SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TPO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2jgz CELL DIVISION
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 ASP A 127
ASP A 145
ARG A  50
THR A  14
 None
None
TPO  A 160 ( 2.8A)
None
 1.35A 1ceaA-2jgzA:
undetectable
1ceaB-2jgzA:
undetectable		 1ceaA-2jgzA:
13.03
1ceaB-2jgzA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 9 LEU A 788
VAL A 792
THR A 778
VAL A 743
ASP A 803
 None
None
TPO  A 780 ( 2.6A)
None
None
 1.46A 1dz8B-4otdA:
undetectable		 1dz8B-4otdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 3m8y PHOSPHOPENTOMUTASE
(Bacillus
cereus) 		5 / 12 PHE A 366
GLY A  88
PHE A  26
ASP A  22
ALA A  20
 None
TPO  A  85 ( 3.8A)
None
None
None
 1.08A 1e3vA-3m8yA:
undetectable		 1e3vA-3m8yA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 3m8y PHOSPHOPENTOMUTASE
(Bacillus
cereus) 		5 / 11 PHE A 366
GLY A  88
PHE A  26
ASP A  22
ALA A  20
 None
TPO  A  85 ( 3.8A)
None
None
None
 1.09A 1e3vB-3m8yA:
0.0		 1e3vB-3m8yA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 11 ASP A   8
GLY A  56
ALA A  57
GLY A  22
ILE A  21
VAL A  96
 None
TPO  A  18 ( 4.6A)
None
TPO  A  18 ( 3.7A)
TPO  A  18 ( 4.2A)
None
 1.40A 1hxwB-3u02A:
undetectable		 1hxwB-3u02A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3m8y PHOSPHOPENTOMUTASE
(Bacillus
cereus) 		5 / 12 LEU A   9
HIS A  89
PHE A 366
THR A 325
ARG A 341
 None
TPO  A  85 ( 4.0A)
None
None
None
 1.38A 1ia0B-3m8yA:
undetectable		 1ia0B-3m8yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3m8y PHOSPHOPENTOMUTASE
(Bacillus
cereus) 		5 / 12 LEU A   9
HIS A  89
PHE A 366
THR A 325
GLY A 329
 None
TPO  A  85 ( 4.0A)
None
None
None
 1.28A 1ia0B-3m8yA:
undetectable		 1ia0B-3m8yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		4 / 6 LYS A 213
VAL A 246
MET A 265
ARG A 310
 CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
 1.09A 1iepA-6f3dA:
23.3		 1iepA-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
MET A  65
PHE A  92
GLY A  95
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 ( 4.7A)
6G2  A 901 ( 4.2A)
 1.01A 1iepB-5j5tA:
21.3		 1iepB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2qkw PROTEIN KINASE
(Solanum
pimpinellifolium) 		4 / 7 VAL B  98
MET B 117
ARG B 163
LEU B 171
 None
None
TPO  B 199 ( 3.5A)
None
 0.72A 1iepB-2qkwB:
23.0		 1iepB-2qkwB:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 7 LYS A  49
ILE A  93
ARG A 139
LEU A 147
 None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
 0.73A 1iepB-2xikA:
19.0		 1iepB-2xikA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens) 		4 / 7 VAL A 787
MET A 816
ARG A 858
LEU A 866
 None
None
TPO  A 893 ( 3.0A)
CJM  A1102 (-4.4A)
 0.72A 1iepB-6b3eA:
23.0		 1iepB-6b3eA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		4 / 7 VAL A 246
MET A 265
ARG A 310
LEU A 318
 None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
 0.87A 1iepB-6f3dA:
23.5		 1iepB-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 ASP A 324
HIS A 453
HIS A 465
HIS A 383
TYR A 387
 TPO  A 280 ( 3.9A)
ZN  A 601 ( 3.2A)
TPO  A 280 (-3.9A)
NA  A 606 ( 3.7A)
None
 1.50A 1ituA-4kavA:
undetectable		 1ituA-4kavA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 ASP A 324
HIS A 453
HIS A 465
HIS A 383
TYR A 387
 TPO  A 280 ( 3.9A)
ZN  A 601 ( 3.2A)
TPO  A 280 (-3.9A)
NA  A 606 ( 3.7A)
None
 1.50A 1ituB-4kavA:
undetectable		 1ituB-4kavA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 12 ILE A  21
VAL A  80
ALA A  33
SER A  30
GLY A   6
LEU A   2
 TPO  A  18 ( 4.2A)
None
None
None
None
None
 1.39A 1nbhB-3u02A:
undetectable		 1nbhB-3u02A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
MET A  65
VAL A  74
PHE A  92
GLY A  95
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
TPO  A 145 ( 4.7A)
 0.71A 1opjB-5j5tA:
20.9		 1opjB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens) 		4 / 6 LEU A 348
LYS A 371
VAL A 393
ARG A 465
 PDS  A 901 (-3.9A)
PDS  A 901 ( 4.5A)
None
TPO  A 500 ( 2.9A)
 0.87A 1opjB-2i0eA:
12.9		 1opjB-2i0eA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 680
LYS A 702
ILE A 743
ARG A 796
 ADP  A2101 ( 4.1A)
ADP  A2101 (-2.7A)
None
TPO  A 844 ( 3.0A)
 0.94A 1opjB-3lj0A:
21.0		 1opjB-3lj0A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3pfq PROTEIN KINASE C
BETA TYPE
(Rattus
norvegicus) 		4 / 6 LEU A 348
LYS A 371
VAL A 393
ARG A 465
 ANP  A 800 ( 4.4A)
ANP  A 800 (-3.3A)
None
TPO  A 500 ( 2.9A)
 1.09A 1opjB-3pfqA:
19.0		 1opjB-3pfqA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 6 LEU A 156
LYS A 179
VAL A 201
ARG A 273
 0XZ  A 501 ( 4.1A)
GOL  A 503 ( 2.8A)
None
TPO  A 308 ( 2.9A)
 1.07A 1opjB-4gv1A:
20.7		 1opjB-4gv1A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE
(Salmonella
enterica) 		5 / 8 ALA A 339
GLY A   9
GLY A  10
PRO A 221
ALA A 219
 None
TPO  A 990 (-3.5A)
None
None
None
 0.96A 1sguA-1lc7A:
undetectable		 1sguA-1lc7A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 10 ASP A   8
GLY A  56
ALA A  57
GLY A  22
ILE A  21
VAL A  96
 None
TPO  A  18 ( 4.6A)
None
TPO  A  18 ( 3.7A)
TPO  A  18 ( 4.2A)
None
 1.44A 1t3rA-3u02A:
undetectable		 1t3rA-3u02A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3m8y PHOSPHOPENTOMUTASE
(Bacillus
cereus) 		5 / 12 LEU A   9
HIS A  89
PHE A 366
THR A 325
ARG A 341
 None
TPO  A  85 ( 4.0A)
None
None
None
 1.38A 1tubB-3m8yA:
undetectable		 1tubB-3m8yA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3m8y PHOSPHOPENTOMUTASE
(Bacillus
cereus) 		5 / 12 LEU A   9
HIS A  89
PHE A 366
THR A 325
GLY A 329
 None
TPO  A  85 ( 4.0A)
None
None
None
 1.28A 1tubB-3m8yA:
undetectable		 1tubB-3m8yA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 ALA A  43
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
None
None
 0.54A 1uwhA-5j5tA:
21.7		 1uwhA-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
LYS A  45
