SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TAM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 HIS A  40
PHE A 219
HIS A 151
ASP A  43
ASP A  42
 CD  A 301 ( 3.4A)
HEZ  A 315 ( 4.4A)
CD  A 301 ( 3.5A)
CD  A 301 ( 2.1A)
TAM  A 309 (-2.7A)
 1.04A 1a4lC-3wl4A:
undetectable		 1a4lC-3wl4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.84A 1a7yA-5mqzA:
undetectable		 1a7yA-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.86A 1a7yB-5mqzA:
undetectable		 1a7yB-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 THR A  68
ASP A 150
HIS A 148
HIS A  40
 None
None
TAM  A 309 (-4.8A)
CD  A 301 ( 3.4A)
 1.16A 1ei6A-3wl4A:
undetectable		 1ei6A-3wl4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.88A 1i3wE-5mqzA:
undetectable		 1i3wE-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.81A 1i3wE-5mqzA:
undetectable		 1i3wE-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.86A 1i3wF-5mqzA:
undetectable		 1i3wF-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.86A 1i3wG-5mqzA:
undetectable		 1i3wG-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.83A 1i3wH-5mqzA:
undetectable		 1i3wH-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 TYR A 169
VAL A   8
ASP A  62
ALA A 146
SER A 145
 TAM  A 201 ( 4.5A)
None
None
None
None
 1.33A 1kiaD-3wyhA:
undetectable		 1kiaD-3wyhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.83A 1mnvD-5mqzA:
undetectable		 1mnvD-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 TYR A 169
VAL A   8
ASP A  62
ALA A 146
SER A 145
 TAM  A 201 ( 4.5A)
None
None
None
None
 1.30A 1nbhC-3wyhA:
undetectable		 1nbhC-3wyhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.84A 1ovfB-5mqzA:
undetectable		 1ovfB-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.84A 1qfiA-5mqzA:
undetectable		 1qfiA-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.84A 1qfiB-5mqzA:
undetectable		 1qfiB-5mqzA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 1s9a CHLOROCATECHOL
1,2-DIOXYGENASE
(Rhodococcus
opacus) 		11 / 11 LEU A  49
ASP A  52
ILE A  74
GLY A  76
PRO A  77
TYR A 134
TYR A 169
ARG A 191
HIS A 194
HIS A 196
CYH A 224
 BEZ  A 306 (-4.5A)
TAM  A 305 ( 2.7A)
None
BEZ  A 306 ( 3.5A)
TAM  A 305 ( 4.4A)
FE  A 300 ( 4.3A)
FE  A 300 ( 4.5A)
BEZ  A 306 (-3.8A)
FE  A 300 ( 3.2A)
FE  A 300 ( 3.4A)
BEZ  A 306 (-3.5A)
 0.00A 1s9aA-1s9aA:
40.7		 1s9aA-1s9aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 1s9a CHLOROCATECHOL
1,2-DIOXYGENASE
(Rhodococcus
opacus) 		12 / 12 LEU A  49
ASP A  52
ILE A  74
GLY A  76
PRO A  77
TYR A 134
TYR A 169
ARG A 191
HIS A 194
HIS A 196
GLN A 210
CYH A 224
 BEZ  A 306 (-4.5A)
TAM  A 305 ( 2.7A)
None
BEZ  A 306 ( 3.5A)
TAM  A 305 ( 4.4A)
FE  A 300 ( 4.3A)
FE  A 300 ( 4.5A)
BEZ  A 306 (-3.8A)
FE  A 300 ( 3.2A)
FE  A 300 ( 3.4A)
BEZ  A 306 ( 4.0A)
BEZ  A 306 (-3.5A)
 0.25A 1s9aB-1s9aA:
36.3		 1s9aB-1s9aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1s9a CHLOROCATECHOL
1,2-DIOXYGENASE
(Rhodococcus
opacus) 		7 / 11 GLY A  76
PRO A  77
TYR A 134
TYR A 169
ARG A 191
HIS A 194
HIS A 196
 BEZ  A 306 ( 3.5A)
