SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TSS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 2pql D7R4 PROTEIN
(Anopheles
gambiae) 		4 / 5 LEU A  10
PRO A  11
LEU A  14
ILE A  21
 None
None
None
TSS  A 145 (-4.8A)
 0.89A 2qd4A-2pqlA:
undetectable		 2qd4A-2pqlA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 2pql D7R4 PROTEIN
(Anopheles
gambiae) 		7 / 7 ILE A  21
ARG A  22
TYR A  24
TYR A  94
PHE A 110
ASP A 111
GLU A 114
 TSS  A 145 (-4.8A)
TSS  A 145 (-3.5A)
TSS  A 145 (-3.4A)
None
TSS  A 145 (-4.4A)
TSS  A 145 (-3.5A)
TSS  A 145 (-3.6A)
 0.31A 2qebA-2pqlA:
29.0		 2qebA-2pqlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 2pql D7R4 PROTEIN
(Anopheles
gambiae) 		7 / 7 ILE A  21
ARG A  22
TYR A  24
TYR A  94
PHE A 110
ASP A 111
GLU A 114
 TSS  A 145 (-4.8A)
TSS  A 145 (-3.5A)
TSS  A 145 (-3.4A)
None
TSS  A 145 (-4.4A)
TSS  A 145 (-3.5A)
TSS  A 145 (-3.6A)
 0.34A 2qebB-2pqlA:
29.0		 2qebB-2pqlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 2pql D7R4 PROTEIN
(Anopheles
gambiae) 		12 / 12 GLU A   7
ARG A  22
TYR A  24
HIS A  35
ILE A  36
VAL A  39
TYR A  94
PHE A 110
ASP A 111
GLU A 114
MET A 135
ASP A 139
 TSS  A 145 ( 4.9A)
TSS  A 145 (-3.5A)
TSS  A 145 (-3.4A)
TSS  A 145 (-4.3A)
None
TSS  A 145 ( 4.6A)
None
TSS  A 145 (-4.4A)
TSS  A 145 (-3.5A)
TSS  A 145 (-3.6A)
TSS  A 145 (-3.5A)
TSS  A 145 ( 4.7A)
 0.36A 2qeoA-2pqlA:
29.0		 2qeoA-2pqlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 2pql D7R4 PROTEIN
(Anopheles
gambiae) 		10 / 10 GLU A   7
ILE A  21
ARG A  22
TYR A  24
HIS A  35
ILE A  36
TYR A  94
ASP A 111
GLU A 114
ASP A 139
 TSS  A 145 ( 4.9A)
TSS  A 145 (-4.8A)
TSS  A 145 (-3.5A)
TSS  A 145 (-3.4A)
TSS  A 145 (-4.3A)
None
None
TSS  A 145 (-3.5A)
TSS  A 145 (-3.6A)
TSS  A 145 ( 4.7A)
 0.43A 2qeoB-2pqlA:
29.0		 2qeoB-2pqlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DYE_A_LNRA600_1
(D7 PROTEIN)		 2pql D7R4 PROTEIN
(Anopheles
gambiae) 		8 / 9 GLU A   7
ILE A  21
ARG A  22
TYR A  24
HIS A  35
TYR A  94
ASP A 111
GLU A 114
 TSS  A 145 ( 4.9A)
TSS  A 145 (-4.8A)
TSS  A 145 (-3.5A)
TSS  A 145 (-3.4A)
TSS  A 145 (-4.3A)
None
TSS  A 145 (-3.5A)
TSS  A 145 (-3.6A)
 0.42A 3dyeA-2pqlA:
16.8		 3dyeA-2pqlA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pql D7R4 PROTEIN
(Anopheles
gambiae) 		4 / 4 LEU A  10
PRO A  11
LEU A  14
ILE A  21
 None
None
None
TSS  A 145 (-4.8A)
 0.93A 4f4dB-2pqlA:
undetectable		 4f4dB-2pqlA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2pql D7R4 PROTEIN
(Anopheles
gambiae) 		3 / 3 THR A 102
THR A 105
PHE A 110
 None
None
TSS  A 145 (-4.4A)
 0.84A 5cxvA-2pqlA:
undetectable		 5cxvA-2pqlA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2pql D7R4 PROTEIN
(Anopheles
gambiae) 		3 / 3 PHE A 110
ARG A  22
ALA A 118
 TSS  A 145 (-4.4A)
TSS  A 145 (-3.5A)
None
 0.90A 6ecfB-2pqlA:
undetectable		 6ecfB-2pqlA:
17.97