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
None
None
 0.53A 1uwhB-5j5tA:
21.5		 1uwhB-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
None
None
 0.62A 1uwjA-5j5tA:
21.3		 1uwjA-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ILE A  22
VAL A  30
ALA A  43
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.8A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
None
None
 0.85A 1uwjB-5j5tA:
21.1		 1uwjB-5j5tA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 4 GLY A 277
SER A 283
ILE A 479
HIS A 511
 None
TPO  A 280 ( 4.5A)
None
None
 1.08A 1yajJ-4kavA:
undetectable		 1yajJ-4kavA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens) 		3 / 3 LYS A 371
ASP A 466
CYH A 502
 PDS  A 901 ( 4.5A)
None
TPO  A 500 ( 3.9A)
 1.46A 2br4F-2i0eA:
undetectable		 2br4F-2i0eA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		3 / 3 LYS A  45
ASP A 139
CYH A 174
 STU  A1550 (-3.6A)
None
TPO  A 172 ( 3.7A)
 1.43A 2br4F-4cfhA:
undetectable		 2br4F-4cfhA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ASP A 137
ASN A 141
ASP A 155
GLY A  21
VAL A  26
 None
ATP  A 381 ( 4.6A)
ATP  A 381 ( 4.4A)
TPO  A 170 (-3.1A)
ATP  A 381 (-4.0A)
 1.25A 2fqyA-1ua2A:
undetectable		 2fqyA-1ua2A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  93
LYS A 138
ASN A 141
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-4.0A)
TPO  B 787 ( 2.7A)
MG  A 302 ( 2.8A)
 0.51A 2fumA-5hu3A:
30.5		 2fumA-5hu3A:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		7 / 12 LEU A 295
GLY A 296
VAL A 303
ALA A 315
TYR A 365
LYS A 418
ASN A 421
 None
None
None
None
None
TPO  A 455 ( 2.9A)
None
 0.98A 2fumB-3ulzA:
22.0		 2fumB-3ulzA:
26.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  93
LYS A 138
ASN A 141
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-4.0A)
TPO  B 787 ( 2.7A)
MG  A 302 ( 2.8A)
 0.52A 2fumB-5hu3A:
30.4		 2fumB-5hu3A:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		7 / 12 LEU A  20
GLY A  21
GLY A  23
VAL A  28
ALA A  41
LYS A 138
ASN A 141
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-2.8A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
TPO  B 787 ( 2.7A)
MG  A 302 ( 2.8A)
 0.80A 2fumD-5hu3A:
28.7		 2fumD-5hu3A:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens) 		4 / 6 LEU A 348
LYS A 371
VAL A 393
ARG A 465
 PDS  A 901 (-3.9A)
PDS  A 901 ( 4.5A)
None
TPO  A 500 ( 2.9A)
 0.84A 2hyyA-2i0eA:
13.2		 2hyyA-2i0eA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 6 LEU A  49
LYS A  72
VAL A 104
ARG A 165
 XFE  A 351 (-4.2A)
None
None
TPO  A 197 ( 3.1A)
 1.01A 2hyyA-3mvjA:
20.8		 2hyyA-3mvjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		5 / 10 HIS A 290
TYR A 473
PHE A 415
GLY A 474
HIS A 412
 None
None
None
None
TPO  A 297 ( 4.0A)
 1.39A 2pcpC-2w8dA:
undetectable
2pcpD-2w8dA:
undetectable		 2pcpC-2w8dA:
18.81
2pcpD-2w8dA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4n7t PHOSPHOPENTOMUTASE
(Streptococcus
mutans) 		5 / 12 ILE A 253
GLY A  95
HIS A 351
ASP A 298
ASP A  13
 TPO  A  92 ( 4.7A)
TPO  A  92 ( 3.9A)
MN  A 502 (-3.2A)
MN  A 502 (-2.2A)
MN  A 501 (-2.0A)
 1.24A 2pgfA-4n7tA:
undetectable		 2pgfA-4n7tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		5 / 11 ASP A   9
ASP A   8
GLY A  22
ILE A  24
ILE A  95
 TPO  A  18 ( 4.7A)
None
TPO  A  18 ( 3.7A)
None
None
 1.03A 2qhcA-3u02A:
undetectable		 2qhcA-3u02A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 8 ARG A 176
ILE A 149
LEU A 141
GLY A 140
 TPO  A 183 ( 3.9A)
None
None
None
 0.78A 2tsrB-1cm8A:
undetectable		 2tsrB-1cm8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
ALA A  43
LYS A  45
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 None
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.81A 3c7qA-5j5tA:
20.1		 3c7qA-5j5tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
ALA A  43
VAL A  74
PHE A  92
CYH A  93
GLY A  95
LEU A 143
 None
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
TPO  A 145 ( 4.7A)
6G2  A 901 (-4.7A)
 1.04A 3c7qA-5j5tA:
20.1		 3c7qA-5j5tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 GLY A  23
ALA A  43
VAL A  74
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 None
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.57A 3c7qA-5j5tA:
20.1		 3c7qA-5j5tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 TYR A 380
HIS A 343
SER A 251
ASP A 471
ASN A 411
 None
None
TPO  A 297 ( 4.3A)
MG  A1636 (-2.6A)
None
 1.50A 3cb8A-2w8dA:
0.1		 3cb8A-2w8dA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
POTASSIUM
VOLTAGE-GATED
CHANNEL PROTEIN EAG
(Drosophila
melanogaster) 		5 / 12 ILE B 788
SER A 182
PRO A 213
PHE A 214
LEU A 222
 TPO  B 787 ( 3.8A)
None
None
None
None
 1.16A 3cd2A-5hu3B:
undetectable		 3cd2A-5hu3B:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 11 VAL A  30
ALA A  43
VAL A  74
CYH A  93
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.45A 3g0eA-5j5tA:
19.7		 3g0eA-5j5tA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 680
LYS A 702
ILE A 743
ARG A 796
 ADP  A2101 ( 4.1A)
ADP  A2101 (-2.7A)
None
TPO  A 844 ( 3.0A)
 1.03A 3ik3A-3lj0A:
21.5		 3ik3A-3lj0A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 680
LYS A 702
ILE A 743
ARG A 796
 ADP  A2101 ( 4.1A)
ADP  A2101 (-2.7A)
None
TPO  A 844 ( 3.0A)
 0.99A 3ik3B-3lj0A:
21.2		 3ik3B-3lj0A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 143
ASP A 157
GLU A  97
ALA A  24
GLU A 140
 ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
ADP  A 301 (-3.5A)
TPO  B 787 (-3.1A)
None
 1.49A 3k39D-5hu3A:
undetectable		 3k39D-5hu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 143
ASP A 157
GLU A  97
ALA A  24
GLU A 140
 ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
ADP  A 301 (-3.5A)
TPO  B 787 (-3.1A)
None
 1.49A 3k39I-5hu3A:
undetectable		 3k39I-5hu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 143
ASP A 157
GLU A  97
ALA A  24
GLU A 140
 ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
ADP  A 301 (-3.5A)
TPO  B 787 (-3.1A)
None
 1.48A 3k39J-5hu3A:
undetectable		 3k39J-5hu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		5 / 12 LEU A 143
ASP A 157
GLU A  97
ALA A  24
GLU A 140
 ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
ADP  A 301 (-3.5A)
TPO  B 787 (-3.1A)
None
 1.48A 3k39L-5hu3A:
undetectable		 3k39L-5hu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5tj3 ALKALINE PHOSPHATASE
PAFA
(Elizabethkingia
meningoseptica) 		5 / 12 ILE A  81
VAL A  78
ILE A  72
VAL A  75
PRO A  76
 None
TPO  A  79 ( 2.9A)
None
None
None
 1.05A 3kpdC-5tj3A:
undetectable		 3kpdC-5tj3A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 10 ASP A   8
GLY A  56
ALA A  57
GLY A  22
ILE A  21
VAL A  96
 None
TPO  A  18 ( 4.6A)
None
TPO  A  18 ( 3.7A)
TPO  A  18 ( 4.2A)
None
 1.35A 3lzvA-3u02A:
undetectable		 3lzvA-3u02A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 11 LEU A 554
VAL A 262
VAL A 250
PHE A 245
LEU A 242
 TPO  A 555 ( 4.1A)
None
None
None
None
 1.48A 3m8pA-1zrzA:
1.1
3m8pB-1zrzA:
0.0		 3m8pA-1zrzA:
20.00
3m8pB-1zrzA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		4 / 6 LYS A 213
VAL A 246
MET A 265
ARG A 310
 CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
 1.02A 3ms9A-6f3dA:
23.3		 3ms9A-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		4 / 6 VAL A 236
VAL A 246
MET A 265
ARG A 310
 None
None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
 1.01A 3ms9A-6f3dA:
23.3		 3ms9A-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		4 / 6 LYS A 213
VAL A 246
MET A 265
ARG A 310
 CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
 1.06A 3mssA-6f3dA:
23.4		 3mssA-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		4 / 6 VAL A 236
VAL A 246
MET A 265
ARG A 310
 None
None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
 1.03A 3mssA-6f3dA:
23.4		 3mssA-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		4 / 6 LYS A 213
VAL A 246
MET A 265
ARG A 310
 CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
 1.12A 3mssC-6f3dA:
23.2		 3mssC-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		4 / 6 VAL A 236
VAL A 246
MET A 265
ARG A 310
 None
None
CJT  A 502 (-4.9A)
TPO  A 345 ( 4.9A)
 1.08A 3mssC-6f3dA:
23.2		 3mssC-6f3dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		5 / 12 GLY A  56
ALA A  57
GLY A  22
ILE A  21
VAL A  96
 TPO  A  18 ( 4.6A)
None
TPO  A  18 ( 3.7A)
TPO  A  18 ( 4.2A)
None
 1.15A 3n3iA-3u02A:
undetectable		 3n3iA-3u02A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 12 ASP A   8
GLY A  56
ALA A  57
GLY A  22
ILE A  21
VAL A  96
 None
TPO  A  18 ( 4.6A)
None
TPO  A  18 ( 3.7A)
TPO  A  18 ( 4.2A)
None
 1.43A 3ndtB-3u02A:
undetectable		 3ndtB-3u02A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 189
ILE A 184
HIS A 229
VAL A 225
 None
None
None
TPO  A 224 ( 3.3A)
 1.20A 3nneG-4x3fA:
undetectable		 3nneG-4x3fA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		5 / 10 GLY A  56
ALA A  57
GLY A  22
ILE A  21
VAL A  96
 TPO  A  18 ( 4.6A)
None
TPO  A  18 ( 3.7A)
TPO  A  18 ( 4.2A)
None
 1.11A 3nu9B-3u02A:
undetectable		 3nu9B-3u02A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.74A 3og7A-5j5tA:
22.1		 3og7A-5j5tA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 680
LYS A 702
ILE A 743
ARG A 796
VAL A 728
 ADP  A2101 ( 4.1A)
ADP  A2101 (-2.7A)
None
TPO  A 844 ( 3.0A)
None
 1.23A 3oxzA-3lj0A:
21.5		 3oxzA-3lj0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 10 ASP A   8
GLY A  56
ALA A  57
GLY A  22
ILE A  21
VAL A  96
 None
TPO  A  18 ( 4.6A)
None
TPO  A  18 ( 3.7A)
TPO  A  18 ( 4.2A)
None
 1.34A 3oy4B-3u02A:
undetectable		 3oy4B-3u02A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 ILE A 205
ALA A 278
LEU A 279
ILE A 264
GLY A 255
 None
None
None
TPO  A 252 ( 4.9A)
None
 1.09A 3ozwB-4wb7A:
undetectable		 3ozwB-4wb7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		5 / 11 ASP A   8
GLY A  22
ILE A  24
ILE A  77
ILE A  95
 None
TPO  A  18 ( 3.7A)
None
None
None
 1.18A 3s53B-3u02A:
undetectable		 3s53B-3u02A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 9 ARG A  81
ASP A   8
GLY A  22
ILE A  24
ILE A  77
ILE A  95
 None
None
TPO  A  18 ( 3.7A)
None
None
None
 1.50A 3s56B-3u02A:
undetectable		 3s56B-3u02A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens) 		5 / 11 ARG A  56
LEU A  90
LEU A  98
GLY A 123
ASP A 124
 TPO  E  31 ( 3.0A)
None
None
None
None
 1.32A 3sfuC-1ib1A:
undetectable		 3sfuC-1ib1A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 3m8y PHOSPHOPENTOMUTASE
(Bacillus
cereus) 		5 / 11 HIS A 328
GLY A  88
PHE A 279
GLY A 239
MET A 225
 MN  A 396 (-3.3A)
TPO  A  85 ( 3.8A)
None
None
None
 1.20A 3v3nD-3m8yA:
undetectable		 3v3nD-3m8yA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ARG A 139
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.71A 3zosA-2xikA:
17.8		 3zosA-2xikA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		8 / 12 LEU A 680
ALA A 700
LYS A 702
GLU A 715
LEU A 788
HIS A 795
ARG A 796
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
 0.98A 3zosA-3lj0A:
20.9		 3zosA-3lj0A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mi9 CELL DIVISION
PROTEIN KINASE 9
(Homo
sapiens) 		7 / 12 ALA A  46
LYS A  48
GLU A  66
HIS A 147
ARG A 148
LEU A 156
ALA A 166
 None
None
None
None
TPO  A 186 ( 2.8A)
None
None
 0.68A 3zosA-3mi9A:
14.9		 3zosA-3mi9A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		8 / 12 LEU A 663
ALA A 684
LYS A 686
GLU A 705
LEU A 773
ARG A 781
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.84A 3zosA-4crsA:
20.6		 3zosA-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 ALA A  44
LYS A  46
LEU A 129
HIS A 136
ARG A 137
LEU A 145
ALA A 164
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.83A 3zosA-5ci7A:
22.4		 3zosA-5ci7A:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens) 		7 / 12 ALA A 754
