SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TP7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BWY_A_SAMA301_0 (COMT PROTEIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 12	VAL A 482 GLU A 487 GLY A 486 TYR A 333 SER A 492	TP7 A9000 (-4.1A) None None None None	1.40A	3bwyA-1mroA: undetectable	3bwyA-1mroA: 18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEG_A_DAHA416_1 (PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL)	1e6v	METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT (Methanopyrus kandleri)	5 / 12	GLN A 434 PHE A 446 GLY A 401 ALA A 405 GLY A 486	None TP7 A1554 (-4.2A) None None None	1.17A	3tegA-1e6vA: 4.1	3tegA-1e6vA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZDY_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1e6v	METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanopyrus kandleri)	5 / 12	GLY A 475 PHE B 376 ILE B 375 GLY B 369 MET A 483	None None None TP7 A1554 ( 3.9A) None	1.20A	4zdyA-1e6vA: 0.0	4zdyA-1e6vA: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_C7HA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1e6v	METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanopyrus kandleri)	4 / 5	TYR B 368 GLY A 332 TYR A 336 GLY A 486	TP7 A1554 (-4.1A) None None None	1.05A	5ayfA-1e6vB: undetectable	5ayfA-1e6vB: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_C7HA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 5	TYR B2365 GLY A1342 TYR A1346 GLY A1503	TP7 A2571 (-3.9A) None None None	1.06A	5ayfA-1e6yB: undetectable	5ayfA-1e6yB: 19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_C7HA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	3sqg	METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT METHYL-COENZYME M REDUCTASE, BETA SUBUNIT (uncultured archaeon)	4 / 5	TYR B 363 GLY A 343 TYR A 347 GLY A 502	TP7 A1002 (-4.1A) None None None	1.05A	5ayfA-3sqgB: undetectable	5ayfA-3sqgB: 19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_C7HA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	5n28	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE, BETA SUBUNIT (Methanotorris formicicus)	4 / 5	TYR B 368 GLY A 331 TYR A 335 GLY A 485	TP7 A 603 (-4.2A) None None TRX A 429 ( 4.5A)	1.02A	5ayfA-5n28B: undetectable	5ayfA-5n28B: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EQB_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1e6v	METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanopyrus kandleri)	5 / 12	GLY A 475 ILE B 375 GLY B 371 GLY B 369 MET A 483	None None None TP7 A1554 ( 3.9A) None	1.03A	5eqbA-1e6vA: 0.0	5eqbA-1e6vA: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESL_A_1YNA701_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1e6v	METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanopyrus kandleri)	5 / 12	GLY A 475 PHE B 376 ILE B 375 GLY B 369 MET A 483	None None None TP7 A1554 ( 3.9A) None	1.20A	5eslA-1e6vA: 0.0	5eslA-1e6vA: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_V_6V8V303_0 (PROTEASOME SUBUNIT BETA TYPE-3 PROTEASOME SUBUNIT BETA TYPE-7)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	5 / 11	ALA A 309 THR A 310 GLY A 490 ASP A 316 LEU A 320	None None None None TP7 A9000 (-4.2A)	1.03A	5lf7V-1mroA: 2.1 5lf7W-1mroA: undetectable	5lf7V-1mroA: 18.23 5lf7W-1mroA: 16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6E8Q_A_X2NA602_0 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1e6v	METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanopyrus kandleri; Methanopyrus kandleri)	5 / 12	GLY A 475 PHE B 376 ILE B 375 GLY B 369 MET A 483	None None None TP7 A1554 ( 3.9A) None	1.21A	6e8qA-1e6vA: undetectable	6e8qA-1e6vA: 11.66

