SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TLM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 174
GLY A 403
SER A 401
ALA A 410
ALA A 290
 None
TLM  A1424 (-3.9A)
None
None
None
 1.13A 3keeA-2wgeA:
undetectable		 3keeA-2wgeA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.10A 3keeA-2wgeA:
undetectable		 3keeA-2wgeA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.11A 3keeB-2wgeA:
undetectable		 3keeB-2wgeA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.09A 3keeC-2wgeA:
undetectable		 3keeC-2wgeA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 174
GLY A 403
SER A 401
ALA A 410
ALA A 290
 None
TLM  A1424 (-3.9A)
None
None
None
 1.13A 3keeD-2wgeA:
undetectable		 3keeD-2wgeA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.06A 3sueA-2wgeA:
undetectable		 3sueA-2wgeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 174
GLY A 403
SER A 401
ALA A 410
ALA A 290
 None
TLM  A1424 (-3.9A)
None
None
None
 1.10A 3sueB-2wgeA:
undetectable		 3sueB-2wgeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.07A 3sueB-2wgeA:
undetectable		 3sueB-2wgeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 174
GLY A 403
SER A 401
ALA A 410
ALA A 290
 None
TLM  A1424 (-3.9A)
None
None
None
 1.10A 3sueC-2wgeA:
undetectable		 3sueC-2wgeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.05A 3sueC-2wgeA:
undetectable		 3sueC-2wgeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.03A 3sufA-2wgeA:
undetectable		 3sufA-2wgeA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 174
GLY A 403
SER A 401
ALA A 410
ALA A 290
 None
TLM  A1424 (-3.9A)
None
None
None
 1.13A 3sufC-2wgeA:
undetectable		 3sufC-2wgeA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		9 / 12 GLY A 115
ALA A 170
CYH A 171
GLU A 199
PHE A 210
HIS A 311
THR A 313
HIS A 345
GLY A 403
 None
None
TLM  A1424 (-3.0A)
GOL  A1421 (-3.9A)
None
TLM  A1424 (-4.0A)
TLM  A1424 (-3.6A)
TLM  A1424 (-3.9A)
TLM  A1424 (-3.9A)
 0.52A 4ls7A-2wgeA:
59.1		 4ls7A-2wgeA:
39.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 115
ALA A 170
GLU A 199
PHE A 210
GLY A 403
PHE A 404
 None
None
GOL  A1421 (-3.9A)
None
TLM  A1424 (-3.9A)
TLM  A1424 (-3.9A)
 0.88A 4ls7A-2wgeA:
59.1		 4ls7A-2wgeA:
39.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 170
CYH A 171
PHE A 210
HIS A 311
THR A 313
HIS A 345
GLY A 403
 None
TLM  A1424 (-3.0A)
None
TLM  A1424 (-4.0A)
TLM  A1424 (-3.6A)
TLM  A1424 (-3.9A)
TLM  A1424 (-3.9A)
 0.45A 4ls7A-2wgeA:
59.1
4ls7B-2wgeA:
59.0		 4ls7A-2wgeA:
39.72
4ls7B-2wgeA:
39.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 405
ASP A 273
GLY A 351
SER A 401
HIS A 311
 None
TLM  A1424 ( 4.6A)
None
None
TLM  A1424 (-4.0A)
 1.19A 5hikA-2wgeA:
undetectable		 5hikA-2wgeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 273
PHE A 402
GLY A 288
GLY A 284
 TLM  A1424 ( 4.6A)
None
None
None
 1.05A 5n9xA-2wgeA:
undetectable		 5n9xA-2wgeA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.06A 6c2mD-2wgeA:
undetectable		 6c2mD-2wgeA:
11.54