LYS A 756
GLU A 774
HIS A 857
ARG A 858
LEU A 866
ALA A 876
 CJM  A1102 (-3.1A)
None
None
None
TPO  A 893 ( 3.0A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.76A 3zosA-6b3eA:
22.2		 3zosA-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		7 / 12 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ARG A 139
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
TPO  A 174 ( 2.9A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.76A 3zosB-2xikA:
17.9		 3zosB-2xikA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		8 / 12 ALA A 700
LYS A 702
GLU A 715
ILE A 729
LEU A 788
HIS A 795
ARG A 796
LEU A 804
 ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
None
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
 0.87A 3zosB-3lj0A:
20.8		 3zosB-3lj0A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mi9 CELL DIVISION
PROTEIN KINASE 9
(Homo
sapiens) 		7 / 12 ALA A  46
LYS A  48
GLU A  66
HIS A 147
ARG A 148
LEU A 156
ALA A 166
 None
None
None
None
TPO  A 186 ( 2.8A)
None
None
 0.67A 3zosB-3mi9A:
22.0		 3zosB-3mi9A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 12 ALA A 684
LYS A 686
GLU A 705
LEU A 773
ARG A 781
LEU A 789
ALA A 799
 AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.79A 3zosB-4crsA:
20.7		 3zosB-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens) 		7 / 12 ALA A 754
LYS A 756
GLU A 774
HIS A 857
ARG A 858
LEU A 866
ALA A 876
 CJM  A1102 (-3.1A)
None
None
None
TPO  A 893 ( 3.0A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.74A 3zosB-6b3eA:
22.3		 3zosB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		5 / 12 GLY A 773
GLY A 771
ARG A 745
ASP A 803
TRP A 804
 None
None
TPO  A 780 ( 2.8A)
None
None
 1.09A 4a6eA-4otdA:
undetectable		 4a6eA-4otdA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 11 ALA A  43
VAL A  74
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.29A 4agdA-5j5tA:
20.1		 4agdA-5j5tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 6 HIS A 472
GLU A 301
ASP A 471
SER A 251
 MG  A1636 (-3.4A)
TPO  A 297 ( 4.7A)
MG  A1636 (-2.6A)
TPO  A 297 ( 4.3A)
 1.29A 4apjA-2w8dA:
undetectable
4apjP-2w8dA:
undetectable		 4apjA-2w8dA:
22.59
4apjP-2w8dA:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens) 		4 / 4 LYS A 756
LEU A 781
MET A 816
ARG A 858
 None
None
None
TPO  A 893 ( 3.0A)
 1.14A 4bkjA-6b3eA:
22.5		 4bkjA-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens) 		4 / 5 LEU A 781
TYR A 815
MET A 816
ARG A 858
 None
CJM  A1102 (-4.1A)
None
TPO  A 893 ( 3.0A)
 0.88A 4bkjB-6b3eA:
22.6		 4bkjB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens) 		4 / 5 LYS A 756
LEU A 781
MET A 816
ARG A 858
 None
None
None
TPO  A 893 ( 3.0A)
 1.12A 4bkjB-6b3eA:
22.6		 4bkjB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		4 / 6 HIS A 261
HIS A 482
SER A 264
ASP A 431
 TPO  A 307 ( 4.5A)
MG  A1645 (-3.2A)
MG  A1645 ( 3.9A)
None
 1.21A 4blvA-4uooA:
2.1		 4blvA-4uooA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 11 LEU A  18
GLY A  19
GLY A  21
VAL A  26
ALA A  39
LEU A 144
 ATP  A 381 (-4.4A)
ATP  A 381 ( 3.9A)
TPO  A 170 (-3.1A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
 0.72A 4ckiA-1ua2A:
21.7		 4ckiA-1ua2A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE
(Salmonella
enterica) 		5 / 12 LEU A 321
ALA A  31
ARG A 337
ASN A  32
TYR A 328
 None
TPO  A 990 (-4.1A)
TPO  A 990 (-2.9A)
TPO  A 990 (-3.9A)
None
 1.36A 4cpzA-1lc7A:
undetectable		 4cpzA-1lc7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE
(Salmonella
enterica) 		5 / 12 LEU A 321
ALA A  31
ARG A 337
ASN A  32
TYR A 328
 None
TPO  A 990 (-4.1A)
TPO  A 990 (-2.9A)
TPO  A 990 (-3.9A)
None
 1.39A 4cpzB-1lc7A:
undetectable		 4cpzB-1lc7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE
(Salmonella
enterica) 		5 / 12 LEU A 321
ALA A  31
ARG A 337
ASN A  32
TYR A 328
 None
TPO  A 990 (-4.1A)
TPO  A 990 (-2.9A)
TPO  A 990 (-3.9A)
None
 1.44A 4cpzD-1lc7A:
undetectable		 4cpzD-1lc7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 10 ASP A   8
GLY A  56
ALA A  57
GLY A  22
ILE A  21
VAL A  96
 None
TPO  A  18 ( 4.6A)
None
TPO  A  18 ( 3.7A)
TPO  A  18 ( 4.2A)
None
 1.37A 4dqfB-3u02A:
undetectable		 4dqfB-3u02A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 6 SER A 325
ASP A 324
ARG A 390
GLU A 352
 None
TPO  A 280 ( 3.9A)
NA  A 606 (-4.1A)
NA  A 606 (-3.2A)
 1.22A 4eysA-4kavA:
undetectable		 4eysA-4kavA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		5 / 11 HIS A 412
GLU A 301
ILE A 407
ASP A 366
TYR A 369
 TPO  A 297 ( 4.0A)
TPO  A 297 ( 4.7A)
TPO  A 297 ( 4.8A)
None
None
 1.48A 4foxH-2w8dA:
undetectable		 4foxH-2w8dA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		3 / 3 LYS A 670
LEU A 672
ALA A 687
 TPO  A 958 ( 2.8A)
None
None
 0.64A 4iizA-4crsA:
undetectable		 4iizA-4crsA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		3 / 3 LYS A 670
LEU A 672
ALA A 687
 TPO  A 958 ( 2.8A)
None
None
 0.55A 4ikiA-4crsA:
undetectable		 4ikiA-4crsA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		3 / 3 TYR A 463
ARG A 415
SER A 469
 None
TPO  A 450 ( 3.3A)
TPO  A 450 ( 4.0A)
 0.61A 4khpI-3ulzA:
undetectable
4khpJ-3ulzA:
undetectable		 4khpI-3ulzA:
20.75
4khpJ-3ulzA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3m8y PHOSPHOPENTOMUTASE
(Bacillus
cereus) 		5 / 11 HIS A 339
ASP A 156
ASP A  13
ASP A 243
ILE A 244
 MN  A 395 (-3.4A)
MN  A 395 (-2.1A)
MN  A 396 (-2.0A)
None
TPO  A  85 ( 4.3A)
 1.36A 4ktvC-3m8yA:
undetectable
4ktvD-3m8yA:
undetectable		 4ktvC-3m8yA:
24.29
4ktvD-3m8yA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 9 ILE A  22
GLY A  25
VAL A  30
ALA A  43
CYH A  93
ASN A 141
LEU A 143
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
TPO  A 145 (-4.1A)
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.50A 4ogrI-5j5tA:
25.9		 4ogrI-5j5tA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE
(Homo
