SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TNR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 1n47 ISOLECTIN B4
(Vicia
villosa) 		4 / 8 MET A  75
LEU A 105
PRO A  42
GLY A 212
 None
None
None
TNR  A1401 ( 3.7A)
 1.02A 1hrkA-1n47A:
undetectable		 1hrkA-1n47A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1n47 ISOLECTIN B4
(Vicia
villosa) 		4 / 8 MET A  75
LEU A 105
PRO A  42
GLY A 212
 None
None
None
TNR  A1401 ( 3.7A)
 0.96A 1hrkB-1n47A:
undetectable		 1hrkB-1n47A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.47A 1j36A-5kdxA:
undetectable		 1j36A-5kdxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.47A 1j36B-5kdxA:
undetectable		 1j36B-5kdxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.47A 1j37A-5kdxA:
2.5		 1j37A-5kdxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.47A 1j37B-5kdxA:
2.5		 1j37B-5kdxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.50A 1o86A-5kdxA:
undetectable		 1o86A-5kdxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1n47 ISOLECTIN B4
(Vicia
villosa) 		4 / 6 LEU A 105
GLY A 103
ASN A 129
ILE A 145
 None
TNR  A1401 (-3.4A)
TNR  A1401 ( 3.1A)
None
 0.86A 1xf1B-1n47A:
undetectable		 1xf1B-1n47A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		6 / 12 GLN A 683
HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 None
ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 1.45A 2c6nA-5kdxA:
2.8		 2c6nA-5kdxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.56A 2c6nB-5kdxA:
undetectable		 2c6nB-5kdxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1n47 ISOLECTIN B4
(Vicia
villosa) 		4 / 8 MET A  75
LEU A 105
PRO A  42
GLY A 212
 None
None
None
TNR  A1401 ( 3.7A)
 0.99A 2po5A-1n47A:
undetectable		 2po5A-1n47A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1n47 ISOLECTIN B4
(Vicia
villosa) 		4 / 8 MET A  75
LEU A 105
PRO A  42
GLY A 212
 None
None
None
TNR  A1401 ( 3.7A)
 0.98A 2po5B-1n47A:
undetectable		 2po5B-1n47A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.88A 2wa2B-4u36A:
undetectable		 2wa2B-4u36A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.46A 2x8zA-5kdxA:
3.3		 2x8zA-5kdxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.49A 2x91A-5kdxA:
undetectable		 2x91A-5kdxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.41A 4c2pA-5kdxA:
undetectable		 4c2pA-5kdxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.87A 4r7lA-5kdxA:
5.9		 4r7lA-5kdxA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1n47 ISOLECTIN B4
(Vicia
villosa) 		5 / 12 GLY A 103
GLY A 102
GLY A  86
ILE A 138
TYR A 135
 TNR  A1401 (-3.4A)
TNR  A1401 ( 3.9A)
None
None
None
 1.05A 4rtmA-1n47A:
undetectable		 4rtmA-1n47A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.84A 5njvD-4u36A:
undetectable		 5njvD-4u36A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		4 / 5 ASP A  87
PRO A  42
GLU A  78
THR A 220
 TNR  A 303 (-2.7A)
None
None
None
 1.37A 5uxcA-4u36A:
undetectable		 5uxcA-4u36A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 GLN A 720
GLY A 699
GLN A 814
ASP A 621
 TNR  A1002 (-3.1A)
None
None
EDO  A1008 (-3.6A)
 1.09A 5vlmE-5kdxA:
1.8		 5vlmE-5kdxA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.98A 5wz1C-4u36A:
undetectable		 5wz1C-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.98A 5wz1D-4u36A:
undetectable		 5wz1D-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.94A 5wz1E-4u36A:
undetectable		 5wz1E-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.98A 5wz1F-4u36A:
undetectable		 5wz1F-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.99A 5wz1G-4u36A:
undetectable		 5wz1G-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.96A 5wz1H-4u36A:
undetectable		 5wz1H-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 1n47 ISOLECTIN B4
(Vicia
villosa) 		5 / 10 ASP A  85
GLY A 102
ASP A 222
THR A 220
SER A 208
 TNR  A1401 (-2.9A)
TNR  A1401 ( 3.9A)
None
None
None
 1.47A 6mn1B-1n47A:
0.0		 6mn1B-1n47A:
15.25