SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TCK'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K4V_D_ROCD201_2 (HIV-1 PROTEASE)	4tkx	LYS-GINGIPAIN W83 (Porphyromonas gingivalis)	4 / 4	GLY L 474 ASP L 516 GLY L 560 THR L 544	None TCK L 720 (-3.0A) None None	1.02A	3k4vC-4tkxL: undetectable	3k4vC-4tkxL: 15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y80_A_IREA402_0 (CYCLIN-G-ASSOCIATED KINASE)	4tkx	LYS-GINGIPAIN W83 (Porphyromonas gingivalis)	5 / 11	ALA L 584 SER L 511 VAL L 521 ASN L 475 THR L 442	None TCK L 720 (-2.6A) NA L 706 (-4.9A) None TCK L 720 (-3.5A)	0.96A	5y80A-4tkxL: undetectable	5y80A-4tkxL: 10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN4_A_AM2A301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	4tkx	LYS-GINGIPAIN W83 (Porphyromonas gingivalis)	4 / 8	ASP L 388 HIS L 444 ASP L 516 GLU L 515	K L 707 (-3.0A) TCK L 720 ( 3.6A) TCK L 720 (-3.0A) None	1.17A	6mn4A-4tkxL: undetectable	6mn4A-4tkxL: 20.05