SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TCR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 ILE B 223
GLY B 219
SER B 170
TYR B 489
MET B 197
 None
None
TCR  B 609 (-2.8A)
None
None
 1.25A 1fm6X-5fbhB:
undetectable		 1fm6X-5fbhB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 GLY B 143
GLY B  36
ASN B 419
ALA B 168
THR B 111
 None
None
None
TCR  B 609 (-4.1A)
None
 1.20A 2vdvE-5fbhB:
undetectable		 2vdvE-5fbhB:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 11 GLY B 143
GLY B  36
ASN B 419
ALA B 168
THR B 111
 None
None
None
TCR  B 609 (-4.1A)
None
 1.20A 2vdvF-5fbhB:
undetectable		 2vdvF-5fbhB:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		4 / 5 ARG B  66
ILE B 416
TYR B 167
THR B 186
 TCR  B 609 ( 3.6A)
BCT  B 604 (-4.5A)
None
None
 1.49A 3dgqA-5fbhB:
undetectable		 3dgqA-5fbhB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 SER B 170
LEU B 276
ASP B 275
SER B 296
ILE B 305
 TCR  B 609 (-2.8A)
None
None
None
None
 1.23A 3ko0M-5fbhB:
undetectable
3ko0N-5fbhB:
undetectable
3ko0O-5fbhB:
undetectable
3ko0P-5fbhB:
undetectable		 3ko0M-5fbhB:
10.00
3ko0N-5fbhB:
10.00
3ko0O-5fbhB:
10.00
3ko0P-5fbhB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 10 SER B 170
SER B 296
ILE B 305
LEU B 276
ASP B 275
 TCR  B 609 (-2.8A)
None
None
None
None
 1.25A 3m0wC-5fbhB:
undetectable
3m0wD-5fbhB:
undetectable
3m0wE-5fbhB:
undetectable
3m0wF-5fbhB:
undetectable		 3m0wC-5fbhB:
9.68
3m0wD-5fbhB:
9.68
3m0wE-5fbhB:
9.68
3m0wF-5fbhB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		4 / 8 SER B 170
SER B 296
LEU B 276
ASP B 275
 TCR  B 609 (-2.8A)
None
None
None
 0.86A 3m0wE-5fbhB:
undetectable
3m0wF-5fbhB:
undetectable
3m0wG-5fbhB:
undetectable
3m0wH-5fbhB:
undetectable		 3m0wE-5fbhB:
9.68
3m0wF-5fbhB:
9.68
3m0wG-5fbhB:
9.68
3m0wH-5fbhB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_F_P77F203_1
(PROTEIN S100-A4)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 9 LEU B 276
ASP B 275
SER B 296
ILE B 305
SER B 170
 None
None
None
None
TCR  B 609 (-2.8A)
 1.27A 3m0wC-5fbhB:
undetectable
3m0wD-5fbhB:
undetectable
3m0wE-5fbhB:
undetectable
3m0wF-5fbhB:
undetectable		 3m0wC-5fbhB:
9.68
3m0wD-5fbhB:
9.68
3m0wE-5fbhB:
9.68
3m0wF-5fbhB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 10 LEU B 276
ASP B 275
SER B 296
ILE B 305
SER B 170
 None
None
None
None
TCR  B 609 (-2.8A)
 1.35A 3m0wE-5fbhB:
undetectable
3m0wF-5fbhB:
undetectable
3m0wG-5fbhB:
undetectable
3m0wH-5fbhB:
undetectable		 3m0wE-5fbhB:
9.68
3m0wF-5fbhB:
9.68
3m0wG-5fbhB:
9.68
3m0wH-5fbhB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 10 LEU B 276
ASP B 275
SER B 296
ILE B 305
SER B 170
 None
None
None
None
TCR  B 609 (-2.8A)
 1.33A 3m0wA-5fbhB:
undetectable
3m0wB-5fbhB:
undetectable
3m0wI-5fbhB:
undetectable
3m0wJ-5fbhB:
undetectable		 3m0wA-5fbhB:
9.68
3m0wB-5fbhB:
9.68
3m0wI-5fbhB:
9.68
3m0wJ-5fbhB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 PHE B 183
ILE B 187
GLY B 148
ALA B 168
THR B 145
 None
None
None
TCR  B 609 (-4.1A)
CL  B 605 ( 3.9A)
 1.13A 4enhA-5fbhB:
undetectable		 4enhA-5fbhB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 11 ARG B 185
ALA B 168
VAL B 420
MET B  74
ILE B 427
 None
TCR  B 609 (-4.1A)
None
None
None
 1.26A 4j4vA-5fbhB:
undetectable		 4j4vA-5fbhB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		6 / 12 GLY B  67
ALA B 168
TYR B 167
ALA B 144
ASP B  99
GLY B 219
 None
TCR  B 609 (-4.1A)
None
CL  B 605 ( 3.8A)
None
None
 1.35A 5hesB-5fbhB:
undetectable		 5hesB-5fbhB:
20.60