SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'THG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PJ6_A_FOLA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3gsi N,N-DIMETHYLGLYCINE
OXIDASE
(Arthrobacter
globiformis) 		8 / 9 LEU A 508
TYR A 539
THR A 554
TYR A 631
PHE A 632
LEU A 649
GLU A 658
TYR A 699
 THG  A2887 (-4.8A)
THG  A2887 (-3.9A)
THG  A2887 (-2.6A)
None
THG  A2887 (-4.2A)
None
THG  A2887 (-2.8A)
THG  A2887 (-4.1A)
 0.21A 1pj6A-3gsiA:
72.7		 1pj6A-3gsiA:
99.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PJ6_A_FOLA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3gsi N,N-DIMETHYLGLYCINE
OXIDASE
(Arthrobacter
globiformis) 		6 / 9 TYR A 539
TYR A 631
PHE A 632
LEU A 649
TYR A 651
TYR A 699
 THG  A2887 (-3.9A)
None
THG  A2887 (-4.2A)
None
THG  A2887 (-4.3A)
THG  A2887 (-4.1A)
 0.56A 1pj6A-3gsiA:
72.7		 1pj6A-3gsiA:
99.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3gsi N,N-DIMETHYLGLYCINE
OXIDASE
(Arthrobacter
globiformis) 		12 / 12 MET A 505
LEU A 508
TYR A 539
GLY A 566
ASN A 568
TYR A 631
PHE A 632
LEU A 649
TYR A 651
TYR A 660
TYR A 699
PHE A 719
 None
THG  A2887 (-4.8A)
THG  A2887 (-3.9A)
THG  A2887 (-3.6A)
THG  A2887 ( 4.1A)
None
THG  A2887 (-4.2A)
None
THG  A2887 (-4.3A)
None
THG  A2887 (-4.1A)
THG  A2887 (-4.6A)
 0.21A 1pj7A-3gsiA:
72.8		 1pj7A-3gsiA:
99.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.22A 1q23B-4cczA:
undetectable		 1q23B-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.31A 1q23C-4cczA:
undetectable		 1q23C-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 11 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.23A 1q23F-4cczA:
undetectable		 1q23F-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 11 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.22A 1q23I-4cczA:
undetectable		 1q23I-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 11 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.14A 1q23J-4cczA:
undetectable		 1q23J-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 11 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.36A 1q23L-4cczA:
undetectable		 1q23L-4cczA:
15.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 ARG A 377
ASP A 449
ASP A 537
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 ( 4.8A)
THG  A1652 (-3.4A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 1.36A 1q8jA-4cczA:
36.8		 1q8jA-4cczA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 379
ASP A 449
ASN A 470
ASP A 537
ARG A 585
 THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.3A)
 0.92A 1q8jA-4cczA:
36.8		 1q8jA-4cczA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
ASN A 379
ASP A 449
ASN A 470
ASP A 537
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.61A 1q8jA-4cczA:
36.8		 1q8jA-4cczA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
ASN A 379
ASP A 449
ASN A 470
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.58A 1q8jB-4cczA:
37.0		 1q8jB-4cczA:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 7 ARG A 122
ASN A 371
TYR A  31
TRP A 256
 DHB  A 502 (-3.7A)
EDO  A 503 (-4.8A)
DHB  A 502 (-4.6A)
THG  A 501 ( 3.3A)
 1.35A 1tdnA-5x1nA:
undetectable		 1tdnA-5x1nA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN
(Candidatus
Pelagibacter
ubique) 		5 / 12 GLY A 202
GLY A 201
GLY A 157
PHE A 168
SER A 195
 None
None
None
None
THG  A 370 ( 4.4A)
 1.16A 1wg8A-3tfjA:
undetectable		 1wg8A-3tfjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 3gsi N,N-DIMETHYLGLYCINE
OXIDASE
(Arthrobacter
globiformis) 		5 / 12 TYR A 539
ASN A 568
TYR A 631
TYR A 651
TYR A 699
 THG  A2887 (-3.9A)
THG  A2887 ( 4.1A)
None
THG  A2887 (-4.3A)
