SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TFC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		4 / 8 GLY A 146
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 0.74A 1ax9A-2fj0A:
49.2		 1ax9A-2fj0A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 GLY A 145
GLY A 146
GLY A 147
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 0.66A 1dx6A-2fj0A:
47.5		 1dx6A-2fj0A:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 PHE A 361
PHE A 259
GLY A 253
ALA A 229
SER A 226
GLY A 146
 TFC  A 600 (-4.4A)
TFC  A 600 (-4.0A)
None
None
TFC  A 600 (-1.4A)
TFC  A 600 (-3.4A)
 1.50A 1igxA-2fj0A:
undetectable		 1igxA-2fj0A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 PHE A 361
PHE A 259
GLY A 253
ALA A 229
SER A 226
GLY A 147
 TFC  A 600 (-4.4A)
TFC  A 600 (-4.0A)
None
None
TFC  A 600 (-1.4A)
TFC  A 600 (-3.6A)
 1.45A 1igxA-2fj0A:
undetectable		 1igxA-2fj0A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 11 LEU A  98
HIS A 471
ALA A 229
GLY A 224
PHE A 458
 None
TFC  A 600 (-4.2A)
None
None
None
 1.20A 1l5rA-2fj0A:
5.4		 1l5rA-2fj0A:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 11 LEU A  98
GLY A 146
GLY A 147
SER A 226
HIS A 471
 None
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.2A)
 0.93A 1mx1A-2fj0A:
49.2		 1mx1A-2fj0A:
30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 12 GLY A 146
GLY A 147
SER A 226
PHE A 425
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
None
TFC  A 600 (-4.2A)
 0.52A 1mx1D-2fj0A:
46.4		 1mx1D-2fj0A:
30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 12 LEU A  98
GLY A 146
GLY A 147
SER A 226
HIS A 471
 None
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.2A)
 0.92A 1mx1D-2fj0A:
46.4		 1mx1D-2fj0A:
30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 12 GLY A 146
GLY A 147
SER A 226
PHE A 425
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
None
TFC  A 600 (-4.2A)
 0.46A 1mx1F-2fj0A:
46.2		 1mx1F-2fj0A:
30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 GLY A 145
GLY A 146
GLY A 147
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 0.68A 1qtiA-2fj0A:
49.1		 1qtiA-2fj0A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 GLY A 145
GLY A 146
GLY A 147
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 1.36A 1qtiA-2fj0A:
49.1		 1qtiA-2fj0A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 GLY A 145
GLY A 146
GLY A 147
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 0.65A 1w6rA-2fj0A:
47.5		 1w6rA-2fj0A:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 GLY A 145
GLY A 146
GLY A 147
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 1.37A 1w6rA-2fj0A:
47.5		 1w6rA-2fj0A:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 GLY A 224
GLY A 228
PHE A 260
PHE A 148
PHE A 425
PHE A 259
 None
None
None
None
None
TFC  A 600 (-4.0A)
 1.42A 1w6rA-2fj0A:
47.5		 1w6rA-2fj0A:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 11 GLY A 146
GLY A 147
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 0.68A 1w76A-2fj0A:
49.2		 1w76A-2fj0A:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 10 GLY A 145
GLY A 146
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 0.62A 1w76B-2fj0A:
49.2		 1w76B-2fj0A:
29.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 8 GLY A 145
GLY A 146
GLY A 147
ALA A 227
LEU A 313
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
 0.77A 1yajC-2fj0A:
45.6		 1yajC-2fj0A:
30.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 8 GLY A 145
GLY A 146
GLY A 147
SER A 226
ALA A 227
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
 0.56A 1yajC-2fj0A:
45.6		 1yajC-2fj0A:
30.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 8 GLY A 228
GLY A 145
GLY A 146
SER A 226
ALA A 227
HIS A 471
 None
TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
 1.15A 1yajC-2fj0A:
45.6		 1yajC-2fj0A:
30.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 9 GLY A 145
GLY A 146
SER A 226
ALA A 227
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
 0.94A 2aceA-2fj0A:
49.1		 2aceA-2fj0A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 9 GLY A 145
GLY A 146
SER A 226
ALA A 227
PHE A 150
PHE A 458
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
None
None
