SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TPP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		4 / 7 TYR A 561
PHE A 412
ILE A 460
GLY A 411
 TPP  A 600 ( 4.2A)
None
None
TPP  A 600 (-3.6A)
 0.88A 11gsA-2ihtA:
undetectable		 11gsA-2ihtA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		4 / 5 HIS A 320
LEU A  71
LEU A 190
GLY A  94
 TPP  A 900 (-4.3A)
None
None
None
 1.06A 1a4lB-3ai7A:
undetectable		 1a4lB-3ai7A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.91A 1c6yB-1v5fA:
undetectable		 1c6yB-1v5fA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 1c6zA-1v5fA:
undetectable		 1c6zA-1v5fA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.38A 1c9sB-3rimA:
undetectable
1c9sC-3rimA:
undetectable		 1c9sB-3rimA:
7.83
1c9sC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 1c9sC-3rimA:
undetectable
1c9sD-3rimA:
undetectable		 1c9sC-3rimA:
7.83
1c9sD-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 1c9sF-3rimA:
undetectable
1c9sG-3rimA:
undetectable		 1c9sF-3rimA:
7.83
1c9sG-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 VAL A 437
LEU A 453
LEU A 467
GLY A 456
SER A 459
 None
None
None
TPP  A 601 (-3.4A)
TPP  A 601 (-4.6A)
 1.03A 1cqeA-2x7jA:
undetectable		 1cqeA-2x7jA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 VAL A 437
LEU A 453
LEU A 467
GLY A 456
SER A 459
 None
None
None
TPP  A 601 (-3.4A)
TPP  A 601 (-4.6A)
 1.04A 1cqeB-2x7jA:
undetectable		 1cqeB-2x7jA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE
(Azoarcus
sp.
BH72) 		4 / 6 LEU A  53
ILE A 425
TRP A  57
GLU A  89
 None
TPP  A1589 ( 4.8A)
None
None
 1.16A 1ditH-4d5gA:
undetectable
1ditP-4d5gA:
undetectable		 1ditH-4d5gA:
19.28
1ditP-4d5gA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		4 / 6 LEU A 157
ASP A 182
MET A  93
HIS A  64
 TPP  A 900 (-4.0A)
CA  A 901 ( 3.0A)
None
None
 1.26A 1errB-3ai7A:
undetectable		 1errB-3ai7A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 446
GLY A 443
GLY A 416
SER A 408
VAL A 384
 TPP  A 557 ( 2.4A)
TPP  A 557 (-3.5A)
None
None
None
 1.12A 1fduA-1pvdA:
3.0		 1fduA-1pvdA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5i51 TRANSKETOLASE
(Scheffersomyces
stipitis) 		5 / 12 GLY A 156
CYH A 157
SER A 163
LEU A 241
TYR A 205
 TPP  A 701 (-3.5A)
None
None
None
None
 1.29A 1fm6D-5i51A:
undetectable		 1fm6D-5i51A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5nd5 TRANSKETOLASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 209
CYH A 210
SER A 216
LEU A 294
TYR A 258
 TPP  A 801 (-3.5A)
None
None
None
None
 1.28A 1fm6D-5nd5A:
undetectable		 1fm6D-5nd5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.91A 1hpvB-1v5fA:
undetectable		 1hpvB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 12 ASP A 382
ALA A 437
ASP A 435
VAL A 459
VAL A 431
 None
TPP  A 600 (-3.1A)
MG  A 601 ( 2.9A)
None
None
 1.07A 1hsgB-1ovmA:
undetectable		 1hsgB-1ovmA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 1hsgB-1v5fA:
undetectable		 1hsgB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		6 / 12 GLY A 462
ALA A 461
ASP A 409
VAL A 407
ILE A 388
ILE A 555
 TPP  A 600 (-3.4A)
None
None
None
None
None
 1.32A 1hshA-2ihtA:
undetectable		 1hshA-2ihtA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 1hxbB-1v5fA:
undetectable		 1hxbB-1v5fA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.92A 1hxwB-1v5fA:
undetectable		 1hxwB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		4 / 8 LEU A 157
LEU A 161
GLU A 186
TRP A 194
 TPP  A 900 (-4.0A)
None
None
None
 1.08A 1i7zA-3ai7A:
undetectable		 1i7zA-3ai7A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 ASN A 473
GLY A 446
THR A 398
GLY A 547
 None
TPP  A3001 (-3.4A)
TPP  A3001 (-3.7A)
None
 0.77A 1jr1B-2q27A:
undetectable		 1jr1B-2q27A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.98A 1k6cB-1v5fA:
undetectable		 1k6cB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vk4 PYRUVATE
DECARBOXYLASE
(Kluyveromyces
lactis) 		5 / 12 THR A 390
SER A 391
LEU A 365
VAL A 512
VAL A 370
 TPP  A 600 (-3.1A)
None
None
None
None
 1.14A 1q23C-2vk4A:
undetectable		 1q23C-2vk4A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vk4 PYRUVATE
DECARBOXYLASE
(Kluyveromyces
lactis) 		5 / 11 THR A 390
SER A 391
LEU A 365
VAL A 512
VAL A 370
 TPP  A 600 (-3.1A)
None
None
None
None
 1.13A 1q23I-2vk4A:
undetectable		 1q23I-2vk4A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 426
ILE A 431
ALA A  60
PHE A 452
SER A 453
 None
None
None
TPP  A3001 (-4.4A)
None
 1.00A 1ri4A-2q27A:
3.5		 1ri4A-2q27A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 1rl8A-1v5fA:
undetectable		 1rl8A-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 1sdtB-1v5fA:
undetectable		 1sdtB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.85A 1t3rB-1v5fA:
undetectable		 1t3rB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 7 ASP A 990
GLY A 839
ILE A 843
THR A 818
 None
TPP  A2236 (-3.3A)
None
None
 0.73A 1t7iB-2c3oA:
undetectable		 1t7iB-2c3oA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 7 ASP A 990
GLY A 839
ILE A 843
THR A 818
 None
TPP  A2236 (-3.3A)
None
None
 0.74A 1t7jB-2c3oA:
undetectable		 1t7jB-2c3oA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37
(Mycoplasma
hyorhinis) 		4 / 7 MET A 332
ALA A 305
PHE A 324
GLU A 308
 None
None
None
TPP  A 551 ( 4.9A)
 1.25A 1t9wA-3e79A:
undetectable		 1t9wA-3e79A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.37A 1utdA-3rimA:
undetectable
1utdB-3rimA:
undetectable		 1utdA-3rimA:
7.83
1utdB-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.38A 1utdD-3rimA:
undetectable
1utdE-3rimA:
undetectable		 1utdD-3rimA:
7.83
1utdE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 7 THR A 448
VAL A 466
GLY A 441
THR A 393
 None
None
TPP  A1602 (-3.6A)
None
 0.96A 2a1mA-1v5fA:
undetectable		 2a1mA-1v5fA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 11 TYR B 121
GLY B  97
VAL B 115
ASP B  90
VAL B  88
 TPP  B 402 (-4.2A)
None
None
MG  B 403 ( 3.1A)
None
 1.04A 2a1nA-5b47B:
undetectable		 2a1nA-5b47B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.87A 2avsA-1v5fA:
undetectable		 2avsA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 2avsB-1v5fA:
undetectable		 2avsB-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 10 TYR B 121
GLY B  97
VAL B 115
ASP B  90
VAL B  88
 TPP  B 402 (-4.2A)
None
None
MG  B 403 ( 3.1A)
None
 1.10A 2cp4A-5b47B:
undetectable		 2cp4A-5b47B:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4k9q BENZOYLFORMATE
DECARBOXYLASE
(Polynucleobacter
necessarius) 		5 / 9 GLN A 433
PHE A 432
GLY A 428
ASN A 456
VAL A 521
 None
None
TPP  A 602 (-3.4A)
MG  A 601 ( 2.7A)
None
 1.37A 2drdA-4k9qA:
undetectable		 2drdA-4k9qA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 1.00A 2f81A-1v5fA:
