SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TLF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	6ap6	PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia x hybrida)	4 / 8	PHE A 158 SER A 219 HIS A 95 SER A 96	TLF A 300 (-4.6A) TLF A 300 (-2.7A) None TLF A 300 (-2.6A)	1.33A	1eqbC-6ap6A: undetectable 1eqbD-6ap6A: undetectable	1eqbC-6ap6A: undetectable 1eqbD-6ap6A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQT_A_ACTA1871_0 (FPRA)	6ap6	PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia x hybrida)	4 / 7	PHE A 174 ALA A 162 PHE A 158 SER A 219	None None TLF A 300 (-4.6A) TLF A 300 (-2.7A)	1.20A	1lqtA-6ap6A: undetectable	1lqtA-6ap6A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQU_A_ACTA1428_0 (FPRA)	6ap6	PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia x hybrida)	4 / 7	PHE A 174 ALA A 162 PHE A 158 SER A 219	None None TLF A 300 (-4.6A) TLF A 300 (-2.7A)	1.19A	1lquA-6ap6A: undetectable	1lquA-6ap6A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_A_DIFA1373_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	6ap6	PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia x hybrida)	4 / 8	PHE A 158 MET A 147 VAL A 143 PHE A 125	TLF A 300 (-4.6A) TLF A 300 ( 4.1A) None TLF A 300 (-4.7A)	1.22A	2wekA-6ap6A: 3.3	2wekA-6ap6A: 12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AP6_A_TLFA300_0 (PROBABLE STRIGOLACTONE ESTERASE DAD2)	6ap6	PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia x hybrida)	12 / 12	PHE A 27 VAL A 97 PHE A 125 PHE A 135 ILE A 140 VAL A 143 TRP A 154 PHE A 158 SER A 190 VAL A 193 PHE A 194 HIS A 246	TLF A 300 (-3.8A) TLF A 300 ( 4.4A) TLF A 300 (-4.7A) TLF A 300 ( 4.5A) None None None TLF A 300 (-4.6A) TLF A 300 (-3.4A) TLF A 300 (-4.1A) TLF A 300 (-4.8A) TLF A 300 (-3.9A)	0.00A	6ap6A-6ap6A: 51.5	6ap6A-6ap6A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AP6_A_TLFA300_0 (PROBABLE STRIGOLACTONE ESTERASE DAD2)	6ap6	PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia x hybrida)	5 / 12	PHE A 194 VAL A 143 TRP A 154 PHE A 158 VAL A 189	TLF A 300 (-4.8A) None None TLF A 300 (-4.6A) None	1.11A	6ap6A-6ap6A: 51.5	6ap6A-6ap6A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AP6_B_TLFB300_0 (PROBABLE STRIGOLACTONE ESTERASE DAD2)	6ap6	PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia x hybrida)	12 / 12	PHE A 27 VAL A 97 PHE A 125 PHE A 135 ILE A 140 VAL A 143 TRP A 154 PHE A 158 SER A 190 VAL A 193 PHE A 194 HIS A 246	TLF A 300 (-3.8A) TLF A 300 ( 4.4A) TLF A 300 (-4.7A) TLF A 300 ( 4.5A) None None None TLF A 300 (-4.6A) TLF A 300 (-3.4A) TLF A 300 (-4.1A) TLF A 300 (-4.8A) TLF A 300 (-3.9A)	0.06A	6ap6B-6ap6A: 50.0	6ap6B-6ap6A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AP6_B_TLFB300_0 (PROBABLE STRIGOLACTONE ESTERASE DAD2)	6ap6	PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia x hybrida)	5 / 12	PHE A 194 VAL A 143 TRP A 154 PHE A 158 VAL A 189	TLF A 300 (-4.8A) None None TLF A 300 (-4.6A) None	1.11A	6ap6B-6ap6A: 50.0	6ap6B-6ap6A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWN_A_AQ4A602_0 (CYTOCHROME P450 1A1)	6ap6	PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia x hybrida)	5 / 12	SER A 57 PHE A 174 ASP A 30 GLY A 28 PHE A 27	None None None None TLF A 300 (-3.8A)	1.18A	6dwnA-6ap6A: undetectable	6dwnA-6ap6A: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWN_C_AQ4C602_0 (CYTOCHROME P450 1A1)	6ap6	PROBABLE STRIGOLACTONE ESTERASE DAD2 (Petunia x hybrida)	5 / 12	SER A 57 PHE A 174 ASP A 30 GLY A 28 PHE A 27	None None None None TLF A 300 (-3.8A)	1.15A	6dwnC-6ap6A: undetectable	6dwnC-6ap6A: 20.48

