SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TMQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
SER A  49
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
 0.71A 1ao8A-4m2xA:
19.4		 1ao8A-4m2xA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  27
PHE A  31
THR A  46
SER A  49
ARG A  60
 TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
None
 1.01A 1ao8A-4m2xA:
19.4		 1ao8A-4m2xA:
34.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
PRO A  51
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
TMQ  A 202 (-4.2A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.40A 1cd2A-4m2xA:
19.5		 1cd2A-4m2xA:
29.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
ARG A  32
ARG A  60
ILE A  94
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 ( 3.8A)
TMQ  A 202 (-4.2A)
 1.22A 1d1gA-4m2xA:
17.3		 1d1gA-4m2xA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
ILE A  94
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 ( 3.8A)
TMQ  A 202 (-4.2A)
 0.45A 1d1gA-4m2xA:
17.3		 1d1gA-4m2xA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
ARG A  32
LEU A  57
ARG A  60
ILE A  94
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
TMQ  A 202 ( 3.8A)
TMQ  A 202 (-4.2A)
 0.94A 1d1gB-4m2xA:
17.3		 1d1gB-4m2xA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
None
 0.57A 1ddrA-4m2xA:
21.7		 1ddrA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
THR A  46
SER A  49
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
None
 0.72A 1ddrA-4m2xA:
21.7		 1ddrA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.16A 1ddrB-4m2xA:
21.6		 1ddrB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.39A 1ddrB-4m2xA:
21.6		 1ddrB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.13A 1ddsA-4m2xA:
22.0		 1ddsA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.44A 1ddsA-4m2xA:
22.0		 1ddsA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.14A 1ddsB-4m2xA:
22.1		 1ddsB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
None
TMQ  A 202 (-4.2A)
 0.44A 1ddsB-4m2xA:
22.1		 1ddsB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		12 / 12 ILE A   5
ALA A   7
ILE A  20
ASP A  27
GLN A  28
LEU A  50
PRO A  51
VAL A  54
LEU A  57
ARG A  60
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 ( 3.6A)
None
TMQ  A 202 (-4.2A)
None
None
None
TMQ  A 202 ( 3.8A)
None
 0.58A 1df7A-4m2xA:
30.3		 1df7A-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		11 / 11 ILE A   5
TRP A   6
ALA A   7
ILE A  20
ASP A  27
PHE A  31
SER A  49
LEU A  50
PRO A  51
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
TMQ  A 202 ( 3.8A)
None
 0.55A 1dg5A-4m2xA:
29.9		 1dg5A-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 TRP A   6
ALA A   7
ASP A  27
LEU A  57
ILE A  94
TYR A 100
 None
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
 1.37A 1dg5A-4m2xA:
29.9		 1dg5A-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
PRO A  51
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
TMQ  A 202 (-4.2A)
None
None
TMQ  A 202 (-4.2A)
 0.47A 1dhfA-4m2xA:
20.7		 1dhfA-4m2xA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.39A 1dhfB-4m2xA:
20.9		 1dhfB-4m2xA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.40A 1dhiA-4m2xA:
21.8		 1dhiA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.71A 1dhiA-4m2xA:
21.8		 1dhiA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ILE A   5
ALA A   7
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.36A 1dhiB-4m2xA:
22.0		 1dhiB-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.41A 1dhjA-4m2xA:
21.8		 1dhjA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
SER A  49
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.70A 1dhjA-4m2xA:
21.8		 1dhjA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
LEU A  57
PRO A  58
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.46A 1dhjB-4m2xA:
22.1		 1dhjB-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
SER A  49
PRO A  51
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
None
None
None
 0.49A 1dlsA-4m2xA:
21.0		 1dlsA-4m2xA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
LEU A  57
ARG A  60
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
None
TMQ  A 202 ( 3.8A)
None
 0.42A 1draA-4m2xA:
21.8		 1draA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A   5
ALA A   7
SER A  49
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
 0.76A 1draA-4m2xA:
21.8		 1draA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.35A 1draB-4m2xA:
22.1		 1draB-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.42A 1drbA-4m2xA:
21.6		 1drbA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.75A 1drbA-4m2xA:
21.6		 1drbA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.38A 1drbB-4m2xA:
22.0		 1drbB-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
PHE A  31
SER A  49
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
None
None
None
 0.56A 1dreA-4m2xA:
22.7		 1dreA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
SER A  49
PRO A  51
LEU A  57
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
None
None
 0.46A 1drfA-4m2xA:
20.8		 1drfA-4m2xA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.05A 1dyiA-4m2xA:
21.9		 1dyiA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.39A 1dyiA-4m2xA:
21.9		 1dyiA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.07A 1dyiB-4m2xA:
22.0		 1dyiB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.34A 1dyiB-4m2xA:
22.0		 1dyiB-4m2xA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ILE A   5
ALA A   7
PHE A  31
PRO A  51
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.2A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.35A 1dyrA-4m2xA:
19.3		 1dyrA-4m2xA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4xt8 RV2671
