SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TMO'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MMK_A_H4BA1427_1 (PHENYLALANINE-4-HYDR OXYLASE)	4xz6	GLYCINE BETAINE/PROLINE ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN (Ruegeria pomeroyi)	5 / 12	LEU A 269 PHE A 106 HIS A 53 TYR A 87 GLU A 98	None TMO A 401 (-4.4A) None None None	1.46A	1mmkA-4xz6A: undetectable	1mmkA-4xz6A: 22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOQ_B_ROFB501_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3o1h	PERIPLASMIC PROTEIN TORT (Vibrio parahaemolyticus)	3 / 3	MET B 52 ASN B 120 GLN B 77	None TMO B 1 ( 4.5A) None	0.96A	1xoqB-3o1hB: undetectable	1xoqB-3o1hB: 26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_A_SAMA301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	4xz6	GLYCINE BETAINE/PROLINE ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN (Ruegeria pomeroyi)	5 / 12	GLY A 173 ASP A 172 LEU A 178 TRP A 177 ALA A 202	None None None TMO A 401 (-3.7A) None	1.09A	4lg1A-4xz6A: undetectable	4lg1A-4xz6A: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_C_SAMC301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	4xz6	GLYCINE BETAINE/PROLINE ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN (Ruegeria pomeroyi)	5 / 12	GLY A 173 ASP A 172 LEU A 178 TRP A 177 ALA A 202	None None None TMO A 401 (-3.7A) None	1.09A	4lg1C-4xz6A: undetectable	4lg1C-4xz6A: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GQB_A_GCSA605_1 (CHITINASE)	4xz6	GLYCINE BETAINE/PROLINE ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN (Ruegeria pomeroyi)	3 / 3	TRP A 55 ILE A 52 SER A 62	TMO A 401 ( 3.8A) None None	0.98A	5gqbA-4xz6A: undetectable	5gqbA-4xz6A: 22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W4Z_A_RBFA502_1 (RIBOFLAVIN LYASE)	4tsm	MALTOSE-BINDING PROTEIN, PILIN CHIMERA (Clostridioides difficile; Escherichia coli)	6 / 12	ALA A 342 ALA A 338 GLY A 166 ALA A 188 PHE A 169 VAL A 181	None TMO A1207 ( 4.5A) None None None None	1.39A	5w4zA-4tsmA: undetectable	5w4zA-4tsmA: 10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W4Z_B_RBFB502_1 (RIBOFLAVIN LYASE)	4tsm	MALTOSE-BINDING PROTEIN, PILIN CHIMERA (Clostridioides difficile; Escherichia coli)	6 / 12	ALA A 342 ALA A 338 GLY A 166 ALA A 188 PHE A 169 VAL A 181	None TMO A1207 ( 4.5A) None None None None	1.43A	5w4zB-4tsmA: undetectable	5w4zB-4tsmA: 10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A93_B_8NUB3001_1 (5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562)	3o1h	PERIPLASMIC PROTEIN TORT (Vibrio parahaemolyticus)	4 / 5	ASP B 272 ILE B 315 ASN B 202 TYR B 44	None None None TMO B 1 (-3.7A)	1.17A	6a93B-3o1hB: undetectable	6a93B-3o1hB: 22.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MMK_A_H4BA1427_1","PHENYLALANINE-4-HYDROXYLASE","4xz6","GLYCINE BETAINE\/PROLINE ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN","Ruegeria pomeroyi",5,"LEU A 269;PHE A 106;HIS A  53;TYR A  87;GLU A  98","None;TMO A 401 (-4.4A);None;None;None","1.46A","1mmkA-4xz6A:undetectable",null],["1XOQ_B_ROFB501_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","3o1h","PERIPLASMIC PROTEIN TORT","Vibrio parahaemolyticus",3,"MET B  52;ASN B 120;GLN B  77","None;TMO B   1 ( 4.5A);None","0.96A","1xoqB-3o1hB:undetectable","1mmkA-4xz6A:22.62"],["4LG1_A_SAMA301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","4xz6","GLYCINE BETAINE\/PROLINE ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN","Ruegeria pomeroyi",5,"GLY A 173;ASP A 172;LEU A 178;TRP A 177;ALA A 202","None;None;None;TMO A 401 (-3.7A);None","1.09A","4lg1A-4xz6A:undetectable","1xoqB-3o1hB:26.11"],["4LG1_C_SAMC301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","4xz6","GLYCINE BETAINE\/PROLINE ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN","Ruegeria pomeroyi",5,"GLY A 173;ASP A 172;LEU A 178;TRP A 177;ALA A 202","None;None;None;TMO A 401 (-3.7A);None","1.09A","4lg1C-4xz6A:undetectable","4lg1A-4xz6A:20.87"],["5GQB_A_GCSA605_1","CHITINASE","4xz6","GLYCINE BETAINE\/PROLINE ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN","Ruegeria pomeroyi",3,"TRP A  55;ILE A  52;SER A  62","TMO A 401 ( 3.8A);None;None","0.98A","5gqbA-4xz6A:undetectable","4lg1C-4xz6A:20.87"],["5W4Z_A_RBFA502_1","RIBOFLAVIN LYASE","4tsm","MALTOSE-BINDING PROTEIN, PILIN CHIMERA","Clostridioides difficile;Escherichia coli",6,"ALA A 342;ALA A 338;GLY A 166;ALA A 188;PHE A 169;VAL A 181","None;TMO A1207 ( 4.5A);None;None;None;None","1.39A","5w4zA-4tsmA:undetectable","5gqbA-4xz6A:22.02"],["5W4Z_B_RBFB502_1","RIBOFLAVIN LYASE","4tsm","MALTOSE-BINDING PROTEIN, PILIN CHIMERA","Clostridioides difficile;Escherichia coli",6,"ALA A 342;ALA A 338;GLY A 166;ALA A 188;PHE A 169;VAL A 181","None;TMO A1207 ( 4.5A);None;None;None;None","1.43A","5w4zB-4tsmA:undetectable","5w4zA-4tsmA:10.51"],["6A93_B_8NUB3001_1","5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562","3o1h","PERIPLASMIC PROTEIN TORT","Vibrio parahaemolyticus",4,"ASP B 272;ILE B 315;ASN B 202;TYR B  44","None;None;None;TMO B   1 (-3.7A)","1.17A","6a93B-3o1hB:undetectable","5w4zB-4tsmA:10.51"]]