SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TPW'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2ji9 OXALYL-COA
DECARBOXYLASE
(Oxalobacter
formigenes) 		5 / 12 ILE A 482
SER A 422
MET A 428
TRP A 285
TYR A 483
 TPW  A1554 (-4.1A)
None
TPW  A1554 (-4.0A)
None
TPW  A1554 (-4.8A)
 1.10A 1kiaA-2ji9A:
undetectable		 1kiaA-2ji9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2ji9 OXALYL-COA
DECARBOXYLASE
(Oxalobacter
formigenes) 		5 / 12 ILE A 482
SER A 422
MET A 428
TRP A 285
TYR A 483
 TPW  A1554 (-4.1A)
None
TPW  A1554 (-4.0A)
None
TPW  A1554 (-4.8A)
 1.09A 1nbhA-2ji9A:
undetectable		 1nbhA-2ji9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2ji9 OXALYL-COA
DECARBOXYLASE
(Oxalobacter
formigenes) 		5 / 12 ILE A 482
SER A 422
MET A 428
TRP A 285
TYR A 483
 TPW  A1554 (-4.1A)
None
TPW  A1554 (-4.0A)
None
TPW  A1554 (-4.8A)
 1.09A 1nbhC-2ji9A:
3.2		 1nbhC-2ji9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2ji9 OXALYL-COA
DECARBOXYLASE
(Oxalobacter
formigenes) 		5 / 12 ILE A 482
SER A 422
MET A 428
TRP A 285
TYR A 483
 TPW  A1554 (-4.1A)
None
TPW  A1554 (-4.0A)
None
TPW  A1554 (-4.8A)
 1.09A 1nbhD-2ji9A:
3.2		 1nbhD-2ji9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2ji9 OXALYL-COA
DECARBOXYLASE
(Oxalobacter
formigenes) 		4 / 8 LEU A 396
SER A 380
GLY A 451
MET A 477
 None
None
TPW  A1554 (-3.4A)
None
 1.10A 2qd5A-2ji9A:
2.3		 2qd5A-2ji9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2ji9 OXALYL-COA
DECARBOXYLASE
(Oxalobacter
formigenes) 		5 / 10 PHE A 457
GLY A 459
VAL A 427
ILE A 476
GLY A 431
 TPW  A1554 (-4.3A)
None
TPW  A1554 ( 4.8A)
None
None
 1.30A 3km6A-2ji9A:
undetectable		 3km6A-2ji9A:
17.80