undetectable		 2f81A-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.97A 2f81B-1v5fA:
undetectable		 2f81B-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 2f8gA-1v5fA:
undetectable		 2f8gA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		4 / 8 TYR A 561
PHE A 412
ILE A 460
GLY A 411
 TPP  A 600 ( 4.2A)
None
None
TPP  A 600 (-3.6A)
 0.92A 2gssA-2ihtA:
undetectable		 2gssA-2ihtA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		4 / 8 TYR A 561
PHE A 412
ILE A 460
GLY A 411
 TPP  A 600 ( 4.2A)
None
None
TPP  A 600 (-3.6A)
 0.92A 2gssB-2ihtA:
undetectable		 2gssB-2ihtA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 496
SER A 552
GLY A 526
HIS A 144
GLN A 140
 None
TPP  A 700 (-2.8A)
None
None
None
 1.20A 2hmaA-1jscA:
undetectable		 2hmaA-1jscA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.97A 2idwA-1v5fA:
undetectable		 2idwA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 2ienB-1v5fA:
undetectable		 2ienB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.85A 2ienB-1v5fA:
undetectable		 2ienB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.92A 2ieoA-1v5fA:
undetectable		 2ieoA-1v5fA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 392
GLY A 413
SER A 446
 None
None
TPP  A 557 ( 2.4A)
 0.38A 2ivuA-1pvdA:
undetectable		 2ivuA-1pvdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2vk4 PYRUVATE
DECARBOXYLASE
(Kluyveromyces
lactis) 		3 / 3 ALA A 392
GLY A 413
SER A 446
 None
TPP  A 600 (-4.9A)
TPP  A 600 (-2.7A)
 0.34A 2ivuA-2vk4A:
undetectable		 2ivuA-2vk4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		4 / 5 LEU A 157
ASP A 182
MET A  93
HIS A  64
 TPP  A 900 (-4.0A)
CA  A 901 ( 3.0A)
None
None
 1.16A 2jfaA-3ai7A:
undetectable		 2jfaA-3ai7A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.96A 2o4sA-1v5fA:
undetectable		 2o4sA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 2ag1 BENZALDEHYDE LYASE
(Pseudomonas
fluorescens) 		4 / 7 ASN A 475
GLY A 479
THR A 481
SER A 450
 MG  A 601 ( 2.8A)
TPP  A 602 (-2.9A)
TPP  A 602 ( 4.0A)
TPP  A 602 (-2.9A)
 1.23A 2o5yH-2ag1A:
undetectable
2o5yL-2ag1A:
undetectable		 2o5yH-2ag1A:
17.66
2o5yL-2ag1A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLY A 547
ARG A 479
TYR A 372
 None
None
TPP  A3001 (-4.4A)
 0.80A 2opxA-2q27A:
undetectable		 2opxA-2q27A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 3s4y THIAMIN
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		5 / 12 GLY A 126
GLY A 127
ALA A 137
GLN A 134
GLY A 130
 None
None
None
TPP  A1301 ( 3.6A)
UNX  A 249 ( 3.5A)
 0.99A 2pkkA-3s4yA:
undetectable		 2pkkA-3s4yA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.83A 2qhcA-1v5fA:
undetectable		 2qhcA-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 2qhcB-1v5fA:
undetectable		 2qhcB-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		4 / 5 LEU A 157
ASP A 182
MET A  93
HIS A  64
 TPP  A 900 (-4.0A)
CA  A 901 ( 3.0A)
None
None
 1.24A 2qxsA-3ai7A:
undetectable		 2qxsA-3ai7A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		4 / 5 LEU A 157
ASP A 182
MET A  93
HIS A  64
 TPP  A 900 (-4.0A)
CA  A 901 ( 3.0A)
None
None
 1.23A 2qxsB-3ai7A:
undetectable		 2qxsB-3ai7A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4k9q BENZOYLFORMATE
DECARBOXYLASE
(Polynucleobacter
necessarius) 		5 / 9 PHE A 465
ILE A 461
ASP A 478
LEU A 477
THR A 471
 None
TPP  A 602 (-3.9A)
None
None
None
 1.50A 2tsrD-4k9qA:
undetectable		 2tsrD-4k9qA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 8 ASP A 963
SER A1002
TYR A 994
TYR A  28
 MG  A2237 ( 2.6A)
None
TPP  A2236 (-4.5A)
None
 1.36A 2v0gA-2c3oA:
undetectable		 2v0gA-2c3oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		4 / 8 ASP B  90
SER B 129
TYR B 121
TYR A 254
 MG  B 403 ( 3.1A)
None
TPP  B 402 (-4.2A)
TPP  B 402 (-4.6A)
 1.34A 2v0gA-5b47B:
undetectable		 2v0gA-5b47B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		5 / 10 VAL A 487
GLY A 462
ASP A 409
LEU A 473
SER A 471
 None
TPP  A 600 (-3.4A)
None
None
None
 0.90A 2v3kA-2ihtA:
undetectable		 2v3kA-2ihtA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_B_CSCB1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4rjk ACETOLACTATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 THR A  98
LEU A  97
TYR A 481
PHE A  66
VAL A 428
 None
None
TPP  A 601 (-4.2A)
None
None
 1.20A 2vaxB-4rjkA:
0.0		 2vaxB-4rjkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4rjk ACETOLACTATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 THR A  98
LEU A  97
TYR A 481
PHE A  66
VAL A 428
 None
None
TPP  A 601 (-4.2A)
None
None
 1.24A 2vaxD-4rjkA:
0.2		 2vaxD-4rjkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_H_CSCH1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4rjk ACETOLACTATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 THR A  98
LEU A  97
TYR A 481
PHE A  66
VAL A 428
 None
None
TPP  A 601 (-4.2A)
None
None
 1.21A 2vaxH-4rjkA:
0.2		 2vaxH-4rjkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_I_CSCI1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4rjk ACETOLACTATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 THR A  98
LEU A  97
TYR A 481
PHE A  66
VAL A 428
 None
None
TPP  A 601 (-4.2A)
None
None
 1.19A 2vaxI-4rjkA:
0.2		 2vaxI-4rjkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_K_CSCK1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4rjk ACETOLACTATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 THR A  98
LEU A  97
TYR A 481
PHE A  66
VAL A 428
 None
None
TPP  A 601 (-4.2A)
None
None
 1.21A 2vaxK-4rjkA:
undetectable		 2vaxK-4rjkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4k9q BENZOYLFORMATE
DECARBOXYLASE
(Polynucleobacter
necessarius) 		3 / 3 TYR A 434
GLU A 372
THR A  84
 TPP  A 602 (-4.3A)
None
None
 1.00A 2y7hB-4k9qA:
undetectable		 2y7hB-4k9qA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 10 THR A 433
GLY A 434
GLY A 411
THR A 413
ILE A 410
 None
TPP  A 600 (-3.2A)
None
None
TPP  A 600 (-4.0A)
 1.37A 2y7wB-1ovmA:
undetectable		 2y7wB-1ovmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 2z54A-1v5fA:
undetectable		 2z54A-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 2z54B-1v5fA:
undetectable		 2z54B-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		5 / 12 SER A 470
GLY A 439
GLY A 465
ILE A 476
GLY A 441
 None
None
TPP  A 600 (-3.5A)
None
None
 0.93A 3axzA-2ihtA:
undetectable		 3axzA-2ihtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37
(Mycoplasma
hyorhinis) 		3 / 3 TYR A 381
GLU A 308
ASP A 294
 None
TPP  A 551 ( 4.9A)
None
 0.77A 3bxoA-3e79A:
undetectable		 3bxoA-3e79A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37
(Mycoplasma
hyorhinis) 		3 / 3 TYR A 381
GLU A 308
ASP A 294
 None
TPP  A 551 ( 4.9A)
None
 0.82A 3bxoB-3e79A:
undetectable		 3bxoB-3e79A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT
(Pseudomonas