(Mycobacterium
tuberculosis) 		4 / 5 GLU A  91
GLY A 195
SER A  59
PHE A  45
 TMQ  A 302 ( 3.2A)
NAP  A 301 (-3.4A)
TMQ  A 302 ( 3.0A)
NAP  A 301 ( 4.1A)
 1.24A 1icrA-4xt8A:
undetectable
1icrB-4xt8A:
undetectable		 1icrA-4xt8A:
25.09
1icrB-4xt8A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4xt8 RV2671
(Mycobacterium
tuberculosis) 		4 / 5 GLU A  91
GLY A 195
SER A  59
PHE A  45
 TMQ  A 302 ( 3.2A)
NAP  A 301 (-3.4A)
TMQ  A 302 ( 3.0A)
NAP  A 301 ( 4.1A)
 1.26A 1icvC-4xt8A:
undetectable
1icvD-4xt8A:
undetectable		 1icvC-4xt8A:
25.09
1icvD-4xt8A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.31A 1j3jA-4m2xA:
19.6		 1j3jA-4m2xA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 9 ALA A   7
ASP A  27
PHE A  31
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.33A 1j3jB-4m2xA:
19.3		 1j3jB-4m2xA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.09A 1jolA-4m2xA:
21.9		 1jolA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
TMQ  A 202 (-4.2A)
 0.42A 1jolA-4m2xA:
21.9		 1jolA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.10A 1jolB-4m2xA:
22.1		 1jolB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
PRO A  58
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.38A 1jolB-4m2xA:
22.1		 1jolB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.12A 1jomA-4m2xA:
21.1		 1jomA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ALA A   7
ASP A  27
PHE A  31
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.47A 1jomA-4m2xA:
21.1		 1jomA-4m2xA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.62A 1qzfA-4m2xA:
12.6		 1qzfA-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.62A 1qzfB-4m2xA:
20.3		 1qzfB-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.62A 1qzfC-4m2xA:
13.2		 1qzfC-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.63A 1qzfD-4m2xA:
12.5		 1qzfD-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.64A 1qzfE-4m2xA:
12.6		 1qzfE-4m2xA:
17.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 1.44A 1ra2A-4m2xA:
21.7		 1ra2A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.36A 1ra2A-4m2xA:
21.7		 1ra2A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 1.45A 1ra3A-4m2xA:
21.9		 1ra3A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.35A 1ra3A-4m2xA:
21.9		 1ra3A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.31A 1ra8A-4m2xA:
21.6		 1ra8A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 1.47A 1rb2A-4m2xA:
22.0		 1rb2A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.40A 1rb2A-4m2xA:
22.0		 1rb2A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.47A 1rb2B-4m2xA:
22.0		 1rb2B-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 10 ILE A   5
ALA A   7
ASP A  27
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.37A 1rb3A-4m2xA:
22.0		 1rb3A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.51A 1rb3B-4m2xA:
22.0		 1rb3B-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.34A 1rd7A-4m2xA:
21.6		 1rd7A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.42A 1rd7B-4m2xA:
21.6		 1rd7B-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.40A 1re7A-4m2xA:
21.7		 1re7A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
PRO A  58
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.50A 1re7B-4m2xA:
21.4		 1re7B-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
THR A  46
SER A  49
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
None
None
None
 0.67A 1rg7A-4m2xA:
20.7		 1rg7A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ASP A  27
PHE A  31
SER A  49
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
None
None
None
 0.46A 1rh3A-4m2xA:
22.7		 1rh3A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.31A 1rx2A-4m2xA:
23.1		 1rx2A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
SER A  49
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
None
None
None
 0.46A 1rx3A-4m2xA:
23.1		 1rx3A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.48A 1rx7A-4m2xA:
21.0		 1rx7A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  57
PRO A  58
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.38A 1rx8A-4m2xA:
22.8		 1rx8A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
 0.47A 1tdrA-4m2xA:
21.7		 1tdrA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.11A 1tdrB-4m2xA:
22.1		 1tdrB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 10 ALA A   7
ASP A  27
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
TMQ  A 202 (-4.2A)
 0.41A 1tdrB-4m2xA:
22.1		 1tdrB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
PRO A  51
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.2A)
None
None
None
 0.60A 1u70A-4m2xA:
20.2		 1u70A-4m2xA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
SER A  49
PRO A  51
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
None
None
None
 0.48A 1u72A-4m2xA:
21.0		 1u72A-4m2xA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
PHE A  31
SER A  49
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
 0.81A 2bl9A-4m2xA:
19.5		 2bl9A-4m2xA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.39A 2bl9A-4m2xA:
19.5		 2bl9A-4m2xA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 11 ILE A   5
ALA A   7
ASP A  27
PHE A  31
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.61A 2blaA-4m2xA:
18.9		 2blaA-4m2xA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
THR A  46
PRO A  51
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.4A)
TMQ  A 202 (-4.2A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.41A 2cd2A-4m2xA:
19.8		 2cd2A-4m2xA:
29.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  57
PRO A  58
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.41A 2d0kA-4m2xA:
21.2		 2d0kA-4m2xA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.41A 2d0kB-4m2xA:
21.1		 2d0kB-4m2xA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  57
ARG A  60
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 ( 3.8A)
None
 0.41A 2drcA-4m2xA:
21.7		 2drcA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
 0.69A 2drcA-4m2xA:
21.7		 2drcA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.35A 2drcB-4m2xA:
22.1		 2drcB-4m2xA:
34.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
 0.67A 2oipA-4m2xA:
21.0		 2oipA-4m2xA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.24A 2oipB-4m2xA:
19.2		 2oipB-4m2xA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.61A 2oipB-4m2xA:
19.2		 2oipB-4m2xA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.69A 2oipC-4m2xA:
20.5		 2oipC-4m2xA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
 0.72A 2oipD-4m2xA:
21.5		 2oipD-4m2xA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
 0.66A 2oipE-4m2xA:
19.9		 2oipE-4m2xA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
ARG A  60
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
 0.79A 2oipE-4m2xA:
19.9		 2oipE-4m2xA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 149
ILE A 117
LEU A  50
PRO A  51
VAL A  54
 None
None
None
TMQ  A 202 (-4.2A)
None
 0.82A 2pnjA-4m2xA:
undetectable		 2pnjA-4m2xA:
17.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
LEU A  57
PRO A  58
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
None
None
None
None
 0.65A 2qk8A-4m2xA:
21.8		 2qk8A-4m2xA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ILE A   5
ALA A   7
PHE A  31
THR A  46
PRO A  51
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
TMQ  A 202 (-4.2A)
None
TMQ  A 202 (-4.2A)
 0.59A 2w3aA-4m2xA:
20.6		 2w3aA-4m2xA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 10 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.43A 2w3aB-4m2xA:
20.6		 2w3aB-4m2xA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
PRO A  51
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
TMQ  A 202 (-4.2A)
None
None
TMQ  A 202 (-4.2A)
 0.44A 2w3bA-4m2xA:
20.9		 2w3bA-4m2xA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
PRO A  51
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.2A)
None
None
TMQ  A 202 (-4.2A)
 0.49A 2w3bB-4m2xA:
20.9		 2w3bB-4m2xA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
PRO A  51
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.2A)
None
None
TMQ  A 202 (-4.2A)
 0.54A 2w3mA-4m2xA:
20.5		 2w3mA-4m2xA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.47A 2w3mB-4m2xA:
20.6		 2w3mB-4m2xA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 TRP A   6
ALA A   7
ASP A  27
LEU A  57
ILE A  94
TYR A 100
THR A 113
 None
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 1.35A 2w3vA-4m2xA:
28.1		 2w3vA-4m2xA:
68.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		10 / 12 TRP A   6
ALA A   7
ILE A  20
ASP A  27
PHE A  31
SER A  49
LEU A  50
ILE A  94
TYR A 100
THR A 113
 None
TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.52A 2w3vA-4m2xA:
28.1		 2w3vA-4m2xA:
68.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ILE A   5
ALA A   7
ASP A  27
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.64A 2w9sA-4m2xA:
23.0		 2w9sA-4m2xA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ILE A   5
ALA A   7
ASP A  27
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.64A 2w9sB-4m2xA:
23.0		 2w9sB-4m2xA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A   5
ALA A   7
ASP A  27
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.63A 2w9sC-4m2xA:
23.0		 2w9sC-4m2xA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A   5
ALA A   7
ASP A  27
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.31A 2w9sD-4m2xA:
22.7		 2w9sD-4m2xA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 8 ILE A   5
ALA A   7
ASP A  27
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 (-4.2A)
 0.28A 2w9sE-4m2xA:
22.8		 2w9sE-4m2xA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 10 ILE A   5
ALA A   7
ASP A  27
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.32A 2w9sF-4m2xA:
22.7		 2w9sF-4m2xA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
None
None
TMQ  A 202 (-4.2A)
 0.29A 2zzaA-4m2xA:
23.4		 2zzaA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ILE A   5
ALA A   7
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
None
None
TMQ  A 202 (-4.2A)
 0.30A 2zzaB-4m2xA:
23.4		 2zzaB-4m2xA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
PRO A  51
LEU A  57
ARG A  60
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.2A)
None
None
TMQ  A 202 ( 3.8A)
None
 0.38A 3cd2A-4m2xA:
19.2		 3cd2A-4m2xA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		10 / 12 ALA A   7
ILE A  20
ASP A  27
THR A  46
SER A  49
PRO A  51
LEU A  57
PRO A  58
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
None
None
None
None
 0.80A 3cl9A-4m2xA:
19.2		 3cl9A-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ALA A   7
ASP A  27
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 1.46A 3clbA-4m2xA:
19.7		 3clbA-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ALA A   7
ILE A  20
ASP A  27
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.38A 3clbA-4m2xA:
19.7		 3clbA-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  20
PRO A  51
LEU A  57
ILE A  94
TYR A 100
 NDP  A 201 (-4.0A)
TMQ  A 202 (-4.2A)
None
TMQ  A 202 ( 3.8A)
None
 0.74A 3clbA-4m2xA:
19.7		 3clbA-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ALA A   7
ILE A  20
ASP A  27
PHE A  31
THR A  46
SER A  49
ILE A  94
TYR A 100
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
 0.65A 3clbB-4m2xA:
18.1		 3clbB-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  20
