SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TCG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		4 / 5 HIS A 246
ASP A 299
HIS A 303
ASP A 367
 None
None
TCG  A 601 (-4.1A)
TCG  A 601 (-3.2A)
 1.17A 3c0zA-3vtrA:
undetectable		 3c0zA-3vtrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		4 / 6 HIS A 246
ASP A 299
HIS A 303
ASP A 367
 None
None
TCG  A 601 (-4.1A)
TCG  A 601 (-3.2A)
 1.17A 3c0zC-3vtrA:
undetectable		 3c0zC-3vtrA:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		10 / 12 ARG A 220
HIS A 246
ASP A 249
ASP A 299
HIS A 303
TRP A 448
TYR A 475
ASP A 477
TRP A 524
GLU A 526
 TCG  A 601 (-2.7A)
None
TCG  A 601 ( 4.9A)
None
TCG  A 601 (-4.1A)
TCG  A 601 (-4.0A)
TCG  A 601 (-4.7A)
TCG  A 601 (-3.2A)
TCG  A 601 (-3.8A)
TCG  A 601 (-2.7A)
 0.45A 3lmyA-3vtrA:
39.5		 3lmyA-3vtrA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		9 / 12 HIS A 246
ASP A 249
ASP A 299
HIS A 303
ASP A 367
TYR A 475
ASP A 477
TRP A 524
GLU A 526
 None
TCG  A 601 ( 4.9A)
None
TCG  A 601 (-4.1A)
TCG  A 601 (-3.2A)
TCG  A 601 (-4.7A)
TCG  A 601 (-3.2A)
TCG  A 601 (-3.8A)
TCG  A 601 (-2.7A)
 0.53A 3lmyA-3vtrA:
39.5		 3lmyA-3vtrA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		10 / 12 ARG A 220
HIS A 246
ASP A 249
ASP A 299
HIS A 303
ASP A 367
TRP A 424
TYR A 475
TRP A 524
GLU A 526
 TCG  A 601 (-2.7A)
None
TCG  A 601 ( 4.9A)
None
TCG  A 601 (-4.1A)
TCG  A 601 (-3.2A)
None
TCG  A 601 (-4.7A)
TCG  A 601 (-3.8A)
TCG  A 601 (-2.7A)
 0.65A 3lmyB-3vtrA:
39.4		 3lmyB-3vtrA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		10 / 12 ARG A 220
HIS A 246
ASP A 249
ASP A 299
HIS A 303
TRP A 424
TRP A 448
TYR A 475
TRP A 524
GLU A 526
 TCG  A 601 (-2.7A)
None
TCG  A 601 ( 4.9A)
None
TCG  A 601 (-4.1A)
None
TCG  A 601 (-4.0A)
TCG  A 601 (-4.7A)
TCG  A 601 (-3.8A)
TCG  A 601 (-2.7A)
 0.55A 3lmyB-3vtrA:
39.4		 3lmyB-3vtrA:
31.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		5 / 12 ASN A 221
SER A 525
GLU A 526
ASP A 217
PRO A 330
 None
None
TCG  A 601 (-2.7A)
None
None
 1.46A 3lpsA-3vtrA:
undetectable		 3lpsA-3vtrA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		5 / 12 HIS A 244
GLU A 297
TYR A 475
TRP A 524
ALA A 522
 None
None
TCG  A 601 (-4.7A)
TCG  A 601 (-3.8A)
None
 1.00A 4jd1A-3vtrA:
undetectable
4jd1B-3vtrA:
undetectable		 4jd1A-3vtrA:
15.76
4jd1B-3vtrA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		5 / 12 HIS A 244
GLU A 297
TYR A 475
TRP A 524
ALA A 522
 None
None
TCG  A 601 (-4.7A)
TCG  A 601 (-3.8A)
None
 1.01A 4jh3A-3vtrA:
undetectable
4jh3B-3vtrA:
undetectable		 4jh3A-3vtrA:
13.01
4jh3B-3vtrA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		3 / 3 HIS A 303
TRP A 448
SER A 250
 TCG  A 601 (-4.1A)
TCG  A 601 (-4.0A)
None
 1.05A 4lrhD-3vtrA:
undetectable		 4lrhD-3vtrA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		5 / 12 LEU A 334
ARG A 220
GLY A 332
HIS A 246
ASP A 299
 None
TCG  A 601 (-2.7A)
None
None
None
 1.03A 5csyB-3vtrA:
11.0		 5csyB-3vtrA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		5 / 9 GLY A 366
GLY A 365
VAL A 369
HIS A 303
ASP A 249
 None
None
None
TCG  A 601 (-4.1A)
TCG  A 601 ( 4.9A)
 1.49A 5f8yA-3vtrA:
undetectable		 5f8yA-3vtrA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3vtr N-ACETYLGLUCOSAMINID
ASE
(Ostrinia
furnacalis) 		5 / 8 GLY A 366
GLY A 365
VAL A 369
HIS A 303
ASP A 249
 None
None
None
TCG  A 601 (-4.1A)
TCG  A 601 ( 4.9A)
 1.44A 5f8yB-3vtrA:
undetectable		 5f8yB-3vtrA:
12.89