SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TDP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 11 ASP A 433
GLY A 434
GLY A 381
PRO A 359
VAL A 527
 MG  A 613 ( 2.7A)
TDP  A 611 (-3.3A)
TDP  A 611 (-3.4A)
None
None
 1.01A 1hxwB-3eyaA:
undetectable		 1hxwB-3eyaA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 12 THR A 247
GLU A 244
ASP A 185
GLY A 156
PHE A 199
 FMT  A 721 (-4.1A)
None
None
TDP  A 701 ( 3.7A)
None
 1.21A 1oltA-3m49A:
undetectable		 1oltA-3m49A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT
(Thermus
thermophilus) 		4 / 6 TYR A  94
TYR A  95
HIS A 273
GLU A 202
 TDP  A1402 (-4.5A)
TDP  A1402 (-4.3A)
TDP  A1402 (-4.3A)
None
 0.95A 1q13A-1umbA:
undetectable		 1q13A-1umbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 1utdT-2panA:
undetectable
1utdU-2panA:
undetectable		 1utdT-2panA:
9.74
1utdU-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Deinococcus
radiodurans) 		4 / 8 ARG A 401
SER A 156
ILE A 371
ASP A  79
 TDP  A1001 ( 4.0A)
TDP  A1001 (-3.3A)
TDP  A1001 (-4.0A)
None
 1.07A 2xadA-2o1xA:
undetectable		 2xadA-2o1xA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Deinococcus
radiodurans) 		4 / 8 ARG A 401
SER A 156
ILE A 371
ASP A  79
 TDP  A1001 ( 4.0A)
TDP  A1001 (-3.3A)
TDP  A1001 (-4.0A)
None
 1.06A 2xadB-2o1xA:
undetectable		 2xadB-2o1xA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Deinococcus
radiodurans) 		4 / 8 ARG A 401
SER A 156
ILE A 371
ASP A  79
 TDP  A1001 ( 4.0A)
TDP  A1001 (-3.3A)
TDP  A1001 (-4.0A)
None
 1.09A 2xadC-2o1xA:
undetectable		 2xadC-2o1xA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Deinococcus
radiodurans) 		4 / 8 ARG A 401
SER A 156
ILE A 371
ASP A  79
 TDP  A1001 ( 4.0A)
TDP  A1001 (-3.3A)
TDP  A1001 (-4.0A)
None
 1.08A 2xadD-2o1xA:
undetectable		 2xadD-2o1xA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 HIS A  51
HIS A 304
HIS A  82
VAL A  80
VAL A 427
 None
TDP  A1001 ( 4.8A)
TDP  A1001 (-3.9A)
TDP  A1001 ( 4.7A)
None
 1.15A 3czvA-2o1xA:
undetectable
3czvB-2o1xA:
undetectable		 3czvA-2o1xA:
18.90
3czvB-2o1xA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		5 / 11 ASP A 433
GLY A 434
GLY A 381
PRO A 359
VAL A 527
 MG  A 613 ( 2.7A)
TDP  A 611 (-3.3A)
TDP  A 611 (-3.4A)
None
None
 1.03A 3el1A-3eyaA:
undetectable		 3el1A-3eyaA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  77
ALA A 154
ASP A 152
GLY A 158
ILE A 150
 None
TDP  A3001 (-3.6A)
MG  A1001 ( 2.7A)
None
None
 1.01A 3nu4A-2o1sA:
undetectable		 3nu4A-2o1sA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  77
ALA A 154
ASP A 152
GLY A 158
ILE A 150
 None
TDP  A3001 (-3.6A)
MG  A1001 ( 2.7A)
None
None
 1.00A 3nuoA-2o1sA:
undetectable		 3nuoA-2o1sA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 11 MET A 161
HIS A  68
GLY A 156
GLY A 193
ASN A 196
 None
TDP  A 701 (-4.0A)
TDP  A 701 ( 3.7A)
None
None
 1.04A 3v3nA-3m49A:
1.1		 3v3nA-3m49A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		5 / 11 MET A 161
HIS A  68
GLY A 156
GLY A 193
ASN A 196
 None
TDP  A 701 (-4.0A)
TDP  A 701 ( 3.7A)
None
None
 1.05A 3v3nD-3m49A:
undetectable		 3v3nD-3m49A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 5 ILE A 168
ALA A 195
HIS A 202
ARG A 242
 None
TDP  A 601 (-3.5A)
None
None
 1.21A 4ac9B-2bfeA:
3.3
4ac9C-2bfeA:
2.8		 4ac9B-2bfeA:
21.70
4ac9C-2bfeA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 5 ILE A 168
ALA A 195
HIS A 202
ARG A 242
 None
TDP  A 601 (-3.5A)
None
None
 1.25A 4acaB-2bfeA:
2.1
4acaC-2bfeA:
3.5		 4acaB-2bfeA:
21.70
4acaC-2bfeA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT
PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT
(Geobacillus
stearothermophil
us;
Geobacillus
stearothermophil
us) 		3 / 3 GLN A 178
ASP B  91
GLN B  96
 TDP  A1370 (-3.9A)
None
None
 0.87A 4aztA-1w85A:
3.4		 4aztA-1w85A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT
(Pseudomonas
putida) 		5 / 12 GLY A 212
GLY A 214
