SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TMA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		6 / 9 ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.41A 1bcuH-4ylqH:
35.3		 1bcuH-4ylqH:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		5 / 9 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.0A)
 0.49A 1dwcH-4ylqH:
34.6		 1dwcH-4ylqH:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		7 / 12 HIS H  57
ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.63A 1etrH-4ylqH:
34.5		 1etrH-4ylqH:
36.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 LYS A 257
GLU A 260
ALA A 254
ALA A 314
 TMA  A 950 (-3.5A)
TMA  A 950 (-3.8A)
None
None
 1.11A 1sn0B-1ek6A:
0.0
1sn0D-1ek6A:
0.0		 1sn0B-1ek6A:
14.94
1sn0D-1ek6A:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		7 / 12 ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
TYR H 228
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
None
 0.30A 2p16A-4ylqH:
38.8		 2p16A-4ylqH:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 6 LEU A  22
TYR A  27
ILE A  86
ILE A 252
 None
TMA  A 952 ( 3.6A)
None
None
 0.99A 2q8hA-1ek6A:
undetectable		 2q8hA-1ek6A:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		8 / 12 ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 218
GLY H 226
TYR H 228
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.5A)
0Z7  H 501 (-3.0A)
None
 0.32A 2w26A-4ylqH:
38.8		 2w26A-4ylqH:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		7 / 11 HIS H  57
ASP H 189
SER H 190
SER H 195
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.40A 3gy3A-4ylqH:
35.2		 3gy3A-4ylqH:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		6 / 6 SER H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.37A 3rxfA-4ylqH:
14.5		 3rxfA-4ylqH:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		5 / 12 HIS H  57
ASP H 189
VAL H 213
TRP H 215
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.0A)
 0.26A 4hfpD-4ylqH:
34.4		 4hfpD-4ylqH:
35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		5 / 12 HIS H  57
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.33A 4rn6B-4ylqH:
29.5		 4rn6B-4ylqH:
35.36