SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TPQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		4 / 6 ILE A 502
SER A 526
ASN A 391
THR A 394
 TPQ  A 478 ( 4.8A)
None
None
None
 1.03A 1h7xA-1w7cA:
undetectable		 1h7xA-1w7cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		4 / 6 ILE A 502
SER A 526
ASN A 391
THR A 394
 TPQ  A 478 ( 4.8A)
None
None
None
 1.01A 1h7xB-1w7cA:
undetectable		 1h7xB-1w7cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		4 / 6 ILE A 502
SER A 526
ASN A 391
THR A 394
 TPQ  A 478 ( 4.8A)
None
None
None
 1.02A 1h7xC-1w7cA:
undetectable		 1h7xC-1w7cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		4 / 6 ILE A 502
SER A 526
ASN A 391
THR A 394
 TPQ  A 478 ( 4.8A)
None
None
None
 1.02A 1h7xD-1w7cA:
undetectable		 1h7xD-1w7cA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 1a2v METHYLAMINE OXIDASE
(Ogataea
angusta) 		8 / 10 TYR A 305
THR A 401
ASN A 404
TYR A 407
HIS A 456
HIS A 458
HIS A 624
MET A 634
 TPQ  A 405 ( 4.7A)
TPQ  A 405 ( 4.0A)
TPQ  A 405 ( 3.3A)
None
CU  A   1 (-3.3A)
CU  A   1 (-3.2A)
CU  A   1 (-3.1A)
None
 0.33A 1ivvA-1a2vA:
47.9		 1ivvA-1a2vA:
34.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 1ksi COPPER AMINE OXIDASE
(Pisum
sativum) 		8 / 10 TYR A 286
THR A 383
ASN A 386
ASP A 388
HIS A 442
HIS A 444
HIS A 603
MET A 613
 TPQ  A 387 ( 4.5A)
TPQ  A 387 ( 3.8A)
TPQ  A 387 ( 3.1A)
TPQ  A 387 ( 3.9A)
CU  A 650 ( 3.3A)
CU  A 650 ( 3.3A)
CU  A 650 ( 3.2A)
None
 0.34A 1ivvA-1ksiA:
48.3		 1ivvA-1ksiA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		5 / 10 THR A 462
ASP A 467
TYR A 468
HIS A 526
HIS A 524
 TPQ  A 466 ( 3.8A)
TPQ  A 466 ( 3.8A)
TPQ  A 466 ( 3.8A)
CU  A 801 (-3.2A)
CU  A 801 (-3.4A)
 1.14A 1ivvA-1qafA:
48.0		 1ivvA-1qafA:
28.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		9 / 10 TYR A 369
THR A 462
ASN A 465
ASP A 467
TYR A 468
HIS A 524
HIS A 526
HIS A 689
MET A 699
 TPQ  A 466 ( 4.4A)
TPQ  A 466 ( 3.8A)
TPQ  A 466 ( 3.3A)
TPQ  A 466 ( 3.8A)
TPQ  A 466 ( 3.8A)
CU  A 801 (-3.4A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 ( 4.6A)
 0.57A 1ivvA-1qafA:
48.0		 1ivvA-1qafA:
28.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		8 / 10 TYR A 384
THR A 474
ASN A 477
ASP A 479
TYR A 480
HIS A 528
HIS A 530
HIS A 694
 TPQ  A 478 ( 4.7A)
TPQ  A 478 ( 3.7A)
IMD  A 821 (-2.7A)
TPQ  A 478 ( 3.8A)
TPQ  A 478 ( 3.9A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.1A)
 0.66A 1ivvA-1w7cA:
37.1		 1ivvA-1w7cA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME
(Bos
taurus) 		7 / 10 TYR A 371
THR A 466
ASP A 471
TYR A 472
HIS A 519
HIS A 521
HIS A 683
 None
TPQ  A 470 ( 4.0A)
TPQ  A 470 (-3.6A)
CLU  A 808 (-3.4A)
CU  A 804 (-3.3A)
CU  A 804 ( 3.3A)
CU  A 804 (-3.2A)
 0.65A 1ivvA-2pncA:
35.8		 1ivvA-2pncA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		9 / 10 TYR A 359
THR A 457
ASN A 460
ASP A 462
TYR A 463
VAL A 485
HIS A 510
HIS A 512
HIS A 675
 None
TPQ  A 461 ( 3.7A)
TPQ  A 461 ( 3.3A)
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.5A)
