB A 1 (-3.9A)TTB A 1 (-3.1A)TTB A 1 ( 4.0A)TTB A 1 ( 4.8A) | 0.69A | 3lbdA-1xapA:38.2 | 3lbdA-1xapA:87.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4DM8_A_REAA501_1 (RETINOIC ACIDRECEPTOR BETA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 11 / 11 | PHE A 221CYH A 228LEU A 259LEU A 262ILE A 263ARG A 269PHE A 279SER A 280LEU A 298LEU A 391ILE A 403 | TTB A 1 (-4.7A)TTB A 1 ( 3.8A)TTB A 1 ( 4.9A)TTB A 1 (-3.9A)TTB A 1 ( 4.9A)TTB A 1 (-3.3A)TTB A 1 (-4.6A)TTB A 1 (-3.1A)NoneNoneTTB A 1 ( 4.8A) | 0.48A | 4dm8A-1xapA:38.3 | 4dm8A-1xapA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4DM8_B_REAB1501_1 (RETINOIC ACIDRECEPTOR BETA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 8 / 12 | PHE A 192LEU A 224LEU A 259ILE A 263ARG A 269SER A 280PHE A 295LEU A 391 | NoneTTB A 1 (-4.4A)TTB A 1 ( 4.9A)TTB A 1 ( 4.9A)TTB A 1 (-3.3A)TTB A 1 (-3.1A)TTB A 1 ( 4.1A)None | 0.78A | 4dm8B-1xapA:38.2 | 4dm8B-1xapA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4DM8_B_REAB1501_1 (RETINOIC ACIDRECEPTOR BETA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 11 / 12 | PHE A 221LEU A 224ALA A 225LEU A 259LEU A 262ILE A 263ARG A 269SER A 280PHE A 295GLY A 384LEU A 391 | TTB A 1 (-4.7A)TTB A 1 (-4.4A)TTB A 1 (-4.0A)TTB A 1 ( 4.9A)TTB A 1 (-3.9A)TTB A 1 ( 4.9A)TTB A 1 (-3.3A)TTB A 1 (-3.1A)TTB A 1 ( 4.1A)TTB A 1 ( 4.0A)None | 0.65A | 4dm8B-1xapA:38.2 | 4dm8B-1xapA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5M24_A_9CRA501_1 (RETINOIC ACIDRECEPTOR GAMMA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 11 / 12 | TRP A 218PHE A 221ALA A 225LEU A 262ILE A 266ARG A 269SER A 280PHE A 295GLY A 384LEU A 391ILE A 403 | NoneTTB A 1 (-4.7A)TTB A 1 (-4.0A)TTB A 1 (-3.9A)TTB A 1 ( 4.0A)TTB A 1 (-3.3A)TTB A 1 (-3.1A)TTB A 1 ( 4.1A)TTB A 1 ( 4.0A)NoneTTB A 1 ( 4.8A) | 0.74A | 5m24A-1xapA:38.4 | 5m24A-1xapA:86.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5UAN_B_REAB503_1 (RETINOIC ACIDRECEPTOR BETA) |
1xap | RETINOIC ACIDRECEPTOR BETA (Homosapiens) | 11 / 12 | PHE A 221ALA A 225CYH A 228LEU A 259LEU A 262ILE A 263ILE A 266PHE A 279SER A 280PHE A 295VAL A 388 | TTB A 1 (-4.7A)TTB A 1 (-4.0A)TTB A 1 ( 3.8A)TTB A 1 ( 4.9A)TTB A 1 (-3.9A)TTB A 1 ( 4.9A)TTB A 1 ( 4.0A)TTB A 1 (-4.6A)TTB A 1 (-3.1A)TTB A 1 ( 4.1A)TTB A 1 (-4.3A) | 0.54A | 5uanB-1xapA:37.1 | 5uanB-1xapA:73.55 |