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EQB_D_GLYD4292_0","SERINE HYDROXYMETHYLTRANSFERASE","6ap6","PROBABLE STRIGOLACTONE ESTERASE DAD2","Petunia x hybrida",4,"PHE A 158;SER A 219;HIS A  95;SER A  96","TLF A 300 (-4.6A);TLF A 300 (-2.7A);None;TLF A 300 (-2.6A)","1.33A","1eqbC-6ap6A:undetectable;1eqbD-6ap6A:undetectable",null],["1LQT_A_ACTA1871_0","FPRA","6ap6","PROBABLE STRIGOLACTONE ESTERASE DAD2","Petunia x hybrida",4,"PHE A 174;ALA A 162;PHE A 158;SER A 219","None;None;TLF A 300 (-4.6A);TLF A 300 (-2.7A)","1.20A","1lqtA-6ap6A:undetectable","1eqbC-6ap6A:undetectable;1eqbD-6ap6A:undetectable"],["1LQU_A_ACTA1428_0","FPRA","6ap6","PROBABLE STRIGOLACTONE ESTERASE DAD2","Petunia x hybrida",4,"PHE A 174;ALA A 162;PHE A 158;SER A 219","None;None;TLF A 300 (-4.6A);TLF A 300 (-2.7A)","1.19A","1lquA-6ap6A:undetectable","1lqtA-6ap6A:undetectable"],["2WEK_A_DIFA1373_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","6ap6","PROBABLE STRIGOLACTONE ESTERASE DAD2","Petunia x hybrida",4,"PHE A 158;MET A 147;VAL A 143;PHE A 125","TLF A 300 (-4.6A);TLF A 300 ( 4.1A);None;TLF A 300 (-4.7A)","1.22A","2wekA-6ap6A:3.3","1lquA-6ap6A:undetectable"],["6AP6_A_TLFA300_0","PROBABLE STRIGOLACTONE ESTERASE DAD2","6ap6","PROBABLE STRIGOLACTONE ESTERASE DAD2","Petunia x hybrida",12,"PHE A  27;VAL A  97;PHE A 125;PHE A 135;ILE A 140;VAL A 143;TRP A 154;PHE A 158;SER A 190;VAL A 193;PHE A 194;HIS A 246","TLF A 300 (-3.8A);TLF A 300 ( 4.4A);TLF A 300 (-4.7A);TLF A 300 ( 4.5A);None;None;None;TLF A 300 (-4.6A);TLF A 300 (-3.4A);TLF A 300 (-4.1A);TLF A 300 (-4.8A);TLF A 300 (-3.9A)","0.00A","6ap6A-6ap6A:51.5","2wekA-6ap6A:12.65"],["6AP6_A_TLFA300_0","PROBABLE STRIGOLACTONE ESTERASE DAD2","6ap6","PROBABLE STRIGOLACTONE ESTERASE DAD2","Petunia x hybrida",5,"PHE A 194;VAL A 143;TRP A 154;PHE A 158;VAL A 189","TLF A 300 (-4.8A);None;None;TLF A 300 (-4.6A);None","1.11A","6ap6A-6ap6A:51.5","6ap6A-6ap6A:undetectable"],["6AP6_B_TLFB300_0","PROBABLE STRIGOLACTONE ESTERASE DAD2","6ap6","PROBABLE STRIGOLACTONE ESTERASE DAD2","Petunia x hybrida",12,"PHE A  27;VAL A  97;PHE A 125;PHE A 135;ILE A 140;VAL A 143;TRP A 154;PHE A 158;SER A 190;VAL A 193;PHE A 194;HIS A 246","TLF A 300 (-3.8A);TLF A 300 ( 4.4A);TLF A 300 (-4.7A);TLF A 300 ( 4.5A);None;None;None;TLF A 300 (-4.6A);TLF A 300 (-3.4A);TLF A 300 (-4.1A);TLF A 300 (-4.8A);TLF A 300 (-3.9A)","0.06A","6ap6B-6ap6A:50.0","6ap6A-6ap6A:undetectable"],["6AP6_B_TLFB300_0","PROBABLE STRIGOLACTONE ESTERASE DAD2","6ap6","PROBABLE STRIGOLACTONE ESTERASE DAD2","Petunia x hybrida",5,"PHE A 194;VAL A 143;TRP A 154;PHE A 158;VAL A 189","TLF A 300 (-4.8A);None;None;TLF A 300 (-4.6A);None","1.11A","6ap6B-6ap6A:50.0","6ap6B-6ap6A:undetectable"],["6DWN_A_AQ4A602_0","CYTOCHROME P450 1A1","6ap6","PROBABLE STRIGOLACTONE ESTERASE DAD2","Petunia x hybrida",5,"SER A  57;PHE A 174;ASP A  30;GLY A  28;PHE A  27","None;None;None;None;TLF A 300 (-3.8A)","1.18A","6dwnA-6ap6A:undetectable","6ap6B-6ap6A:undetectable"],["6DWN_C_AQ4C602_0","CYTOCHROME P450 1A1","6ap6","PROBABLE STRIGOLACTONE ESTERASE DAD2","Petunia x hybrida",5,"SER A  57;PHE A 174;ASP A  30;GLY A  28;PHE A  27","None;None;None;None;TLF A 300 (-3.8A)","1.15A","6dwnC-6ap6A:undetectable","6dwnA-6ap6A:20.48"]]