TPQ  A 461 ( 4.1A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.45A 1ivvA-3higA:
38.7		 1ivvA-3higA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 3loy COPPER AMINE OXIDASE
(Ogataea
angusta) 		8 / 10 TYR A 288
THR A 382
ASN A 385
TYR A 388
HIS A 436
HIS A 438
HIS A 597
MET A 607
 TPQ  A 386 ( 4.3A)
TPQ  A 386 ( 4.1A)
TPQ  A 386 ( 3.2A)
TPQ  A 386 ( 4.1A)
CU  A 635 (-3.2A)
CU  A 635 (-3.2A)
CU  A 635 (-3.0A)
None
 0.36A 1ivvA-3loyA:
49.2		 1ivvA-3loyA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		8 / 10 TYR A 409
THR A 500
ASN A 503
ASP A 505
TYR A 506
HIS A 552
HIS A 554
HIS A 718
 TPQ  A 504 ( 4.7A)
TPQ  A 504 ( 3.5A)
TPQ  A 504 ( 3.7A)
TPQ  A 504 ( 3.8A)
TPQ  A 504 ( 4.2A)
CU  A 901 (-3.2A)
CU  A 901 (-3.2A)
CU  A 901 (-3.1A)
 0.56A 1ivvA-3pgbA:
38.7		 1ivvA-3pgbA:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 1a2v METHYLAMINE OXIDASE
(Ogataea
angusta) 		8 / 10 TYR A 305
THR A 401
ASN A 404
TYR A 407
HIS A 456
HIS A 458
HIS A 624
MET A 634
 TPQ  A 405 ( 4.7A)
TPQ  A 405 ( 4.0A)
TPQ  A 405 ( 3.3A)
None
CU  A   1 (-3.3A)
CU  A   1 (-3.2A)
CU  A   1 (-3.1A)
None
 0.41A 1ivvB-1a2vA:
51.6		 1ivvB-1a2vA:
34.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 1ksi COPPER AMINE OXIDASE
(Pisum
sativum) 		5 / 10 THR A 383
ASN A 386
ASP A 388
HIS A 603
HIS A 444
 TPQ  A 387 ( 3.8A)
TPQ  A 387 ( 3.1A)
TPQ  A 387 ( 3.9A)
CU  A 650 ( 3.2A)
CU  A 650 ( 3.3A)
 1.43A 1ivvB-1ksiA:
50.2		 1ivvB-1ksiA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 1ksi COPPER AMINE OXIDASE
(Pisum
sativum) 		8 / 10 TYR A 286
THR A 383
ASN A 386
ASP A 388
HIS A 442
HIS A 444
HIS A 603
MET A 613
 TPQ  A 387 ( 4.5A)
TPQ  A 387 ( 3.8A)
TPQ  A 387 ( 3.1A)
TPQ  A 387 ( 3.9A)
CU  A 650 ( 3.3A)
CU  A 650 ( 3.3A)
CU  A 650 ( 3.2A)
None
 0.41A 1ivvB-1ksiA:
50.2		 1ivvB-1ksiA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		9 / 10 TYR A 369
THR A 462
ASN A 465
ASP A 467
TYR A 468
HIS A 524
HIS A 526
HIS A 689
MET A 699
 TPQ  A 466 ( 4.4A)
TPQ  A 466 ( 3.8A)
TPQ  A 466 ( 3.3A)
TPQ  A 466 ( 3.8A)
TPQ  A 466 ( 3.8A)
CU  A 801 (-3.4A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 ( 4.6A)
 0.60A 1ivvB-1qafA:
46.3		 1ivvB-1qafA:
28.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		8 / 10 TYR A 384
THR A 474
ASN A 477
ASP A 479
TYR A 480
HIS A 528
HIS A 530
HIS A 694
 TPQ  A 478 ( 4.7A)
TPQ  A 478 ( 3.7A)
IMD  A 821 (-2.7A)
TPQ  A 478 ( 3.8A)
TPQ  A 478 ( 3.9A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.1A)
 0.70A 1ivvB-1w7cA:
36.9		 1ivvB-1w7cA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME
(Bos
taurus) 		7 / 10 TYR A 371
THR A 466
ASP A 471
TYR A 472
HIS A 519
HIS A 521
HIS A 683
 None
TPQ  A 470 ( 4.0A)
TPQ  A 470 (-3.6A)
CLU  A 808 (-3.4A)
CU  A 804 (-3.3A)
CU  A 804 ( 3.3A)
CU  A 804 (-3.2A)
 0.68A 1ivvB-2pncA:
36.8		 1ivvB-2pncA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		7 / 10 THR A 457
ASN A 460
ASP A 462
TYR A 463
VAL A 485
HIS A 675
HIS A 512
 TPQ  A 461 ( 3.7A)
TPQ  A 461 ( 3.3A)
