SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TC0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		7 / 12 GLY A  11
ALA A  31
VAL A  64
VAL A  83
ASN A 131
LEU A 133
ASP A 144
 TC0  A 500 ( 4.2A)
TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-4.4A)
None
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.71A 1fmoE-4bbmA:
23.3		 1fmoE-4bbmA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
VAL A  64
VAL A  83
ASN A 131
LEU A 133
ASP A 144
 None
TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-4.4A)
None
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.71A 1fmoE-4bbmA:
23.3		 1fmoE-4bbmA:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		7 / 12 VAL A  18
VAL A  64
PHE A  80
VAL A  83
ASN A 131
LEU A 133
ASP A 144
 None
TC0  A 500 (-4.7A)
TC0  A 500 (-3.4A)
TC0  A 500 (-4.4A)
None
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.56A 2eufB-4bbmA:
27.0		 2eufB-4bbmA:
35.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		6 / 12 TYR A  15
VAL A  18
ALA A  31
VAL A  64
PHE A  82
LEU A 133
 TC0  A 500 (-4.0A)
None
TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-4.2A)
TC0  A 500 (-4.3A)
 0.53A 2hyyC-4bbmA:
22.2		 2hyyC-4bbmA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		5 / 12 ALA A  31
LEU A  63
VAL A  64
HIS A 124
LEU A 133
 TC0  A 500 (-3.5A)
None
TC0  A 500 (-4.7A)
None
TC0  A 500 (-4.3A)
 0.69A 3ik3A-4bbmA:
21.5		 3ik3A-4bbmA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		5 / 9 ALA A  31
VAL A  64
PHE A  80
PHE A  82
LEU A 133
 TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-3.4A)
TC0  A 500 (-4.2A)
TC0  A 500 (-4.3A)
 0.61A 3ti1A-4bbmA:
29.3		 3ti1A-4bbmA:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		5 / 9 ALA A  31
VAL A  64
PHE A  82
LEU A 133
ASP A 144
 TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-4.2A)
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.77A 3ti1A-4bbmA:
29.3		 3ti1A-4bbmA:
40.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		4 / 8 VAL A  64
LEU A 133
CYH A 143
ASP A 144
 TC0  A 500 (-4.7A)
TC0  A 500 (-4.3A)
TC0  A 500 ( 3.9A)
TC0  A 500 (-4.8A)
 0.68A 3wzeA-4bbmA:
21.0		 3wzeA-4bbmA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		5 / 6 GLY A  11
VAL A  10
ALA A  31
THR A  86
LEU A 133
 TC0  A 500 ( 4.2A)
None
TC0  A 500 (-3.5A)
TC0  A 500 ( 4.5A)
TC0  A 500 (-4.3A)
 1.19A 4o0wA-4bbmA:
24.7		 4o0wA-4bbmA:
27.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		5 / 8 VAL A  18
ALA A  31
ASN A 131
LEU A 133
ASP A 144
 None
TC0  A 500 (-3.5A)
None
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.57A 4ogrA-4bbmA:
27.8		 4ogrA-4bbmA:
34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 133
ASP A 144
 None
TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-3.4A)
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.58A 5l2iA-4bbmA:
13.2		 5l2iA-4bbmA:
33.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 133
ASP A 144
 None
TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-3.4A)
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.71A 5l2tA-4bbmA:
13.9		 5l2tA-4bbmA:
33.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		5 / 12 ALA A  31
LEU A  63
VAL A  64
HIS A 124
LEU A 133
 TC0  A 500 (-3.5A)
None
TC0  A 500 (-4.7A)
None
TC0  A 500 (-4.3A)
 0.73A 5mo4A-4bbmA:
19.4		 5mo4A-4bbmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		4 / 6 ASN A 112
VAL A 140
LEU A 133
GLN A 109
 None
None
TC0  A 500 (-4.3A)
None
 1.22A 5xdhA-4bbmA:
undetectable
5xdhC-4bbmA:
0.1		 5xdhA-4bbmA:
14.83
5xdhC-4bbmA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		4 / 6 GLN A 109
ASN A 112
VAL A 140
LEU A 133
 None
None
None
TC0  A 500 (-4.3A)
 1.07A 5xdhA-4bbmA:
undetectable
5xdhC-4bbmA:
0.1		 5xdhA-4bbmA:
14.83
5xdhC-4bbmA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2
(Homo
sapiens) 		4 / 6 GLN A 109
HIS A 124
VAL A 140
LEU A 133
 None
None
None
TC0  A 500 (-4.3A)
 1.22A 5xdhA-4bbmA:
undetectable
5xdhC-4bbmA:
0.1		 5xdhA-4bbmA:
14.83
5xdhC-4bbmA:
14.83