SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TDS'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4S0V_A_SUVA2001_2 (HUMAN OREXIN RECEPTOR TYPE 2 FUSION PROTEIN TO P. ABYSII GLYCOGEN SYNTHASE)	1q90	CYTOCHROME B6 CYTOCHROME B6-F COMPLEX IRON-SULFUR SUBUNIT (Chlamydomonas reinhardtii)	4 / 5	ILE B 165 PRO B 155 HIS C 155 VAL B 175	TDS D 920 ( 4.7A) TDS D 920 ( 4.7A) FES C 210 ( 3.0A) None	1.35A	4s0vA-1q90B: 6.0	4s0vA-1q90B: 17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AP6_A_TLFA300_0 (PROBABLE STRIGOLACTONE ESTERASE DAD2)	1q90	CYTOCHROME B6 (Chlamydomonas reinhardtii)	5 / 12	VAL B 151 PHE B 183 VAL B 190 SER B 130 VAL B 133	TDS D 920 (-4.1A) None None CLA D 910 (-3.6A) CLA D 910 (-4.0A)	0.88A	6ap6A-1q90B: undetectable	6ap6A-1q90B: 21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AP6_B_TLFB300_0 (PROBABLE STRIGOLACTONE ESTERASE DAD2)	1q90	CYTOCHROME B6 (Chlamydomonas reinhardtii)	5 / 12	VAL B 151 PHE B 183 VAL B 190 SER B 130 VAL B 133	TDS D 920 (-4.1A) None None CLA D 910 (-3.6A) CLA D 910 (-4.0A)	0.90A	6ap6B-1q90B: undetectable	6ap6B-1q90B: 21.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4S0V_A_SUVA2001_2","HUMAN OREXIN RECEPTOR TYPE 2 FUSION PROTEIN TO P. ABYSII GLYCOGEN SYNTHASE","1q90","CYTOCHROME B6;CYTOCHROME B6-F COMPLEX IRON-SULFUR SUBUNIT","Chlamydomonas reinhardtii",4,"ILE B 165;PRO B 155;HIS C 155;VAL B 175","TDS D 920 ( 4.7A);TDS D 920 ( 4.7A);FES C 210 ( 3.0A);None","1.35A","4s0vA-1q90B:6.0",null],["6AP6_A_TLFA300_0","PROBABLE STRIGOLACTONE ESTERASE DAD2","1q90","CYTOCHROME B6","Chlamydomonas reinhardtii",5,"VAL B 151;PHE B 183;VAL B 190;SER B 130;VAL B 133","TDS D 920 (-4.1A);None;None;CLA D 910 (-3.6A);CLA D 910 (-4.0A)","0.88A","6ap6A-1q90B:undetectable","4s0vA-1q90B:17.70"],["6AP6_B_TLFB300_0","PROBABLE STRIGOLACTONE ESTERASE DAD2","1q90","CYTOCHROME B6","Chlamydomonas reinhardtii",5,"VAL B 151;PHE B 183;VAL B 190;SER B 130;VAL B 133","TDS D 920 (-4.1A);None;None;CLA D 910 (-3.6A);CLA D 910 (-4.0A)","0.90A","6ap6B-1q90B:undetectable","6ap6A-1q90B:21.11"]]