SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TFB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		4 / 5 TYR A 288
LEU A 257
VAL A 164
ASP A 135
 TFB  A2002 (-4.7A)
FAD  A2001 (-3.8A)
FAD  A2001 (-4.1A)
TFB  A2002 ( 3.7A)
 1.38A 1dz6A-4h6qA:
undetectable		 1dz6A-4h6qA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 TYR A 485
LEU A 449
VAL A 338
ASP A 306
 TFB  A2003 (-4.9A)
FAD  A2001 (-4.1A)
FAD  A2001 (-4.3A)
TFB  A2003 ( 3.5A)
 1.29A 1dz6A-5kf7A:
undetectable		 1dz6A-5kf7A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 ARG A 488
ALA A 372
TYR A 485
GLU A 492
 TFB  A2003 (-3.8A)
FAD  A2001 (-3.5A)
TFB  A2003 (-4.9A)
FAD  A2001 (-2.7A)
 1.29A 1oniB-5kf7A:
undetectable
1oniC-5kf7A:
undetectable		 1oniB-5kf7A:
8.27
1oniC-5kf7A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 TYR A 485
GLU A 492
ARG A 488
ALA A 372
 TFB  A2003 (-4.9A)
FAD  A2001 (-2.7A)
TFB  A2003 (-3.8A)
FAD  A2001 (-3.5A)
 1.28A 1oniE-5kf7A:
undetectable
1oniF-5kf7A:
undetectable		 1oniE-5kf7A:
8.27
1oniF-5kf7A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TJ2_A_ACTA2002_0
(BIFUNCTIONAL PUTA
PROTEIN)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 5 LYS A  98
ALA A 192
TYR A 288
ARG A 291
ARG A 292
 TFB  A2002 (-2.8A)
FAD  A2001 (-3.1A)
TFB  A2002 (-4.7A)
TFB  A2002 (-3.8A)
TFB  A2002 ( 2.6A)
 0.42A 1tj2A-4h6qA:
31.5		 1tj2A-4h6qA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TJ2_A_ACTA2002_0
(BIFUNCTIONAL PUTA
PROTEIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 5 LYS A 265
ALA A 372
TYR A 485
ARG A 488
ARG A 489
 TFB  A2003 (-2.8A)
FAD  A2001 (-3.5A)
TFB  A2003 (-4.9A)
TFB  A2003 (-3.8A)
TFB  A2003 ( 2.6A)
 0.37A 1tj2A-5kf7A:
62.5		 1tj2A-5kf7A:
32.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 ASP A 306
GLU A 492
TYR A 402
 TFB  A2003 ( 3.5A)
FAD  A2001 (-2.7A)
None
 0.73A 1wsvA-5kf7A:
undetectable		 1wsvA-5kf7A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 LYS A 265
SER A 219
ASP A 221
ARG A 367
 TFB  A2003 (-2.8A)
None
None
FAD  A2001 (-4.1A)
 1.48A 2rk8B-5kf7A:
undetectable		 2rk8B-5kf7A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 ASN A 493
MET A 190
LEU A 482
TYR A 485
LEU A 490
 None
None
None
TFB  A2003 (-4.9A)
None
 1.46A 3h52B-5kf7A:
0.0		 3h52B-5kf7A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		3 / 3 LYS A  98
ARG A 292
LEU A  62
 TFB  A2002 (-2.8A)
TFB  A2002 ( 2.6A)
None
 0.94A 3v4tE-4h6qA:
1.8		 3v4tE-4h6qA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 TYR A 278
ASP A  60
GLN A 166
VAL A 164
ILE A 132
 TFB  A2002 ( 3.5A)
None
FAD  A2001 (-3.7A)
FAD  A2001 (-4.1A)
None
 1.26A 4drhA-4h6qA:
undetectable		 4drhA-4h6qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 TYR A 278
ASP A  60
GLN A 166
VAL A 164
ILE A 132
 TFB  A2002 ( 3.5A)
None
FAD  A2001 (-3.7A)
FAD  A2001 (-4.1A)
None
 1.24A 4drhD-4h6qA:
undetectable		 4drhD-4h6qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 ILE A 264
LEU A 266
LYS A 265
ASN A 304
 None
None
TFB  A2003 (-2.8A)
None
 1.12A 4g19A-5kf7A:
undetectable		 4g19A-5kf7A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 11 GLY A 239
GLY A 240
GLY A 241
ALA A 238
TRP A 267
 None
None
None
None
TFB  A1810 (-4.9A)
 1.09A 4l8fB-1kb0A:
undetectable		 4l8fB-1kb0A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Comamonas
testosteroni) 		5 / 11 GLY A 239
GLY A 240
GLY A 241
ALA A 238
TRP A 267
 None
None
None
None
TFB  A1810 (-4.9A)
 1.09A 4l8fD-1kb0A:
undetectable		 4l8fD-1kb0A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Comamonas
testosteroni) 		4 / 6 TYR A 390
PHE A 606
THR A 442
TRP A 440
 TFB  A1810 ( 3.8A)
None
None
None
 1.20A 5g08A-1kb0A:
undetectable		 5g08A-1kb0A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		4 / 7 SER A  96
ASP A 135
TYR A 288
ASN A  58
 None
TFB  A2002 ( 3.7A)
TFB  A2002 (-4.7A)
None
 1.16A 5l1fC-4h6qA:
undetectable		 5l1fC-4h6qA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 8 ASP A 306
MET A 222
TYR A 473
VAL A 196
 TFB  A2003 ( 3.5A)
None
TFB  A2003 ( 3.6A)
None
 1.06A 6giqL-5kf7A:
undetectable
6giqP-5kf7A:
undetectable
6giqT-5kf7A:
undetectable		 6giqL-5kf7A:
17.71
6giqP-5kf7A:
11.08
6giqT-5kf7A:
3.93