 1.08A 2aceA-2fj0A:
49.1		 2aceA-2fj0A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 9 GLY A 146
GLY A 147
SER A 226
ALA A 227
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
 0.70A 2aceA-2fj0A:
49.1		 2aceA-2fj0A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		4 / 7 GLY A 146
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 0.79A 2ackA-2fj0A:
13.7		 2ackA-2fj0A:
29.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		4 / 8 GLY A 146
GLY A 147
ALA A 227
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
 0.30A 2ha4A-2fj0A:
46.5		 2ha4A-2fj0A:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		4 / 7 GLY A 146
GLY A 147
ALA A 227
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
 0.29A 2ha4B-2fj0A:
47.8		 2ha4B-2fj0A:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		4 / 4 LEU A 313
THR A 314
ILE A 472
HIS A 471
 TFC  A 600 (-4.2A)
TFC  A 600 ( 4.6A)
None
TFC  A 600 (-4.2A)
 1.26A 2jfaB-2fj0A:
undetectable		 2jfaB-2fj0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		3 / 3 PRO A 318
PHE A 259
ALA A 230
 None
TFC  A 600 (-4.0A)
None
 0.73A 3itaD-2fj0A:
undetectable		 3itaD-2fj0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 7 GLY A 145
GLY A 146
SER A 226
LEU A 313
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.2A)
TFC  A 600 (-4.2A)
 1.05A 3o9mA-2fj0A:
49.9		 3o9mA-2fj0A:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 7 GLY A 146
GLY A 147
SER A 226
PHE A 425
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
None
TFC  A 600 (-4.2A)
 0.75A 3o9mA-2fj0A:
49.9		 3o9mA-2fj0A:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 6 GLY A 145
GLY A 146
SER A 226
LEU A 313
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.2A)
TFC  A 600 (-4.2A)
 1.09A 3o9mB-2fj0A:
49.8		 3o9mB-2fj0A:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		4 / 6 GLY A 146
GLY A 147
SER A 226
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.2A)
 0.80A 3o9mB-2fj0A:
49.8		 3o9mB-2fj0A:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 12 PHE A 458
ILE A 508
LEU A 140
GLY A 224
SER A 226
 None
None
None
None
TFC  A 600 (-1.4A)
 1.31A 4djfB-2fj0A:
undetectable		 4djfB-2fj0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 GLY A 145
GLY A 146
GLY A 147
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 0.64A 4ey6A-2fj0A:
48.2		 4ey6A-2fj0A:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 GLY A 145
GLY A 146
GLY A 147
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 1.44A 4ey6A-2fj0A:
48.2		 4ey6A-2fj0A:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 GLY A 145
GLY A 146
GLY A 147
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 0.64A 4ey6B-2fj0A:
42.4		 4ey6B-2fj0A:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		6 / 12 GLY A 145
GLY A 146
GLY A 147
SER A 226
PHE A 361
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.4A)
TFC  A 600 (-4.2A)
 1.44A 4ey6B-2fj0A:
42.4		 4ey6B-2fj0A:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		4 / 8 SER A 226
ALA A 227
HIS A 471
LEU A 313
 TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
TFC  A 600 (-4.2A)
 0.99A 5dzkd-2fj0A:
2.4
5dzkr-2fj0A:
undetectable		 5dzkd-2fj0A:
17.60
5dzkr-2fj0A:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		4 / 8 SER A 226
ALA A 227
HIS A 471
LEU A 313
 TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
TFC  A 600 (-4.2A)
 1.09A 5dzkF-2fj0A:
2.5
5dzkT-2fj0A:
undetectable		 5dzkF-2fj0A:
17.60
5dzkT-2fj0A:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		4 / 6 PHE A 260
SER A 226
ALA A 227
HIS A 471
 None
TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
 1.28A 5dzkg-2fj0A:
2.5
5dzku-2fj0A:
undetectable		 5dzkg-2fj0A:
17.60
5dzku-2fj0A:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		5 / 11 GLU A 357
PHE A 259
SER A 226
ALA A 227
LEU A 308
 None
TFC  A 600 (-4.0A)
TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
None
 1.36A 6efnA-2fj0A:
2.2		 6efnA-2fj0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fj0 CARBOXYLIC ESTER
HYDROLASE
(Manduca
sexta) 		3 / 3 ARG A 362
PHE A 458
PHE A 365
 None
None
TFC  A 600 ( 4.9A)
 1.06A 6nknC-2fj0A:
undetectable
6nknJ-2fj0A:
undetectable		 6nknC-2fj0A:
18.71
6nknJ-2fj0A:
8.17