SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TF4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		5 / 8 LEU A  87
TYR A 114
ARG A 188
ILE A 191
ARG A 192
 None
TF4  A 438 (-3.8A)
TF4  A 438 (-4.2A)
TF4  A 438 (-3.4A)
TF4  A 438 ( 4.8A)
 0.82A 2bu8A-2q8hA:
46.0		 2bu8A-2q8hA:
68.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		5 / 8 LEU A  87
TYR A 114
ILE A 145
ARG A 188
ILE A 191
 None
TF4  A 438 (-3.8A)
None
TF4  A 438 (-4.2A)
TF4  A 438 (-3.4A)
 0.61A 2bu8A-2q8hA:
46.0		 2bu8A-2q8hA:
68.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 8 LEU A  83
ILE A 191
LEU A 195
LEU A 121
 None
TF4  A 438 (-3.4A)
None
None
 0.76A 2xfhA-2q8hA:
undetectable		 2xfhA-2q8hA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 6 ILE A 397
ILE A 191
LEU A 194
PHE A  62
 None
TF4  A 438 (-3.4A)
None
None
 1.07A 5vkqA-2q8hA:
undetectable
5vkqB-2q8hA:
undetectable		 5vkqA-2q8hA:
12.68
5vkqB-2q8hA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 6 ILE A 397
ILE A 191
LEU A 194
PHE A  62
 None
TF4  A 438 (-3.4A)
None
None
 1.05A 5vkqA-2q8hA:
undetectable
5vkqD-2q8hA:
undetectable		 5vkqA-2q8hA:
12.68
5vkqD-2q8hA:
12.68