protegens) 		4 / 8 GLY A 395
ASN A 396
PHE A 482
TYR A 264
 TPP  A 700 (-3.4A)
TPP  A 700 (-4.0A)
None
FAD  A 701 (-4.8A)
 1.43A 3ccfA-5ahkA:
undetectable		 3ccfA-5ahkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN A 678
ILE A 680
PHE A 682
ARG A 540
 MG  A2002 ( 2.7A)
None
None
TPP  A2001 (-3.7A)
 1.14A 3ccfB-3zhrA:
2.5		 3ccfB-3zhrA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.91A 3cywA-1v5fA:
undetectable		 3cywA-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 3cywB-1v5fA:
undetectable		 3cywB-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 3d1zB-1v5fA:
undetectable		 3d1zB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.99A 3d20A-1v5fA:
undetectable		 3d20A-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 1.01A 3d20A-1v5fA:
undetectable		 3d20A-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 3ekpB-1v5fA:
undetectable		 3ekpB-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 1.01A 3ekpC-1v5fA:
undetectable		 3ekpC-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 1.02A 3ektA-1v5fA:
undetectable		 3ektA-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.98A 3ektB-1v5fA:
undetectable		 3ektB-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.96A 3ektD-1v5fA:
undetectable		 3ektD-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.97A 3ektD-1v5fA:
undetectable		 3ektD-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 9 ASP A 382
ALA A 437
ASP A 435
VAL A 459
VAL A 431
 None
TPP  A 600 (-3.1A)
MG  A 601 ( 2.9A)
None
None
 0.96A 3ekvB-1ovmA:
undetectable		 3ekvB-1ovmA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.84A 3ekvB-1v5fA:
undetectable		 3ekvB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 3ekxB-1v5fA:
undetectable		 3ekxB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 3em3A-1v5fA:
undetectable		 3em3A-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 3em3B-1v5fA:
undetectable		 3em3B-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 3em6B-1v5fA:
undetectable		 3em6B-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT
(Pseudomonas
protegens) 		3 / 3 ASN A 397
MET A 520
PHE A 376
 TPP  A 700 (-4.0A)
None
None
 1.01A 3g4lD-5ahkA:
undetectable		 3g4lD-5ahkA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		5 / 11 GLY A 124
ILE A  40
SER A  36
VAL A 165
SER A 168
 None
None
TPP  A 301 (-2.9A)
None
None
 1.12A 3gyqB-4tkrA:
undetectable		 3gyqB-4tkrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5i51 TRANSKETOLASE
(Scheffersomyces
stipitis) 		5 / 10 ASN A  64
LEU A  62
GLY A  65
HIS A  66
PHE A  90
 None
None
None
TPP  A 701 ( 3.5A)
None
 1.24A 3h9uB-5i51A:
undetectable		 3h9uB-5i51A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3mos TRANSKETOLASE
(Homo
sapiens) 		5 / 10 LEU A 262
ILE A 248
SER A  43
SER A  40
GLY A 245
 None
None
TPP  A 700 ( 4.3A)
TPP  A 700 (-2.5A)
None
 1.19A 3ijxB-3mosA:
undetectable
3ijxD-3mosA:
undetectable		 3ijxB-3mosA:
20.36
3ijxD-3mosA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3mos TRANSKETOLASE
(Homo
sapiens) 		5 / 10 ILE A 248
SER A  43
SER A  40
GLY A 245
LEU A 262
 None
TPP  A 700 ( 4.3A)
TPP  A 700 (-2.5A)
None
None
 1.43A 3ik6B-3mosA:
undetectable
3ik6E-3mosA:
undetectable		 3ik6B-3mosA:
20.36
3ik6E-3mosA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3mos TRANSKETOLASE
(Homo
sapiens) 		5 / 10 LEU A 262
ILE A 248
SER A  43
SER A  40
GLY A 245
 None
None
TPP  A 700 ( 4.3A)
TPP  A 700 (-2.5A)
None
 1.19A 3ik6B-3mosA:
undetectable
3ik6E-3mosA:
undetectable		 3ik6B-3mosA:
20.36
3ik6E-3mosA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3mos TRANSKETOLASE
(Homo
sapiens) 		5 / 11 ILE A 248
SER A  43
SER A  40
GLY A 245
LEU A 262
 None
TPP  A 700 ( 4.3A)
TPP  A 700 (-2.5A)
None
None
 1.21A 3iluB-3mosA:
undetectable
3iluE-3mosA:
undetectable		 3iluB-3mosA:
20.36
3iluE-3mosA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.84A 3jvyA-1v5fA:
undetectable		 3jvyA-1v5fA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1pox PYRUVATE OXIDASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 448
ASN A 469
VAL A 467
GLY A 425
ILE A 426
 TPP  A 611 (-3.4A)
None
None
None
None
 1.23A 3k13B-1poxA:
undetectable		 3k13B-1poxA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 395
GLY A 476
ASN A 474
PHE A 472
ILE A 477
 TPP  A3001 (-3.2A)
MG  A1001 ( 4.1A)
MG  A1001 ( 2.7A)
None
TPP  A3001 (-4.4A)
 1.13A 3k13C-2q27A:
undetectable		 3k13C-2q27A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 440
GLY A 420
ALA A 421
ASP A  59
ILE A 415
ILE A 385
 None
None
None
None
TPP  A 557 ( 3.8A)
None
 1.33A 3k4vA-1pvdA:
undetectable		 3k4vA-1pvdA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.91A 3k4vC-1v5fA:
undetectable		 3k4vC-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 GLY A 961
VAL A 986
GLY A 964
LEU A1025
ILE A1066
 None
None
TPP  A2236 (-3.2A)
None
None
 0.91A 3ku1C-2c3oA:
undetectable		 3ku1C-2c3oA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 8 ILE A 419
PRO A 422
GLY A 418
ASN A  87
 None
None
None
TPP  A1602 ( 4.8A)
 0.83A 3lslA-1v5fA:
2.3
3lslD-1v5fA:
undetectable		 3lslA-1v5fA:
19.06
3lslD-1v5fA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 2ag1 BENZALDEHYDE LYASE
(Pseudomonas
fluorescens) 		3 / 3 ASP A 448
ASN A 541
SER A 477
 MG  A 601 ( 2.4A)
None
TPP  A 602 ( 4.6A)
 0.97A 3lslA-2ag1A:
2.4
3lslD-2ag1A:
2.5		 3lslA-2ag1A:
18.36
3lslD-2ag1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 8 ASN A  87
ILE A 419
PRO A 422
GLY A 418
 TPP  A1602 ( 4.8A)
None
None
None
 0.85A 3lslA-1v5fA:
2.3
3lslD-1v5fA:
undetectable		 3lslA-1v5fA:
19.06
3lslD-1v5fA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 2ag1 BENZALDEHYDE LYASE
(Pseudomonas
fluorescens) 		3 / 3 SER A 477
ASP A 448
ASN A 541
 TPP  A 602 ( 4.6A)
MG  A 601 ( 2.4A)
None
 0.85A 3lslA-2ag1A:
undetectable
3lslD-2ag1A:
2.5		 3lslA-2ag1A:
18.36
3lslD-2ag1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 3lzsA-1v5fA:
undetectable		 3lzsA-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 3lzsB-1v5fA:
undetectable		 3lzsB-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 3lzuA-1v5fA:
undetectable		 3lzuA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.87A 3lzuB-1v5fA:
undetectable		 3lzuB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.83A 3mwsA-1v5fA:
undetectable		 3mwsA-1v5fA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.86A 3mwsA-1v5fA:
undetectable		 3mwsA-1v5fA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.97A 3mwsB-1v5fA:
undetectable		 3mwsB-1v5fA:
10.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MYU_A_VIBA500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37
(Mycoplasma
hyorhinis) 		5 / 10 TYR A 215
TRP A 314
TYR A 343
ASP A 344
GLY A 380
 TPP  A 551 (-3.7A)
TPP  A 551 (-3.7A)
TPP  A 551 (-4.2A)
TPP  A 551 (-3.3A)