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3BWY_A_SAMA301_0","COMT PROTEIN","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"VAL A 482;GLU A 487;GLY A 486;TYR A 333;SER A 492","TP7 A9000 (-4.1A);None;None;None;None","1.40A","3bwyA-1mroA:undetectable",null],["3TEG_A_DAHA416_1","PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL","1e6v","METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT","Methanopyrus kandleri",5,"GLN A 434;PHE A 446;GLY A 401;ALA A 405;GLY A 486","None;TP7 A1554 (-4.2A);None;None;None","1.17A","3tegA-1e6vA:4.1","3bwyA-1mroA:18.11"],["4ZDY_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","1e6v","METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE I BETA SUBUNIT","Methanopyrus kandleri",5,"GLY A 475;PHE B 376;ILE B 375;GLY B 369;MET A 483","None;None;None;TP7 A1554 ( 3.9A);None","1.20A","4zdyA-1e6vA:0.0","3tegA-1e6vA:21.58"],["5AYF_A_C7HA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE SETD7","1e6v","METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE I BETA SUBUNIT","Methanopyrus kandleri",4,"TYR B 368;GLY A 332;TYR A 336;GLY A 486","TP7 A1554 (-4.1A);None;None;None","1.05A","5ayfA-1e6vB:undetectable","4zdyA-1e6vA:20.89"],["5AYF_A_C7HA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE SETD7","1e6y","METHYL-COENZYME M REDUCTASE I BETA SUBUNIT;METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA","Methanosarcina barkeri",4,"TYR B2365;GLY A1342;TYR A1346;GLY A1503","TP7 A2571 (-3.9A);None;None;None","1.06A","5ayfA-1e6yB:undetectable","5ayfA-1e6vB:20.22"],["5AYF_A_C7HA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE SETD7","3sqg","METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE, BETA SUBUNIT","uncultured archaeon",4,"TYR B 363;GLY A 343;TYR A 347;GLY A 502","TP7 A1002 (-4.1A);None;None;None","1.05A","5ayfA-3sqgB:undetectable","5ayfA-1e6yB:19.95"],["5AYF_A_C7HA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE SETD7","5n28","METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE, BETA SUBUNIT","Methanotorris formicicus",4,"TYR B 368;GLY A 331;TYR A 335;GLY A 485","TP7 A 603 (-4.2A);None;None;TRX A 429 ( 4.5A)","1.02A","5ayfA-5n28B:undetectable","5ayfA-3sqgB:19.04"],["5EQB_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","1e6v","METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE I BETA SUBUNIT","Methanopyrus kandleri",5,"GLY A 475;ILE B 375;GLY B 371;GLY B 369;MET A 483","None;None;None;TP7 A1554 ( 3.9A);None","1.03A","5eqbA-1e6vA:0.0","5ayfA-5n28B:19.82"],["5ESL_A_1YNA701_1","LANOSTEROL 14-ALPHA DEMETHYLASE","1e6v","METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE I BETA SUBUNIT","Methanopyrus kandleri",5,"GLY A 475;PHE B 376;ILE B 375;GLY B 369;MET A 483","None;None;None;TP7 A1554 ( 3.9A);None","1.20A","5eslA-1e6vA:0.0","5eqbA-1e6vA:20.89"],["5LF7_V_6V8V303_0","PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7","1mro","METHYL-COENZYME M REDUCTASE","Methanothermobacter marburgensis",5,"ALA A 309;THR A 310;GLY A 490;ASP A 316;LEU A 320","None;None;None;None;TP7 A9000 (-4.2A)","1.03A","5lf7V-1mroA:2.1;5lf7W-1mroA:undetectable","5eslA-1e6vA:20.89"],["6E8Q_A_X2NA602_0","LANOSTEROL 14-ALPHA DEMETHYLASE","1e6v","METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT;METHYL-COENZYME M REDUCTASE I BETA SUBUNIT","Methanopyrus kandleri;Methanopyrus kandleri",5,"GLY A 475;PHE B 376;ILE B 375;GLY B 369;MET A 483","None;None;None;TP7 A1554 ( 3.9A);None","1.21A","6e8qA-1e6vA:undetectable","5lf7V-1mroA:18.23;5lf7W-1mroA:16.24"]]