SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TQI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.28A 1os2A-2y6cA:
26.0		 1os2A-2y6cA:
53.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.21A 1os2D-2y6cA:
25.9		 1os2D-2y6cA:
53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 10 THR A 180
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 TQI  A1269 (-4.2A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.53A 1r55A-2y6cA:
8.5		 1r55A-2y6cA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.13A 1uttA-2y6cA:
26.0		 1uttA-2y6cA:
54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.20A 1utzA-2y6cA:
26.3		 1utzA-2y6cA:
54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.18A 1utzB-2y6cA:
26.1		 1utzB-2y6cA:
54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.35A 1y93A-2y6cA:
26.2		 1y93A-2y6cA:
53.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.17A 2hu6A-2y6cA:
26.3		 2hu6A-2y6cA:
53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.46A 2jihA-2y6cA:
9.1		 2jihA-2y6cA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 8 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.21A 2jihB-2y6cA:
9.3		 2jihB-2y6cA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.47A 2ow9A-2y6cA:
25.2		 2ow9A-2y6cA:
51.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.21A 2ow9B-2y6cA:
25.0		 2ow9B-2y6cA:
51.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.25A 2ozrC-2y6cA:
25.6		 2ozrC-2y6cA:
51.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.30A 2ozrD-2y6cA:
25.9		 2ozrD-2y6cA:
51.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.30A 2ozrE-2y6cA:
25.6		 2ozrE-2y6cA:
51.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 183
GLU A 220
HIS A 223
 ZN  A1266 ( 3.3A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
 0.43A 3ba0A-2y6cA:
23.8		 3ba0A-2y6cA:
54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.46A 3hy7A-2y6cA:
9.4		 3hy7A-2y6cA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.44A 3hy7B-2y6cA:
9.4		 3hy7B-2y6cA:
23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 5 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.20A 3kecA-2y6cA:
25.2		 3kecA-2y6cA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		3 / 3 HIS A 219
GLU A 220
HIS A 223
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
 0.14A 3kecB-2y6cA:
24.8		 3kecB-2y6cA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.43A 3likA-2y6cA:
26.3		 3likA-2y6cA:
53.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.18A 3lilA-2y6cA:
26.5		 3lilA-2y6cA:
53.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 5 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.20A 3ljgA-2y6cA:
26.3		 3ljgA-2y6cA:
53.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.41A 3lkaA-2y6cA:
26.2		 3lkaA-2y6cA:
54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.46A 4a7bA-2y6cA:
25.6		 4a7bA-2y6cA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
 0.15A 4a7bB-2y6cA:
25.6		 4a7bB-2y6cA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.19A 5n5jA-2y6cA:
26.5		 5n5jA-2y6cA:
54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2y6c MATRILYSIN
(Homo
sapiens) 		4 / 5 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.20A 5n5kA-2y6cA:
25.9		 5n5kA-2y6cA:
56.41