SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'TAK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.70A 1iepA-3q4tA:
23.9		 1iepA-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.73A 1iepB-3q4tA:
24.0		 1iepB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
GLU A 248
LEU A 281
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-3.3A)
None
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.78A 1m17A-4c02A:
26.9		 1m17A-4c02A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
LEU A 281
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.68A 1m17A-4c02A:
26.9		 1m17A-4c02A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 9 GLY A 215
VAL A 222
ALA A 233
LEU A 263
TYR A 285
LEU A 343
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-4.7A)
 0.88A 1muoA-4c02A:
7.8		 1muoA-4c02A:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
GLU A 232
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.78A 1opjB-3q4tA:
23.7		 1opjB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.82A 1uwhA-3q4tA:
25.3		 1uwhA-3q4tA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 233
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.37A 1uwhA-4c02A:
24.8		 1uwhA-4c02A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 VAL A 206
VAL A 235
ILE A 246
ILE A 318
 TAK  A   2 ( 4.9A)
EDO  A 489 ( 4.8A)
None
None
 0.55A 1uwhA-3q4tA:
25.3		 1uwhA-3q4tA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
LYS A 219
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.93A 1uwhB-3q4tA:
25.2		 1uwhB-3q4tA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
LYS A 235
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.58A 1uwhB-4c02A:
24.7		 1uwhB-4c02A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.86A 1uwjA-3q4tA:
6.9		 1uwjA-3q4tA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.48A 1uwjA-4c02A:
6.9		 1uwjA-4c02A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.85A 1uwjB-3q4tA:
24.3		 1uwjB-3q4tA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.47A 1uwjB-4c02A:
7.0		 1uwjB-4c02A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
GLY A 273
LEU A 329
ASP A 340
PHE A 341
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
None
 0.88A 1xkkA-3q4tA:
24.6		 1xkkA-3q4tA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
THR A 283
GLY A 289
ASP A 293
LEU A 343
ASP A 354
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.73A 1xkkA-4c02A:
19.4		 1xkkA-4c02A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 11 GLY A 215
VAL A 222
ALA A 233
TYR A 285
SER A 290
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.6A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.76A 2evaA-4c02A:
26.1		 2evaA-4c02A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 11 VAL A 214
GLY A 215
VAL A 222
ALA A 233
TYR A 285
SER A 290
LEU A 343
 TAK  A1507 ( 4.3A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.6A)
None
TAK  A1507 (-4.7A)
 0.66A 2evaA-4c02A:
26.1		 2evaA-4c02A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
GLU A 232
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.54A 2gqgA-3q4tA:
26.4		 2gqgA-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
GLU A 248
THR A 283
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.69A 2gqgA-4c02A:
27.2		 2gqgA-4c02A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.56A 2hyyA-3q4tA:
24.5		 2hyyA-3q4tA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.69A 2hyyB-3q4tA:
24.4		 2hyyB-3q4tA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.61A 2hyyC-3q4tA:
24.4		 2hyyC-3q4tA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
GLU A 232
LEU A 265
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.73A 2itoA-3q4tA:
25.6		 2itoA-3q4tA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
GLU A 248
LEU A 281
GLY A 289
ASP A 293
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
None
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
 0.92A 2itoA-4c02A:
26.9		 2itoA-4c02A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
GLU A 248
THR A 283
GLY A 289
ASP A 293
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
 0.91A 2itoA-4c02A:
26.9		 2itoA-4c02A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		9 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
THR A 283
GLY A 289
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.79A 2ityA-4c02A:
20.8		 2ityA-4c02A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 VAL A 206
ALA A 217
LYS A 219
GLU A 232
GLY A 273
ASP A 277
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.0A)
TAK  A   2 (-4.6A)
None
 1.01A 2itzA-3q4tA:
25.4		 2itzA-3q4tA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		9 / 12 VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
GLY A 289
ASP A 293
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.92A 2itzA-4c02A:
26.7		 2itzA-4c02A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 GLY A 215
VAL A 222
ALA A 233
LEU A 263
TYR A 285
GLY A 289
ALA A 353
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 ( 4.2A)
 0.77A 2wgjA-4c02A:
24.7		 2wgjA-4c02A:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
LYS A 219
GLU A 232
THR A 267
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.59A 2zvaA-3q4tA:
26.7		 2zvaA-3q4tA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.61A 3bbtB-4c02A:
18.9		 3bbtB-4c02A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 VAL A 206
ALA A 217
LEU A 265
THR A 267
GLY A 273
LEU A 329
ASP A 340
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
None
 1.00A 3bbtD-3q4tA:
24.0		 3bbtD-3q4tA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 281
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.84A 3bbtD-4c02A:
19.5		 3bbtD-4c02A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.71A 3bbtD-4c02A:
19.5		 3bbtD-4c02A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
GLY A 273
HIS A 320
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.44A 3cs9A-3q4tA:
24.1		 3cs9A-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
VAL A 235
THR A 267
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.62A 3cs9A-3q4tA:
24.1		 3cs9A-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
THR A 283
GLY A 289
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.32A 3cs9A-4c02A:
25.0		 3cs9A-4c02A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
THR A 267
GLY A 273
HIS A 320
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 ( 4.2A)
 0.52A 3cs9B-3q4tA:
24.2		 3cs9B-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
VAL A 235
THR A 267
GLY A 273
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.53A 3cs9B-3q4tA:
24.2		 3cs9B-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 233
THR A 283
GLY A 289
HIS A 334
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 ( 4.2A)
 0.33A 3cs9B-4c02A:
25.2		 3cs9B-4c02A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
GLU A 232
VAL A 235
THR A 267
PHE A 269
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
 0.74A 3cs9C-3q4tA:
23.9		 3cs9C-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
THR A 267
PHE A 269
HIS A 320
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
None
TAK  A   2 ( 4.2A)
 0.49A 3cs9C-3q4tA:
23.9		 3cs9C-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
VAL A 235
THR A 267
PHE A 269
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 ( 4.2A)
 0.60A 3cs9C-3q4tA:
23.9		 3cs9C-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
GLU A 232
VAL A 235
THR A 267
PHE A 269
GLY A 273
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
 0.68A 3cs9D-3q4tA:
23.2		 3cs9D-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
HIS A 320
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
None
TAK  A   2 ( 4.2A)
 0.49A 3cs9D-3q4tA:
23.2		 3cs9D-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
VAL A 235
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.62A 3cs9D-3q4tA:
23.2		 3cs9D-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 233
THR A 283
GLY A 289
HIS A 334
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 ( 4.2A)
 0.27A 3cs9D-4c02A:
24.0		 3cs9D-4c02A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 GLY A 201
GLY A 204
VAL A 206
ALA A 217
SER A 274
ASN A 327
LEU A 329
ASP A 340
 None
None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
None
TAK  A   2 (-4.6A)
None
 0.68A 3eygA-3q4tA:
27.8		 3eygA-3q4tA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 10 VAL A 222
ALA A 233
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.82A 3g0fB-4c02A:
24.7		 3g0fB-4c02A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
THR A 267
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.56A 3g5dA-3q4tA:
25.8		 3g5dA-3q4tA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.59A 3g5dA-4c02A:
26.5		 3g5dA-4c02A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.50A 3g5dA-4c02A:
26.5		 3g5dA-4c02A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 VAL A 222
ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.63A 3g5dB-4c02A:
26.4		 3g5dB-4c02A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.52A 3g5dB-4c02A:
26.4		 3g5dB-4c02A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 214
VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
 TAK  A1507 ( 4.3A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
 0.92A 3hegA-4c02A:
16.6		 3hegA-4c02A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.65A 3k54A-4c02A:
25.6		 3k54A-4c02A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.84A 3k5vA-3q4tA:
23.7		 3k5vA-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.67A 3k5vA-3q4tA:
23.7		 3k5vA-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.87A 3k5vB-3q4tA:
23.7		 3k5vB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.67A 3k5vB-3q4tA:
23.7		 3k5vB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 8 VAL A 214
ALA A 233
LYS A 235
THR A 283
 TAK  A1507 ( 4.3A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
 0.43A 3lfaA-4c02A:
18.8		 3lfaA-4c02A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 9 ALA A 217
LYS A 219
PHE A 269
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.71A 3miyB-3q4tA:
25.1		 3miyB-3q4tA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.73A 3ms9A-3q4tA:
23.9		 3ms9A-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.69A 3ms9B-3q4tA:
23.9		 3ms9B-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.73A 3mssA-3q4tA:
24.0		 3mssA-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.35A 3mssB-3q4tA:
23.9		 3mssB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.72A 3mssC-3q4tA:
24.0		 3mssC-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.36A 3mssD-3q4tA:
23.9		 3mssD-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.54A 3octA-4c02A:
25.4		 3octA-4c02A:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.45A 3oezA-4c02A:
24.4		 3oezA-4c02A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.62A 3oezB-4c02A:
24.8		 3oezB-4c02A:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
 0.82A 3og7A-3q4tA:
25.1		 3og7A-3q4tA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
GLY A 356
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
None
 0.73A 3og7A-4c02A:
25.0		 3og7A-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.32A 3og7A-4c02A:
25.0		 3og7A-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 214
GLY A 215
VAL A 222
ALA A 233
LYS A 235
THR A 283
LEU A 343
 TAK  A1507 ( 4.3A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-4.7A)
 0.85A 3ohtA-4c02A:
4.5		 3ohtA-4c02A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 214
VAL A 222
ALA A 233
LYS A 235
THR A 283
ASP A 354
 TAK  A1507 ( 4.3A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
 0.83A 3ohtA-4c02A:
4.5		 3ohtA-4c02A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
THR A 283
LEU A 343
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-4.7A)
 0.84A 3ohtB-4c02A:
4.5		 3ohtB-4c02A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.40A 3pyyA-3q4tA:
23.7		 3pyyA-3q4tA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 VAL A 222
ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.71A 3qlgA-4c02A:
25.5		 3qlgA-4c02A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.67A 3qlgA-4c02A:
25.5		 3qlgA-4c02A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		9 / 12 VAL A 222
ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
TAK  A1507 (-3.5A)
 0.71A 3qlgB-4c02A:
26.5		 3qlgB-4c02A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 GLY A 220
VAL A 222
ALA A 233
LYS A 235
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.79A 3v5wA-4c02A:
7.5		 3v5wA-4c02A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 ALA A 217
LYS A 219
THR A 267
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.5A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.02A 3zosA-3q4tA:
22.9		 3zosA-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
THR A 283
LEU A 319
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.76A 3zosA-4c02A:
23.7		 3zosA-4c02A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 ALA A 217
LYS A 219
GLU A 232
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.20A 3zosB-3q4tA:
23.1		 3zosB-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 ALA A 217
LYS A 219
THR A 267
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.5A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.02A 3zosB-3q4tA:
23.1		 3zosB-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
THR A 283
LEU A 319
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.78A 3zosB-4c02A:
23.9		 3zosB-4c02A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 11 ALA A 217
LYS A 219
PHE A 269
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.53A 4agdA-3q4tA:
23.4		 4agdA-3q4tA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 LEU A 281
ASP A 336
LYS A 338
ASN A 341
ASP A 354
GLY A 356
 None
None
FLC  A1504 (-2.8A)
None
TAK  A1507 (-3.5A)
None
 1.33A 4an2A-4c02A:
22.5		 4an2A-4c02A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 LYS A 235
ASP A 336
LYS A 338
ASN A 341
ASP A 354
 TAK  A1507 ( 4.5A)
None
FLC  A1504 (-2.8A)
None
TAK  A1507 (-3.5A)
 0.65A 4an2A-4c02A:
22.5		 4an2A-4c02A:
26.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
LYS A 219
GLU A 232
LEU A 247
THR A 267
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.71A 4c8bA-3q4tA:
24.0		 4c8bA-3q4tA:
32.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
LYS A 219
LEU A 247
THR A 267
HIS A 320
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.57A 4c8bA-3q4tA:
24.0		 4c8bA-3q4tA:
32.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
LEU A 263
THR A 283
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.52A 4c8bA-4c02A:
24.2		 4c8bA-4c02A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 5 VAL A 222
ILE A 262
TYR A 285
ILE A 352
 TAK  A1507 (-4.7A)
None
TAK  A1507 ( 4.6A)
None
 0.76A 4c8bA-4c02A:
24.2		 4c8bA-4c02A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
ILE A 246
LEU A 247
THR A 267
HIS A 320
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
None
None
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.52A 4c8bB-3q4tA:
24.6		 4c8bB-3q4tA:
32.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 ALA A 233
LYS A 235
ILE A 262
LEU A 263
THR A 283
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.69A 4c8bB-4c02A:
24.2		 4c8bB-4c02A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 11 GLY A 201
VAL A 206
ALA A 217
GLY A 273
SER A 274
LEU A 329
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
 0.48A 4ckiA-3q4tA:
28.0		 4ckiA-3q4tA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 10 GLY A 215
GLY A 217
VAL A 222
ALA A 233
SER A 290
LEU A 343
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-4.7A)
 0.40A 4ckjA-4c02A:
28.4		 4ckjA-4c02A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