THG  A2887 (-4.1A)
 0.73A 1wopA-3gsiA:
47.9		 1wopA-3gsiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 414
GLY A 576
SER A 578
ASN A 579
ARG A 591
 None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.99A 2e7fA-4cczA:
30.0		 2e7fA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A 376
ASP A 449
ASN A 470
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.41A 2e7fA-4cczA:
30.0		 2e7fA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A 376
ASN A 470
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.39A 2e7fB-4cczA:
30.1		 2e7fB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A 376
ASP A 449
ASN A 470
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.38A 2ogyA-4cczA:
29.9		 2ogyA-4cczA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A 376
ASP A 449
ASN A 470
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.38A 2ogyB-4cczA:
30.1		 2ogyB-4cczA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 ILE A 590
ASN A 579
GLU A 376
ASN A 613
GLU A 592
 None
THG  A1652 (-3.1A)
THG  A1652 (-3.5A)
None
None
 1.48A 2piwA-4cczA:
undetectable		 2piwA-4cczA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN
(Candidatus
Pelagibacter
ubique) 		5 / 10 ILE A 302
PHE A 368
LEU A 244
ILE A 299
GLY A 294
 None
None
THG  A 370 ( 4.8A)
None
None
 1.33A 2v0mA-3tfjA:
undetectable		 2v0mA-3tfjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 8 ARG A 163
ARG A 227
GLN A 223
HIS A  60
 THG  A 501 ( 4.4A)
None
None
DHB  A 502 (-4.3A)
 1.37A 2vxaA-5x1nA:
undetectable
2vxaC-5x1nA:
undetectable
2vxaE-5x1nA:
undetectable		 2vxaA-5x1nA:
9.25
2vxaC-5x1nA:
9.25
2vxaE-5x1nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 8 ARG A 227
GLN A 223
ARG A 163
HIS A  60
 None
None
THG  A 501 ( 4.4A)
DHB  A 502 (-4.3A)
 1.31A 2vxaA-5x1nA:
undetectable
2vxaB-5x1nA:
undetectable
2vxaK-5x1nA:
undetectable		 2vxaA-5x1nA:
9.25
2vxaB-5x1nA:
9.25
2vxaK-5x1nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 8 ARG A 227
GLN A 223
ARG A 163
HIS A  60
 None
None
THG  A 501 ( 4.4A)
DHB  A 502 (-4.3A)
 1.33A 2vxaB-5x1nA:
undetectable
2vxaC-5x1nA:
undetectable
2vxaG-5x1nA:
undetectable		 2vxaB-5x1nA:
9.25
2vxaC-5x1nA:
9.25
2vxaG-5x1nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 8 ARG A 163
ARG A 227
GLN A 223
HIS A  60
 THG  A 501 ( 4.4A)
None
None
DHB  A 502 (-4.3A)
 1.32A 2vxaD-5x1nA:
undetectable
2vxaF-5x1nA:
undetectable
2vxaI-5x1nA:
undetectable		 2vxaD-5x1nA:
9.25
2vxaF-5x1nA:
9.25
2vxaI-5x1nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 8 ARG A 227
GLN A 223
ARG A 163
HIS A  60
 None
None
THG  A 501 ( 4.4A)
DHB  A 502 (-4.3A)
 1.36A 2vxaD-5x1nA:
undetectable
2vxaE-5x1nA:
undetectable
2vxaL-5x1nA:
undetectable		 2vxaD-5x1nA:
9.25
2vxaE-5x1nA:
9.25
2vxaL-5x1nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 8 HIS A  60
ARG A 227
GLN A 223
ARG A 163
 DHB  A 502 (-4.3A)
None
None
THG  A 501 ( 4.4A)
 1.34A 2vxaB-5x1nA:
undetectable
2vxaG-5x1nA:
undetectable
2vxaH-5x1nA:
undetectable		 2vxaB-5x1nA:
9.25
2vxaG-5x1nA:
9.25
2vxaH-5x1nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 8 ARG A 227
GLN A 223
ARG A 163
HIS A  60
 None
None
THG  A 501 ( 4.4A)
DHB  A 502 (-4.3A)
 1.33A 2vxaH-5x1nA:
undetectable
2vxaI-5x1nA:
undetectable
2vxaJ-5x1nA:
undetectable		 2vxaH-5x1nA:
9.25
2vxaI-5x1nA:
9.25
2vxaJ-5x1nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 8 HIS A  60
ARG A 163
ARG A 227
GLN A 223
 DHB  A 502 (-4.3A)
THG  A 501 ( 4.4A)
None
None
 1.35A 2vxaD-5x1nA:
undetectable
2vxaJ-5x1nA:
undetectable
2vxaL-5x1nA:
undetectable		 2vxaD-5x1nA:
9.25
2vxaJ-5x1nA:
9.25
2vxaL-5x1nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 8 HIS A  60
