SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TB6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5u5d (S)-2-HYDROXYPROPYLP
HOSPHONIC ACID
EPOXIDASE
(Pseudomonas
syringae) 		5 / 12 LEU A 112
PHE A 173
LEU A 157
HIS A 171
GLU A 132
 TB6  A 302 (-4.2A)
TB6  A 302 (-4.9A)
None
MN  A 301 ( 3.6A)
MN  A 301 ( 2.5A)
 1.35A 1mmkA-5u5dA:
undetectable		 1mmkA-5u5dA:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BNN_A_FCNA1199_1
(EPOXIDASE)		 5u5d (S)-2-HYDROXYPROPYLP
HOSPHONIC ACID
EPOXIDASE
(Pseudomonas
syringae) 		8 / 9 ARG A  87
TYR A  95
LEU A 110
ASN A 125
HIS A 128
GLU A 132
HIS A 171
ALA A 186
 TB6  A 302 (-3.0A)
TB6  A 302 (-4.3A)
None
TB6  A 302 (-3.9A)
MN  A 301 ( 3.5A)
MN  A 301 ( 2.5A)
MN  A 301 ( 3.6A)
TB6  A 302 ( 3.8A)
 0.42A 2bnnA-5u5dA:
19.1
2bnnB-5u5dA:
17.6		 2bnnA-5u5dA:
30.35
2bnnB-5u5dA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5u5d (S)-2-HYDROXYPROPYLP
HOSPHONIC ACID
EPOXIDASE
(Pseudomonas
syringae) 		4 / 8 TYR A  93
HIS A 128
GLU A 132
ALA A 186
 TB6  A 302 ( 4.6A)
MN  A 301 ( 3.5A)
MN  A 301 ( 2.5A)
TB6  A 302 ( 3.8A)
 0.76A 2bnnA-5u5dA:
19.1
2bnnB-5u5dA:
17.6		 2bnnA-5u5dA:
30.35
2bnnB-5u5dA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5u5d (S)-2-HYDROXYPROPYLP
HOSPHONIC ACID
EPOXIDASE
(Pseudomonas
syringae) 		7 / 8 TYR A  95
LEU A 110
ASN A 125
HIS A 128
GLU A 132
HIS A 171
ALA A 186
 TB6  A 302 (-4.3A)
None
TB6  A 302 (-3.9A)
MN  A 301 ( 3.5A)
MN  A 301 ( 2.5A)
MN  A 301 ( 3.6A)
TB6  A 302 ( 3.8A)
 0.44A 2bnnA-5u5dA:
19.1
2bnnB-5u5dA:
17.6		 2bnnA-5u5dA:
30.35
2bnnB-5u5dA:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5u5d (S)-2-HYDROXYPROPYLP
HOSPHONIC ACID
EPOXIDASE
(Pseudomonas
syringae) 		4 / 5 LEU A 112
HIS A 171
GLU A 132
HIS A 128
 TB6  A 302 (-4.2A)
MN  A 301 ( 3.6A)
MN  A 301 ( 2.5A)
MN  A 301 ( 3.5A)
 1.16A 4a7bB-5u5dA:
undetectable		 4a7bB-5u5dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5u5d (S)-2-HYDROXYPROPYLP
HOSPHONIC ACID
EPOXIDASE
(Pseudomonas
syringae) 		4 / 7 ASN A 125
LEU A 124
ARG A  87
LEU A 122
 TB6  A 302 (-3.9A)
None
TB6  A 302 (-3.0A)
None
 0.82A 4wg0L-5u5dA:
undetectable
4wg0M-5u5dA:
undetectable		 4wg0L-5u5dA:
10.48
4wg0M-5u5dA:
10.48