THR A  46
SER A  49
PRO A  51
TYR A 100
 NDP  A 201 (-4.0A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
None
 0.95A 3clbB-4m2xA:
18.1		 3clbB-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ALA A   7
ILE A  20
ASP A  27
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.50A 3clbC-4m2xA:
10.9		 3clbC-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  20
THR A  46
PRO A  51
LEU A  57
ILE A  94
TYR A 100
 NDP  A 201 (-4.0A)
NDP  A 201 (-3.4A)
TMQ  A 202 (-4.2A)
None
TMQ  A 202 ( 3.8A)
None
 0.64A 3clbC-4m2xA:
10.9		 3clbC-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A   7
ASP A  27
PRO A  58
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.07A 3clbD-4m2xA:
19.4		 3clbD-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 10 ALA A   7
ILE A  20
ASP A  27
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.45A 3clbD-4m2xA:
19.4		 3clbD-4m2xA:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
ALA A  29
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
None
 0.41A 3dauA-4m2xA:
23.1		 3dauA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
TMQ  A 202 (-4.2A)
 0.70A 3dfrA-4m2xA:
21.9		 3dfrA-4m2xA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
SER A  49
PRO A  51
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
None
TMQ  A 202 (-4.2A)
 0.79A 3dfrA-4m2xA:
21.9		 3dfrA-4m2xA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  57
ARG A  60
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 ( 3.8A)
None
 0.41A 3drcA-4m2xA:
21.8		 3drcA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
 0.70A 3drcA-4m2xA:
21.8		 3drcA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.35A 3drcB-4m2xA:
22.2		 3drcB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
SER A  49
PRO A  51
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
None
None
None
 0.68A 3eigA-4m2xA:
20.5		 3eigA-4m2xA:
32.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 10 ALA A   7
ILE A  20
ASP A  27
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
 0.40A 3hbbA-4m2xA:
19.8		 3hbbA-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  20
PRO A  51
LEU A  57
ILE A  94
TYR A 100
 NDP  A 201 (-4.0A)
TMQ  A 202 (-4.2A)
None
TMQ  A 202 ( 3.8A)
None
 0.74A 3hbbA-4m2xA:
19.8		 3hbbA-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 9 ALA A   7
ILE A  20
ASP A  27
THR A  46
SER A  49
ILE A  94
TYR A 100
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
 0.71A 3hbbB-4m2xA:
18.4		 3hbbB-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ALA A   7
ASP A  27
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 1.45A 3hbbC-4m2xA:
19.5		 3hbbC-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ALA A   7
ILE A  20
ASP A  27
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.46A 3hbbC-4m2xA:
19.5		 3hbbC-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  20
PRO A  51
LEU A  57
ILE A  94
TYR A 100
 NDP  A 201 (-4.0A)
TMQ  A 202 (-4.2A)
None
TMQ  A 202 ( 3.8A)
None
 0.70A 3hbbC-4m2xA:
19.5		 3hbbC-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A   7
ASP A  27
PRO A  58
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.10A 3hbbD-4m2xA:
19.6		 3hbbD-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 10 ALA A   7
ILE A  20
ASP A  27
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.44A 3hbbD-4m2xA:
19.6		 3hbbD-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  20
ASP A  27
PRO A  51
ILE A  94
TYR A 100
 NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.2A)
TMQ  A 202 ( 3.8A)
None
 0.68A 3hbbD-4m2xA:
19.6		 3hbbD-4m2xA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.65A 3hj3A-4m2xA:
21.3		 3hj3A-4m2xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
 0.69A 3hj3B-4m2xA:
21.6		 3hj3B-4m2xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
PHE A  31
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.71A 3hj3C-4m2xA:
19.8		 3hj3C-4m2xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.65A 3hj3C-4m2xA:
19.8		 3hj3C-4m2xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
PHE A  31
LEU A  57
ARG A  60
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
 0.72A 3hj3D-4m2xA:
11.6		 3hj3D-4m2xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
 0.63A 3hj3D-4m2xA:
11.6		 3hj3D-4m2xA:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
SER A  49
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.6A)
None
None
None
 0.69A 3ia4A-4m2xA:
22.9		 3ia4A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 4 ILE A   5
PHE A  31
ILE A  94
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.8A)
TMQ  A 202 (-4.2A)
 0.22A 3ia4A-4m2xA:
22.9		 3ia4A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
SER A  49
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.6A)
None
None
None
 0.63A 3ia4B-4m2xA:
23.0		 3ia4B-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
PHE A  31
SER A  49
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
None
None
None
 0.61A 3ia4C-4m2xA:
22.9		 3ia4C-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
SER A  49
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
None
None
None
 0.56A 3ia4D-4m2xA:
23.0		 3ia4D-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
TRP A   6
ALA A   7
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.5A)
None
None
TMQ  A 202 (-4.2A)
 0.66A 3ix9A-4m2xA:
21.4		 3ix9A-4m2xA:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A   5
ALA A   7
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
None
TMQ  A 202 (-4.2A)
 0.53A 3ix9B-4m2xA:
21.3		 3ix9B-4m2xA:
31.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
ASP A  27
ARG A  32
THR A  46
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
NDP  A 201 (-3.4A)
None