ARG A 227
GLN A 223
ARG A 163
 DHB  A 502 (-4.3A)
None
None
THG  A 501 ( 4.4A)
 1.36A 2vxaH-5x1nA:
undetectable
2vxaJ-5x1nA:
undetectable
2vxaK-5x1nA:
undetectable		 2vxaH-5x1nA:
9.25
2vxaJ-5x1nA:
9.25
2vxaK-5x1nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 8 HIS A  60
ARG A 227
GLN A 223
ARG A 163
 DHB  A 502 (-4.3A)
None
None
THG  A 501 ( 4.4A)
 1.36A 2vxaA-5x1nA:
undetectable
2vxaK-5x1nA:
undetectable
2vxaL-5x1nA:
undetectable		 2vxaA-5x1nA:
9.25
2vxaK-5x1nA:
9.25
2vxaL-5x1nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 414
ASP A 537
GLY A 576
SER A 578
ASN A 579
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
 0.90A 2ycjA-4cczA:
30.6		 2ycjA-4cczA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 449
ASN A 470
ASP A 537
GLY A 575
ILE A 611
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
None
THG  A1652 (-4.2A)
 1.14A 2ycjA-4cczA:
30.6		 2ycjA-4cczA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 ASP A 449
ASN A 470
ASP A 537
GLY A 576
SER A 578
ASN A 579
ILE A 611
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-4.2A)
 0.34A 2ycjA-4cczA:
30.6		 2ycjA-4cczA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		5 / 12 MET A  61
ASP A 106
ILE A 108
VAL A 120
PHE A 189
 THG  A 501 (-3.4A)
None
THG  A 501 (-3.7A)
THG  A 501 (-4.0A)
THG  A 501 (-4.1A)
 0.54A 3a8iA-5x1nA:
28.2		 3a8iA-5x1nA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		5 / 12 MET A  61
ASP A 106
ILE A 108
VAL A 120
PHE A 189
 THG  A 501 (-3.4A)
None
THG  A 501 (-3.7A)
THG  A 501 (-4.0A)
THG  A 501 (-4.1A)
 0.53A 3a8iB-5x1nA:
28.0		 3a8iB-5x1nA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		5 / 12 MET A  61
ASP A 106
ILE A 108
VAL A 120
PHE A 189
 THG  A 501 (-3.4A)
None
THG  A 501 (-3.7A)
THG  A 501 (-4.0A)
THG  A 501 (-4.1A)
 0.57A 3a8iD-5x1nA:
28.2		 3a8iD-5x1nA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 ASP A 537
ILE A 611
GLY A 610
PRO A 445
ILE A 468
 THG  A1652 (-3.4A)
THG  A1652 (-4.2A)
None
None
None
 1.09A 3em4V-4cczA:
undetectable		 3em4V-4cczA:
11.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
ASN A 579
PHE A 582
ARG A 585
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-3.1A)
THG  A1652 (-4.5A)
THG  A1652 (-3.3A)
 1.45A 3k13A-4cczA:
43.4		 3k13A-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 379
GLY A 382
ASP A 449
GLY A 375
ARG A 591
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.0A)
 1.26A 3k13A-4cczA:
43.4		 3k13A-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		11 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
SER A 578
ASN A 579
PHE A 582
ARG A 585
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-4.5A)
THG  A1652 (-3.3A)
THG  A1652 (-4.2A)
 0.38A 3k13A-4cczA:
43.4		 3k13A-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 470
ASP A 537
ARG A 585
 THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.3A)
 0.64A 3k13A-4cczA:
43.4		 3k13A-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 470
ASP A 537
ARG A 591
 THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.0A)
 0.19A 3k13A-4cczA:
43.4		 3k13A-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
 1.50A 3k13B-4cczA:
43.2		 3k13B-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 ASN A 379
GLY A 382
ASP A 449
ASN A 470
VAL A 496
ASN A 579
ARG A 585
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
None
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
 1.45A 3k13B-4cczA:
43.2		 3k13B-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 449
ASN A 470
VAL A 496
GLY A 575
ILE A 611
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
None
None
THG  A1652 (-4.2A)