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.5A)
TPQ  A 461 ( 4.1A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
 1.47A 1ivvB-3higA:
38.7		 1ivvB-3higA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		9 / 10 TYR A 359
THR A 457
ASN A 460
ASP A 462
TYR A 463
VAL A 485
HIS A 510
HIS A 512
HIS A 675
 None
TPQ  A 461 ( 3.7A)
TPQ  A 461 ( 3.3A)
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.5A)
TPQ  A 461 ( 4.1A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.45A 1ivvB-3higA:
38.7		 1ivvB-3higA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 3loy COPPER AMINE OXIDASE
(Ogataea
angusta) 		8 / 10 TYR A 288
THR A 382
ASN A 385
TYR A 388
HIS A 436
HIS A 438
HIS A 597
MET A 607
 TPQ  A 386 ( 4.3A)
TPQ  A 386 ( 4.1A)
TPQ  A 386 ( 3.2A)
TPQ  A 386 ( 4.1A)
CU  A 635 (-3.2A)
CU  A 635 (-3.2A)
CU  A 635 (-3.0A)
None
 0.42A 1ivvB-3loyA:
47.5		 1ivvB-3loyA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		8 / 10 TYR A 409
THR A 500
ASN A 503
ASP A 505
TYR A 506
HIS A 552
HIS A 554
HIS A 718
 TPQ  A 504 ( 4.7A)
TPQ  A 504 ( 3.5A)
TPQ  A 504 ( 3.7A)
TPQ  A 504 ( 3.8A)
TPQ  A 504 ( 4.2A)
CU  A 901 (-3.2A)
CU  A 901 (-3.2A)
CU  A 901 (-3.1A)
 0.57A 1ivvB-3pgbA:
37.2		 1ivvB-3pgbA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		5 / 12 ASN A 661
TYR A 664
ALA A 382
ALA A 215
LEU A 219
 None
None
TPQ  A 478 ( 4.6A)
None
None
 1.14A 1udtA-1w7cA:
undetectable		 1udtA-1w7cA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME
(Bos
taurus) 		5 / 12 TYR A 371
THR A 381
SER A 522
ILE A 494
TYR A 472
 None
None
None
TPQ  A 470 ( 4.8A)
CLU  A 808 (-3.4A)
 1.48A 1xvaA-2pncA:
undetectable		 1xvaA-2pncA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 11 HIS A 552
GLN A 529
TYR A 421
ASP A 423
LEU A 556
 CU  A 901 (-3.2A)
TPQ  A 504 ( 4.6A)
TPQ  A 504 ( 3.8A)
TPQ  A 504 ( 4.3A)
None
 1.27A 2a5hA-3pgbA:
undetectable		 2a5hA-3pgbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 11 HIS A 554
HIS A 552
GLN A 529
TYR A 421
LEU A 556
 CU  A 901 (-3.2A)
CU  A 901 (-3.2A)
TPQ  A 504 ( 4.6A)
TPQ  A 504 ( 3.8A)
None
 1.48A 2a5hA-3pgbA:
undetectable		 2a5hA-3pgbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 12 HIS A 552
GLN A 529
TYR A 421
ASP A 423
LEU A 556
 CU  A 901 (-3.2A)
TPQ  A 504 ( 4.6A)
TPQ  A 504 ( 3.8A)
TPQ  A 504 ( 4.3A)
None
 1.26A 2a5hB-3pgbA:
undetectable		 2a5hB-3pgbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 12 HIS A 554
HIS A 552
GLN A 529
TYR A 421
LEU A 556
 CU  A 901 (-3.2A)
CU  A 901 (-3.2A)
TPQ  A 504 ( 4.6A)
TPQ  A 504 ( 3.8A)
None
 1.47A 2a5hB-3pgbA:
undetectable		 2a5hB-3pgbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 12 HIS A 552
GLN A 529
TYR A 421
ASP A 423
LEU A 556
 CU  A 901 (-3.2A)
TPQ  A 504 ( 4.6A)
TPQ  A 504 ( 3.8A)
TPQ  A 504 ( 4.3A)
None
 1.26A 2a5hC-3pgbA:
undetectable		 2a5hC-3pgbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 12 HIS A 554
HIS A 552
GLN A 529
TYR A 421
LEU A 556
 CU  A 901 (-3.2A)
CU  A 901 (-3.2A)
TPQ  A 504 ( 4.6A)
TPQ  A 504 ( 3.8A)
None