TPP  A 551 (-3.5A)
 0.32A 3myuA-3e79A:
41.0		 3myuA-3e79A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37
(Mycoplasma
hyorhinis) 		5 / 10 ASN A 200
TYR A 215
TYR A 343
ASP A 344
GLY A 380
 TPP  A 551 (-3.3A)
TPP  A 551 (-3.7A)
TPP  A 551 (-4.2A)
TPP  A 551 (-3.3A)
TPP  A 551 (-3.5A)
 0.79A 3myuB-3e79A:
40.8		 3myuB-3e79A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37
(Mycoplasma
hyorhinis) 		5 / 10 TYR A 215
TRP A 314
TYR A 343
ASP A 344
GLY A 380
 TPP  A 551 (-3.7A)
TPP  A 551 (-3.7A)
TPP  A 551 (-4.2A)
TPP  A 551 (-3.3A)
TPP  A 551 (-3.5A)
 0.39A 3myuB-3e79A:
40.8		 3myuB-3e79A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		4 / 8 TYR A 561
PHE A 412
ILE A 460
GLY A 411
 TPP  A 600 ( 4.2A)
None
None
TPP  A 600 (-3.6A)
 0.91A 3n9jA-2ihtA:
undetectable		 3n9jA-2ihtA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3s4y THIAMIN
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		4 / 4 ARG A 131
ASP A  46
ASP A  73
ASP A  71
 TPP  A1301 (-3.3A)
CA  A1303 ( 3.3A)
TPP  A1301 (-2.5A)
CA  A1303 ( 2.8A)
 1.15A 3naiB-3s4yA:
undetectable		 3naiB-3s4yA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 440
GLY A 420
ALA A 421
ASP A  59
ILE A 415
ILE A 385
 None
None
None
None
TPP  A 557 ( 3.8A)
None
 1.36A 3ndtA-1pvdA:
undetectable		 3ndtA-1pvdA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 3ndtD-1v5fA:
undetectable		 3ndtD-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 3ndwA-1v5fA:
undetectable		 3ndwA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.96A 3nu5B-1v5fA:
undetectable		 3nu5B-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.91A 3nu6A-1v5fA:
undetectable		 3nu6A-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 3nu6B-1v5fA:
undetectable		 3nu6B-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 3nujB-1v5fA:
undetectable		 3nujB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 3nuoB-1v5fA:
undetectable		 3nuoB-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		3 / 3 TYR A 472
ASP A 442
ASP A 388
 TPP  A1602 ( 4.3A)
MG  A1603 ( 2.8A)
None
 0.99A 3ou7B-1v5fA:
undetectable		 3ou7B-1v5fA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 3oxcA-1v5fA:
undetectable		 3oxcA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 3oxvC-1v5fA:
undetectable		 3oxvC-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 11 ASP A 382
ALA A 437
ASP A 435
VAL A 459
VAL A 431
 None
TPP  A 600 (-3.1A)
MG  A 601 ( 2.9A)
None
None
 1.07A 3oxvD-1ovmA:
undetectable		 3oxvD-1ovmA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 3oxvD-1v5fA:
undetectable		 3oxvD-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 3oxwB-1v5fA:
undetectable		 3oxwB-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.97A 3oxwD-1v5fA:
undetectable		 3oxwD-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 3oy4A-1v5fA:
undetectable		 3oy4A-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 3pwmA-1v5fA:
undetectable		 3pwmA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 3pwmB-1v5fA:
undetectable		 3pwmB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 3pwrB-1v5fA:
undetectable		 3pwrB-1v5fA:
11.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RLB_A_VIBA191_1
(THIT)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		6 / 10 GLU A  82
TYR A  83
HIS A 131
GLY A 135
TRP A 139
ASN A 157
 TPP  A 301 (-2.8A)
TPP  A 301 (-4.6A)
TPP  A 301 (-3.6A)
TPP  A 301 (-3.3A)
TPP  A 301 (-3.4A)
TPP  A 301 (-3.1A)
 0.19A 3rlbA-4tkrA:
27.0		 3rlbA-4tkrA:
37.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RLB_B_VIBB187_1
(THIT)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		7 / 12 GLU A  82
TYR A  83
TYR A 128
HIS A 131
GLY A 135
TRP A 139
ASN A 157
 TPP  A 301 (-2.8A)
TPP  A 301 (-4.6A)
None
TPP  A 301 (-3.6A)
TPP  A 301 (-3.3A)
TPP  A 301 (-3.4A)
TPP  A 301 (-3.1A)
 0.37A 3rlbB-4tkrA:
27.1		 3rlbB-4tkrA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 5a65 THIAMINE
TRIPHOSPHATASE
(Mus
musculus) 		4 / 5 GLU A 157
ARG A  55
LYS A 193
GLU A 159
 MG  A 500 (-2.7A)
TPP  A1000 (-3.2A)
TPP  A1000 (-2.8A)
MG  A 501 (-1.9A)
 1.11A 3tj7C-5a65A:
11.1		 3tj7C-5a65A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 5a65 THIAMINE
TRIPHOSPHATASE
(Mus
musculus) 		4 / 5 GLU A 157
ARG A  57
LYS A 193
GLU A 159
 MG  A 500 (-2.7A)
TPP  A1000 ( 3.2A)
TPP  A1000 (-2.8A)
MG  A 501 (-1.9A)
 1.10A 3tj7C-5a65A:
11.1		 3tj7C-5a65A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 1.00A 3tkgD-1v5fA:
undetectable		 3tkgD-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 3tkwA-1v5fA:
undetectable		 3tkwA-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		4 / 7 TRP A 194
PRO A 210
GLY A  94
PRO A  95
 None
None
None
TPP  A 900 ( 4.6A)
 1.23A 3ucbB-3ai7A:
undetectable		 3ucbB-3ai7A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT
(Pseudomonas
protegens) 		4 / 5 ASP A  87
SER A 421
GLY A 420
ASP A  91
 None
TPP  A 700 ( 4.2A)
FAD  A 701 (-3.7A)
FAD  A 701 ( 4.8A)
 1.39A 3w9tB-5ahkA:
undetectable		 3w9tB-5ahkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 5 SER B  47
GLY B  48
TRP B  11
ASP B  10
 TPP  B 402 (-3.0A)
None
None
None
 1.13A 3w9tB-5b47B:
undetectable		 3w9tB-5b47B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT
(Pseudomonas
protegens) 		4 / 5 ASP A  87
SER A 421
GLY A 420
ASP A  91
 None
TPP  A 700 ( 4.2A)
FAD  A 701 (-3.7A)
FAD  A 701 ( 4.8A)
 1.40A 3w9tC-5ahkA:
undetectable		 3w9tC-5ahkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 5 SER B  47
GLY B  48
TRP B  11
ASP B  10
 TPP  B 402 (-3.0A)
None
None
None
 1.13A 3w9tC-5b47B:
undetectable		 3w9tC-5b47B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT
(Pseudomonas
protegens) 		4 / 5 ASP A  87
SER A 421
GLY A 420
ASP A  91
 None
TPP  A 700 ( 4.2A)
FAD  A 701 (-3.7A)
FAD  A 701 ( 4.8A)
 1.39A 3w9tD-5ahkA:
undetectable		 3w9tD-5ahkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 5 SER B  47
GLY B  48
TRP B  11
ASP B  10
 TPP  B 402 (-3.0A)
None
None
None
 1.14A 3w9tD-5b47B:
undetectable		 3w9tD-5b47B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 135
GLY A 136
ILE A 174
VAL A 173
 TPP  A1002 (-3.9A)
None
None
None
 0.90A 3wriB-3rimA:
undetectable		 3wriB-3rimA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE
(Bacillus
subtilis) 		4 / 8 ILE A 433
ASN A 404
GLY A 403
ILE A 455
 TPP  A 601 (-4.0A)
None
None
None
 0.91A 3wxoA-2x7jA:
undetectable		 3wxoA-2x7jA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 504
GLY A 549
ILE A 547
ASP A 550
GLU A 578
 None
TPP  A 700 (-3.6A)
None
MG  A 699 ( 2.8A)
None
 1.03A 4dcmA-1jscA:
3.7		 4dcmA-1jscA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		5 / 11 ASP A 409
GLY A 462
GLY A 464
ILE A 410
GLU A 556
 None
TPP  A 600 (-3.4A)
TPP  A 600 (-3.5A)
TPP  A 600 (-4.5A)
None
 1.12A 4dcmA-2ihtA:
undetectable		 4dcmA-2ihtA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4rjk ACETOLACTATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 MET A 483
ASN A 269
ASP A 273
GLY A 265
GLN A 424
 TPP  A 601 (-4.0A)
None
None
None
None
 1.38A 4djeB-4rjkA:
undetectable		 4djeB-4rjkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4dqbA-1v5fA:
undetectable		 4dqbA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 10 ASP A 382
ALA A 437
ASP A 435
VAL A 459
VAL A 431
 None
TPP  A 600 (-3.1A)
MG  A 601 ( 2.9A)
None
None
 1.09A 4dqcA-1ovmA:
undetectable		 4dqcA-1ovmA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4dqcA-1v5fA:
undetectable		 4dqcA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 1.07A 4dqcB-1v5fA:
undetectable		 4dqcB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 4dqeA-1v5fA:
undetectable		 4dqeA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4dqhA-1v5fA:
undetectable		 4dqhA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		4 / 6 ALA A 164
GLY A  94
PRO A  95
VAL A 180
 None
None
TPP  A 900 ( 4.6A)
None
 0.95A 4dubA-3ai7A:
undetectable		 4dubA-3ai7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5i51 TRANSKETOLASE
(Scheffersomyces
stipitis) 		5 / 12 GLY A 156
CYH A 157
SER A 163
LEU A 241
TYR A 205
 TPP  A 701 (-3.5A)
None
None
None
None
 1.23A 4emaA-5i51A:
undetectable		 4emaA-5i51A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5nd5 TRANSKETOLASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 209
CYH A 210
SER A 216
LEU A 294
TYR A 258
 TPP  A 801 (-3.5A)
None
None
None
None
 1.22A 4emaA-5nd5A:
undetectable		 4emaA-5nd5A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 ASN A 473
GLY A 446
THR A 398
GLY A 547
 None
TPP  A3001 (-3.4A)
TPP  A3001 (-3.7A)
None
 0.67A 4fo4B-2q27A:
undetectable		 4fo4B-2q27A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2vk4 PYRUVATE
DECARBOXYLASE
(Kluyveromyces
lactis) 		5 / 11 SER A 296
ILE A 476
LEU A 540
GLY A 394
PHE A 393
 None
TPP  A 600 (-3.6A)
None
None
None
 1.28A 4fogA-2vk4A:
undetectable		 4fogA-2vk4A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE
(Azoarcus
sp.
BH72) 		5 / 10 ALA A 453
LEU A 454
ILE A 508
ALA A 509
ALA A 464
 TPP  A1589 (-3.3A)
None
None
None
None
 1.05A 4j14A-4d5gA:
undetectable		 4j14A-4d5gA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.85A 4jecB-1v5fA:
undetectable		 4jecB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 8 ARG A  47
GLY A 350
THR A 349
THR A 353
 None
None
TPP  B 402 ( 4.5A)
None
 0.88A 4k87A-5b47A:
2.7		 4k87A-5b47A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 5 MET A 433
LEU A 380
ARG A 393
SER A 438
 None
None
None
TPP  A2000 (-2.5A)
 1.43A 4kmmB-2vbiA:
2.1		 4kmmB-2vbiA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		5 / 11 GLY A 181
ALA A 160
GLY A  96
ILE A 598
LEU A 562
 TPP  A 900 (-3.2A)
None
None
None
None
 0.95A 4kt0A-3ai7A:
undetectable
4kt0J-3ai7A:
undetectable		 4kt0A-3ai7A:
21.06
4kt0J-3ai7A:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 8 ASP A 382
ALA A 437
ASP A 435
VAL A 459
VAL A 431
 None
TPP  A 600 (-3.1A)
MG  A 601 ( 2.9A)
None
None
 1.21A 4ll3A-1ovmA:
undetectable		 4ll3A-1ovmA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 8 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 1.00A 4ll3A-1v5fA:
undetectable		 4ll3A-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 9 ASP A 382
ALA A 437
ASP A 435
VAL A 459
VAL A 431
 None
TPP  A 600 (-3.1A)
MG  A 601 ( 2.9A)
None
None
 1.17A 4ll3B-1ovmA:
undetectable		 4ll3B-1ovmA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.97A 4ll3B-1v5fA:
undetectable		 4ll3B-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		4 / 5 THR A 223
THR A  67
HIS A  97
LEU A 157
 CA  A 901 ( 4.8A)
TPP  A 900 (-3.4A)
TPP  A 900 (-3.8A)
TPP  A 900 (-4.0A)
 1.41A 4lvcA-3ai7A:
2.1		 4lvcA-3ai7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 12 ALA A 541
GLY A 384
PHE A 388
ASP A 289
THR A 290
 None
TPP  A 600 (-3.5A)
None
None
None
 1.14A 4mm8A-1ovmA:
0.0		 4mm8A-1ovmA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 12 GLY A 384
PHE A 388
GLY A 540
ASP A 289
THR A 290
 TPP  A 600 (-3.5A)
None
None
None
None
 1.12A 4mm8A-1ovmA:
0.0		 4mm8A-1ovmA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		5 / 12 GLY A  94
PRO A  95
GLY A  96
PHE A 143
LEU A 161
 None
TPP  A 900 ( 4.6A)
None
None
None
 0.95A 4n49A-3ai7A:
undetectable		 4n49A-3ai7A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4njtA-1v5fA:
undetectable		 4njtA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.90A 4njtC-1v5fA:
undetectable		 4njtC-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.82A 4njvA-1v5fA:
undetectable		 4njvA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.95A 4njvA-1v5fA:
undetectable		 4njvA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 1.01A 4njvB-1v5fA:
undetectable		 4njvB-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.84A 4njvD-1v5fA:
undetectable		 4njvD-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.94A 4njvD-1v5fA:
undetectable		 4njvD-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		3 / 3 ALA A 420
GLN A 404
GLY A 408
 None
None
TPP  A 600 (-4.9A)
 0.61A 4odoC-1ovmA:
undetectable		 4odoC-1ovmA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT
(Pseudomonas
protegens) 		5 / 12 GLN A 450
LEU A 451
GLY A 445
ASN A 472
ASN A 396
 None
None
TPP  A 700 (-3.6A)
None
TPP  A 700 (-4.0A)
 1.34A 4pclB-5ahkA:
4.3		 4pclB-5ahkA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2q27 OXALYL-COA
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 THR A 398
GLY A 395
ASP A 400
ILE A 471
ASN A 397
 TPP  A3001 (-3.7A)
TPP  A3001 (-3.2A)
None
None
TPP  A3001 (-3.9A)
 1.36A 4pooB-2q27A:
3.3		 4pooB-2q27A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		3 / 3 GLY A 319
PRO A 318
ALA A 346
 TPP  B 402 ( 4.6A)
TPP  B 402 (-4.6A)
None
 0.47A 4qn9B-5b47A:
undetectable		 4qn9B-5b47A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 11 GLY A 317
GLY A 319
MET A 323
ILE A 256
GLY A 356
 None
TPP  B 402 ( 4.6A)
None
TPP  B 402 (-3.9A)
None
 1.19A 4qoiA-5b47A:
4.4
4qoiB-5b47A:
4.8		 4qoiA-5b47A:
16.72
4qoiB-5b47A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		5 / 12 GLY A 441
ILE A 410
SER A 437
ILE A 446
ALA A 444
 None
TPP  A 600 (-4.5A)
TPP  A 600 (-3.5A)
None
None
 1.12A 4qtuB-2ihtA:
undetectable		 4qtuB-2ihtA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		5 / 12 GLY A 441
ILE A 410
SER A 437
ILE A 446
ALA A 444
 None
TPP  A 600 (-4.5A)
TPP  A 600 (-3.5A)
None
None
 1.08A 4qtuD-2ihtA:
undetectable		 4qtuD-2ihtA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 4 THR A 206
GLY A 167
ASP A 196
SER A 201
 None
TPP  A1002 ( 3.9A)
None
None
 1.40A 4rfqA-1itzA:
1.8		 4rfqA-1itzA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE
(Azoarcus
sp.
