SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TSB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 10 ARG A 421
SER A 423
ALA A 465
ALA A 466
THR A 488
 None
None
None
None
TSB  A1002 ( 4.5A)
 1.19A 1gtnB-1nyqA:
0.0
1gtnC-1nyqA:
0.0		 1gtnB-1nyqA:
7.93
1gtnC-1nyqA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 10 ARG A 421
SER A 423
ALA A 465
ALA A 466
THR A 488
 None
None
None
None
TSB  A1002 ( 4.5A)
 1.19A 1gtnH-1nyqA:
0.0
1gtnI-1nyqA:
0.0		 1gtnH-1nyqA:
7.93
1gtnI-1nyqA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 VAL A 215
LEU A 197
THR A 199
LEU A 200
 TSB  A 999 (-3.8A)
None
None
None
 0.87A 1jgsA-1wk9A:
undetectable		 1jgsA-1wk9A:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NYR_A_THRA1004_0
(THREONYL-TRNA
SYNTHETASE 1)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		8 / 10 MET A 332
CYH A 334
ARG A 363
ASP A 383
HIS A 385
TYR A 462
GLN A 484
HIS A 511
 TSB  A2002 (-3.4A)
ZN  A   1 ( 2.4A)
TSB  A2002 (-2.7A)
TSB  A2002 (-2.8A)
ZN  A   1 ( 3.3A)
None
TSB  A2002 (-3.3A)
ZN  A   1 ( 3.2A)
 0.35A 1nyrA-1evlA:
52.6		 1nyrA-1evlA:
41.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NYR_A_THRA1004_0
(THREONYL-TRNA
SYNTHETASE 1)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		10 / 10 MET A 334
CYH A 336
MET A 363
ARG A 365
LEU A 383
ASP A 385
HIS A 387
TYR A 468
GLN A 490
HIS A 517
 TSB  A1002 (-3.2A)
ZN  A1001 ( 2.1A)
TSB  A1002 ( 4.1A)
TSB  A1002 (-2.5A)
TSB  A1002 (-4.6A)
TSB  A1002 (-3.1A)
ZN  A1001 ( 3.3A)
None
TSB  A1002 (-3.6A)
ZN  A1001 ( 3.0A)
 0.42A 1nyrA-1nyqA:
59.1		 1nyrA-1nyqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NYR_B_THRB2004_0
(THREONYL-TRNA
SYNTHETASE 1)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		8 / 10 MET A 332
CYH A 334
ARG A 363
ASP A 383
HIS A 385
TYR A 462
GLN A 484
HIS A 511
 TSB  A2002 (-3.4A)
ZN  A   1 ( 2.4A)
TSB  A2002 (-2.7A)
TSB  A2002 (-2.8A)
ZN  A   1 ( 3.3A)
None
TSB  A2002 (-3.3A)
ZN  A   1 ( 3.2A)
 0.73A 1nyrB-1evlA:
49.3		 1nyrB-1evlA:
41.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NYR_B_THRB2004_0
(THREONYL-TRNA
SYNTHETASE 1)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		10 / 10 MET A 334
CYH A 336
MET A 363
ARG A 365
LEU A 383
ASP A 385
HIS A 387
TYR A 468
GLN A 490
HIS A 517
 TSB  A1002 (-3.2A)
ZN  A1001 ( 2.1A)
TSB  A1002 ( 4.1A)
TSB  A1002 (-2.5A)
TSB  A1002 (-4.6A)
TSB  A1002 (-3.1A)
ZN  A1001 ( 3.3A)
None
TSB  A1002 (-3.6A)
ZN  A1001 ( 3.0A)
 0.60A 1nyrB-1nyqA:
53.8		 1nyrB-1nyqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 THR A 523
GLU A 484
HIS A 243
 TSB  A1002 (-2.9A)
None
None
 0.84A 1xwfA-1nyqA:
0.0		 1xwfA-1nyqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 THR A 523
GLU A 484
HIS A 243
 TSB  A1002 (-2.9A)
None
None
 0.82A 1xwfB-1nyqA:
0.0		 1xwfB-1nyqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 THR A 523
GLU A 484
HIS A 243
 TSB  A1002 (-2.9A)
None
None
 0.85A 1xwfC-1nyqA:
0.0		 1xwfC-1nyqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 THR A 523
GLU A 484
HIS A 243
 TSB  A1002 (-2.9A)
None
None
 0.80A 1xwfD-1nyqA:
2.1		 1xwfD-1nyqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 TYR A 313
ARG A 363
TYR A 462
GLY A 459
ALA A 460
 None
TSB  A2002 (-2.7A)
None
None
None
 1.24A 2cojA-1evlA:
undetectable
2cojB-1evlA:
undetectable		 2cojA-1evlA:
23.97
2cojB-1evlA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 LEU A 277
GLY A 516
GLN A 381
THR A 380
 None
TSB  A2002 (-3.3A)
TSB  A2002 (-3.2A)
None
 0.71A 2wd9B-1evlA:
undetectable		 2wd9B-1evlA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
HIS A 275
LEU A 288
ALA A 227
THR A 214
 TSB  A 999 (-4.1A)
None
None
None
TSB  A 999 (-4.4A)