 1.49A 2a5hC-3pgbA:
undetectable		 2a5hC-3pgbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 12 HIS A 552
GLN A 529
TYR A 421
ASP A 423
LEU A 556
 CU  A 901 (-3.2A)
TPQ  A 504 ( 4.6A)
TPQ  A 504 ( 3.8A)
TPQ  A 504 ( 4.3A)
None
 1.26A 2a5hD-3pgbA:
undetectable		 2a5hD-3pgbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 12 HIS A 554
HIS A 552
GLN A 529
TYR A 421
LEU A 556
 CU  A 901 (-3.2A)
CU  A 901 (-3.2A)
TPQ  A 504 ( 4.6A)
TPQ  A 504 ( 3.8A)
None
 1.47A 2a5hD-3pgbA:
undetectable		 2a5hD-3pgbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 8 HIS A 510
GLY A 507
PHE A 673
ASN A 460
 CU  A 801 (-3.3A)
None
None
TPQ  A 461 ( 3.3A)
 0.78A 2a8tB-3higA:
undetectable		 2a8tB-3higA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		4 / 7 TYR A 480
GLY A 402
ASN A 405
ASP A 175
 TPQ  A 478 ( 3.9A)
None
None
None
 1.03A 2g72B-1w7cA:
undetectable		 2g72B-1w7cA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1a2v METHYLAMINE OXIDASE
(Ogataea
angusta) 		4 / 7 TYR A 305
ASP A 319
TYR A 407
HIS A 458
 TPQ  A 405 ( 4.7A)
TPQ  A 405 ( 4.7A)
None
CU  A   1 (-3.2A)
 0.40A 2pncA-1a2vA:
38.7		 2pncA-1a2vA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		4 / 7 TYR A 369
TYR A 381
TYR A 468
HIS A 526
 TPQ  A 466 ( 4.4A)
TPQ  A 466 ( 4.1A)
TPQ  A 466 ( 3.8A)
CU  A 801 (-3.2A)
 0.57A 2pncA-1qafA:
37.6		 2pncA-1qafA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		6 / 7 ALA A 382
TYR A 384
TYR A 396
ASP A 398
TYR A 480
HIS A 530
 TPQ  A 478 ( 4.6A)
TPQ  A 478 ( 4.7A)
IMD  A 821 (-3.5A)
IMD  A 821 (-2.6A)
TPQ  A 478 ( 3.9A)
CU  A 801 (-3.2A)
 0.52A 2pncA-1w7cA:
39.9		 2pncA-1w7cA:
28.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		6 / 7 ALA A 357
TYR A 359
TYR A 371
ASP A 373
TYR A 463
HIS A 512
 TPQ  A 461 ( 4.9A)
None
BRN  A 901 (-3.3A)
BRN  A 901 (-3.3A)
TPQ  A 461 ( 4.5A)
CU  A 801 (-3.2A)
 0.68A 2pncA-3higA:
46.1		 2pncA-3higA:
40.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3loy COPPER AMINE OXIDASE
(Ogataea
angusta) 		4 / 7 TYR A 288
ASP A 302
TYR A 388
HIS A 438
 TPQ  A 386 ( 4.3A)
TPQ  A 386 ( 4.9A)
TPQ  A 386 ( 4.1A)
CU  A 635 (-3.2A)
 0.67A 2pncA-3loyA:
35.9		 2pncA-3loyA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		6 / 7 ALA A 407
TYR A 409
TYR A 421
ASP A 423
TYR A 506
HIS A 554
 TPQ  A 504 ( 3.9A)
TPQ  A 504 ( 4.7A)
TPQ  A 504 ( 3.8A)
TPQ  A 504 ( 4.3A)
TPQ  A 504 ( 4.2A)
CU  A 901 (-3.2A)
 0.52A 2pncA-3pgbA:
38.2		 2pncA-3pgbA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		5 / 6 ALA A 382
TYR A 396
ASP A 398
TYR A 480
HIS A 530
 TPQ  A 478 ( 4.6A)
IMD  A 821 (-3.5A)
IMD  A 821 (-2.6A)
TPQ  A 478 ( 3.9A)
CU  A 801 (-3.2A)
 0.48A 2pncB-1w7cA:
43.7		 2pncB-1w7cA:
28.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 6 ALA A 357
TYR A 371
ASP A 373
TYR A 463
HIS A 512
 TPQ  A 461 ( 4.9A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.3A)
TPQ  A 461 ( 4.5A)
CU  A 801 (-3.2A)
 0.66A 2pncB-3higA:
50.4		 2pncB-3higA:
40.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 6 ALA A 407
TYR A 421