BH72) 		5 / 12 GLY A 429
GLY A 450
ALA A 453
ASN A 400
SER A 376
 None
TPP  A1589 (-3.3A)
TPP  A1589 (-3.3A)
TPP  A1589 (-4.3A)
None
 1.02A 4rtmA-4d5gA:
undetectable		 4rtmA-4d5gA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 ILE A 248
GLY A 249
PRO A  30
ALA A  15
VAL A 260
 TPP  A1671 (-4.4A)
None
None
None
None
 1.12A 4rvdA-1r9jA:
2.8		 4rvdA-1r9jA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 ILE A 248
GLY A 249
PRO A  30
ALA A  15
VAL A 260
 TPP  A1671 (-4.4A)
None
None
None
None
 1.13A 4rvgA-1r9jA:
3.4		 4rvgA-1r9jA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4rvjB-1v5fA:
undetectable		 4rvjB-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4rvjD-1v5fA:
undetectable		 4rvjD-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 2ag1 BENZALDEHYDE LYASE
(Pseudomonas
fluorescens) 		4 / 5 GLY A 393
THR A 446
HIS A 415
GLY A 422
 TPP  A 602 (-3.6A)
None
None
None
 1.01A 4v20A-2ag1A:
undetectable		 4v20A-2ag1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1qgd PROTEIN
(TRANSKETOLASE)
(Escherichia
coli) 		5 / 12 VAL A  19
GLY A  67
TYR A  72
SER A  15
HIS A  66
 None
None
None
None
TPP  A 670 ( 3.8A)
 1.44A 4xueB-1qgdA:
4.0		 4xueB-1qgdA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 PHE A 124
PRO A  32
THR A  31
ARG A 114
GLY A 839
 None
None
PYR  A2239 (-3.6A)
PYR  A2239 (-3.0A)
TPP  A2236 (-3.3A)
 1.17A 4ydqB-2c3oA:
2.1		 4ydqB-2c3oA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 177
HIS A  85
LEU A  52
THR A  89
ALA A  49
 MG  A1001 ( 2.9A)
TPP  A1002 (-4.0A)
None
None
None
 1.24A 4yhaB-3rimA:
undetectable		 4yhaB-3rimA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		5 / 12 SER A 470
GLY A 439
GLY A 465
ILE A 476
GLY A 441
 None
None
TPP  A 600 (-3.5A)
None
None
 0.96A 4yvgA-2ihtA:
undetectable		 4yvgA-2ihtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5npu ANC27
(synthetic
construct) 		4 / 5 ALA A 422
HIS A 415
ALA A  83
GLU A 410
 None
TPP  A 602 (-3.0A)
None
None
 1.47A 5a06C-5npuA:
3.1
5a06D-5npuA:
2.2		 5a06C-5npuA:
undetectable
5a06D-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 443
GLY A 445
THR A 450
ASP A 444
ILE A 538
 TPP  A 557 (-3.5A)
TPP  A 557 (-3.4A)
None
MG  A 558 (-2.8A)
None
 0.93A 5bw4A-1pvdA:
3.6		 5bw4A-1pvdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeuA-3rimA:
undetectable
5eeuB-3rimA:
undetectable		 5eeuA-3rimA:
7.83
5eeuB-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eeuB-3rimA:
undetectable
5eeuC-3rimA:
undetectable		 5eeuB-3rimA:
7.83
5eeuC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeuD-3rimA:
undetectable
5eeuE-3rimA:
undetectable		 5eeuD-3rimA:
7.83
5eeuE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.35A 5eeuE-3rimA:
undetectable
5eeuF-3rimA:
undetectable		 5eeuE-3rimA:
7.83
5eeuF-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeuH-3rimA:
undetectable
5eeuI-3rimA:
undetectable		 5eeuH-3rimA:
7.83
5eeuI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeuJ-3rimA:
undetectable
5eeuK-3rimA:
undetectable		 5eeuJ-3rimA:
7.83
5eeuK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eeuA-3rimA:
undetectable
5eeuK-3rimA:
undetectable		 5eeuA-3rimA:
7.83
5eeuK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.38A 5eevB-3rimA:
undetectable
5eevC-3rimA:
undetectable		 5eevB-3rimA:
7.83
5eevC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eevD-3rimA:
undetectable
5eevE-3rimA:
undetectable		 5eevD-3rimA:
7.83
5eevE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.35A 5eevE-3rimA:
undetectable
5eevF-3rimA:
undetectable		 5eevE-3rimA:
7.83
5eevF-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eevH-3rimA:
undetectable
5eevI-3rimA:
undetectable		 5eevH-3rimA:
7.83
5eevI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eevJ-3rimA:
undetectable
5eevK-3rimA:
undetectable		 5eevJ-3rimA:
7.83
5eevK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eevA-3rimA:
undetectable
5eevK-3rimA:
undetectable		 5eevA-3rimA:
7.83
5eevK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eewB-3rimA:
undetectable
5eewC-3rimA:
undetectable		 5eewB-3rimA:
7.83
5eewC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eewD-3rimA:
undetectable
5eewE-3rimA:
undetectable		 5eewD-3rimA:
7.83
5eewE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.35A 5eewE-3rimA:
undetectable
5eewF-3rimA:
undetectable		 5eewE-3rimA:
7.83
5eewF-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eewH-3rimA:
undetectable
5eewI-3rimA:
undetectable		 5eewH-3rimA:
7.83
5eewI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eewJ-3rimA:
undetectable
5eewK-3rimA:
undetectable		 5eewJ-3rimA:
7.83
5eewK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eewA-3rimA:
undetectable
5eewK-3rimA:
undetectable		 5eewA-3rimA:
7.83
5eewK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.38A 5eexB-3rimA:
undetectable
5eexC-3rimA:
undetectable		 5eexB-3rimA:
7.83
5eexC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eexD-3rimA:
undetectable
5eexE-3rimA:
undetectable		 5eexD-3rimA:
7.83
5eexE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.35A 5eexE-3rimA:
undetectable
5eexF-3rimA:
undetectable		 5eexE-3rimA:
7.83
5eexF-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eexH-3rimA:
undetectable
5eexI-3rimA:
undetectable		 5eexH-3rimA:
7.83
5eexI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eexJ-3rimA:
undetectable
5eexK-3rimA:
undetectable		 5eexJ-3rimA:
7.83
5eexK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eexA-3rimA:
undetectable
5eexK-3rimA:
undetectable		 5eexA-3rimA:
7.83
5eexK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.40A 5eexQ-3rimA:
undetectable
5eexR-3rimA:
undetectable		 5eexQ-3rimA:
7.83
5eexR-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eeyB-3rimA:
undetectable
5eeyC-3rimA:
undetectable		 5eeyB-3rimA:
7.83
5eeyC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeyD-3rimA:
undetectable
5eeyE-3rimA:
undetectable		 5eeyD-3rimA:
7.83
5eeyE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.35A 5eeyE-3rimA:
undetectable
5eeyF-3rimA:
undetectable		 5eeyE-3rimA:
7.83
5eeyF-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eeyH-3rimA:
undetectable
5eeyI-3rimA:
undetectable		 5eeyH-3rimA:
7.83
5eeyI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeyJ-3rimA:
undetectable
5eeyK-3rimA:
undetectable		 5eeyJ-3rimA:
7.83
5eeyK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eeyA-3rimA:
undetectable
5eeyK-3rimA:
undetectable		 5eeyA-3rimA:
7.83
5eeyK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eezB-3rimA:
undetectable
5eezC-3rimA:
undetectable		 5eezB-3rimA:
7.83
5eezC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eezD-3rimA:
undetectable
5eezE-3rimA:
undetectable		 5eezD-3rimA:
7.83
5eezE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eezH-3rimA:
undetectable
5eezI-3rimA:
undetectable		 5eezH-3rimA:
7.83
5eezI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eezJ-3rimA:
undetectable
5eezK-3rimA:
undetectable		 5eezJ-3rimA:
7.83
5eezK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eezA-3rimA:
undetectable
5eezK-3rimA:
undetectable		 5eezA-3rimA:
7.83
5eezK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef0B-3rimA:
undetectable
5ef0C-3rimA:
undetectable		 5ef0B-3rimA:
7.83
5ef0C-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef0D-3rimA:
undetectable
5ef0E-3rimA:
undetectable		 5ef0D-3rimA:
7.83
5ef0E-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef0H-3rimA:
undetectable
5ef0I-3rimA:
undetectable		 5ef0H-3rimA:
7.83
5ef0I-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef0J-3rimA:
undetectable
5ef0K-3rimA:
undetectable		 5ef0J-3rimA:
7.83
5ef0K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5ef0A-3rimA:
undetectable
5ef0K-3rimA:
undetectable		 5ef0A-3rimA:
7.83
5ef0K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef1B-3rimA:
undetectable
5ef1C-3rimA:
undetectable		 5ef1B-3rimA:
7.83
5ef1C-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef1D-3rimA:
undetectable
5ef1E-3rimA:
undetectable		 5ef1D-3rimA:
7.83
5ef1E-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef1H-3rimA:
undetectable
5ef1I-3rimA:
undetectable		 5ef1H-3rimA:
7.83
5ef1I-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef1J-3rimA:
undetectable
5ef1K-3rimA:
undetectable		 5ef1J-3rimA:
7.83
5ef1K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5ef1A-3rimA:
undetectable
5ef1K-3rimA:
undetectable		 5ef1A-3rimA:
7.83
5ef1K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef2B-3rimA:
undetectable
5ef2C-3rimA:
undetectable		 5ef2B-3rimA:
7.83
5ef2C-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef2D-3rimA:
undetectable
5ef2E-3rimA:
undetectable		 5ef2D-3rimA:
7.83
5ef2E-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef2H-3rimA:
undetectable
5ef2I-3rimA:
undetectable		 5ef2H-3rimA:
7.83
5ef2I-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef2J-3rimA:
undetectable
5ef2K-3rimA:
undetectable		 5ef2J-3rimA:
7.83
5ef2K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5ef2A-3rimA:
undetectable
5ef2K-3rimA:
undetectable		 5ef2A-3rimA:
7.83
5ef2K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef3B-3rimA:
undetectable
5ef3C-3rimA:
undetectable		 5ef3B-3rimA:
7.83
5ef3C-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef3D-3rimA:
undetectable
5ef3E-3rimA:
undetectable		 5ef3D-3rimA:
7.83
5ef3E-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef3H-3rimA:
undetectable
5ef3I-3rimA:
undetectable		 5ef3H-3rimA:
7.83
5ef3I-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef3J-3rimA:
undetectable
5ef3K-3rimA:
undetectable		 5ef3J-3rimA:
7.83
5ef3K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5ef3A-3rimA:
undetectable
5ef3K-3rimA:
undetectable		 5ef3A-3rimA:
7.83
5ef3K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 6 LYS A 204
TYR A 205
GLY A 161
GLU A 160
 None
None
None
TPP  A1671 (-3.9A)
 0.95A 5emlA-1r9jA:
undetectable		 5emlA-1r9jA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 8 GLU A 292
GLY B  91
THR A 257
TYR A 253
 None
TPP  B 402 (-3.4A)
PYR  A 701 (-3.0A)
None
 0.96A 5flcB-5b47A:
undetectable		 5flcB-5b47A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 8 GLU A 292
GLY B  91
THR A 257
TYR A 253
 None
TPP  B 402 (-3.4A)
PYR  A 701 (-3.0A)
None
 0.96A 5flcF-5b47A:
undetectable		 5flcF-5b47A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		3 / 3 PRO A 544
ILE A 348
SER A 392
 None
None
TPP  A1602 (-2.7A)
 0.78A 5fsaA-1v5fA:
undetectable		 5fsaA-1v5fA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5npu ANC27
(synthetic
construct) 		5 / 12 ASP A 391
THR A 472
GLY A 440
SER A 443
THR A 389
 None
TPP  A 602 (-3.4A)
TPP  A 602 (-3.3A)
TPP  A 602 (-2.7A)
TPP  A 602 ( 4.5A)
 1.32A 5hfjB-5npuA:
undetectable		 5hfjB-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2ag1 BENZALDEHYDE LYASE
(Pseudomonas
fluorescens) 		5 / 9 LEU A 395
ILE A 549
HIS A 483
ARG A 356
VAL A 445
 TPP  A 602 (-3.4A)
None
None
None
None
 1.28A 5igzA-2ag1A:
undetectable		 5igzA-2ag1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE
(Bifidobacterium
longum) 		4 / 5 PHE A 237
LEU A 190
GLY A 181
ILE A 295
 None
None
TPP  A 900 (-3.2A)
None
 0.79A 5ik1A-3ai7A:
undetectable		 5ik1A-3ai7A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT
(Pseudomonas
protegens) 		5 / 7 GLY A 395
GLY A 445
GLY A 448
VAL A 394
LEU A 451
 TPP  A 700 (-3.4A)
TPP  A 700 (-3.6A)
TPP  A 700 (-3.7A)
TPP  A 700 (-4.9A)
None
 1.42A 5izjB-5ahkA:
undetectable		 5izjB-5ahkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5i51 TRANSKETOLASE
(Scheffersomyces
stipitis) 		5 / 12 GLY A 156
CYH A 157
SER A 163
LEU A 241
TYR A 205
 TPP  A 701 (-3.5A)
None
None
None
None
 1.22A 5ji0D-5i51A:
undetectable		 5ji0D-5i51A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5nd5 TRANSKETOLASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 209
CYH A 210
SER A 216