sapiens) 		4 / 8 LYS B 304
ALA B 305
GLY B 434
LEU B 362
 TPO  B 446 ( 3.2A)
None
None
None
 0.87A 4po0A-2a1aB:
undetectable		 4po0A-2a1aB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 11 ASP A   8
GLY A  56
ALA A  57
GLY A  22
ILE A  21
VAL A  96
 None
TPO  A  18 ( 4.6A)
None
TPO  A  18 ( 3.7A)
TPO  A  18 ( 4.2A)
None
 1.34A 4q1xA-3u02A:
undetectable		 4q1xA-3u02A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 10 ASP A   8
GLY A  56
ALA A  57
GLY A  22
ILE A  21
VAL A  96
 None
TPO  A  18 ( 4.6A)
None
TPO  A  18 ( 3.7A)
TPO  A  18 ( 4.2A)
None
 1.33A 4q1yA-3u02A:
undetectable		 4q1yA-3u02A:
16.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 GLY A  23
VAL A  30
ALA A  43
MET A  90
GLY A  94
LEU A 143
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
TPO  A 145 ( 4.9A)
6G2  A 901 (-4.7A)
 0.67A 4qmzA-5j5tA:
31.1		 4qmzA-5j5tA:
38.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ILE A  22
GLY A  23
VAL A  30
ALA A  43
GLY A  94
LEU A 143
 6G2  A 901 (-3.8A)
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
TPO  A 145 ( 4.9A)
6G2  A 901 (-4.7A)
 0.49A 4qmzA-5j5tA:
31.1		 4qmzA-5j5tA:
38.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		5 / 12 ALA A  47
GLU A  66
LEU A 131
ARG A 139
ALA A 157
 J60  A1294 (-3.3A)
None
None
TPO  A 174 ( 2.9A)
J60  A1294 ( 4.2A)
 0.85A 4qrcA-2xikA:
18.7		 4qrcA-2xikA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3pfq PROTEIN KINASE C
BETA TYPE
(Rattus
norvegicus) 		5 / 12 ALA A 369
GLU A 390
LEU A 457
ARG A 465
ALA A 483
 ANP  A 800 (-3.6A)
None
None
TPO  A 500 ( 2.9A)
ANP  A 800 ( 3.8A)
 1.14A 4qrcA-3pfqA:
16.5		 4qrcA-3pfqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		5 / 12 ALA A 684
GLU A 705
LEU A 773
ARG A 781
ALA A 799
 AGS  A1985 (-3.5A)
None
None
TPO  A 816 ( 3.0A)
AGS  A1985 ( 4.5A)
 0.86A 4qrcA-4crsA:
16.0		 4qrcA-4crsA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 12 ALA A  44
GLU A  63
LEU A 129
ARG A 137
ALA A 164
 51W  A 401 (-3.4A)
None
None
TPO  A 180 ( 2.9A)
None
 1.11A 4qrcA-5ci7A:
19.0		 4qrcA-5ci7A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 388
GLU A 409
MET A 413
LEU A 475
ARG A 483
 EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
None
None
TPO  A 517 ( 3.0A)
 1.05A 4qrcA-6c0tA:
16.3		 4qrcA-6c0tA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
CYH A  93
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
TPO  A 145 (-4.1A)
6G2  A 901 (-4.7A)
 0.66A 4r7iA-5j5tA:
20.8		 4r7iA-5j5tA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 5 LEU A  49
VAL A 104
TYR A 122
ARG A 165
 XFE  A 351 (-4.2A)
None
None
TPO  A 197 ( 3.1A)
 0.75A 4r7iA-3mvjA:
15.1		 4r7iA-3mvjA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 5 LEU A 663
VAL A 721
TYR A 739
ARG A 781
 AGS  A1985 (-4.2A)
None
None
TPO  A 816 ( 3.0A)
 0.72A 4r7iA-4crsA:
20.5		 4r7iA-4crsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		4 / 5 LEU A 627
VAL A 685
TYR A 703
ARG A 745
 None
None
None
TPO  A 780 ( 2.8A)
 0.83A 4r7iA-4otdA:
21.6		 4r7iA-4otdA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 5 LEU A 104
VAL A 159
TYR A 177
ARG A 220
 ATP  A 501 ( 4.3A)
None
None
TPO  A 252 ( 2.9A)
 0.76A 4r7iA-4wb7A:
15.3		 4r7iA-4wb7A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 7 ASN A 324
GLU A 322
GLU A 319
TYR A 326
 None
None
None
TPO  A 308 ( 4.5A)
 1.34A 4r87I-4gv1A:
0.1		 4r87I-4gv1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.82A 4rzvB-5j5tA:
22.7		 4rzvB-5j5tA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens) 		4 / 6 VAL A 356
LYS A 371
ARG A 465
ILE A 482
 PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
TPO  A 500 ( 2.9A)
None
 0.68A 4tyjA-2i0eA:
15.1		 4tyjA-2i0eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 6 VAL A  34
LYS A  49
ARG A 139
ILE A  78
 J60  A1294 ( 4.9A)
None
TPO  A 174 ( 2.9A)
None
 0.73A 4tyjA-2xikA:
19.4		 4tyjA-2xikA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 6 VAL A  30
ILE A  76
ARG A 138
ILE A 155
 None
None
TPO  A 172 ( 2.4A)
None
 0.70A 4tyjA-4cfhA:
23.5		 4tyjA-4cfhA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 6 LEU A 663
VAL A 671
ARG A 781
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
TPO  A 816 ( 3.0A)
None
 0.73A 4tyjA-4crsA:
21.3		 4tyjA-4crsA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		4 / 6 VAL A  30
ILE A  75
ARG A 137
ILE A 163
 51W  A 401 ( 4.3A)
None
TPO  A 180 ( 2.9A)
None
 0.72A 4tyjA-5ci7A:
23.7		 4tyjA-5ci7A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 6 LEU A  99
VAL A 107
ILE A 153
ARG A 140
ILE A 232
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
None
TPO  A 248 ( 4.5A)
None
 1.06A 4tyjA-5eykA:
19.6		 4tyjA-5eykA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens) 		6 / 10 LEU A 348
VAL A 356
GLU A 390
TYR A 422
ARG A 465
ILE A 482
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
None
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
 0.82A 4u0iA-2i0eA:
20.2		 4u0iA-2i0eA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 10 LEU A  22
VAL A  30
ILE A  76
TYR A  95
ARG A 138
ILE A 155
 STU  A1550 (-4.3A)
None
None
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
None
 0.78A 4u0iA-4cfhA:
22.3		 4u0iA-4cfhA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 10 VAL A  30
LEU A  70
ILE A  75
VAL A  76
TYR A  94
ARG A 137
ILE A 163
 51W  A 401 ( 4.3A)
None
None
None
51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
None
 0.69A 4u0iA-5ci7A:
23.2		 4u0iA-5ci7A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
LYS A  45
CYH A  93
GLY A  96
HIS A 134
LEU A 143
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 (-4.7A)
 0.55A 4u0iA-5j5tA:
21.0		 4u0iA-5j5tA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 7 VAL A  41
ILE A  87
ARG A 152
ILE A 169
 ANP  A 400 (-4.1A)
ANP  A 400 (-4.9A)
TPO  A 183 ( 2.8A)
None
 0.75A 4uxqA-1cm8A:
