SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TIR'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_A_SAMA301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	2y3s	TAML (Streptomyces sp. 307-9)	5 / 12	GLY A 137 GLY A 119 LEU A 102 TYR A 444 TYR A 447	FAD A 600 ( 4.5A) None None FAD A 600 (-4.5A) TIR A 700 (-4.0A)	1.04A	4lg1A-2y3sA: undetectable	4lg1A-2y3sA: 16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_B_SAMB301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	2y3s	TAML (Streptomyces sp. 307-9)	5 / 12	GLY A 137 GLY A 119 LEU A 102 TYR A 444 TYR A 447	FAD A 600 ( 4.5A) None None FAD A 600 (-4.5A) TIR A 700 (-4.0A)	1.04A	4lg1B-2y3sA: undetectable	4lg1B-2y3sA: 16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_C_SAMC301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	2y3s	TAML (Streptomyces sp. 307-9)	5 / 12	GLY A 137 GLY A 119 LEU A 102 TYR A 444 TYR A 447	FAD A 600 ( 4.5A) None None FAD A 600 (-4.5A) TIR A 700 (-4.0A)	1.05A	4lg1C-2y3sA: undetectable	4lg1C-2y3sA: 16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_C7HA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	2y3s	TAML (Streptomyces sp. 307-9)	4 / 5	TYR A 447 GLY A 120 TYR A 64 GLY A 61	TIR A 700 (-4.0A) FAD A 600 (-3.3A) FAD A 600 ( 4.6A) FAD A 600 (-3.3A)	1.02A	5ayfA-2y3sA: undetectable	5ayfA-2y3sA: 17.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4LG1_A_SAMA301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","2y3s","TAML","Streptomyces sp. 307-9",5,"GLY A 137;GLY A 119;LEU A 102;TYR A 444;TYR A 447","FAD A 600 ( 4.5A);None;None;FAD A 600 (-4.5A);TIR A 700 (-4.0A)","1.04A","4lg1A-2y3sA:undetectable",null],["4LG1_B_SAMB301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","2y3s","TAML","Streptomyces sp. 307-9",5,"GLY A 137;GLY A 119;LEU A 102;TYR A 444;TYR A 447","FAD A 600 ( 4.5A);None;None;FAD A 600 (-4.5A);TIR A 700 (-4.0A)","1.04A","4lg1B-2y3sA:undetectable","4lg1A-2y3sA:16.89"],["4LG1_C_SAMC301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","2y3s","TAML","Streptomyces sp. 307-9",5,"GLY A 137;GLY A 119;LEU A 102;TYR A 444;TYR A 447","FAD A 600 ( 4.5A);None;None;FAD A 600 (-4.5A);TIR A 700 (-4.0A)","1.05A","4lg1C-2y3sA:undetectable","4lg1B-2y3sA:16.89"],["5AYF_A_C7HA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE SETD7","2y3s","TAML","Streptomyces sp. 307-9",4,"TYR A 447;GLY A 120;TYR A  64;GLY A  61","TIR A 700 (-4.0A);FAD A 600 (-3.3A);FAD A 600 ( 4.6A);FAD A 600 (-3.3A)","1.02A","5ayfA-2y3sA:undetectable","4lg1C-2y3sA:16.89"]]