 1.11A 3k13B-4cczA:
43.2		 3k13B-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		11 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 449
ASN A 470
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.30A 3k13B-4cczA:
43.2		 3k13B-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		10 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.27A 3k13C-4cczA:
43.2		 3k13C-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 470
ASP A 537
ARG A 585
 THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.3A)
 0.81A 3k13C-4cczA:
43.2		 3k13C-4cczA:
30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN
(Candidatus
Pelagibacter
ubique) 		4 / 6 SER A 122
ILE A 152
TYR A 206
ASP A 181
 THG  A 370 (-3.8A)
None
None
None
 0.90A 3q70A-3tfjA:
undetectable		 3q70A-3tfjA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_A_CLMA221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.40A 3u9fA-4cczA:
0.0		 3u9fA-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.36A 3u9fE-4cczA:
undetectable		 3u9fE-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.31A 3u9fJ-4cczA:
undetectable
3u9fK-4cczA:
undetectable		 3u9fJ-4cczA:
15.66
3u9fK-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.35A 3u9fK-4cczA:
undetectable		 3u9fK-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.32A 3u9fR-4cczA:
undetectable		 3u9fR-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A 376
ASN A 379
ASP A 449
ASP A 537
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.77A 4djeA-4cczA:
29.6		 4djeA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 ASP A 414
ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 585
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
 1.17A 4djeB-4cczA:
29.3		 4djeB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
ASP A 414
ASP A 449
ASN A 470
ASP A 537
GLY A 576
SER A 578
ASN A 579
ARG A 591
 THG  A1652 (-3.5A)
None
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.59A 4djeB-4cczA:
29.3		 4djeB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 379
ASP A 537
ASN A 579
ARG A 585
ILE A 611
 THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
THG  A1652 (-4.2A)
 1.36A 4djfA-4cczA:
29.7		 4djfA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 416
ASP A 537
GLY A 576
ASN A 579
ILE A 611
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-3.1A)
THG  A1652 (-4.2A)
 1.11A 4djfA-4cczA:
29.7		 4djfA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A 376
ASN A 379
ASP A 537
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.48A 4djfA-4cczA:
29.7		 4djfA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A 376
ASP A 414
ASP A 449
ASN A 470
GLY A 576
SER A 578
ARG A 591
 THG  A1652 (-3.5A)
None
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
 0.56A 4djfB-4cczA:
29.6		 4djfB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		3 / 3 ARG A 163
TRP A 162
GLY A 218
 THG  A 501 ( 4.4A)
None
None
 1.03A 4e7cA-5x1nA:
undetectable		 4e7cA-5x1nA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A 376
ASN A 379
ASP A 449
ASP A 537
GLY A 576
ILE A 611
ASN A 616
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
None
 1.08A 4o1eA-4cczA:
28.3		 4o1eA-4cczA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 GLU A 376
ASN A 379
ASP A 449
GLY A 576
ILE A 611
ASN A 616
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
None
 1.11A 4o1eB-4cczA:
27.6		 4o1eB-4cczA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 5 TYR A 220
SER A 161
GLU A 215
ASP A  63
 None
None
THG  A 501 (-2.8A)
None
 1.37A 4xueA-5x1nA:
undetectable		 4xueA-5x1nA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE
(Sphingobium
sp.
