SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TD2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5h9p GALECTIN-3
(Homo
sapiens) 		5 / 12 PHE A 192
ARG A 144
ILE A 145
ASN A 160
PHE A 163
 None
TD2  A 301 (-3.5A)
None
TD2  A 301 (-4.0A)
None
 1.45A 2vdyB-5h9pA:
undetectable		 2vdyB-5h9pA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 5h9p GALECTIN-3
(Homo
sapiens) 		6 / 6 HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
 TD2  A 301 (-3.8A)
TD2  A 301 (-4.0A)
TD2  A 301 (-2.8A)
TD2  A 301 (-3.8A)
TD2  A 301 ( 3.7A)
TD2  A 301 (-2.9A)
 0.19A 3galA-5h9pA:
23.0		 3galA-5h9pA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5h9p GALECTIN-3
(Homo
sapiens) 		6 / 6 HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
 TD2  A 301 (-3.8A)
TD2  A 301 (-4.0A)
TD2  A 301 (-2.8A)
TD2  A 301 (-3.8A)
TD2  A 301 ( 3.7A)
TD2  A 301 (-2.9A)
 0.31A 3galB-5h9pA:
23.2		 3galB-5h9pA:
35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VXI_A_ASCA502_0
(DYP)		 5h9p GALECTIN-3
(Homo
sapiens) 		4 / 5 ALA A 146
ARG A 144
PRO A 161
HIS A 158
 TD2  A 301 (-3.2A)
TD2  A 301 (-3.5A)
None
TD2  A 301 (-3.8A)
 1.06A 3vxiA-5h9pA:
undetectable		 3vxiA-5h9pA:
16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5h9p GALECTIN-3
(Homo
sapiens) 		4 / 7 ARG A 186
ASN A 166
GLU A 165
ARG A 162
 TD2  A 301 (-3.9A)
None
TD2  A 301 ( 4.9A)
TD2  A 301 (-2.8A)
 1.29A 6b8kA-5h9pA:
29.6		 6b8kA-5h9pA:
80.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5h9p GALECTIN-3
(Homo
sapiens) 		7 / 7 HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
ARG A 186
 TD2  A 301 (-3.8A)
TD2  A 301 (-4.0A)
TD2  A 301 (-2.8A)
TD2  A 301 (-3.8A)
TD2  A 301 ( 3.7A)
TD2  A 301 (-2.9A)
TD2  A 301 (-3.9A)
 0.13A 6b8kA-5h9pA:
29.6		 6b8kA-5h9pA:
80.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 5h9p GALECTIN-3
(Homo
sapiens) 		7 / 8 HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
ARG A 186
 TD2  A 301 (-3.8A)
TD2  A 301 (-4.0A)
TD2  A 301 (-2.8A)
TD2  A 301 (-3.8A)
TD2  A 301 ( 3.7A)
TD2  A 301 (-2.9A)
TD2  A 301 (-3.9A)
 0.45A 6b94A-5h9pA:
19.8		 6b94A-5h9pA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 5h9p GALECTIN-3
(Homo
sapiens) 		7 / 10 HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
ARG A 186
 TD2  A 301 (-3.8A)
TD2  A 301 (-4.0A)
TD2  A 301 (-2.8A)
TD2  A 301 (-3.8A)
TD2  A 301 ( 3.7A)
TD2  A 301 (-2.9A)
TD2  A 301 (-3.9A)
 0.38A 6b94A-5h9pA:
19.8
6b94B-5h9pA:
19.3		 6b94A-5h9pA:
32.43
6b94B-5h9pA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FK2_A_SORA302_0
(GALECTIN-3)		 5h9p GALECTIN-3
(Homo
sapiens) 		4 / 4 ARG A 162
GLU A 165
GLU A 184
ARG A 186
 TD2  A 301 (-2.8A)
TD2  A 301 ( 4.9A)
TD2  A 301 (-2.9A)
TD2  A 301 (-3.9A)
 0.12A 6fk2A-5h9pA:
29.8		 6fk2A-5h9pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FK2_A_SORA302_0
(GALECTIN-3)		 5h9p GALECTIN-3
(Homo
sapiens) 		4 / 4 ARG A 186
GLU A 184
GLU A 165
ARG A 162
 TD2  A 301 (-3.9A)
TD2  A 301 (-2.9A)
TD2  A 301 ( 4.9A)
TD2  A 301 (-2.8A)
 1.07A 6fk2A-5h9pA:
29.8		 6fk2A-5h9pA:
100.00