ASP A 423
TYR A 506
HIS A 554
 TPQ  A 504 ( 3.9A)
TPQ  A 504 ( 3.8A)
TPQ  A 504 ( 4.3A)
TPQ  A 504 ( 4.2A)
CU  A 901 (-3.2A)
 0.48A 2pncB-3pgbA:
41.6		 2pncB-3pgbA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		4 / 6 PHE A 470
TYR A 528
TRP A 703
THR A 462
 None
None
None
TPQ  A 466 ( 3.8A)
 1.39A 2x2iB-1qafA:
0.0		 2x2iB-1qafA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3loy COPPER AMINE OXIDASE
(Ogataea
angusta) 		5 / 11 LEU A 101
ALA A 103
GLY A 307
ILE A 106
VAL A 383
 None
None
None
None
TPQ  A 386 ( 4.4A)
 1.05A 3gyqB-3loyA:
undetectable		 3gyqB-3loyA:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		12 / 12 TYR A 148
THR A 185
ASP A 186
TYR A 371
ASP A 373
TRP A 376
GLY A 377
SER A 380
VAL A 381
TYR A 404
TYR A 459
ASN A 460
 BRN  A 901 (-3.7A)
BRN  A 901 ( 4.2A)
BRN  A 901 (-3.9A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.5A)
None
None
None
None
BRN  A 901 (-3.2A)
TPQ  A 461 ( 3.3A)
 0.38A 3hiiA-3higA:
67.6		 3hiiA-3higA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		6 / 12 TYR A 148
THR A 185
ASP A 373
GLY A 375
TYR A 459
ASN A 460
 BRN  A 901 (-3.7A)
BRN  A 901 ( 4.2A)
BRN  A 901 (-3.3A)
None
BRN  A 901 (-3.2A)
TPQ  A 461 ( 3.3A)
 1.42A 3hiiA-3higA:
67.6		 3hiiA-3higA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		12 / 12 TYR A 148
THR A 185
ASP A 186
TYR A 371
ASP A 373
TRP A 376
GLY A 377
SER A 380
VAL A 381
TYR A 404
TYR A 459
ASN A 460
 BRN  A 901 (-3.7A)
BRN  A 901 ( 4.2A)
BRN  A 901 (-3.9A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.5A)
None
None
None
None
BRN  A 901 (-3.2A)
TPQ  A 461 ( 3.3A)
 0.36A 3hiiB-3higA:
62.8		 3hiiB-3higA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		6 / 12 TYR A 148
THR A 185
ASP A 373
GLY A 375
TYR A 459
ASN A 460
 BRN  A 901 (-3.7A)
BRN  A 901 ( 4.2A)
BRN  A 901 (-3.3A)
None
BRN  A 901 (-3.2A)
TPQ  A 461 ( 3.3A)
 1.45A 3hiiB-3higA:
62.8		 3hiiB-3higA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 11 VAL A 520
GLY A 736
ALA A 524
TYR A 506
PHE A 508
 None
None
None
TPQ  A 504 ( 4.2A)
None
 1.44A 3qxyB-3pgbA:
undetectable
3qxyQ-3pgbA:
undetectable		 3qxyB-3pgbA:
19.65
3qxyQ-3pgbA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		4 / 8 TYR A 396
ASP A 388
TYR A 384
SER A 526
 IMD  A 821 (-3.5A)
None
TPQ  A 478 ( 4.7A)
None
 0.98A 3rodA-1w7cA:
undetectable		 3rodA-1w7cA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		4 / 8 TYR A 396
SER A 386
TYR A 384
SER A 526
 IMD  A 821 (-3.5A)
None
TPQ  A 478 ( 4.7A)
None
 1.07A 3rodA-1w7cA:
undetectable		 3rodA-1w7cA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 9 TYR A 421
ASP A 413
ALA A 411
TYR A 409
SER A 550
 TPQ  A 504 ( 3.8A)
None
None
TPQ  A 504 ( 4.7A)
None
 1.31A 3rodB-3pgbA:
undetectable		 3rodB-3pgbA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 1ksi COPPER AMINE OXIDASE
(Pisum
sativum) 		3 / 3 LYS A 296
VAL A 284
HIS A 442
 TPQ  A 387 ( 2.8A)
TPQ  A 387 ( 4.7A)
CU  A 650 ( 3.3A)
 0.90A 3tj7A-1ksiA:
0.0		 3tj7A-1ksiA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aspergillus