19.2		 4uxqA-1cm8A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens) 		4 / 7 VAL A 356
LYS A 371
ARG A 465
ILE A 482
 PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
TPO  A 500 ( 2.9A)
None
 0.88A 4uxqA-2i0eA:
14.5		 4uxqA-2i0eA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 689
ILE A 729
ARG A 796
ILE A 826
 ADP  A2101 (-4.5A)
None
TPO  A 844 ( 3.0A)
None
 0.88A 4uxqA-3lj0A:
21.7		 4uxqA-3lj0A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		4 / 7 VAL A 671
ALA A 740
ARG A 781
ILE A 798
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.9A)
TPO  A 816 ( 3.0A)
None
 0.49A 4uxqA-4crsA:
16.0		 4uxqA-4crsA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		4 / 7 VAL A 200
LYS A 213
ARG A 310
ILE A 327
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.0A)
TPO  A 345 ( 4.9A)
None
 0.87A 4uxqA-6f3dA:
24.0		 4uxqA-6f3dA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens) 		6 / 9 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
 0.72A 4v01A-2i0eA:
13.1		 4v01A-2i0eA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		6 / 9 LEU A 680
VAL A 689
ILE A 729
ARG A 796
LEU A 804
ILE A 826
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
None
 0.76A 4v01A-3lj0A:
21.6		 4v01A-3lj0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A  49
VAL A  57
LYS A  72
TYR A 122
ARG A 165
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
TPO  A 197 ( 3.1A)
XFE  A 351 (-4.6A)
 0.92A 4v01A-3mvjA:
20.2		 4v01A-3mvjA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3pfq PROTEIN KINASE C
BETA TYPE
(Rattus
norvegicus) 		6 / 9 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.3A)
ANP  A 800 (-4.2A)
TPO  A 500 ( 2.9A)
None
 0.99A 4v01A-3pfqA:
19.0		 4v01A-3pfqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 9 LEU A  22
VAL A  30
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 (-4.3A)
None
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.84A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 9 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
 0.93A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
 0.79A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 9 LEU A 663
VAL A 671
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.48A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 9 LEU A 627
VAL A 635
LYS A 650
TYR A 703
ARG A 745
LEU A 753
 None
None
None
None
TPO  A 780 ( 2.8A)
None
 0.96A 4v01A-4otdA:
21.2		 4v01A-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 9 LEU A 627
VAL A 635
TYR A 703
ARG A 745
LEU A 753
ILE A 762
 None
None
None
TPO  A 780 ( 2.8A)
None
None
 0.69A 4v01A-4otdA:
21.2		 4v01A-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A 104
VAL A 112
LYS A 127
TYR A 177
ARG A 220
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
TPO  A 252 ( 2.9A)
ATP  A 501 (-4.5A)
 0.86A 4v01A-4wb7A:
20.2		 4v01A-4wb7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 9 VAL A  30
TYR A  94
ARG A 137
LEU A 145
ILE A 163
 51W  A 401 ( 4.3A)
51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.47A 4v01A-5ci7A:
17.5		 4v01A-5ci7A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		6 / 9 VAL A 200
LYS A 213
TYR A 264
ARG A 310
LEU A 318
ILE A 327
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
None
 0.69A 4v01A-6f3dA:
22.7		 4v01A-6f3dA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens) 		6 / 9 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
 0.90A 4v01B-2i0eA:
13.2		 4v01B-2i0eA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		7 / 9 LEU A 680
VAL A 689
LYS A 702
ILE A 729
ARG A 796
LEU A 804
ILE A 826
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-2.7A)
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
None
 0.79A 4v01B-3lj0A:
22.0		 4v01B-3lj0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 9 VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.84A 4v01B-4cfhA:
23.2		 4v01B-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		7 / 9 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.82A 4v01B-4crsA:
20.8		 4v01B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		6 / 9 LEU A 156
VAL A 164
LYS A 179
TYR A 229
ARG A 273
ILE A 290
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
GOL  A 503 ( 2.8A)
0XZ  A 501 ( 4.9A)
TPO  A 308 ( 2.9A)
None
 0.84A 4v01B-4gv1A:
21.2		 4v01B-4gv1A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 9 LEU A 627
VAL A 635
TYR A 703
ARG A 745
LEU A 753
ILE A 762
 None
None
None
TPO  A 780 ( 2.8A)
None
None
 1.02A 4v01B-4otdA:
21.6		 4v01B-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 9 VAL A  30
LYS A  46
TYR A  94
ARG A 137
LEU A 145
ILE A 163
 51W  A 401 ( 4.3A)
GOL  A 404 ( 3.1A)
51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.83A 4v01B-5ci7A:
17.7		 4v01B-5ci7A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		6 / 9 VAL A 200
LYS A 213
TYR A 264
ARG A 310
LEU A 318
ILE A 327
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
None
 0.95A 4v01B-6f3dA:
23.3		 4v01B-6f3dA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		5 / 8 ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.96A 4v04A-4cfhA:
22.7		 4v04A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		5 / 8 LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
 1.08A 4v04A-4cfhA:
22.7		 4v04A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		4 / 8 TYR A  94
ARG A 137
LEU A 145
ILE A 163
 51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.88A 4v04A-5ci7A:
18.6		 4v04A-5ci7A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		5 / 8 LYS A 213
TYR A 264
ARG A 310
LEU A 318
ILE A 327
 CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
None
 1.05A 4v04A-6f3dA:
23.0		 4v04A-6f3dA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens) 		6 / 10 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
 0.95A 4v04B-2i0eA:
14.3		 4v04B-2i0eA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		6 / 10 LEU A 680