None
None
 0.86A 3k2hA-4m2xA:
21.1		 3k2hA-4m2xA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
None
 0.76A 3k2hB-4m2xA:
4.3		 3k2hB-4m2xA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ILE A  20
ASP A  27
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
None
None
None
 0.57A 3k2hB-4m2xA:
4.3		 3k2hB-4m2xA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  32
THR A  46
THR A 113
 None
NDP  A 201 (-3.4A)
TMQ  A 202 (-4.2A)
 0.61A 3k2hB-4m2xA:
20.3		 3k2hB-4m2xA:
15.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.51A 3n0hA-4m2xA:
20.7		 3n0hA-4m2xA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
THR A  46
PRO A  51
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
TMQ  A 202 (-4.2A)
TMQ  A 202 (-4.2A)
 0.52A 3nrrA-4m2xA:
20.3		 3nrrA-4m2xA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
THR A  46
PRO A  51
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
TMQ  A 202 (-4.2A)
TMQ  A 202 (-4.2A)
 0.54A 3nrrB-4m2xA:
21.2		 3nrrB-4m2xA:
15.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.06A 3qfxA-4m2xA:
19.3		 3qfxA-4m2xA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		10 / 12 ALA A   7
ILE A  20
ASP A  27
PHE A  31
THR A  46
SER A  49
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.42A 3qfxA-4m2xA:
19.3		 3qfxA-4m2xA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.04A 3qfxB-4m2xA:
19.3		 3qfxB-4m2xA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		10 / 12 ALA A   7
ILE A  20
ASP A  27
PHE A  31
THR A  46
SER A  49
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.40A 3qfxB-4m2xA:
19.3		 3qfxB-4m2xA:
32.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.35A 3qg2A-4m2xA:
10.0		 3qg2A-4m2xA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ILE A   5
ALA A   7
ASP A  27
PHE A  31
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.36A 3qg2B-4m2xA:
19.3		 3qg2B-4m2xA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A   7
ASP A  27
PHE A  31
SER A  49
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
 0.84A 3qgtA-4m2xA:
19.5		 3qgtA-4m2xA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.33A 3qgtA-4m2xA:
19.5		 3qgtA-4m2xA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A   7
ASP A  27
PHE A  31
SER A  49
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
 0.86A 3qgtB-4m2xA:
10.2		 3qgtB-4m2xA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.35A 3qgtB-4m2xA:
10.2		 3qgtB-4m2xA:
15.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.29A 3ql0A-4m2xA:
23.3		 3ql0A-4m2xA:
35.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.34A 3ql3A-4m2xA:
23.1		 3ql3A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.54A 3s3vA-4m2xA:
20.4		 3s3vA-4m2xA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 9 ILE A   5
ALA A   7
ASP A  27
PHE A  31
SER A  49
ILE A  94
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
TMQ  A 202 (-4.2A)
 0.51A 3tq8A-4m2xA:
23.0		 3tq8A-4m2xA:
35.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
ILE A  94
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
TMQ  A 202 ( 3.8A)
TMQ  A 202 (-4.2A)
 0.46A 3tq9A-4m2xA:
23.0		 3tq9A-4m2xA:
35.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
ILE A  94
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 ( 3.8A)
TMQ  A 202 (-4.2A)
 0.50A 3tqbA-4m2xA:
22.3		 3tqbA-4m2xA:
35.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 10 ILE A   5
ASP A  27
PHE A  31
THR A  46
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.39A 3um5A-4m2xA:
19.3		 3um5A-4m2xA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 10 ILE A   5
ASP A  27
PHE A  31
THR A  46
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.46A 3um5B-4m2xA:
10.6		 3um5B-4m2xA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.46A 4cd2A-4m2xA:
18.3		 4cd2A-4m2xA:
29.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
None
 0.45A 4dfrA-4m2xA:
21.7		 4dfrA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
THR A  46
SER A  49
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
NDP  A 201 (-3.6A)
None
 0.74A 4dfrA-4m2xA:
21.7		 4dfrA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 1.49A 4dfrB-4m2xA:
22.0		 4dfrB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.32A 4dfrB-4m2xA:
22.0		 4dfrB-4m2xA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
PHE A  31
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
None
None
TMQ  A 202 (-4.2A)
 0.72A 4eckA-4m2xA:
19.0		 4eckA-4m2xA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
TMQ  A 202 (-4.2A)
 0.80A 4eckB-4m2xA:
18.6		 4eckB-4m2xA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.41A 4eilA-4m2xA:
20.1		 4eilA-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.54A 4eilB-4m2xA:
20.3		 4eilB-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.43A 4eilC-4m2xA:
20.1		 4eilC-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.42A 4eilE-4m2xA:
20.7		 4eilE-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.53A 4eilF-4m2xA:
19.6		 4eilF-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.42A 4eilG-4m2xA:
20.1		 4eilG-4m2xA:
17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
 0.33A 4ej1A-4m2xA:
21.6		 4ej1A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.34A 4ej1B-4m2xA:
21.6		 4ej1B-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.38A 4fhbA-4m2xA:
22.0		 4fhbA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 10 ILE A   5
ALA A   7
PHE A  31
SER A  49
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.54A 4g8zX-4m2xA:
19.8		 4g8zX-4m2xA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 10 ILE A   5
PHE A  31
SER A  49
PRO A  51
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.76A 4g8zX-4m2xA:
19.8		 4g8zX-4m2xA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
PRO A  51
LEU A  57
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
None
None
None
 0.36A 4gh8A-4m2xA:
23.9		 4gh8A-4m2xA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
PRO A  51
ARG A  60
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
TMQ  A 202 (-4.2A)
None
None
 0.33A 4gh8B-4m2xA:
23.6		 4gh8B-4m2xA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
 0.31A 4i13A-4m2xA:
21.5		 4i13A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  27
ARG A  60
THR A 113
 TMQ  A 202 ( 2.7A)
None
TMQ  A 202 (-4.2A)
 0.39A 4i13A-4m2xA:
21.5		 4i13A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.03A 4i1nA-4m2xA:
21.6		 4i1nA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 11 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.41A 4i1nA-4m2xA:
21.6		 4i1nA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.41A 4kebB-4m2xA:
20.8		 4kebB-4m2xA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
PRO A  51
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.2A)
None
None
TMQ  A 202 (-4.2A)
 0.49A 4kfjB-4m2xA:
21.0		 4kfjB-4m2xA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ALA A  29
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
 0.27A 4kjjA-4m2xA:
22.5		 4kjjA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
 0.32A 4kjkA-4m2xA:
22.9		 4kjkA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
ARG A  55
LEU A  57
ILE A  94
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
None
None
TMQ  A 202 ( 3.8A)
TMQ  A 202 (-4.2A)
 1.23A 4kjlA-4m2xA:
22.7		 4kjlA-4m2xA:
35.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.32A 4kjlA-4m2xA:
22.7		 4kjlA-4m2xA:
35.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		10 / 10 ILE A   5
TRP A   6
ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.63A 4km0A-4m2xA:
27.2		 4km0A-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 TRP A   6
ALA A   7
ASP A  27
LEU A  57
TYR A 100
 None
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
 1.09A 4km0A-4m2xA:
27.2		 4km0A-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		10 / 12 ILE A   5
TRP A   6
ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.60A 4km0B-4m2xA:
27.2		 4km0B-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		10 / 12 ILE A   5
TRP A   6
ALA A   7
ILE A  20
ASP A  27
PHE A  31
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.63A 4km0B-4m2xA:
27.2		 4km0B-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 TRP A   6
ALA A   7
ASP A  27
LEU A  57
TYR A 100
 None
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
 1.09A 4km0B-4m2xA:
27.2		 4km0B-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 TRP A   6
ASP A  27
GLN A  28
THR A  46
TYR A 100
THR A 113
 None
TMQ  A 202 ( 2.7A)
TMQ  A 202 ( 3.6A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 (-4.2A)
 1.20A 4km0B-4m2xA:
27.2		 4km0B-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 TRP A   6
ILE A  20
ASP A  27
GLN A  28
TYR A 100
THR A 113
 None
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 ( 3.6A)
None
TMQ  A 202 (-4.2A)
 1.31A 4km0B-4m2xA:
27.2		 4km0B-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.09A 4km2A-4m2xA:
27.7		 4km2A-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
ILE A  20
ASP A  27
PHE A  31
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.53A 4km2A-4m2xA:
27.7		 4km2A-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A   5
ILE A  20
VAL A  54
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
NDP  A 201 (-4.0A)
None
TMQ  A 202 ( 3.8A)
None
 0.75A 4km2A-4m2xA:
27.7		 4km2A-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
PHE A  31
THR A  46
LEU A  50
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 ( 3.8A)
None
 0.63A 4km2A-4m2xA:
27.7		 4km2A-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
THR A  46
LEU A  50
VAL A  54
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 ( 3.8A)
None
 0.59A 4km2A-4m2xA:
27.7		 4km2A-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
ILE A  20
ASP A  27
PHE A  31
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.52A 4km2B-4m2xA:
27.0		 4km2B-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ILE A  20
VAL A  54
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
NDP  A 201 (-4.0A)
None
None
TMQ  A 202 ( 3.8A)
None
 0.96A 4km2B-4m2xA:
27.0		 4km2B-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
PHE A  31
THR A  46
LEU A  50
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 ( 3.8A)
None
 0.53A 4km2B-4m2xA:
27.0		 4km2B-4m2xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
THR A  46
LEU A  50
VAL A  54
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 ( 3.8A)
None
 0.58A 4km2B-4m2xA:
27.0		 4km2B-4m2xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
TMQ  A 202 (-4.2A)
 0.70A 4ky8A-4m2xA:
14.2		 4ky8A-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
TMQ  A 202 (-4.2A)
 0.72A 4ky8B-4m2xA:
15.3		 4ky8B-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.65A 4ky8C-4m2xA:
21.2		 4ky8C-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
TMQ  A 202 (-4.2A)
 0.77A 4ky8D-4m2xA:
17.7		 4ky8D-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
TMQ  A 202 (-4.2A)
 0.77A 4ky8E-4m2xA:
21.1		 4ky8E-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.43A 4kyaA-4m2xA:
20.1		 4kyaA-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.56A 4kyaB-4m2xA:
20.1		 4kyaB-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.45A 4kyaC-4m2xA:
14.6		 4kyaC-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.56A 4kyaD-4m2xA:
13.0		 4kyaD-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.43A 4kyaE-4m2xA:
20.2		 4kyaE-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.54A 4kyaF-4m2xA:
13.0		 4kyaF-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ALA A   7
ASP A  27
THR A  46
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.44A 4kyaG-4m2xA:
20.1		 4kyaG-4m2xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 0.58A 4kyaH-4m2xA:
19.4		 4kyaH-4m2xA:
17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
PRO A  51
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
TMQ  A 202 (-4.2A)
None
None
TMQ  A 202 (-4.2A)
 0.43A 4m6kA-4m2xA:
21.1		 4m6kA-4m2xA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
 0.26A 4nx6A-4m2xA:
23.2		 4nx6A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 4 ILE A   5
ASP A  27
ARG A  60
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 (-4.2A)
 0.37A 4nx6A-4m2xA:
23.2		 4nx6A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
 0.22A 4nx7A-4m2xA:
23.5		 4nx7A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 4 ILE A   5
ASP A  27
ARG A  60
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 (-4.2A)
 0.35A 4nx7A-4m2xA:
23.5		 4nx7A-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
PRO A  58
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 ( 3.8A)
None
 0.38A 4p3qA-4m2xA:
23.2		 4p3qA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
 0.23A 4p3rA-4m2xA:
23.6		 4p3rA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  27
ARG A  60
THR A 113
 TMQ  A 202 ( 2.7A)
None
TMQ  A 202 (-4.2A)
 0.40A 4p3rA-4m2xA:
23.6		 4p3rA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ALA A   7
ASP A  27
LEU A  50
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 1.43A 4p66A-4m2xA:
23.2		 4p66A-4m2xA:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.31A 4p66A-4m2xA:
23.2		 4p66A-4m2xA:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 11 ILE A   5
ASP A  27
PHE A  31
SER A  49
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.41A 4p68A-4m2xA:
22.9		 4p68A-4m2xA:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ALA A  29
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
 0.25A 4pssA-4m2xA:
undetectable		 4pssA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.30A 4pstA-4m2xA:
undetectable		 4pstA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 ILE A   5
ASP A  27
ARG A  60
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 2.7A)
None
 0.33A 4pstA-4m2xA:
undetectable		 4pstA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ALA A  29
PHE A  31
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
None
TMQ  A 202 (-4.0A)
None
None
TMQ  A 202 (-4.2A)
 0.28A 4psyA-4m2xA:
23.6		 4psyA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
THR A  46
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.26A 4pthA-4m2xA:
23.5		 4pthA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.30A 4ptjA-4m2xA:
23.2		 4ptjA-4m2xA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
TMQ  A 202 (-4.2A)
 0.66A 4q0dA-4m2xA:
21.2		 4q0dA-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
TMQ  A 202 (-4.2A)
 0.67A 4q0dB-4m2xA:
21.3		 4q0dB-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.30A 4q0dC-4m2xA:
21.2		 4q0dC-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
TMQ  A 202 (-4.2A)
 0.67A 4q0dC-4m2xA:
21.2		 4q0dC-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.67A 4q0dC-4m2xA:
21.2		 4q0dC-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.30A 4q0dD-4m2xA:
21.2		 4q0dD-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
TMQ  A 202 (-4.2A)
 0.67A 4q0dD-4m2xA:
21.2		 4q0dD-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.67A 4q0dD-4m2xA:
21.2		 4q0dD-4m2xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A   7
ASP A  27
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
TMQ  A 202 (-4.2A)
 0.67A 4q0dE-4m2xA:
21.3		 4q0dE-4m2xA:
17.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
TMQ  A 202 (-4.2A)
 0.43A 4qi9A-4m2xA:
19.9		 4qi9A-4m2xA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
TMQ  A 202 (-4.2A)
 0.58A 4qi9A-4m2xA:
19.9		 4qi9A-4m2xA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.14A 4qi9B-4m2xA:
20.5		 4qi9B-4m2xA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
TMQ  A 202 (-4.2A)
 0.45A 4qi9B-4m2xA:
20.5		 4qi9B-4m2xA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.62A 4qi9B-4m2xA:
20.5		 4qi9B-4m2xA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.14A 4qi9C-4m2xA:
19.8		 4qi9C-4m2xA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
None
TMQ  A 202 (-4.2A)
 0.44A 4qi9C-4m2xA:
19.8		 4qi9C-4m2xA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ILE A   5
ALA A   7
ASP A  27
SER A  49
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
TMQ  A 202 (-4.2A)
 0.62A 4qi9C-4m2xA:
19.8		 4qi9C-4m2xA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.06A 4qleA-4m2xA:
22.5		 4qleA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.34A 4qleA-4m2xA:
22.5		 4qleA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.08A 4qleB-4m2xA:
22.6		 4qleB-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 11 ILE A   5
ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
None
TMQ  A 202 (-4.2A)
 0.60A 4qleB-4m2xA:
22.6		 4qleB-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.12A 4qlfA-4m2xA:
19.8		 4qlfA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 11 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.39A 4qlfA-4m2xA:
19.8		 4qlfA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.03A 4qlgA-4m2xA:
22.4		 4qlgA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.40A 4qlgA-4m2xA:
22.4		 4qlgA-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.07A 4qlgB-4m2xA:
22.0		 4qlgB-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.43A 4qlgB-4m2xA:
22.0		 4qlgB-4m2xA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.00A 4rgcA-4m2xA:
23.3		 4rgcA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
None
None
None
TMQ  A 202 (-4.2A)
 0.36A 4rgcA-4m2xA:
23.3		 4rgcA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.32A 4x5fA-4m2xA:
21.6		 4x5fA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.34A 4x5fB-4m2xA:
21.7		 4x5fB-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.02A 4x5gA-4m2xA:
22.2		 4x5gA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.32A 4x5gA-4m2xA:
22.2		 4x5gA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
THR A  46
LEU A  57
ARG A  60
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.27A 4x5gB-4m2xA:
22.4		 4x5gB-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.29A 4x5hA-4m2xA:
22.6		 4x5hA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.37A 4x5iA-4m2xA:
22.6		 4x5iA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.29A 4x5jA-4m2xA:
22.5		 4x5jA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XT7_A_TOPA302_1
(RV2671)		 4xt8 RV2671
(Mycobacterium
tuberculosis) 		11 / 11 ASN A  44
ILE A  46
THR A  58
SER A  59
GLY A  60
ASP A  67
ARG A  68
PHE A  71
GLU A  91
GLU A 193
THR A 214
 TMQ  A 302 (-2.9A)
TMQ  A 302 ( 3.5A)
NAP  A 301 (-4.6A)
TMQ  A 302 ( 3.0A)
TMQ  A 302 ( 3.9A)
TMQ  A 302 (-2.7A)
None
TMQ  A 302 (-3.6A)
TMQ  A 302 ( 3.2A)
None
TMQ  A 302 (-4.0A)
 0.45A 4xt7A-4xt8A:
44.0		 4xt7A-4xt8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A   5
PHE A  31
ARG A  60
ILE A  40
 TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.0A)
None
None
 1.27A 4zzcA-4m2xA:
undetectable
4zzcB-4m2xA:
undetectable		 4zzcA-4m2xA:
20.74
4zzcB-4m2xA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A   5
PHE A  31
ARG A  60
ILE A  40
 TMQ  A 202 (-4.0A)
TMQ  A 202 (-4.0A)
None
None
 1.27A 4zzcB-4m2xA:
undetectable
4zzcC-4m2xA:
undetectable		 4zzcB-4m2xA:
20.74
4zzcC-4m2xA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4xt8 RV2671
(Mycobacterium
tuberculosis) 		5 / 12 SER A  59
TYR A 252
ASN A  44
GLU A  91
LEU A 191
 TMQ  A 302 ( 3.0A)
None
TMQ  A 302 (-2.9A)
TMQ  A 302 ( 3.2A)
None
 1.28A 5czyA-4xt8A:
undetectable		 5czyA-4xt8A:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.24A 5e8qA-4m2xA:
22.0		 5e8qA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  27
LEU A  57
ARG A  60
 TMQ  A 202 ( 2.7A)
None
None
 0.43A 5e8qA-4m2xA:
22.0		 5e8qA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.28A 5e8qB-4m2xA:
22.3		 5e8qB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.36A 5eajA-4m2xA:
22.1		 5eajA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
PRO A  58
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.35A 5eajB-4m2xA:
22.3		 5eajB-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
None
TMQ  A 202 (-4.2A)
 0.64A 5hi6A-4m2xA:
21.7		 5hi6A-4m2xA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   7
ASP A  27
LEU A  50
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
TMQ  A 202 (-4.2A)
 1.16A 5hi6B-4m2xA:
21.9		 5hi6B-4m2xA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
SER A  49
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
NDP  A 201 (-3.6A)
None
None
None
TMQ  A 202 (-4.2A)
 0.72A 5hi6B-4m2xA:
21.9		 5hi6B-4m2xA:
34.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 8 ILE A   5
ALA A   7
ASP A  27
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.25A 5uihA-4m2xA:
21.6		 5uihA-4m2xA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.40A 5ujxA-4m2xA:
22.0		 5ujxA-4m2xA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
None
TMQ  A 202 (-4.2A)
 0.25A 5ujxB-4m2xA:
22.3		 5ujxB-4m2xA:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4xt8 RV2671
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 216
THR A 214
THR A 253
ALA A  43
 None
TMQ  A 302 (-4.0A)
None
None
 0.92A 5x2tI-4xt8A:
undetectable
5x2tJ-4xt8A:
undetectable
5x2tK-4xt8A:
undetectable
5x2tL-4xt8A:
undetectable		 5x2tI-4xt8A:
19.92
5x2tJ-4xt8A:
22.92
5x2tK-4xt8A:
19.92
5x2tL-4xt8A:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
ARG A  60
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
None
TMQ  A 202 (-4.2A)
 0.33A 5z6fA-4m2xA:
22.8		 5z6fA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.26A 5z6jA-4m2xA:
23.5		 5z6jA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.26A 5z6kA-4m2xA:
23.8		 5z6kA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A   5
ALA A   7
ASP A  27
PRO A  58
ARG A  60
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
None
 0.45A 5z6lA-4m2xA:
23.8		 5z6lA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 ALA A   7
ASP A  27
PHE A  31
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.67A 5z6mA-4m2xA:
23.1		 5z6mA-4m2xA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 11 ILE A   5
ALA A   7
PHE A  31
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.56A 5z6mA-4m2xA:
23.1		 5z6mA-4m2xA:
36.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 10 ALA A   7
ASP A  27
HIS A  30
PHE A  31
THR A  46
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 (-4.2A)
 0.48A 6aogA-4m2xA:
20.0		 6aogA-4m2xA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		7 / 10 ALA A   7
ASP A  27
HIS A  30
PHE A  31
THR A  46
TYR A 100
THR A 113
 TMQ  A 202 ( 3.5A)
TMQ  A 202 ( 2.7A)
None
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 (-4.2A)
 0.48A 6aogB-4m2xA:
20.0		 6aogB-4m2xA:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m2x DIHYDROFOLATE
REDUCTASE
(Mycobacterium
tuberculosis) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  57
ILE A  94
TYR A 100
THR A 113
 TMQ  A 202 (-4.0A)
TMQ  A 202 ( 3.5A)
TMQ  A 202 (-4.0A)
NDP  A 201 (-3.4A)
None
TMQ  A 202 ( 3.8A)
None
TMQ  A 202 (-4.2A)
 0.45A 7dfrA-4m2xA:
22.9		 7dfrA-4m2xA:
35.50