SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TFP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A29_A_TFPA153_1
(CALMODULIN)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		5 / 8 ILE A  36
LEU A  41
MET A  60
GLU A  63
VAL A  72
 None
None
TFP  A 202 ( 4.0A)
None
None
 0.64A 1a29A-1wrkA:
11.2		 1a29A-1wrkA:
60.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		5 / 9 ILE A  36
LEU A  41
MET A  60
GLU A  63
VAL A  72
 None
None
TFP  A 202 ( 4.0A)
None
None
 0.62A 1ctrA-1wrkA:
10.4		 1ctrA-1wrkA:
60.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		5 / 11 ILE A  36
LEU A  41
MET A  45
LEU A  48
MET A  60
 None
None
TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 ( 4.0A)
 0.55A 1dtlA-1wrkA:
14.4		 1dtlA-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		5 / 11 LEU A  41
MET A  45
LEU A  48
MET A  60
VAL A  64
 None
TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 ( 4.0A)
None
 0.48A 1dtlA-1wrkA:
14.4		 1dtlA-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		5 / 12 ALA A  23
ILE A  26
PHE A  77
MET A  81
LEU A  48
 TFP  A 204 ( 4.7A)
None
None
TFP  A 202 ( 3.3A)
TFP  A 202 (-4.1A)
 0.71A 1dtlA-1wrkA:
14.4		 1dtlA-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		4 / 8 MET A  45
GLN A  50
PRO A  52
GLU A  56
 TFP  A 202 (-3.6A)
TFP  A 202 (-3.4A)
None
TFP  A 202 ( 4.6A)
 0.40A 1dtlA-1wrkA:
14.4		 1dtlA-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA156_1
(CALMODULIN)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		5 / 8 ILE A  36
LEU A  41
MET A  60
ILE A  61
GLU A  63
 None
None
TFP  A 202 ( 4.0A)
None
None
 0.45A 1linA-1wrkA:
11.1		 1linA-1wrkA:
60.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA156_1
(CALMODULIN)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		5 / 8 LEU A  41
MET A  60
ILE A  61
GLU A  63
VAL A  64
 None
TFP  A 202 ( 4.0A)
None
None
None
 0.41A 1linA-1wrkA:
11.1		 1linA-1wrkA:
60.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		7 / 12 ILE A  36
LEU A  41
MET A  45
ILE A  61
GLU A  63
VAL A  72
MET A  81
 None
None
TFP  A 202 (-3.6A)
None
None
None
TFP  A 202 ( 3.3A)
 0.91A 1lxfC-1wrkA:
11.4		 1lxfC-1wrkA:
97.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		7 / 12 ILE A  36
LEU A  41
MET A  60
ILE A  61
GLU A  63
VAL A  72
MET A  81
 None
None
TFP  A 202 ( 4.0A)
None
None
None
TFP  A 202 ( 3.3A)
 0.85A 1lxfC-1wrkA:
11.4		 1lxfC-1wrkA:
97.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		7 / 12 ILE A  36
LEU A  48
MET A  60
ILE A  61
GLU A  63
VAL A  72
MET A  81
 None
TFP  A 202 (-4.1A)
TFP  A 202 ( 4.0A)
None
None
None
TFP  A 202 ( 3.3A)
 0.86A 1lxfC-1wrkA:
11.4		 1lxfC-1wrkA:
97.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		7 / 12 ILE A  36
MET A  45
LEU A  48
ILE A  61
GLU A  63
VAL A  72
MET A  81
 None
TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
None
None
None
TFP  A 202 ( 3.3A)
 0.92A 1lxfC-1wrkA:
11.4		 1lxfC-1wrkA:
97.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		7 / 9 MET A  45
LEU A  48
GLN A  50
GLU A  56
MET A  60
MET A  80
SER A  84
 TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 (-3.4A)
TFP  A 202 ( 4.6A)
TFP  A 202 ( 4.0A)
TFP  A 202 (-3.5A)
TFP  A 204 (-2.9A)
 0.56A 1wrlA-1wrkA:
17.9
1wrlB-1wrkA:
17.7		 1wrlA-1wrkA:
100.00
1wrlB-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		6 / 7 PHE A  27
LEU A  48
PHE A  77
MET A  81
VAL A  82
SER A  84
 TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
TFP  A 204 ( 4.9A)
TFP  A 204 (-2.9A)
 0.48A 1wrlA-1wrkA:
17.9
1wrlB-1wrkA:
17.7		 1wrlA-1wrkA:
100.00
1wrlB-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_B_TFPB201_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		7 / 9 MET A  45
LEU A  48
GLN A  50
GLU A  56
MET A  60
MET A  80
MET A  81
 TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 (-3.4A)
TFP  A 202 ( 4.6A)
TFP  A 202 ( 4.0A)
