SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TRX'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA130_1 (FATTY ACID-BINDING PROTEIN)	5n28	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE, GAMMA SUBUNIT (Methanotorris formicicus; Methanotorris formicicus)	3 / 3	TYR A 490 ARG C 245 GLN A 453	TRX A 429 ( 4.8A) None None	0.98A	1tw4A-5n28A: undetectable	1tw4A-5n28A: 13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQ4_A_SAMA500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2)	5n28	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanotorris formicicus)	5 / 12	TYR A 430 GLY A 425 SER A 468 TYR A 477 CYH A 454	TRX A 429 ( 3.6A) None None None None	1.50A	3rq4A-5n28A: 2.9	3rq4A-5n28A: 19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEG_A_DAHA416_1 (PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL)	5n28	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanotorris formicicus)	5 / 12	GLN A 433 PHE A 445 GLY A 400 ALA A 404 GLY A 485	TRX A 429 ( 4.3A) GL3 A 447 (-4.1A) MGN A 402 ( 4.4A) None TRX A 429 ( 4.5A)	1.14A	3tegA-5n28A: 4.0	3tegA-5n28A: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UJ7_B_SAMB302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	5n28	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanotorris formicicus)	5 / 12	GLY A 428 GLY A 425 ILE A 493 ALA A 376 LEU A 435	TRX A 429 ( 2.4A) None None None None	1.15A	3uj7B-5n28A: undetectable	3uj7B-5n28A: 18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_C7HA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	5n28	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE, BETA SUBUNIT (Methanotorris formicicus)	4 / 5	TYR B 368 GLY A 331 TYR A 335 GLY A 485	TP7 A 603 (-4.2A) None None TRX A 429 ( 4.5A)	1.02A	5ayfA-5n28B: undetectable	5ayfA-5n28B: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YSI_A_NCAA1001_0 (UBIQUITINATING/DEUBI QUITINATING ENZYME SDEA)	5n28	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanotorris formicicus)	4 / 6	GLY A 428 SER A 414 THR A 419 VAL A 372	TRX A 429 ( 2.4A) None None None	1.22A	5ysiA-5n28A: undetectable	5ysiA-5n28A: 13.19

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1TW4_A_CHDA130_1","FATTY ACID-BINDING PROTEIN","5n28","METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE, GAMMA SUBUNIT","Methanotorris formicicus;Methanotorris formicicus",3,"TYR A 490;ARG C 245;GLN A 453","TRX A 429 ( 4.8A);None;None","0.98A","1tw4A-5n28A:undetectable",null],["3RQ4_A_SAMA500_0","HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2","5n28","METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA","Methanotorris formicicus",5,"TYR A 430;GLY A 425;SER A 468;TYR A 477;CYH A 454","TRX A 429 ( 3.6A);None;None;None;None","1.50A","3rq4A-5n28A:2.9","1tw4A-5n28A:13.70"],["3TEG_A_DAHA416_1","PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL","5n28","METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA","Methanotorris formicicus",5,"GLN A 433;PHE A 445;GLY A 400;ALA A 404;GLY A 485","TRX A 429 ( 4.3A);GL3 A 447 (-4.1A);MGN A 402 ( 4.4A);None;TRX A 429 ( 4.5A)","1.14A","3tegA-5n28A:4.0","3rq4A-5n28A:19.62"],["3UJ7_B_SAMB302_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE","5n28","METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA","Methanotorris formicicus",5,"GLY A 428;GLY A 425;ILE A 493;ALA A 376;LEU A 435","TRX A 429 ( 2.4A);None;None;None;None","1.15A","3uj7B-5n28A:undetectable","3tegA-5n28A:21.03"],["5AYF_A_C7HA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE SETD7","5n28","METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE, BETA SUBUNIT","Methanotorris formicicus",4,"TYR B 368;GLY A 331;TYR A 335;GLY A 485","TP7 A 603 (-4.2A);None;None;TRX A 429 ( 4.5A)","1.02A","5ayfA-5n28B:undetectable","3uj7B-5n28A:18.44"],["5YSI_A_NCAA1001_0","UBIQUITINATING\/DEUBIQUITINATING ENZYME SDEA","5n28","METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA","Methanotorris formicicus",4,"GLY A 428;SER A 414;THR A 419;VAL A 372","TRX A 429 ( 2.4A);None;None;None","1.22A","5ysiA-5n28A:undetectable","5ayfA-5n28B:19.82"]]