SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TK1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 6 CYH X 233
ASN X 254
CYH X 252
ILE X 211
 None
GLC  X 500 ( 4.6A)
None
TK1  X 501 (-4.3A)
 1.34A 3w9tB-3h1vX:
undetectable		 3w9tB-3h1vX:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3h1v GLUCOKINASE
(Homo
sapiens) 		5 / 9 ALA X 201
ALA X 456
ALA X 454
ALA X 449
SER X  76
 None
TK1  X 501 ( 4.5A)
None
None
None
 1.21A 4twdA-3h1vX:
undetectable
4twdB-3h1vX:
undetectable
4twdC-3h1vX:
undetectable
4twdD-3h1vX:
undetectable
4twdE-3h1vX:
undetectable		 4twdA-3h1vX:
18.98
4twdB-3h1vX:
18.98
4twdC-3h1vX:
18.98
4twdD-3h1vX:
18.98
4twdE-3h1vX:
18.98