VAL A 689
ILE A 729
ARG A 796
LEU A 804
ILE A 826
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
None
 1.09A 4v04B-3lj0A:
22.1		 4v04B-3lj0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 10 LEU A  49
VAL A  57
LYS A  72
TYR A 122
ARG A 165
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
TPO  A 197 ( 3.1A)
XFE  A 351 (-4.6A)
 1.02A 4v04B-3mvjA:
20.7		 4v04B-3mvjA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3pfq PROTEIN KINASE C
BETA TYPE
(Rattus
norvegicus) 		6 / 10 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.3A)
ANP  A 800 (-4.2A)
TPO  A 500 ( 2.9A)
None
 1.11A 4v04B-3pfqA:
19.6		 4v04B-3pfqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 10 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.96A 4v04B-4cfhA:
23.0		 4v04B-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
 0.96A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens) 		6 / 10 LEU A 663
VAL A 671
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.79A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 10 LEU A 627
VAL A 635
LYS A 650
TYR A 703
ARG A 745
LEU A 753
 None
None
None
None
TPO  A 780 ( 2.8A)
None
 1.11A 4v04B-4otdA:
21.6		 4v04B-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens) 		6 / 10 LEU A 627
VAL A 635
TYR A 703
ARG A 745
LEU A 753
ILE A 762
 None
None
None
TPO  A 780 ( 2.8A)
None
None
 0.90A 4v04B-4otdA:
21.6		 4v04B-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 10 LEU A 104
VAL A 112
LYS A 127
TYR A 177
ARG A 220
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
TPO  A 252 ( 2.9A)
ATP  A 501 (-4.5A)
 0.96A 4v04B-4wb7A:
20.6		 4v04B-4wb7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		6 / 10 VAL A 200
LYS A 213
TYR A 264
ARG A 310
LEU A 318
ILE A 327
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
None
 1.03A 4v04B-6f3dA:
23.3		 4v04B-6f3dA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4n7t PHOSPHOPENTOMUTASE
(Streptococcus
mutans) 		4 / 8 ASP A  13
ASP A 339
ILE A 104
ASP A  91
 MN  A 501 (-2.0A)
MN  A 501 (-2.2A)
None
TPO  A  92 ( 4.0A)
 1.02A 4xjeA-4n7tA:
2.7		 4xjeA-4n7tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
LYS A  45
CYH A  93
ASP A 154
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.4A)
None
 0.68A 4xv2A-5j5tA:
22.4		 4xv2A-5j5tA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 ALA A  43
LYS A  45
CYH A  93
ASP A 154
PHE A 155
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.4A)
None
 0.71A 4xv2B-5j5tA:
22.7		 4xv2B-5j5tA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		5 / 11 ALA A 285
GLY A 311
VAL A 316
LEU A 349
LEU A 360
 None
TPO  A 312 ( 2.5A)
None
None
None
 1.09A 4zmeA-3ulzA:
4.8		 4zmeA-3ulzA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 7 HIS A 343
GLY A 381
ASN A 345
HIS A 412
 None
None
None
TPO  A 297 ( 4.0A)
 1.08A 5a5zC-2w8dA:
undetectable		 5a5zC-2w8dA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
LYS A  45
PHE A  92
CYH A  93
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.97A 5ajqA-5j5tA:
30.0		 5ajqA-5j5tA:
36.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
PHE A  92
CYH A  93
GLY A  96
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.49A 5ajqA-5j5tA:
30.0		 5ajqA-5j5tA:
36.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 GLY A  23
ALA A  43
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 None
6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.66A 5ajqA-5j5tA:
30.0		 5ajqA-5j5tA:
36.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 5 ARG A  73
ARG A 152
LEU A 174
VAL A 186
 TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
None
PTR  A 185 ( 2.8A)
 0.95A 5cshB-1cm8A:
29.4		 5cshB-1cm8A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.70A 5cswA-5j5tA:
22.2		 5cswA-5j5tA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.72A 5cswB-5j5tA:
22.1		 5cswB-5j5tA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens) 		4 / 5 HIS A 857
ILE A 917
ILE A 897
TYR A 913
 None
None
None
TPO  A 893 ( 4.4A)
 1.06A 5dnvA-6b3eA:
undetectable		 5dnvA-6b3eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		6 / 12 ARG A  81
ASP A   8
GLY A  22
ILE A  24
ILE A  77
ILE A  95
 None
None
TPO  A  18 ( 3.7A)
None
None
None
 1.32A 5e5jB-3u02A:
undetectable		 5e5jB-3u02A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
LYS A  45
GLU A  61
CYH A  93
LEU A 127
HIS A 134
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
None
None
 0.62A 5hi2A-5j5tA:
21.6		 5hi2A-5j5tA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS
(Pyrococcus
furiosus) 		4 / 6 ILE A  24
GLY A   6
MET A  60
ILE A  21
 None
None
None
TPO  A  18 ( 4.2A)
 0.94A 5j4nB-3u02A:
undetectable		 5j4nB-3u02A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5tj3 ALKALINE PHOSPHATASE
PAFA
(Elizabethkingia
meningoseptica) 		5 / 12 ILE A 265
SER A 166
HIS A  83
PHE A 180
GLY A 271
 None
None
TPO  A  79 ( 4.1A)
None
None
 1.08A 5l6eA-5tj3A:
undetectable		 5l6eA-5tj3A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		5 / 12 VAL A 289
HIS A 390
THR A 438
ARG A 402
GLY A 467
 TPO  A 285 ( 3.6A)
None
None
None
None
 1.29A 5ogcB-5k4pA:
undetectable		 5ogcB-5k4pA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 HIS A 482
SER A 310
LYS A 308
 MG  A1645 (-3.2A)
TPO  A 307 ( 2.4A)
TPO  A 307 ( 2.9A)
 1.13A 5os7A-4uooA:
undetectable		 5os7A-4uooA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 5 ARG A  73
ARG A 152
LEU A 174
VAL A 186
 TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
None
PTR  A 185 ( 2.8A)
 1.00A 5os7B-1cm8A:
29.8		 5os7B-1cm8A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS8_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Drosophila
melanogaster) 		4 / 5 LYS A  57
ARG A  60
ARG A 135
LEU A 160
 None
None
None
TPO  B 787 ( 4.7A)
 0.95A 5os8A-5hu3A:
27.0		 5os8A-5hu3A:
25.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OSR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 5 LYS A  69
ARG A  73
ARG A 152
LEU A 174
 TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
None
 0.81A 5osrA-1cm8A:
28.8		 5osrA-1cm8A:
30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 5 LYS A  60
ARG A  63
ARG A 138
LEU A 160
 TPO  A 172 ( 3.5A)
TPO  A 172 ( 3.6A)
TPO  A 172 ( 2.4A)
None
 0.70A 5osrA-4cfhA:
6.8		 5osrA-4cfhA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OTR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 5 LYS A  69
ARG A  73
ARG A 152
LEU A 174
 TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
None
 0.97A 5otrA-1cm8A:
28.5		 5otrA-1cm8A:
30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 5 LYS A  60
ARG A  63
ARG A 138
LEU A 160
 TPO  A 172 ( 3.5A)
TPO  A 172 ( 3.6A)
TPO  A 172 ( 2.4A)
None
 0.77A 5otrA-4cfhA:
7.8		 5otrA-4cfhA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 8 ALA A  43
GLU A  61
CYH A  93
LEU A 143
ASP A 154
 6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.32A 5owrA-5j5tA:
32.1		 5owrA-5j5tA:
38.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		3 / 3 GLY A 105
LEU A 107
HIS A  89
 None
TPO  A  15 ( 2.5A)
None
 0.64A 5u63A-2kb3A:
undetectable		 5u63A-2kb3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR
(Corynebacterium
glutamicum) 		3 / 3 GLY A 105
LEU A 107
HIS A  89
 None
TPO  A  15 ( 2.5A)
None
 0.60A 5u63B-2kb3A:
undetectable		 5u63B-2kb3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ALA A  43
GLU A  61
CYH A  93
GLY A  96
ASP A 100
ASP A 154
 6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.68A 5vc3A-5j5tA:
23.1		 5vc3A-5j5tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ILE A  22
ALA A  43
GLU A  61
CYH A  93
GLY A  96
ASP A 100
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.2A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.83A 5vc3A-5j5tA:
23.1		 5vc3A-5j5tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 ILE A  22
GLY A  23
ALA A  43
CYH A  93
GLY A  96
ASP A 100
 6G2  A 901 (-3.8A)
None
6G2  A 901 (-3.2A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.59A 5vc3A-5j5tA:
23.1		 5vc3A-5j5tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  94
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
TPO  A 145 ( 4.9A)
 0.85A 5vcyA-5j5tA:
22.7		 5vcyA-5j5tA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 9 ALA A  43
VAL A  74
MET A  90
CYH A  93
GLY A  95
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-3.5A)
TPO  A 145 (-4.1A)
TPO  A 145 ( 4.7A)
 0.97A 5w5vA-5j5tA:
9.7		 5w5vA-5j5tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		5 / 9 ALA A  43
VAL A  74
MET A  90
CYH A  93
GLY A  96
 6G2  A 901 (-3.2A)
None
6G2  A 901 (-3.5A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
 0.71A 5w5vA-5j5tA:
9.7		 5w5vA-5j5tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4n7t PHOSPHOPENTOMUTASE
(Streptococcus
mutans) 		4 / 6 HIS A  96
ASN A 251
VAL A 247
LEU A 294
 TPO  A  92 ( 3.9A)
None
None
None
 1.37A 5xdhA-4n7tA:
undetectable
5xdhC-4n7tA:
undetectable		 5xdhA-4n7tA:
12.26
5xdhC-4n7tA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.49A 5y7zA-5j5tA:
14.0		 5y7zA-5j5tA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.49A 5y7zA-5j5tA:
14.0		 5y7zA-5j5tA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		7 / 12 ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.44A 5y7zB-5j5tA:
13.7		 5y7zB-5j5tA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.46A 5y80A-5j5tA:
22.5		 5y80A-5j5tA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		3 / 3 LYS A 186
LEU A 174
ARG A 152
 PTR  A 185 ( 3.6A)
None
TPO  A 183 ( 2.8A)
 0.72A 5yw0A-1cm8A:
0.0		 5yw0A-1cm8A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1ib1 SEROTONIN
N-ACETYLTRANSFERASE
(Ovis
aries) 		3 / 3 ARG E  28
ILE E  20
SER E  18
 TPO  E  31 ( 4.8A)
None
None
 0.81A 5zw2A-1ib1E:
undetectable		 5zw2A-1ib1E:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 3m8y PHOSPHOPENTOMUTASE
(Bacillus
cereus) 		3 / 3 ARG A 193
LYS A  86
ARG A 212
 None
TPO  A  85 ( 2.9A)
None
 1.45A 6az3C-3m8yA:
undetectable
6az3L-3m8yA:
undetectable
6az3M-3m8yA:
undetectable		 6az3C-3m8yA:
11.02
6az3L-3m8yA:
10.70
6az3M-3m8yA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 ASN A 356
SER A 382
ASN A 323
HIS A 378
LEU A 377
 None
None
None
TPO  A 280 ( 4.8A)
None
 1.33A 6chgC-4kavA:
undetectable		 6chgC-4kavA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens) 		4 / 6 PHE A 253
ARG A 298
ILE A 264
MET A 260
 TPO  A 252 ( 4.1A)
None
None
TPO  A 252 ( 4.2A)
 1.18A 6dhbA-3a62A:
undetectable		 6dhbA-3a62A:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 1ib1 14-3-3 ZETA ISOFORM
SEROTONIN
N-ACETYLTRANSFERASE
(Homo
sapiens;
Ovis
aries) 		4 / 5 SER A  45
VAL A  46
ASN A  50
PRO E  33
 None
None
None
TPO  E  31 ( 4.0A)
 0.46A 6fi4A-1ib1A:
30.8
6fi4B-1ib1A:
undetectable		 6fi4A-1ib1A:
72.65
6fi4B-1ib1A:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4n7t PHOSPHOPENTOMUTASE
(Streptococcus
mutans) 		4 / 7 ASP A  13
ASP A 339
LYS A 249
LYS A  93
 MN  A 501 (-2.0A)
MN  A 501 (-2.2A)
TPO  A  92 ( 3.6A)
TPO  A  92 ( 2.9A)
 1.19A 6g31A-4n7tA:
undetectable		 6g31A-4n7tA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 5 ARG A  73
ARG A 152
LEU A 174
VAL A 186
 TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
None
PTR  A 185 ( 2.8A)
 1.00A 6gmdA-1cm8A:
29.8		 6gmdA-1cm8A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4uoo LIPOTEICHOIC ACID
SYNTHASE
(Listeria
monocytogenes) 		3 / 3 HIS A 482
SER A 310
LYS A 308
 MG  A1645 (-3.2A)
TPO  A 307 ( 2.4A)
TPO  A 307 ( 2.9A)
 1.13A 6gmdB-4uooA:
undetectable		 6gmdB-4uooA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens) 		4 / 7 ILE A  93
GLY A 101
ARG A 139
ALA A 157
 None
J60  A1294 ( 3.8A)
TPO  A 174 ( 2.9A)
J60  A1294 ( 4.2A)
 0.64A 6hd6B-2xikA:
18.3		 6hd6B-2xikA:
15.05