SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TEN'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RH3_A_MTXA161_1 (DIHYDROFOLATE REDUCTASE)	1eyw	PHOSPHOTRIESTERASE (Brevundimonas diminuta)	5 / 12	ILE A 106 ASP A 100 LEU A 113 ARG A 76 LEU A 66	TEN A 403 ( 4.6A) None None None None	1.32A	1rh3A-1eywA: undetectable	1rh3A-1eywA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PGR_A_DCFA501_1 (ADENOSINE DEAMINASE)	1eyw	PHOSPHOTRIESTERASE (Brevundimonas diminuta)	5 / 12	HIS A 55 HIS A 57 ILE A 106 HIS A 230 ASP A 301	ZN A 401 (-3.2A) ZN A 401 (-3.3A) TEN A 403 ( 4.6A) ZN A 402 (-3.3A) ZN A 401 ( 2.6A)	0.88A	2pgrA-1eywA: 5.8	2pgrA-1eywA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CR4_X_PNTX101_0 (PROTEIN S100-B)	1eyw	PHOSPHOTRIESTERASE (Brevundimonas diminuta)	3 / 3	CYH A 59 HIS A 57 PHE A 306	None ZN A 401 (-3.3A) TEN A 403 (-4.4A)	0.92A	3cr4X-1eywA: undetectable	3cr4X-1eywA: 13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_A_ACTA802_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1eyw	PHOSPHOTRIESTERASE (Brevundimonas diminuta)	4 / 6	HIS A 55 ASP A 301 HIS A 57 TRP A 131	ZN A 401 (-3.2A) ZN A 401 ( 2.6A) ZN A 401 (-3.3A) TEN A 403 (-4.4A)	1.24A	5m45A-1eywA: 0.0	5m45A-1eywA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_D_ACTD802_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1eyw	PHOSPHOTRIESTERASE (Brevundimonas diminuta)	4 / 6	HIS A 55 ASP A 301 HIS A 57 TRP A 131	ZN A 401 (-3.2A) ZN A 401 ( 2.6A) ZN A 401 (-3.3A) TEN A 403 (-4.4A)	1.25A	5m45D-1eywA: 0.0	5m45D-1eywA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_G_ACTG802_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1eyw	PHOSPHOTRIESTERASE (Brevundimonas diminuta)	4 / 6	HIS A 55 ASP A 301 HIS A 57 TRP A 131	ZN A 401 (-3.2A) ZN A 401 ( 2.6A) ZN A 401 (-3.3A) TEN A 403 (-4.4A)	1.25A	5m45G-1eywA: 0.0	5m45G-1eywA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_J_ACTJ802_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1eyw	PHOSPHOTRIESTERASE (Brevundimonas diminuta)	4 / 6	HIS A 55 ASP A 301 HIS A 57 TRP A 131	ZN A 401 (-3.2A) ZN A 401 ( 2.6A) ZN A 401 (-3.3A) TEN A 403 (-4.4A)	1.25A	5m45J-1eywA: 0.0	5m45J-1eywA: 19.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RH3_A_MTXA161_1","DIHYDROFOLATE REDUCTASE","1eyw","PHOSPHOTRIESTERASE","Brevundimonas diminuta",5,"ILE A 106;ASP A 100;LEU A 113;ARG A  76;LEU A  66","TEN A 403 ( 4.6A);None;None;None;None","1.32A","1rh3A-1eywA:undetectable",null],["2PGR_A_DCFA501_1","ADENOSINE DEAMINASE","1eyw","PHOSPHOTRIESTERASE","Brevundimonas diminuta",5,"HIS A  55;HIS A  57;ILE A 106;HIS A 230;ASP A 301"," ZN A 401 (-3.2A); ZN A 401 (-3.3A);TEN A 403 ( 4.6A); ZN A 402 (-3.3A); ZN A 401 ( 2.6A)","0.88A","2pgrA-1eywA:5.8","1rh3A-1eywA:17.89"],["3CR4_X_PNTX101_0","PROTEIN S100-B","1eyw","PHOSPHOTRIESTERASE","Brevundimonas diminuta",3,"CYH A  59;HIS A  57;PHE A 306","None; ZN A 401 (-3.3A);TEN A 403 (-4.4A)","0.92A","3cr4X-1eywA:undetectable","2pgrA-1eywA:21.84"],["5M45_A_ACTA802_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1eyw","PHOSPHOTRIESTERASE","Brevundimonas diminuta",4,"HIS A  55;ASP A 301;HIS A  57;TRP A 131"," ZN A 401 (-3.2A); ZN A 401 ( 2.6A); ZN A 401 (-3.3A);TEN A 403 (-4.4A)","1.24A","5m45A-1eywA:0.0","3cr4X-1eywA:13.76"],["5M45_D_ACTD802_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1eyw","PHOSPHOTRIESTERASE","Brevundimonas diminuta",4,"HIS A  55;ASP A 301;HIS A  57;TRP A 131"," ZN A 401 (-3.2A); ZN A 401 ( 2.6A); ZN A 401 (-3.3A);TEN A 403 (-4.4A)","1.25A","5m45D-1eywA:0.0","5m45A-1eywA:19.33"],["5M45_G_ACTG802_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1eyw","PHOSPHOTRIESTERASE","Brevundimonas diminuta",4,"HIS A  55;ASP A 301;HIS A  57;TRP A 131"," ZN A 401 (-3.2A); ZN A 401 ( 2.6A); ZN A 401 (-3.3A);TEN A 403 (-4.4A)","1.25A","5m45G-1eywA:0.0","5m45D-1eywA:19.33"],["5M45_J_ACTJ802_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1eyw","PHOSPHOTRIESTERASE","Brevundimonas diminuta",4,"HIS A  55;ASP A 301;HIS A  57;TRP A 131"," ZN A 401 (-3.2A); ZN A 401 ( 2.6A); ZN A 401 (-3.3A);TEN A 403 (-4.4A)","1.25A","5m45J-1eywA:0.0","5m45G-1eywA:19.33"]]