SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TDK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 6 ILE A 624
TYR A 599
MET A 528
ILE A 519
 None
TDK  A 887 (-4.3A)
None
None
 1.20A 3eteA-2g28A:
3.1
3eteE-2g28A:
2.4		 3eteA-2g28A:
21.87
3eteE-2g28A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		4 / 5 ILE A 624
TYR A 599
MET A 528
ILE A 519
 None
TDK  A 887 (-4.3A)
None
None
 1.15A 3eteB-2g28A:
2.4
3eteC-2g28A:
3.2		 3eteB-2g28A:
21.87
3eteC-2g28A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		5 / 11 PHE A 807
SER A 657
GLU A 522
TYR A 598
GLY A 625
 None
None
TDK  A 887 (-4.3A)
None
None
 1.20A 4qb9F-2g28A:
undetectable		 4qb9F-2g28A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		3 / 3 SER A 600
TYR A 599
TYR A 598
 None
TDK  A 887 (-4.3A)
None
 0.53A 5lakA-2g28A:
undetectable
5lakI-2g28A:
undetectable		 5lakA-2g28A:
16.07
5lakI-2g28A:
0.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT
(Escherichia
coli) 		3 / 3 SER A 600
TYR A 599
TYR A 598
 None
TDK  A 887 (-4.3A)
None
 0.54A 5lakC-2g28A:
undetectable
5lakJ-2g28A:
undetectable		 5lakC-2g28A:
16.07
5lakJ-2g28A:
0.66