SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TCL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifA-3am3A:
4.4		 1kifA-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifA-3f4bA:
3.8		 1kifA-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifB-3am3A:
4.4		 1kifB-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifB-3f4bA:
3.9		 1kifB-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifC-3am3A:
4.4		 1kifC-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifC-3f4bA:
3.8		 1kifC-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifD-3am3A:
4.4		 1kifD-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifD-3f4bA:
4.4		 1kifD-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifE-3am3A:
4.4		 1kifE-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifE-3f4bA:
3.9		 1kifE-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifF-3am3A:
4.5		 1kifF-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifF-3f4bA:
3.8		 1kifF-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifG-3am3A:
4.5		 1kifG-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifG-3f4bA:
3.9		 1kifG-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifH-3am3A:
4.4		 1kifH-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifH-3f4bA:
4.5		 1kifH-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 1.01A 1ve9A-3am3A:
4.4		 1ve9A-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.12A 1ve9A-3f4bA:
4.5		 1ve9A-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 8 TYR A 277
PHE A 368
ALA A 319
MET A 372
 TCL  A 802 (-4.4A)
TCL  A 802 (-4.8A)
TCL  A 802 ( 3.3A)
None
 1.08A 1x8vA-3am3A:
undetectable		 1x8vA-3am3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 1.03A 2du8G-3am3A:
4.5		 2du8G-3am3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.11A 2du8G-3f4bA:
4.5		 2du8G-3f4bA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 1.04A 2du8J-3am3A:
4.4		 2du8J-3am3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE
(Plasmodium
berghei) 		4 / 5 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.12A 2du8J-3f4bA:
4.4		 2du8J-3f4bA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3p9t REPRESSOR
(Stenotrophomonas
maltophilia) 		4 / 6 LEU A  74
MET A 110
MET A 113
LEU A 174
 None
TCL  A 221 ( 3.4A)
TCL  A 222 ( 4.7A)
None
 1.38A 2oz7A-3p9tA:
undetectable		 2oz7A-3p9tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 7 PHE A 368
THR A 367
ASN A 324
ILE A 323
 TCL  A 802 (-4.8A)
None
None
None
 0.97A 3t01A-3am3A:
undetectable		 3t01A-3am3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		5 / 9 ALA A 284
ALA A 219
GLY A 280
GLY A 233
SER A 239
 None
TCL  A 802 (-3.8A)
None
None
None
 1.21A 6bklE-3am3A:
undetectable
6bklF-3am3A:
undetectable
6bklG-3am3A:
undetectable
6bklH-3am3A:
undetectable		 6bklE-3am3A:
3.95
6bklF-3am3A:
3.95
6bklG-3am3A:
3.95
6bklH-3am3A:
3.95