nidulans) 		5 / 12 ILE A 501
GLY A 429
GLY A 427
ALA A 432
LEU A 465
 TPQ  A 504 ( 4.8A)
None
None
None
None
 0.80A 3uj7B-3pgbA:
undetectable		 3uj7B-3pgbA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 1ksi COPPER AMINE OXIDASE
(Pisum
sativum) 		4 / 6 ASN A 386
GLY A 409
ASP A 388
ILE A 381
 TPQ  A 387 ( 3.1A)
TPQ  A 387 ( 4.9A)
TPQ  A 387 ( 3.9A)
None
 0.87A 3w9tF-1ksiA:
0.0		 3w9tF-1ksiA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME
(Bos
taurus) 		5 / 12 PHE A 609
ILE A 494
ASP A 689
PHE A 681
HIS A 521
 None
TPQ  A 470 ( 4.8A)
None
None
CU  A 804 ( 3.3A)
 1.43A 3welA-2pncA:
2.9		 3welA-2pncA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 1a2v METHYLAMINE OXIDASE
(Ogataea
angusta) 		4 / 7 LEU A 429
ASP A 630
TYR A 305
HIS A 458
 None
None
TPQ  A 405 ( 4.7A)
CU  A   1 (-3.2A)
 0.98A 4arcA-1a2vA:
0.0		 4arcA-1a2vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 1ksi COPPER AMINE OXIDASE
(Pisum
sativum) 		4 / 7 LEU A 411
ASP A 609
TYR A 286
HIS A 444
 None
None
TPQ  A 387 ( 4.5A)
CU  A 650 ( 3.3A)
 0.96A 4arcA-1ksiA:
undetectable		 4arcA-1ksiA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3loy COPPER AMINE OXIDASE
(Ogataea
angusta) 		4 / 7 LEU A 410
ASP A 603
TYR A 288
HIS A 438
 None
None
TPQ  A 386 ( 4.3A)
CU  A 635 (-3.2A)
 1.02A 4arcA-3loyA:
undetectable		 4arcA-3loyA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 HIS A 285
GLY A 209
PHE A 211
ASP A 462
GLY A 483
 None
None
None
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.4A)
 1.00A 4lxzA-3higA:
undetectable		 4lxzA-3higA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 HIS A 285
GLY A 209
PHE A 211
ASP A 462
GLY A 483
 None
None
None
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.4A)
 1.01A 4lxzC-3higA:
undetectable		 4lxzC-3higA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 HIS A 285
GLY A 209
PHE A 211
ASP A 462
GLY A 483
 None
None
None
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.4A)
 0.91A 4qa0A-3higA:
undetectable		 4qa0A-3higA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ksi COPPER AMINE OXIDASE
(Pisum
sativum) 		5 / 8 TYR A 446
PHE A 306
GLY A 385
ASN A 389
ILE A 410
 None
None
TPQ  A 387 ( 4.4A)
TPQ  A 387 ( 4.6A)
None
 1.37A 4qoiA-1ksiA:
undetectable
4qoiB-1ksiA:
undetectable		 4qoiA-1ksiA:
15.48
4qoiB-1ksiA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		4 / 4 ASN A 465
VAL A 492
THR A 223
ILE A 246
 TPQ  A 466 ( 3.3A)
None
None
None
 1.26A 4retA-1qafA:
undetectable		 4retA-1qafA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		4 / 4 ASN A 465
VAL A 492
THR A 223
ILE A 246
 TPQ  A 466 ( 3.3A)
None
None
None
 1.26A 4retC-1qafA:
undetectable		 4retC-1qafA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 6 LYS A 462
ASP A 466
TYR A 463
LEU A 378
 TPQ  A 461 ( 3.4A)
None
TPQ  A 461 ( 4.5A)
None
 1.32A 5bmvB-3higA:
undetectable		 5bmvB-3higA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		5 / 11 VAL A 463
MET A 365
TYR A 528
SER A 461
GLY A 485