THR A 267
GLY A 273
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.57A 4hjoA-3q4tA:
24.5		 4hjoA-3q4tA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.69A 4hjoA-4c02A:
25.2		 4hjoA-4c02A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
ASP A 293
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.78A 4i22A-4c02A:
24.7		 4i22A-4c02A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
GLY A 289
ASP A 293
LEU A 343
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
 0.71A 4i22A-4c02A:
24.7		 4i22A-4c02A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
ASP A 322
LYS A 324
ASN A 327
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
EDO  A  18 (-3.0A)
None
TAK  A   2 (-4.6A)
None
 0.71A 4i41A-3q4tA:
23.4		 4i41A-3q4tA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 5 GLN A 248
THR A 267
HIS A 320
LEU A 303
 None
TAK  A   2 (-3.5A)
None
None
 1.34A 4lvcC-3q4tA:
undetectable		 4lvcC-3q4tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 GLY A 201
VAL A 206
ALA A 217
LYS A 219
GLY A 273
LEU A 329
ASP A 340
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.80A 4mkcA-3q4tA:
25.3		 4mkcA-3q4tA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		9 / 12 VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.99A 4mxoB-4c02A:
26.3		 4mxoB-4c02A:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.57A 4mxxA-4c02A:
26.4		 4mxxA-4c02A:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.54A 4mxxB-4c02A:
24.7		 4mxxB-4c02A:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 11 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 263
ASN A 341
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.67A 4o0sA-4c02A:
24.9		 4o0sA-4c02A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 6 VAL A 206
ALA A 217
LYS A 219
LEU A 247
LEU A 329
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-4.6A)
 0.71A 4o0uA-3q4tA:
7.2		 4o0uA-3q4tA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 6 ALA A 233
LYS A 235
LEU A 263
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-4.7A)
 0.79A 4o0uA-4c02A:
8.0		 4o0uA-4c02A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 6 VAL A 222
ALA A 233
LEU A 263
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-4.7A)
 0.42A 4o0uA-4c02A:
8.0		 4o0uA-4c02A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 8 GLY A 201
VAL A 206
ALA A 217
ASN A 327
LEU A 329
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
 0.61A 4ogrA-3q4tA:
26.0		 4ogrA-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 8 VAL A 206
ALA A 217
ASN A 327
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
None
 0.41A 4ogrA-3q4tA:
26.0		 4ogrA-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 7 ALA A 217
ASN A 327
LEU A 329
ASP A 340
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
None
 0.26A 4ogrE-3q4tA:
24.9		 4ogrE-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 9 GLY A 201
VAL A 206
ALA A 217
ASN A 327
LEU A 329
ASP A 340
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
None
 0.67A 4ogrI-3q4tA:
26.4		 4ogrI-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.61A 4otwA-4c02A:
19.2		 4otwA-4c02A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
GLU A 232
LEU A 303
ARG A 321
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
None
TAK  A   2 ( 4.2A)
 1.12A 4qrcA-3q4tA:
24.7		 4qrcA-3q4tA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LYS A 219
GLU A 232
THR A 267
LEU A 329
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.6A)
 0.67A 4r7iA-3q4tA:
23.9		 4r7iA-3q4tA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
LEU A 247
THR A 267
SER A 274
PHE A 341
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.96A 4rzvA-3q4tA:
25.4		 4rzvA-3q4tA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 233
LYS A 235
LEU A 263
THR A 283
SER A 290
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
 0.74A 4rzvA-4c02A:
7.3		 4rzvA-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
SER A 274
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.97A 4rzvB-3q4tA:
25.4		 4rzvB-3q4tA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
SER A 290
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
 0.70A 4rzvB-4c02A:
24.6		 4rzvB-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
THR A 267
GLY A 273
HIS A 320
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
 0.60A 4u0iA-3q4tA:
24.1		 4u0iA-3q4tA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 11 GLY A 217
VAL A 222
ALA A 233
TYR A 285
GLY A 289
ASN A 341
LEU A 343
ALA A 353
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.69A 4u5jA-4c02A:
27.6		 4u5jA-4c02A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 ALA A 233
LEU A 319
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.33A 4uxqA-4c02A:
25.5		 4uxqA-4c02A:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 9 VAL A 222
LYS A 235
TYR A 285
ARG A 335
LEU A 343
ILE A 352
 TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
TAK  A1507 ( 4.6A)
None
TAK  A1507 (-4.7A)
None
 1.01A 4v01B-4c02A:
24.8		 4v01B-4c02A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
GLU A 232
LEU A 303
HIS A 320
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
None
TAK  A   2 ( 4.2A)
 1.01A 4v04A-3q4tA:
23.6		 4v04A-3q4tA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 11 ALA A 217
