SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TLZ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H7X_A_URFA1033_1 (DIHYDROPYRIMIDINE DEHYDROGENASE)	4ry9	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Verminephrobacte r eiseniae)	4 / 6	ASN A 171 ASN A 280 SER A 138 ASN A 140	TLZ A 401 (-3.0A) TLZ A 401 (-3.7A) None None	1.27A	1h7xA-4ry9A: 4.2	1h7xA-4ry9A: 16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_A_SAMA6735_1 (16S RRNA METHYLASE)	4ry9	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Verminephrobacte r eiseniae)	3 / 3	ASP A 260 GLU A 264 SER A 124	TLZ A 401 ( 2.7A) None TLZ A 401 (-2.8A)	0.73A	3p2kA-4ry9A: undetectable	3p2kA-4ry9A: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TKA_A_SAMA400_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE H)	4ry9	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Verminephrobacte r eiseniae)	5 / 12	ARG A 177 GLY A 144 ASP A 260 PHE A 323 SER A 138	TLZ A 401 (-2.9A) None TLZ A 401 ( 2.7A) GOL A 406 (-4.8A) None	1.10A	3tkaA-4ry9A: 3.9	3tkaA-4ry9A: 24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NUJ_A_Z80A201_1 (BETA-LACTOGLOBULIN)	4ry9	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Verminephrobacte r eiseniae)	4 / 8	ALA A 51 ILE A 122 ASN A 98 VAL A 40	None None TLZ A 401 ( 4.4A) None	0.81A	5nujA-4ry9A: undetectable	5nujA-4ry9A: 16.78

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1H7X_A_URFA1033_1","DIHYDROPYRIMIDINE DEHYDROGENASE","4ry9","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Verminephrobacter eiseniae",4,"ASN A 171;ASN A 280;SER A 138;ASN A 140","TLZ A 401 (-3.0A);TLZ A 401 (-3.7A);None;None","1.27A","1h7xA-4ry9A:4.2",null],["3P2K_A_SAMA6735_1","16S RRNA METHYLASE","4ry9","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Verminephrobacter eiseniae",3,"ASP A 260;GLU A 264;SER A 124","TLZ A 401 ( 2.7A);None;TLZ A 401 (-2.8A)","0.73A","3p2kA-4ry9A:undetectable","1h7xA-4ry9A:16.28"],["3TKA_A_SAMA400_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE H","4ry9","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Verminephrobacter eiseniae",5,"ARG A 177;GLY A 144;ASP A 260;PHE A 323;SER A 138","TLZ A 401 (-2.9A);None;TLZ A 401 ( 2.7A);GOL A 406 (-4.8A);None","1.10A","3tkaA-4ry9A:3.9","3p2kA-4ry9A:20.90"],["5NUJ_A_Z80A201_1","BETA-LACTOGLOBULIN","4ry9","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Verminephrobacter eiseniae",4,"ALA A  51;ILE A 122;ASN A  98;VAL A  40","None;None;TLZ A 401 ( 4.4A);None","0.81A","5nujA-4ry9A:undetectable","3tkaA-4ry9A:24.06"]]