 TPQ  A 466 ( 4.5A)
None
None
None
None
 1.47A 5g6sA-1qafA:
undetectable
5g6sG-1qafA:
undetectable		 5g6sA-1qafA:
18.36
5g6sG-1qafA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		5 / 11 VAL A 463
MET A 365
TYR A 528
SER A 461
GLY A 485
 TPQ  A 466 ( 4.5A)
None
None
None
None
 1.46A 5g6sB-1qafA:
undetectable
5g6sC-1qafA:
undetectable		 5g6sB-1qafA:
18.36
5g6sC-1qafA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		5 / 12 SER A 461
GLY A 485
VAL A 463
MET A 365
TYR A 528
 None
None
TPQ  A 466 ( 4.5A)
None
None
 1.45A 5g6sB-1qafA:
undetectable
5g6sC-1qafA:
undetectable		 5g6sB-1qafA:
18.36
5g6sC-1qafA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_D_RAUD400_1
(IMINE REDUCTASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		5 / 10 VAL A 463
MET A 365
TYR A 528
SER A 461
GLY A 485
 TPQ  A 466 ( 4.5A)
None
None
None
None
 1.46A 5g6sD-1qafA:
0.0
5g6sF-1qafA:
0.0		 5g6sD-1qafA:
18.36
5g6sF-1qafA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		5 / 11 VAL A 463
MET A 365
TYR A 528
SER A 461
GLY A 485
 TPQ  A 466 ( 4.5A)
None
None
None
None
 1.45A 5g6sE-1qafA:
undetectable
5g6sH-1qafA:
undetectable		 5g6sE-1qafA:
18.36
5g6sH-1qafA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_F_RAUF400_1
(IMINE REDUCTASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		5 / 10 SER A 461
GLY A 485
VAL A 463
MET A 365
TYR A 528
 None
None
TPQ  A 466 ( 4.5A)
None
None
 1.41A 5g6sD-1qafA:
undetectable
5g6sF-1qafA:
0.0		 5g6sD-1qafA:
18.36
5g6sF-1qafA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_G_RAUG400_1
(IMINE REDUCTASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		5 / 10 SER A 461
GLY A 485
VAL A 463
MET A 365
TYR A 528
 None
None
TPQ  A 466 ( 4.5A)
None
None
 1.46A 5g6sA-1qafA:
0.0
5g6sG-1qafA:
0.0		 5g6sA-1qafA:
18.36
5g6sG-1qafA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_H_RAUH400_1
(IMINE REDUCTASE)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		5 / 10 SER A 461
GLY A 485
VAL A 463
MET A 365
TYR A 528
 None
None
TPQ  A 466 ( 4.5A)
None
None
 1.46A 5g6sE-1qafA:
0.0
5g6sH-1qafA:
0.0		 5g6sE-1qafA:
18.36
5g6sH-1qafA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1w7c LYSYL OXIDASE
(Komagataella
pastoris) 		5 / 12 ASP A 479
THR A 426
PHE A 407
THR A 423
SER A 473
 TPQ  A 478 ( 3.8A)
None
None
NAG  A1786 (-3.0A)
None
 1.36A 5hfjH-1w7cA:
undetectable		 5hfjH-1w7cA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1qaf PROTEIN (COPPER
AMINE OXIDASE)
(Escherichia
coli) 		5 / 12 ASP A 467
GLY A 488
ASN A 465
ALA A 258
ASN A 255
 TPQ  A 466 ( 3.8A)
TPQ  A 466 ( 4.5A)
TPQ  A 466 ( 3.3A)
None
None
 1.38A 5kbwA-1qafA:
undetectable		 5kbwA-1qafA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 6 TYR A 463
LEU A 358
GLU A 354
LEU A 372
 TPQ  A 461 ( 4.5A)
None
None
None
 1.35A 5xooA-3higA:
undetectable		 5xooA-3higA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 7 GLY A 507
GLY A 498
ASN A 684
THR A 685
 None
None
None
TPQ  A 461 ( 2.4A)
 0.78A 5ybbB-3higA:
undetectable		 5ybbB-3higA:
21.56