SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TLO'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_B_P1ZB1357_1 (PROSTAGLANDIN REDUCTASE 2)	4j7h	EVAA 2,3-DEHYDRATASE (Amycolatopsis orientalis)	4 / 6	LEU A 145 ASN A 52 LYS A 137 ASP A 216	None None TLO A 501 ( 4.8A) None	1.38A	2w98A-4j7hA: undetectable 2w98B-4j7hA: undetectable	2w98A-4j7hA: 22.33 2w98B-4j7hA: 22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IMS_A_ACTA708_0 (ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL)	4j7h	EVAA 2,3-DEHYDRATASE (Amycolatopsis orientalis)	3 / 3	GLY A 406 GLY A 407 GLN A 153	None None TLO A 501 (-4.0A)	0.44A	5imsA-4j7hA: undetectable	5imsA-4j7hA: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3rc2	SUGAR 3-KETOREDUCTASE (Actinomadura kijaniata)	3 / 3	MET A 236 ASP A 182 ARG A 23	None NAP A 336 (-3.5A) TLO A 335 ( 2.5A)	1.22A	5z6kA-3rc2A: undetectable	5z6kA-3rc2A: 19.71