TAM  A 305 ( 4.4A)
FE  A 300 ( 4.3A)
FE  A 300 ( 4.5A)
BEZ  A 306 (-3.8A)
FE  A 300 ( 3.2A)
FE  A 300 ( 3.4A)
 0.30A 1tmxA-1s9aA:
28.4		 1tmxA-1s9aA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1s9a CHLOROCATECHOL
1,2-DIOXYGENASE
(Rhodococcus
opacus) 		6 / 11 PRO A  77
TYR A 134
TYR A 169
ILE A 171
HIS A 194
HIS A 196
 TAM  A 305 ( 4.4A)
FE  A 300 ( 4.3A)
FE  A 300 ( 4.5A)
None
FE  A 300 ( 3.2A)
FE  A 300 ( 3.4A)
 0.82A 1tmxA-1s9aA:
28.4		 1tmxA-1s9aA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1s9a CHLOROCATECHOL
1,2-DIOXYGENASE
(Rhodococcus
opacus) 		7 / 12 GLY A  76
PRO A  77
TYR A 134
TYR A 169
ARG A 191
HIS A 194
HIS A 196
 BEZ  A 306 ( 3.5A)
TAM  A 305 ( 4.4A)
FE  A 300 ( 4.3A)
FE  A 300 ( 4.5A)
BEZ  A 306 (-3.8A)
FE  A 300 ( 3.2A)
FE  A 300 ( 3.4A)
 0.37A 1tmxB-1s9aA:
27.7		 1tmxB-1s9aA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1s9a CHLOROCATECHOL
1,2-DIOXYGENASE
(Rhodococcus
opacus) 		6 / 12 PRO A  77
TYR A 134
TYR A 169
ILE A 171
HIS A 194
HIS A 196
 TAM  A 305 ( 4.4A)
FE  A 300 ( 4.3A)
FE  A 300 ( 4.5A)
None
FE  A 300 ( 3.2A)
FE  A 300 ( 3.4A)
 0.89A 1tmxB-1s9aA:
27.7		 1tmxB-1s9aA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.83A 1unjF-5mqzA:
undetectable		 1unjF-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.84A 1unjF-5mqzA:
undetectable		 1unjF-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.79A 1unjL-5mqzA:
undetectable		 1unjL-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.81A 1unjL-5mqzA:
undetectable		 1unjL-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.82A 1unjR-5mqzA:
undetectable		 1unjR-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.83A 1unjR-5mqzA:
undetectable		 1unjR-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.79A 1unjW-5mqzA:
undetectable		 1unjW-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.80A 1unjX-5mqzA:
undetectable		 1unjX-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.79A 1unjX-5mqzA:
undetectable		 1unjX-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.77A 1unmE-5mqzA:
undetectable		 1unmE-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.81A 1unmE-5mqzA:
undetectable		 1unmE-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 3wyh LYSOZYME G
(Struthio
camelus) 		4 / 6 GLU A  73
TYR A 147
ASP A  97
ARG A  99
 TAM  A 201 (-2.9A)
P6G  A 202 ( 3.5A)
TAM  A 201 ( 3.4A)
None
 1.41A 2a3bB-3wyhA:
undetectable		 2a3bB-3wyhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 ILE A 144
GLY A 150
GLY A 143
SER A 100
ASN A 148
 None
P6G  A 202 (-3.4A)
None
None
TAM  A 201 ( 3.5A)
 1.14A 2okcA-3wyhA:
undetectable		 2okcA-3wyhA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3wyh LYSOZYME G
(Struthio
camelus) 		5 / 12 ILE A 144
GLY A 150
GLY A 143
SER A 100
ASN A 148
 None
P6G  A 202 (-3.4A)
None
None
TAM  A 201 ( 3.5A)
 1.15A 2okcB-3wyhA:
undetectable		 2okcB-3wyhA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 8 HIS A  40
ARG A  88
ASP A 111
HIS A 148
ASP A 150
 CD  A 301 ( 3.4A)
TAM  A 309 ( 4.3A)
None
TAM  A 309 (-4.8A)
None
 0.38A 2xadA-3wl4A:
20.2		 2xadA-3wl4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 8 HIS A  40
ARG A  88
ASP A 111
HIS A 148
ASP A 150
 CD  A 301 ( 3.4A)
TAM  A 309 ( 4.3A)
None
TAM  A 309 (-4.8A)
None
 0.39A 2xadB-3wl4A:
20.1		 2xadB-3wl4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 8 HIS A  40
ARG A  88
ASP A 111
HIS A 148
ASP A 150
 CD  A 301 ( 3.4A)
TAM  A 309 ( 4.3A)
None
TAM  A 309 (-4.8A)
None
 0.39A 2xadC-3wl4A:
20.2		 2xadC-3wl4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 8 HIS A  40
ARG A  88
ASP A 111
HIS A 148
ASP A 150
 CD  A 301 ( 3.4A)
TAM  A 309 ( 4.3A)
None
TAM  A 309 (-4.8A)
None
 0.38A 2xadD-3wl4A:
20.2		 2xadD-3wl4A:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 1s9a CHLOROCATECHOL
1,2-DIOXYGENASE
(Rhodococcus
opacus) 		10 / 12 LEU A  49
ASP A  52
ILE A  74
GLY A  76
PRO A  77
TYR A 134
TYR A 169
ARG A 191
HIS A 194
HIS A 196
 BEZ  A 306 (-4.5A)
TAM  A 305 ( 2.7A)
None
BEZ  A 306 ( 3.5A)
TAM  A 305 ( 4.4A)
FE  A 300 ( 4.3A)
FE  A 300 ( 4.5A)
BEZ  A 306 (-3.8A)
FE  A 300 ( 3.2A)
FE  A 300 ( 3.4A)
 0.36A 3hgiA-1s9aA:
30.7		 3hgiA-1s9aA:
38.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A  68
ASP A 150
HIS A 148
HIS A  40
 None
None
TAM  A 309 (-4.8A)
CD  A 301 ( 3.4A)
 1.12A 3t01A-3wl4A:
undetectable		 3t01A-3wl4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 HIS A 148
GLU A  38
ASP A 111
GLU A  91
 TAM  A 309 (-4.8A)
None
None
None
 1.17A 3vywA-3wl4A:
2.9		 3vywA-3wl4A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE
(Aspergillus
flavus) 		4 / 7 GLY A 192
THR A 191
SER A 501
THR A 499
 SO4  A 602 (-3.3A)
TAM  A 603 (-3.1A)
None
None
 0.98A 4ac9C-5j7xA:
undetectable		 4ac9C-5j7xA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 199
PRO A 201
THR A 228
 None
None
TAM  A 303 (-3.9A)
 0.84A 4hivD-5mqzA:
undetectable		 4hivD-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.98A 4w5oA-3wl4A:
2.5		 4w5oA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.88A 4w5qA-3wl4A:
3.1		 4w5qA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.82A 4w5tA-3wl4A:
2.5		 4w5tA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.95A 4z4cA-3wl4A:
2.5		 4z4cA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.93A 4z4dA-3wl4A:
2.9		 4z4dA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.88A 4z4eA-3wl4A:
2.9		 4z4eA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.95A 4z4gA-3wl4A:
2.3		 4z4gA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 1s9a CHLOROCATECHOL
1,2-DIOXYGENASE
(Rhodococcus
opacus) 		4 / 8 HIS A 194
TYR A 169
PHE A  78
PRO A  77
 FE  A 300 ( 3.2A)
FE  A 300 ( 4.5A)
BEZ  A 306 (-4.9A)
TAM  A 305 ( 4.4A)
 1.22A 5v4vA-1s9aA:
undetectable		 5v4vA-1s9aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 1s9a CHLOROCATECHOL
1,2-DIOXYGENASE
(Rhodococcus
opacus) 		4 / 8 HIS A 194
TYR A 169
PHE A  78
PRO A  77
 FE  A 300 ( 3.2A)
FE  A 300 ( 4.5A)
BEZ  A 306 (-4.9A)
TAM  A 305 ( 4.4A)
 1.19A 5v4vB-1s9aA:
undetectable		 5v4vB-1s9aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.81A 6cbdA-3wl4A:
2.2		 6cbdA-3wl4A:
14.25