 0.96A 3dfrA-1wk9A:
undetectable		 3dfrA-1wk9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 285
PHE A 358
MET A 518
GLY A 516
LEU A 515
 None
None
None
TSB  A2002 (-3.3A)
None
 1.23A 4j7xB-1evlA:
undetectable		 4j7xB-1evlA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		7 / 8 ARG A 363
ARG A 375
PHE A 379
GLN A 479
GLY A 481
THR A 482
ARG A 520
 TSB  A2002 (-2.7A)
None
TSB  A2002 (-3.6A)
TSB  A2002 (-3.6A)
None
TSB  A2002 (-4.3A)
TSB  A2002 (-3.9A)
 0.70A 4k87A-1evlA:
27.2		 4k87A-1evlA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 8 ARG A 365
THR A 488
THR A 523
ARG A 526
 TSB  A1002 (-2.5A)
TSB  A1002 ( 4.5A)
TSB  A1002 (-2.9A)
TSB  A1002 (-3.5A)
 0.70A 4k87A-1nyqA:
27.3		 4k87A-1nyqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 THR A 219
THR A 272
ASP A 223
TYR A 202
 TSB  A 999 (-3.8A)
TSB  A 999 (-2.5A)
None
None
 1.19A 4oltA-1wk9A:
undetectable		 4oltA-1wk9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 THR A 219
THR A 272
ASP A 223
TYR A 202
 TSB  A 999 (-3.8A)
TSB  A 999 (-2.5A)
None
None
 1.18A 4oltB-1wk9A:
undetectable		 4oltB-1wk9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 THR A 219
THR A 272
ASP A 223
TYR A 202
 TSB  A 999 (-3.8A)
TSB  A 999 (-2.5A)
None
None
 1.18A 4qwpA-1wk9A:
undetectable		 4qwpA-1wk9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 THR A 219
THR A 272
ASP A 223
TYR A 202
 TSB  A 999 (-3.8A)
TSB  A 999 (-2.5A)
None
None
 1.14A 4qwpB-1wk9A:
0.0		 4qwpB-1wk9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 12 TYR A 468
PHE A 493
ASN A 335
LEU A 383
MET A 363
 None
None
None
TSB  A1002 (-4.6A)
TSB  A1002 ( 4.1A)
 1.40A 5l7iA-1nyqA:
0.0		 5l7iA-1nyqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1wk9 VALYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 THR A 219
PRO A 217
TYR A 198
GLY A 195
 TSB  A 999 (-3.8A)
None
None
None
 0.77A 5nzyA-1wk9A:
undetectable		 5nzyA-1wk9A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLU A 365
PRO A 331
ARG A 363
HIS A 385
THR A 482
 TSB  A2002 (-3.7A)
None
TSB  A2002 (-2.7A)
ZN  A   1 ( 3.3A)
TSB  A2002 (-4.3A)
 1.40A 5xioB-1evlA:
27.5		 5xioB-1evlA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 12 GLU A 367
PRO A 333
ARG A 365
HIS A 387
THR A 488
 TSB  A1002 ( 3.9A)
None
TSB  A1002 (-2.5A)
ZN  A1001 ( 3.3A)
TSB  A1002 ( 4.5A)
 1.37A 5xioB-1nyqA:
27.3		 5xioB-1nyqA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 12 PRO A 333
ARG A 365
HIS A 387
THR A 488
GLY A 519
 None
TSB  A1002 (-2.5A)
ZN  A1001 ( 3.3A)
TSB  A1002 ( 4.5A)
TSB  A1002 ( 4.5A)
 0.75A 5xipA-1nyqA:
27.4		 5xipA-1nyqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 12 PRO A 333
ARG A 365
HIS A 387
THR A 488
GLY A 519
 None
TSB  A1002 (-2.5A)
ZN  A1001 ( 3.3A)
TSB  A1002 ( 4.5A)
TSB  A1002 ( 4.5A)
 0.75A 5xiqD-1nyqA:
27.5		 5xiqD-1nyqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 ARG A 363
GLU A 365
PHE A 379
GLY A 516
ARG A 520
 TSB  A2002 (-2.7A)
TSB  A2002 (-3.7A)
TSB  A2002 (-3.6A)
TSB  A2002 (-3.3A)
TSB  A2002 (-3.9A)
 0.66A 6bniA-1evlA:
11.2		 6bniA-1evlA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 ARG A 363
GLU A 365
PHE A 379
GLY A 516
ARG A 520
 TSB  A2002 (-2.7A)
TSB  A2002 (-3.7A)
TSB  A2002 (-3.6A)
TSB  A2002 (-3.3A)
TSB  A2002 (-3.9A)
 0.63A 6bniB-1evlA:
12.7		 6bniB-1evlA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 HIS A 339
ASN A 335
LEU A 383
 None
None
TSB  A1002 (-4.6A)
 0.90A 6f7lB-1nyqA:
undetectable		 6f7lB-1nyqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 8 ASP A 385
ARG A 518
HIS A 387
GLU A 285
 TSB  A1002 (-3.1A)
None
ZN  A1001 ( 3.3A)
None
 1.18A 6mn4D-1nyqA:
undetectable		 6mn4D-1nyqA:
18.10