SYK-6) 		4 / 4 TYR A 220
SER A 161
GLU A 215
ASP A  63
 None
None
THG  A 501 (-2.8A)
None
 1.34A 5lsaA-5x1nA:
undetectable		 5lsaA-5x1nA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
PHE A 582
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-4.5A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.63A 5vooA-4cczA:
38.6		 5vooA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASN A 379
ASP A 449
ASN A 470
ASP A 537
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 0.23A 5vooA-4cczA:
38.6		 5vooA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
PHE A 582
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.5A)
 1.42A 5vooB-4cczA:
38.4		 5vooB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
PHE A 582
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-4.5A)
THG  A1652 (-4.2A)
 0.54A 5vooB-4cczA:
38.4		 5vooB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 5 ASP A 414
ASP A 537
ASN A 579
ARG A 591
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.88A 5vooB-4cczA:
38.4		 5vooB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 585
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
 1.22A 5vooB-4cczA:
38.4		 5vooB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 591
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.33A 5vooB-4cczA:
38.4		 5vooB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
PHE A 582
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-4.5A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.60A 5vooC-4cczA:
38.7		 5vooC-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 5 ASN A 379
ASP A 414
ASP A 537
ASN A 579
 THG  A1652 (-4.6A)
None
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 1.49A 5vooC-4cczA:
38.7		 5vooC-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASN A 379
ASP A 449
ASN A 470
ASP A 537
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 0.22A 5vooC-4cczA:
38.7		 5vooC-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-4.2A)
 0.43A 5vooD-4cczA:
38.6		 5vooD-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 5 ASP A 414
ASP A 537
ASN A 579
ARG A 591
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.88A 5vooD-4cczA:
38.6		 5vooD-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 585
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
 1.20A 5vooD-4cczA:
38.6		 5vooD-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 591
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.34A 5vooD-4cczA:
38.6		 5vooD-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A 376
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.48A 5vooE-4cczA:
38.6		 5vooE-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 5 ASN A 379
ASP A 414
ASP A 537
ASN A 579
 THG  A1652 (-4.6A)
None
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 1.43A 5vooE-4cczA:
38.6		 5vooE-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASN A 379
ASP A 449
ASN A 470
ASP A 537
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 0.25A 5vooE-4cczA:
38.6		 5vooE-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
PHE A 582
ARG A 591
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
THG  A1652 (-4.5A)
THG  A1652 (-3.0A)
 0.76A 5vooF-4cczA:
38.6		 5vooF-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.44A 5vooF-4cczA:
38.6		 5vooF-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 4 ASP A 449
ASN A 470
ASP A 537
ASN A 579
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 0.23A 5vooF-4cczA:
38.6		 5vooF-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-3.1A)
 1.32A 5vopA-4cczA:
38.9		 5vopA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		10 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.48A 5vopA-4cczA:
38.9		 5vopA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 449
ASN A 470
ASP A 537
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
 0.20A 5vopA-4cczA:
38.9		 5vopA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-3.1A)
 1.36A 5vopB-4cczA:
38.6		 5vopB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 416
ASP A 414
VAL A 496
GLY A 576
ILE A 611
 None
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
 1.14A 5vopB-4cczA:
38.6		 5vopB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		10 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.42A 5vopB-4cczA:
38.6		 5vopB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 449
ASN A 470
ASP A 537
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
 0.15A 5vopB-4cczA:
38.6		 5vopB-4cczA:
16.87