ASP A 213
ALA A 185
TYR A 133
 TDP  A 500 (-3.4A)
TDP  A 500 (-3.5A)
MG  A 501 ( 2.9A)
None
TDP  A 500 (-4.6A)
 0.92A 4lg1A-1qs0A:
undetectable		 4lg1A-1qs0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 GLY A 174
GLY A 176
ASP A 175
ALA A 147
TYR A  95
 TDP  A1402 (-3.2A)
TDP  A1402 (-3.5A)
MG  A1401 ( 2.6A)
None
TDP  A1402 (-4.3A)
 1.06A 4lg1A-1umbA:
undetectable		 4lg1A-1umbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT
(Pseudomonas
putida) 		5 / 12 GLY A 212
GLY A 214
ASP A 213
ALA A 185
TYR A 133
 TDP  A 500 (-3.4A)
TDP  A 500 (-3.5A)
MG  A 501 ( 2.9A)
None
TDP  A 500 (-4.6A)
 0.96A 4lg1C-1qs0A:
undetectable		 4lg1C-1qs0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT
(Thermus
thermophilus) 		5 / 12 GLY A 174
GLY A 176
ASP A 175
ALA A 147
TYR A  95
 TDP  A1402 (-3.2A)
TDP  A1402 (-3.5A)
MG  A1401 ( 2.6A)
None
TDP  A1402 (-4.3A)
 1.09A 4lg1C-1umbA:
undetectable		 4lg1C-1umbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 12 CYH A 219
ALA A 201
GLY A 194
GLY A 192
TYR A 234
 None
None
TDP  A 601 (-3.5A)
TDP  A 601 (-3.4A)
None
 1.06A 4lg1C-2bfeA:
undetectable		 4lg1C-2bfeA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 8 ASP A  77
ALA A 154
ASP A 152
VAL A 176
ILE A 150
 None
TDP  A3001 (-3.6A)
MG  A1001 ( 2.7A)
None
None
 1.43A 4ll3A-2o1sA:
undetectable		 4ll3A-2o1sA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		3 / 3 ASP A 379
TRP A  22
SER A 407
 None
None
TDP  A 611 ( 4.0A)
 1.03A 4lrhA-3eyaA:
undetectable		 4lrhA-3eyaA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 151
ILE A 280
GLN A  81
LEU A  59
THR A 282
 TDP  A3001 (-3.2A)
None
None
None
None
 0.95A 4o5fA-2o1sA:
undetectable
4o5fB-2o1sA:
2.0		 4o5fA-2o1sA:
19.74
4o5fB-2o1sA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLN A  81
LEU A  59
THR A 282
GLY A 151
ILE A 280
 None
None
None
TDP  A3001 (-3.2A)
None
 0.97A 4o5fA-2o1sA:
undetectable
4o5fB-2o1sA:
undetectable		 4o5fA-2o1sA:
19.74
4o5fB-2o1sA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ASP A  77
ALA A 154
ASP A 152
GLY A 158
ILE A 150
 None
TDP  A3001 (-3.6A)
MG  A1001 ( 2.7A)
None
None
 1.03A 4q1wB-2o1sA:
undetectable		 4q1wB-2o1sA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  78
ALA A 154
LEU A 178
ASN A 179
PHE A 277
 None
TDP  A3001 (-3.6A)
None
None
None
 1.48A 4qdcA-2o1sA:
0.0		 4qdcA-2o1sA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT
2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 ALA A 154
GLY B  65
GLN B  97
ILE A 146
ALA A 177
 None
None
None
TDP  A1402 (-4.1A)
TDP  A1402 (-3.9A)
 1.02A 4r29D-1umbA:
undetectable		 4r29D-1umbA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 ASP A  77
ALA A 154
ASP A 152
GLY A 158
ILE A 150
 None
TDP  A3001 (-3.6A)
MG  A1001 ( 2.7A)
None
None
 0.98A 4rvjA-2o1sA:
undetectable		 4rvjA-2o1sA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 ASP A  77
ALA A 154
ASP A 152
GLY A 158
ILE A 150
 None
TDP  A3001 (-3.6A)
MG  A1001 ( 2.7A)
None
None
 0.99A 4rvjC-2o1sA:
undetectable		 4rvjC-2o1sA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Deinococcus
radiodurans) 		5 / 12 GLY A 155
GLY A 153
ASN A 181
ASP A 368
ALA A 193
 TDP  A1001 (-3.6A)
TDP  A1001 (-3.2A)
None
None
None
 1.14A 4uckB-2o1xA:
undetectable		 4uckB-2o1xA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		3 / 3 GLU A  52
ILE A 393
ALA A 427
 None
TDP  A 801 ( 4.1A)
None
 0.57A 4wnwB-2panA:
undetectable		 4wnwB-2panA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]
(Escherichia
coli) 		4 / 7 MET A 438
HIS A 405
GLY A  84
ASN A  83
 TDP  A 611 ( 3.7A)
None
None
None
 1.16A 5a5zC-3eyaA:
undetectable		 5a5zC-3eyaA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 151
ILE A 280
GLN A  81
LEU A  59
THR A 282
 TDP  A3001 (-3.2A)
None
None
None
None
 0.94A 5b8hA-2o1sA:
2.4
5b8hB-2o1sA:
2.9		 5b8hA-2o1sA:
19.13
5b8hB-2o1sA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLN A  81
LEU A  59