TFP  A 202 (-3.5A)
TFP  A 202 ( 3.3A)
 0.38A 1wrlA-1wrkA:
17.9
1wrlB-1wrkA:
17.7		 1wrlA-1wrkA:
100.00
1wrlB-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		6 / 6 PHE A  27
VAL A  44
LEU A  48
PHE A  77
MET A  81
SER A  84
 TFP  A 204 (-4.4A)
None
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
TFP  A 204 (-2.9A)
 0.40A 1wrlB-1wrkA:
17.7		 1wrlB-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_C_TFPC206_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		7 / 9 MET A  45
LEU A  48
GLN A  50
GLU A  56
MET A  60
MET A  80
MET A  81
 TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 (-3.4A)
TFP  A 202 ( 4.6A)
TFP  A 202 ( 4.0A)
TFP  A 202 (-3.5A)
TFP  A 202 ( 3.3A)
 0.37A 1wrlC-1wrkA:
17.3
1wrlD-1wrkA:
17.0		 1wrlC-1wrkA:
100.00
1wrlD-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		4 / 5 PHE A  27
LEU A  48
PHE A  77
MET A  81
 TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
 0.35A 1wrlC-1wrkA:
17.3		 1wrlC-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		7 / 10 MET A  45
LEU A  48
GLN A  50
GLU A  56
MET A  60
MET A  80
MET A  81
 TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 (-3.4A)
TFP  A 202 ( 4.6A)
TFP  A 202 ( 4.0A)
TFP  A 202 (-3.5A)
TFP  A 202 ( 3.3A)
 0.34A 1wrlC-1wrkA:
17.3
1wrlD-1wrkA:
17.0		 1wrlC-1wrkA:
100.00
1wrlD-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		5 / 10 MET A  45
LEU A  48
GLN A  50
MET A  80
SER A  84
 TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 (-3.4A)
TFP  A 202 (-3.5A)
TFP  A 204 (-2.9A)
 1.20A 1wrlC-1wrkA:
17.3
1wrlD-1wrkA:
17.0		 1wrlC-1wrkA:
100.00
1wrlD-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		6 / 8 LEU A  12
PHE A  20
PHE A  27
LEU A  48
PHE A  77
MET A  81
 None
TFP  A 204 ( 4.6A)
TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
 0.27A 1wrlC-1wrkA:
17.3
1wrlD-1wrkA:
17.0		 1wrlC-1wrkA:
100.00
1wrlD-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_E_TFPE210_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		7 / 9 MET A  45
LEU A  48
GLN A  50
GLU A  56
MET A  60
MET A  80
SER A  84
 TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 (-3.4A)
TFP  A 202 ( 4.6A)
TFP  A 202 ( 4.0A)
TFP  A 202 (-3.5A)
TFP  A 204 (-2.9A)
 0.56A 1wrlE-1wrkA:
17.6
1wrlF-1wrkA:
16.5		 1wrlE-1wrkA:
100.00
1wrlF-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		6 / 7 PHE A  20
PHE A  27
LEU A  48
PHE A  77
MET A  81
SER A  84
 TFP  A 204 ( 4.6A)
TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
TFP  A 204 (-2.9A)
 0.57A 1wrlE-1wrkA:
17.6		 1wrlE-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		6 / 7 PHE A  27
LEU A  48
PHE A  77
MET A  81
SER A  84
MET A  85
 TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
TFP  A 204 (-2.9A)
None
 1.15A 1wrlE-1wrkA:
17.6		 1wrlE-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		7 / 10 MET A  45
LEU A  48
GLN A  50
GLU A  56
MET A  60
MET A  80
MET A  81
 TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 (-3.4A)
TFP  A 202 ( 4.6A)
TFP  A 202 ( 4.0A)
TFP  A 202 (-3.5A)
TFP  A 202 ( 3.3A)
 0.40A 1wrlE-1wrkA:
17.6
1wrlF-1wrkA:
16.5		 1wrlE-1wrkA:
100.00
1wrlF-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		5 / 10 MET A  45
LEU A  48
GLN A  50
MET A  80
SER A  84
 TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 (-3.4A)
TFP  A 202 (-3.5A)
TFP  A 204 (-2.9A)
 1.10A 1wrlE-1wrkA:
17.6
1wrlF-1wrkA:
16.5		 1wrlE-1wrkA:
100.00
1wrlF-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		5 / 7 PHE A  20
PHE A  27
LEU A  48
PHE A  77
MET A  81
 TFP  A 204 ( 4.6A)
TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
 0.32A 1wrlE-1wrkA:
17.6
1wrlF-1wrkA:
16.5		 1wrlE-1wrkA:
100.00
1wrlF-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens) 		4 / 8 ILE A  36
LEU A  41
MET A  60
VAL A  72
 None
None
TFP  A 202 ( 4.0A)
None
 0.45A 4rjdA-1wrkA:
10.6		 4rjdA-1wrkA:
44.29