SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TRD'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CYM_A_T27A601_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	4zr1	CERAMIDE VERY LONG CHAIN FATTY ACID HYDROXYLASE SCS7 (Saccharomyces cerevisiae)	5 / 12	LEU A 243 TYR A 322 TYR A 319 PHE A 288 LEU A 291	None None None TRD A 409 (-4.7A) TRD A 409 ( 4.4A)	1.33A	5cymA-4zr1A: undetectable	5cymA-4zr1A: 18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CYQ_A_T27A601_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	4zr1	CERAMIDE VERY LONG CHAIN FATTY ACID HYDROXYLASE SCS7 (Saccharomyces cerevisiae)	5 / 12	LEU A 243 TYR A 322 TYR A 319 PHE A 288 LEU A 291	None None None TRD A 409 (-4.7A) TRD A 409 ( 4.4A)	1.32A	5cyqA-4zr1A: undetectable	5cyqA-4zr1A: 18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ELI_A_T27A701_1 (REVERSE TRANSCRIPTASE)	4zr1	CERAMIDE VERY LONG CHAIN FATTY ACID HYDROXYLASE SCS7 (Saccharomyces cerevisiae)	5 / 12	LEU A 243 TYR A 322 TYR A 319 PHE A 288 LEU A 291	None None None TRD A 409 (-4.7A) TRD A 409 ( 4.4A)	1.31A	6eliA-4zr1A: undetectable	6eliA-4zr1A: 12.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5CYM_A_T27A601_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","4zr1","CERAMIDE VERY LONG CHAIN FATTY ACID HYDROXYLASE SCS7","Saccharomyces cerevisiae",5,"LEU A 243;TYR A 322;TYR A 319;PHE A 288;LEU A 291","None;None;None;TRD A 409 (-4.7A);TRD A 409 ( 4.4A)","1.33A","5cymA-4zr1A:undetectable",null],["5CYQ_A_T27A601_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","4zr1","CERAMIDE VERY LONG CHAIN FATTY ACID HYDROXYLASE SCS7","Saccharomyces cerevisiae",5,"LEU A 243;TYR A 322;TYR A 319;PHE A 288;LEU A 291","None;None;None;TRD A 409 (-4.7A);TRD A 409 ( 4.4A)","1.32A","5cyqA-4zr1A:undetectable","5cymA-4zr1A:18.23"],["6ELI_A_T27A701_1","REVERSE TRANSCRIPTASE","4zr1","CERAMIDE VERY LONG CHAIN FATTY ACID HYDROXYLASE SCS7","Saccharomyces cerevisiae",5,"LEU A 243;TYR A 322;TYR A 319;PHE A 288;LEU A 291","None;None;None;TRD A 409 (-4.7A);TRD A 409 ( 4.4A)","1.31A","6eliA-4zr1A:undetectable","5cyqA-4zr1A:18.23"]]