THR A 282
GLY A 151
ILE A 280
 None
None
None
TDP  A3001 (-3.2A)
None
 0.96A 5b8hA-2o1sA:
2.4
5b8hB-2o1sA:
2.9		 5b8hA-2o1sA:
19.13
5b8hB-2o1sA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5eeuF-2panA:
undetectable
5eeuG-2panA:
undetectable		 5eeuF-2panA:
9.74
5eeuG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5eeuI-2panA:
undetectable
5eeuJ-2panA:
undetectable		 5eeuI-2panA:
9.74
5eeuJ-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.12A 5eeuO-2panA:
undetectable
5eeuP-2panA:
undetectable		 5eeuO-2panA:
9.74
5eeuP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eeuQ-2panA:
undetectable
5eeuR-2panA:
undetectable		 5eeuQ-2panA:
9.74
5eeuR-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5eevF-2panA:
undetectable
5eevG-2panA:
undetectable		 5eevF-2panA:
9.74
5eevG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.09A 5eevI-2panA:
undetectable
5eevJ-2panA:
undetectable		 5eevI-2panA:
9.74
5eevJ-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eevO-2panA:
undetectable
5eevP-2panA:
undetectable		 5eevO-2panA:
9.74
5eevP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eevQ-2panA:
undetectable
5eevR-2panA:
undetectable		 5eevQ-2panA:
9.74
5eevR-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5eewF-2panA:
undetectable
5eewG-2panA:
undetectable		 5eewF-2panA:
9.74
5eewG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 12 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.09A 5eewI-2panA:
undetectable
5eewJ-2panA:
undetectable		 5eewI-2panA:
9.74
5eewJ-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.12A 5eewO-2panA:
undetectable
5eewP-2panA:
undetectable		 5eewO-2panA:
9.74
5eewP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eewQ-2panA:
undetectable
5eewR-2panA:
undetectable		 5eewQ-2panA:
9.74
5eewR-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5eexF-2panA:
undetectable
5eexG-2panA:
undetectable		 5eexF-2panA:
9.74
5eexG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.12A 5eexO-2panA:
undetectable
5eexP-2panA:
undetectable		 5eexO-2panA:
9.74
5eexP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.11A 5eeyF-2panA:
undetectable
5eeyG-2panA:
undetectable		 5eeyF-2panA:
9.74
5eeyG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eeyO-2panA:
undetectable
5eeyP-2panA:
undetectable		 5eeyO-2panA:
9.74
5eeyP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.11A 5eezF-2panA:
undetectable
5eezG-2panA:
undetectable		 5eezF-2panA:
9.74
5eezG-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5eezO-2panA:
undetectable
5eezP-2panA:
undetectable		 5eezO-2panA:
9.74
5eezP-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.10A 5ef0F-2panA:
undetectable
5ef0G-2panA:
undetectable		 5ef0F-2panA:
9.74
5ef0G-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5ef0O-2panA:
undetectable
5ef0P-2panA:
undetectable		 5ef0O-2panA:
9.74
5ef0P-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.11A 5ef1F-2panA:
undetectable
5ef1G-2panA:
undetectable		 5ef1F-2panA:
9.74
5ef1G-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 GLY A 394
ALA A 399
THR A 259
THR A 391
ALA A 400
 TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
None
None
 1.13A 5ef1O-2panA:
undetectable
5ef1P-2panA:
undetectable		 5ef1O-2panA:
9.74
5ef1P-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.11A 5ef2F-2panA:
undetectable
5ef2G-2panA:
undetectable		 5ef2F-2panA:
9.74
5ef2G-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2pan GLYOXYLATE
CARBOLIGASE
(Escherichia
coli) 		5 / 10 THR A 391
ALA A 400
GLY A 394
ALA A 399
THR A 259
 None
None
TDP  A 801 (-3.6A)
None
FAD  A 701 (-3.2A)
 1.11A 5ef3F-2panA:
undetectable
5ef3G-2panA:
undetectable		 5ef3F-2panA:
9.74
5ef3G-2panA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3m49 TRANSKETOLASE
(Bacillus
anthracis) 		3 / 3 HIS A  68
HIS A 102
ARG A  93
 TDP  A 701 (-4.0A)
None
None
 1.00A 6b58A-3m49A:
4.0		 6b58A-3m49A:
23.31