SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TDC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		5 / 11 ILE A  99
ARG A  94
VAL A 145
LEU A  60
ALA A  89
 None
None
None
TDC  A 301 ( 4.9A)
None
 1.18A 1n4hA-5mruA:
undetectable		 1n4hA-5mruA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 12 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 0.66A 2fj1A-5mruA:
23.8		 2fj1A-5mruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		8 / 12 HIS A  64
SER A  67
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.83A 2fj1A-5mruA:
23.8		 2fj1A-5mruA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		5 / 12 HIS A  64
SER A  67
ASN A  82
HIS A 100
ILE A 137
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
MG  A 302 ( 3.2A)
TDC  A 301 ( 4.5A)
 1.39A 2o7oA-5mruA:
23.8		 2o7oA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		9 / 12 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 0.66A 2o7oA-5mruA:
23.8		 2o7oA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		9 / 12 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.72A 2o7oA-5mruA:
23.8		 2o7oA-5mruA:
47.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 12 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 0.60A 2tctA-5mruA:
23.8		 2tctA-5mruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 12 HIS A  64
SER A  67
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 0.65A 2tctA-5mruA:
23.8		 2tctA-5mruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 12 HIS A  64
SER A  67
PHE A  86
PRO A 105
THR A 112
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.3A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.84A 2tctA-5mruA:
23.8		 2tctA-5mruA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 11 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
TDC  A 301 (-2.8A)
 0.54A 2trtA-5mruA:
23.9		 2trtA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 11 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.62A 2trtA-5mruA:
23.9		 2trtA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		5 / 11 HIS A  64
SER A  67
ASN A  82
HIS A 100
ILE A 137
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
MG  A 302 ( 3.2A)
TDC  A 301 ( 4.5A)
 1.42A 2trtA-5mruA:
23.9		 2trtA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 11 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.73A 2trtA-5mruA:
23.9		 2trtA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		5 / 11 HIS A  64
SER A  67
ASN A  82
HIS A 100
ILE A 137
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
MG  A 302 ( 3.2A)
TDC  A 301 ( 4.5A)
 1.32A 2vkeA-5mruA:
24.0		 2vkeA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		8 / 11 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
TDC  A 301 (-2.8A)
 0.65A 2vkeA-5mruA:
24.0		 2vkeA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		8 / 11 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
PRO A 105
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.70A 2vkeA-5mruA:
24.0		 2vkeA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		5 / 12 HIS A  64
SER A  67
ASN A  82
HIS A 100
ILE A 137
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
MG  A 302 ( 3.2A)
TDC  A 301 ( 4.5A)
 1.46A 2xpvA-5mruA:
24.0		 2xpvA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		9 / 12 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 0.69A 2xpvA-5mruA:
24.0		 2xpvA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		9 / 12 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.77A 2xpvA-5mruA:
24.0		 2xpvA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		6 / 12 LEU A  60
HIS A  64
SER A  67
ASN A  82
HIS A 100
ILE A 137
 TDC  A 301 ( 4.9A)
TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
MG  A 302 ( 3.2A)
TDC  A 301 ( 4.5A)
 1.43A 2xpwA-5mruA:
23.4		 2xpwA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		9 / 12 LEU A  60
HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 116
 TDC  A 301 ( 4.9A)
TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
TDC  A 301 (-2.8A)
 0.68A 2xpwA-5mruA:
23.4		 2xpwA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		9 / 12 LEU A  60
HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
PRO A 105
GLN A 116
SER A 138
 TDC  A 301 ( 4.9A)
TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.70A 2xpwA-5mruA:
23.4		 2xpwA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		5 / 12 HIS A  64
SER A  67
ASN A  82
HIS A 100
ILE A 137
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
MG  A 302 ( 3.2A)
TDC  A 301 ( 4.5A)
 1.31A 2xrlA-5mruA:
23.2		 2xrlA-5mruA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		9 / 12 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.81A 2xrlA-5mruA:
23.2		 2xrlA-5mruA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		6 / 12 HIS A  64
SER A  67
ASN A  82
THR A 112
GLN A 116
LEU A 117
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
None
TDC  A 301 (-2.8A)
None
 0.61A 2xrlA-5mruA:
23.2		 2xrlA-5mruA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		9 / 12 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.78A 4abzA-5mruA:
23.2		 4abzA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		5 / 12 SER A  67
ARG A 104
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.3A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 1.03A 4abzA-5mruA:
23.2		 4abzA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		6 / 12 HIS A  64
ASN A  82
ARG A 104
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 0.94A 4ac0A-5mruA:
24.9		 4ac0A-5mruA:
44.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 0.68A 4ac0A-5mruA:
24.9		 4ac0A-5mruA:
44.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 12 LEU A  60
HIS A  64
ASN A  82
PHE A  86
ARG A 104
PRO A 105
GLN A 116
 TDC  A 301 ( 4.9A)
TDC  A 301 (-3.8A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
TDC  A 301 (-2.8A)
 0.58A 4b3aA-5mruA:
24.0		 4b3aA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 12 LEU A  60
HIS A  64
ASN A  82
PHE A  86
PRO A 105
GLN A 116
SER A 138
 TDC  A 301 ( 4.9A)
TDC  A 301 (-3.8A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
TDC  A 301 (-4.5A)
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.68A 4b3aA-5mruA:
24.0		 4b3aA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		5 / 12 LEU A  60
HIS A  64
SER A  67
ASN A  82
ILE A 137
 TDC  A 301 ( 4.9A)
TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 ( 4.5A)
 1.33A 4b3aA-5mruA:
24.0		 4b3aA-5mruA:
47.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		7 / 12 LEU A  60
HIS A  64
SER A  67
ASN A  82
PHE A  86
GLN A 116
SER A 138
 TDC  A 301 ( 4.9A)
TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.73A 4b3aA-5mruA:
24.0		 4b3aA-5mruA:
47.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		8 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 0.61A 4v2gB-5mruA:
23.2		 4v2gB-5mruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		5 / 12 HIS A  64
SER A  67
ASN A  82
HIS A 100
ILE A 137
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
MG  A 302 ( 3.2A)
TDC  A 301 ( 4.5A)
 1.43A 4v2gB-5mruA:
23.2		 4v2gB-5mruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		9 / 12 HIS A  64
SER A  67
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.2A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.75A 4v2gB-5mruA:
23.2		 4v2gB-5mruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 5mru TETRACYCLINE
REPRESSOR, CLASS A
(Pseudomonas
sp.) 		5 / 10 THR A 136
ILE A 137
LEU A 191
PHE A 140
GLY A 197
 None
TDC  A 301 ( 4.5A)
None
None
None
 1.11A 5mxbA-5mruA:
undetectable		 5mxbA-5mruA:
12.20