SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TEO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 THR A  54
GLY A  51
ASP A 407
HIS A 395
ARG A 286
 None
TEO  A1589 ( 3.1A)
None
None
TEO  A1589 (-2.9A)
 1.18A 1wg8A-2wu5A:
3.2		 1wg8A-2wu5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		4 / 8 ASP A 298
GLY A 131
PHE A 130
THR A 265
 None
None
None
TEO  A1002 (-3.7A)
 0.99A 2aouA-2h88A:
undetectable		 2aouA-2h88A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 ASP A 287
GLY A 120
PHE A 119
THR A 254
 None
None
None
TEO  A1589 (-3.8A)
 0.96A 2aouA-2wu5A:
undetectable		 2aouA-2wu5A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 ILE A 264
HIS A 253
PHE A 130
GLY A 131
MET A 367
 None
TEO  A1002 (-4.0A)
None
None
None
 1.42A 2nyrB-2h88A:
2.8		 2nyrB-2h88A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 THR A 134
GLY A 401
GLY A 120
ARG A 258
LEU A 315
 None
TEO  A1589 (-3.4A)
None
None
None
 1.20A 3t7vA-2wu5A:
undetectable		 3t7vA-2wu5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		5 / 12 HIS A 253
THR A 255
GLU A 266
GLY A 131
GLY A  63
 TEO  A1002 (-4.0A)
None
None
None
FAD  A1001 (-4.1A)
 1.42A 4uinH-2h88A:
undetectable
4uinL-2h88A:
undetectable		 4uinH-2h88A:
16.59
4uinL-2h88A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 HIS A 242
THR A 244
GLU A 255
GLY A 120
GLY A  52
 TEO  A1589 (-3.9A)
None
None
None
FAD  A 601 (-4.1A)
 1.40A 4uinH-2wu5A:
undetectable
4uinL-2wu5A:
undetectable		 4uinH-2wu5A:
16.95
4uinL-2wu5A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 7 GLU A 388
SER A 404
ARG A 399
GLY A 402
 FAD  A 601 ( 3.3A)
FAD  A 601 (-2.9A)
TEO  A1589 (-2.9A)
FAD  A 601 ( 3.2A)
 0.89A 5e26A-2wu5A:
undetectable
5e26B-2wu5A:
undetectable		 5e26A-2wu5A:
21.22
5e26B-2wu5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 7 ALA A  49
GLU A 388
SER A 404
ARG A 399
GLY A 402
 FAD  A 601 (-3.3A)
FAD  A 601 ( 3.3A)
FAD  A 601 (-2.9A)
TEO  A1589 (-2.9A)
FAD  A 601 ( 3.2A)
 1.40A 5e26A-2wu5A:
undetectable
5e26B-2wu5A:
undetectable		 5e26A-2wu5A:
21.22
5e26B-2wu5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 5 GLU A 388
SER A 404
ARG A 399
GLY A 402
 FAD  A 601 ( 3.3A)
FAD  A 601 (-2.9A)
TEO  A1589 (-2.9A)
FAD  A 601 ( 3.2A)
 1.03A 5kprA-2wu5A:
undetectable		 5kprA-2wu5A:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Gallus
gallus) 		3 / 3 HIS A 253
HIS A 364
ARG A 408
 TEO  A1002 (-4.0A)
TEO  A1002 ( 3.8A)
TEO  A1002 ( 2.8A)
 0.56A 6b58A-2h88A:
45.2		 6b58A-2h88A:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 HIS A 242
HIS A 354
ARG A 399
 TEO  A1589 (-3.9A)
TEO  A1589 ( 3.8A)
TEO  A1589 (-2.9A)
 0.49A 6b58A-2wu5A:
46.1		 6b58A-2wu5A:
42.95