SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TRE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 9 VAL A  26
GLY A  27
ASP A  52
ALA A  96
ILE A 116
 None
TRE  A 334 ( 4.0A)
TRE  A 334 (-2.5A)
TRE  A 334 (-3.6A)
TRE  A 334 ( 4.6A)
 0.53A 1cetA-1v6aA:
38.5		 1cetA-1v6aA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 9 VAL A  26
GLY A  27
ASP A  52
TYR A  83
ALA A  96
 None
TRE  A 334 ( 4.0A)
TRE  A 334 (-2.5A)
None
TRE  A 334 (-3.6A)
 0.57A 1cetA-1v6aA:
38.5		 1cetA-1v6aA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		3 / 3 ASP A 180
ASP A 174
LYS A 187
 TRE  A2001 (-4.0A)
None
None
 1.00A 1lqtB-3a9gA:
undetectable		 1lqtB-3a9gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		3 / 3 ASP A 180
ASP A 174
LYS A 187
 TRE  A2001 (-4.0A)
None
None
 1.00A 1lquB-3a9gA:
undetectable		 1lquB-3a9gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 6 TYR A 128
GLU A 186
TYR A 259
GLY A 262
 None
None
TRE  A 563 (-4.1A)
None
 1.10A 1maaB-1eu8A:
undetectable
1maaD-1eu8A:
undetectable		 1maaB-1eu8A:
24.35
1maaD-1eu8A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4zrw MINCLE PROTEIN
(Bos
taurus) 		5 / 11 GLU A 135
GLU A 176
PRO A 195
ALA A 179
GLY A 139
 TRE  A 301 (-2.7A)
TRE  A 301 (-2.6A)
None
None
None
 1.34A 1mjqA-4zrwA:
undetectable
1mjqB-4zrwA:
undetectable		 1mjqA-4zrwA:
18.12
1mjqB-4zrwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4zrw MINCLE PROTEIN
(Bos
taurus) 		5 / 10 GLU A 135
GLU A 176
PRO A 195
ALA A 179
GLY A 139
 TRE  A 301 (-2.7A)
TRE  A 301 (-2.6A)
None
None
None
 1.31A 1mjqC-4zrwA:
undetectable
1mjqD-4zrwA:
undetectable		 1mjqC-4zrwA:
18.12
1mjqD-4zrwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4zrw MINCLE PROTEIN
(Bos
taurus) 		5 / 11 GLU A 135
GLU A 176
PRO A 195
ALA A 179
GLY A 139
 TRE  A 301 (-2.7A)
TRE  A 301 (-2.6A)
None
None
None
 1.32A 1mjqI-4zrwA:
undetectable
1mjqJ-4zrwA:
undetectable		 1mjqI-4zrwA:
18.12
1mjqJ-4zrwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		5 / 12 GLU A  47
ASP A  70
ARG A 364
ILE A 377
ALA A 402
 None
TRE  A 563 (-2.8A)
TRE  A 563 (-2.8A)
None
None
 1.33A 1oltA-1eu8A:
0.2		 1oltA-1eu8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 296
ARG A 199
TYR A 351
TYR A 352
 None
None
None
TRE  A 801 (-4.8A)
 1.18A 2ajvH-5m4aA:
undetectable
2ajvL-5m4aA:
undetectable		 2ajvH-5m4aA:
17.29
2ajvL-5m4aA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 5 GLU A  17
PRO A  15
ILE A  18
GLY A  13
 TRE  A 563 (-2.9A)
None
None
TRE  A 563 (-3.1A)
 1.14A 2qeuA-1eu8A:
0.0
2qeuC-1eu8A:
0.0		 2qeuA-1eu8A:
16.54
2qeuC-1eu8A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		3 / 3 ARG A 143
ARG A 142
PRO A  37
 None
TRE  A 403 (-3.8A)
TRE  A 403 (-4.0A)
 1.07A 2wljA-5dxiA:
3.1		 2wljA-5dxiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 8 TYR A 177
GLU A 178
SER A 374
GLN A 378
 TRE  A 563 (-4.7A)
None
None
None
 0.82A 3b9lA-1eu8A:
0.4		 3b9lA-1eu8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 714
ILE A 189
GLY A 705
PHE A 706
LEU A 318
 None
None
None
TRE  A 801 (-4.7A)
None
 1.28A 3elzB-5m4aA:
undetectable		 3elzB-5m4aA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 10 GLN A 357
MET A 330
ASN A 348
GLY A 308
GLY A 300
 TRE  A 801 (-3.7A)
None
None
None
None
 1.35A 3v3oD-5m4aA:
undetectable		 3v3oD-5m4aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 7 ASP A 230
GLY A  66
THR A  29
LYS A 188
 MG  A 401 (-2.6A)
TRE  A 403 ( 3.4A)
None
BEF  A 402 (-2.7A)
 1.07A 3vnsA-5dxiA:
undetectable		 3vnsA-5dxiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 6 TYR A 121
ARG A  49
GLN A 322
GLU A  27
 TRE  A 563 (-4.5A)
TRE  A 563 (-3.9A)
None
None
 1.08A 4azvA-1eu8A:
undetectable		 4azvA-1eu8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 6czs -
(-) 		4 / 4 ASN A 320
ALA A 326
GLY A 323
THR A 275
 TRE  A 413 (-4.1A)
None
None
None
 1.25A 4bboC-6czsA:
undetectable		 4bboC-6czsA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		8 / 9 ASP A  52
VAL A  53
TYR A  83
ALA A  96
ARG A  99
ARG A 112
ILE A 116
ILE A 120
 TRE  A 334 (-2.5A)
TRE  A 334 ( 4.9A)
None
TRE  A 334 (-3.6A)
TRE  A 334 (-4.6A)
None
TRE  A 334 ( 4.6A)
None
 1.04A 4oknB-1v6aA:
51.3		 4oknB-1v6aA:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 ASP A 123
TYR A 121
TRP A 257
 TRE  A 563 (-3.5A)
TRE  A 563 (-4.5A)
TRE  A 563 (-3.5A)
 1.36A 4p7nA-1eu8A:
undetectable		 4p7nA-1eu8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 6 TYR A 187
GLY A 179
GLU A 239
ASP A  45
 None
TRE  A 563 (-3.5A)
TRE  A 563 (-2.9A)
None
 1.00A 5emlA-1eu8A:
undetectable		 5emlA-1eu8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1tex STF0
SULFOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLN A 105
THR A 106
LEU A 138
LEU A  11
 TRE  A 501 (-4.6A)
None
None
None
 1.32A 5m5kB-1texA:
undetectable		 5m5kB-1texA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 4 SER A  65
THR A 138
ASP A 115
ASP A  68
 BEF  A 402 ( 2.4A)
TRE  A 403 ( 3.9A)
None
None
 1.44A 5vimA-5dxiA:
undetectable		 5vimA-5dxiA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 4 SER A  65
THR A 138
ASP A 115
ASP A  68
 BEF  A 402 ( 2.4A)
TRE  A 403 ( 3.9A)
None
None
 1.46A 5vimB-5dxiA:
undetectable		 5vimB-5dxiA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 214
GLY A 260
ASN A 231
SER A 150
PHE A 228
 None
None
TRE  A1152 ( 4.5A)
None
None
 1.47A 5yf0A-1f0pA:
2.0		 5yf0A-1f0pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrobaculum
aerophilum) 		5 / 12 VAL A 229
THR A 231
PHE A 311
VAL A 265
TYR A 250
 None
None
None
TRE  A2002 (-3.8A)
None
 1.16A 6drzA-3a9gA:
undetectable		 6drzA-3a9gA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 478
ARG A 473
VAL A 709
ARG A 199
 TRE  A 801 (-2.8A)
TRE  A 801 (-4.2A)
None
None
 1.09A 6fbvD-5m4aA:
undetectable		 6fbvD-5m4aA:
18.43