LEU A 294
TYR A 258
 TPP  A 801 (-3.5A)
None
None
None
None
 1.23A 5ji0D-5nd5A:
undetectable		 5ji0D-5nd5A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 5 TYR A 347
GLY A 259
THR A 241
GLY A 435
 None
None
None
TPP  A 600 (-3.4A)
 0.84A 5jlcA-4cokA:
undetectable		 5jlcA-4cokA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 VAL A 437
LEU A 453
LEU A 467
GLY A 456
SER A 459
 None
None
None
TPP  A 601 (-3.4A)
TPP  A 601 (-4.6A)
 0.86A 5jvzA-2x7jA:
undetectable		 5jvzA-2x7jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE
(Bacillus
subtilis) 		5 / 12 VAL A 437
LEU A 453
LEU A 467
GLY A 456
SER A 459
 None
None
None
TPP  A 601 (-3.4A)
TPP  A 601 (-4.6A)
 0.89A 5jvzB-2x7jA:
undetectable		 5jvzB-2x7jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 3mos TRANSKETOLASE
(Homo
sapiens) 		3 / 3 LYS A 244
ASP A 253
ILE A  47
 TPP  A 700 (-2.7A)
None
None
 0.82A 5kc4E-3mosA:
undetectable		 5kc4E-3mosA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 1.05A 5kr0B-1v5fA:
undetectable		 5kr0B-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		3 / 3 SER A  36
SER A  34
PHE A  87
 TPP  A 301 (-2.9A)
TPP  A 301 (-3.0A)
TPP  A 301 (-4.8A)
 0.50A 5mugA-4tkrA:
undetectable		 5mugA-4tkrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5npu ANC27
(synthetic
construct) 		5 / 12 GLY A 390
SER A 392
ASN A 467
LEU A 531
LEU A 437
 TPP  A 602 ( 3.7A)
TPP  A 602 ( 4.5A)
None
None
None
 1.24A 5nwwA-5npuA:
undetectable		 5nwwA-5npuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 GLY A 435
ILE A 461
MET A 471
TYR A 466
VAL A 480
 TPP  A 600 (-3.4A)
TPP  A 600 ( 4.7A)
None
TPP  A 600 (-3.6A)
None
 1.05A 5nz0A-4cokA:
undetectable		 5nz0A-4cokA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 1.02A 5t2zA-1v5fA:
undetectable		 5t2zA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE
(Enterobacter
cloacae) 		5 / 8 GLY A 434
LEU A 542
VAL A 467
ILE A 410
GLY A 411
 TPP  A 600 (-3.2A)
None
TPP  A 600 (-3.4A)
TPP  A 600 (-4.0A)
None
 1.21A 5vkqB-1ovmA:
undetectable
5vkqC-1ovmA:
undetectable		 5vkqB-1ovmA:
15.67
5vkqC-1ovmA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1qgd PROTEIN
(TRANSKETOLASE)
(Escherichia
coli) 		4 / 7 ASP A 183
ASP A 155
GLY A 156
ASN A  64
 None
CA  A 675 (-3.3A)
TPP  A 670 ( 3.5A)
None
 1.06A 5x7pA-1qgdA:
0.0		 5x7pA-1qgdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5i51 TRANSKETOLASE
(Scheffersomyces
stipitis) 		4 / 7 ASP A 183
ASP A 155
GLY A 156
ASN A  64
 None
CA  A 703 ( 3.2A)
TPP  A 701 (-3.5A)
None
 1.09A 5x7pA-5i51A:
undetectable		 5x7pA-5i51A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3mos TRANSKETOLASE
(Homo
sapiens) 		3 / 3 TYR A  83
LEU A  73
ASP A 183
 None
EDO  A 627 (-4.4A)
TPP  A 700 ( 4.5A)
 0.84A 5zv2B-3mosA:
undetectable		 5zv2B-3mosA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		3 / 3 HIS A  66
HIS A 100
ARG A  91
 TPP  A1671 (-3.8A)
None
None
 1.02A 6b58A-1r9jA:
2.9		 6b58A-1r9jA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5i51 TRANSKETOLASE
(Scheffersomyces
stipitis) 		3 / 3 HIS A  66
HIS A 100
ARG A  91
 TPP  A 701 ( 3.5A)
F6R  A 702 (-3.9A)
F6R  A 702 ( 4.8A)
 0.97A 6b58A-5i51A:
undetectable		 6b58A-5i51A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5nd5 TRANSKETOLASE
(Chlamydomonas
reinhardtii) 		3 / 3 HIS A 117
HIS A 152
ARG A 143
 TPP  A 801 (-3.9A)
None
None
 1.04A 6b58A-5nd5A:
3.6		 6b58A-5nd5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2iht CARBOXYETHYLARGININE
SYNTHASE
(Streptomyces
clavuligerus) 		5 / 12 LEU A 495
GLY A 494
LEU A 459
VAL A 486
ASP A 463
 TPP  A 600 ( 4.3A)
TPP  A 600 (-3.2A)
None
None
MG  A 601 ( 2.8A)
 1.20A 6bxmA-2ihtA:
3.1		 6bxmA-2ihtA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 500
GLY A 498
LEU A 529
GLY A 526
SER A 552
 TPP  A 700 (-3.9A)
TPP  A 700 (-3.3A)
None
None
TPP  A 700 (-2.8A)
 1.13A 6c2mA-1jscA:
undetectable		 6c2mA-1jscA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1qgd PROTEIN
(TRANSKETOLASE)
(Escherichia
coli) 		5 / 12 GLY A  65
VAL A 109
GLY A 154
ALA A 151
ALA A 180
 None
None
TPP  A 670 ( 4.1A)
None
None
 1.06A 6c2mD-1qgdA:
undetectable		 6c2mD-1qgdA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 6dgxA-1v5fA:
undetectable		 6dgxA-1v5fA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 6dh3A-1v5fA:
undetectable		 6dh3A-1v5fA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 6dh6A-1v5fA:
undetectable		 6dh6A-1v5fA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5i51 TRANSKETOLASE
(Scheffersomyces
stipitis) 		5 / 12 ASN A  64
LEU A  62
GLY A  65
HIS A  66
PHE A  90
 None
None
None
TPP  A 701 ( 3.5A)
None
 1.26A 6exiA-5i51A:
undetectable		 6exiA-5i51A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5i51 TRANSKETOLASE
(Scheffersomyces
stipitis) 		5 / 12 ASN A  64
LEU A  62
GLY A  65
HIS A  66
PHE A  90
 None
None
None
TPP  A 701 ( 3.5A)
None
 1.28A 6exiD-5i51A:
undetectable		 6exiD-5i51A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3s4y THIAMIN
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		4 / 6 ASP A  71
ASP A  73
GLN A  96
GLN A 134
 CA  A1303 ( 2.8A)
TPP  A1301 (-2.5A)
TPP  A1301 (-3.9A)
TPP  A1301 ( 3.6A)
 1.26A 6g31B-3s4yA:
undetectable		 6g31B-3s4yA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT
(Pseudomonas
protegens) 		5 / 12 GLY A 448
VAL A 470
THR A  83
GLY A  84
GLN A 454
 TPP  A 700 (-3.7A)
None
None
None
None
 1.19A 6gngA-5ahkA:
2.2		 6gngA-5ahkA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2xt6 2-OXOGLUTARATE
DECARBOXYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 746
HIS A 747
ARG A 745
GLU A 749
GLY A 750
 None
TPP  A2001 (-4.5A)
None
None
None
 1.35A 6gngA-2xt6A:
undetectable		 6gngA-2xt6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1jsc ACETOHYDROXY-ACID
SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 173
GLY A 523
GLY A 526
GLY A 496
ALA A 531
 None
TPP  A 700 (-4.9A)
None
None
None
 1.03A 6nj9K-1jscA:
3.6		 6nj9K-1jscA:
20.62