SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TPS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2qry THIAMINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 5 ALA A  31
ALA A  56
TYR A  27
GLN A 243
 None
None
TPS  A 400 (-4.0A)
TPS  A 400 ( 4.7A)
 1.09A 1xl6A-2qryA:
undetectable
1xl6B-2qryA:
undetectable		 1xl6A-2qryA:
21.01
1xl6B-2qryA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2qry THIAMINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 6 LEU A  86
TYR A 215
ASP A 121
GLU A 245
 None
TPS  A 400 (-4.3A)
None
TPS  A 400 (-3.3A)
 1.45A 6djzC-2qryA:
undetectable		 6djzC-2qryA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 2qry THIAMINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 5 THR A 216
THR A 162
GLN A 243
ASP A  59
 None
TPS  A 400 (-3.9A)
TPS  A 400 ( 4.7A)
TPS  A 400 (-3.7A)
 1.40A 6ecxA-2qryA:
undetectable		 6ecxA-2qryA:
22.19