THR A 267
GLY A 273
ASN A 327
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.57A 4wa9A-3q4tA:
23.4		 4wa9A-3q4tA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 11 ALA A 233
THR A 283
GLY A 289
ASN A 341
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.39A 4wa9A-4c02A:
24.0		 4wa9A-4c02A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
ASN A 327
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.65A 4wa9B-3q4tA:
25.5		 4wa9B-3q4tA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
GLY A 273
ASN A 327
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.70A 4wa9B-3q4tA:
25.5		 4wa9B-3q4tA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
THR A 283
GLY A 289
ASN A 341
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.74A 4wa9B-4c02A:
26.0		 4wa9B-4c02A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
LYS A 219
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.68A 4xeyA-3q4tA:
26.2		 4xeyA-3q4tA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.55A 4xeyA-3q4tA:
26.2		 4xeyA-3q4tA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.55A 4xeyA-4c02A:
26.7		 4xeyA-4c02A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.55A 4xeyB-3q4tA:
26.1		 4xeyB-3q4tA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.54A 4xeyB-4c02A:
26.5		 4xeyB-4c02A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.64A 4xliA-4c02A:
27.6		 4xliA-4c02A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.59A 4xliB-4c02A:
27.4		 4xliB-4c02A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.62A 4xliB-4c02A:
27.4		 4xliB-4c02A:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
ASP A 340
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.86A 4xv2A-3q4tA:
25.2		 4xv2A-3q4tA:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.41A 4xv2A-4c02A:
24.3		 4xv2A-4c02A:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
LEU A 247
THR A 267
ASP A 340
PHE A 341
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.79A 4xv2B-3q4tA:
25.5		 4xv2B-3q4tA:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
PHE A 269
GLY A 273
LEU A 329
ALA A 339
ASP A 340
 TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
None
 0.69A 5ajqA-3q4tA:
22.2		 5ajqA-3q4tA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.72A 5bvwA-4c02A:
24.2		 5bvwA-4c02A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
 0.63A 5cswA-3q4tA:
25.3		 5cswA-3q4tA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.85A 5cswA-4c02A:
24.3		 5cswA-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.41A 5cswA-4c02A:
24.3		 5cswA-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
 0.64A 5cswB-3q4tA:
24.8		 5cswB-3q4tA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.84A 5cswB-4c02A:
24.3		 5cswB-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.51A 5cswB-4c02A:
24.3		 5cswB-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.63A 5h2uA-3q4tA:
24.9		 5h2uA-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LEU A 263
THR A 283
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.71A 5h2uA-4c02A:
24.8		 5h2uA-4c02A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.69A 5h2uB-3q4tA:
25.1		 5h2uB-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LEU A 263
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.80A 5h2uB-4c02A:
25.1		 5h2uB-4c02A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
LEU A 247
THR A 267
GLY A 273
ASP A 340
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
 0.56A 5h2uC-3q4tA:
24.9		 5h2uC-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.56A 5h2uC-3q4tA:
24.9		 5h2uC-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
ASP A 340
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.54A 5h2uD-3q4tA:
25.1		 5h2uD-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 LYS A 219
PHE A 249
SER A 274
ASP A 340
 TAK  A   2 (-2.9A)
None
None
None
 0.95A 5hesA-3q4tA:
8.6		 5hesA-3q4tA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 6 LYS A 235
PHE A 265
SER A 290
ASP A 354
 TAK  A1507 ( 4.5A)
None
None
TAK  A1507 (-3.5A)
 1.01A 5hesA-4c02A:
24.5		 5hesA-4c02A:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
ASP A 293
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
None
 0.78A 5hesB-4c02A:
24.4		 5hesB-4c02A:
28.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.86A 5hi2A-3q4tA:
25.1		 5hi2A-3q4tA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
LYS A 235
LEU A 263
THR A 283
LEU A 319
HIS A 334
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
None
 0.67A 5hi2A-4c02A:
24.9		 5hi2A-4c02A:
30.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 GLY A 201
VAL A 206
ALA A 217
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
 0.57A 5hieA-3q4tA:
25.7		 5hieA-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
 0.55A 5hieA-3q4tA:
25.7		 5hieA-3q4tA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.77A 5hieA-4c02A:
24.3		 5hieA-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.37A 5hieA-4c02A:
24.3		 5hieA-4c02A:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 GLY A 201
VAL A 206
ALA A 217
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
 0.58A 5hieB-3q4tA:
25.7		 5hieB-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
 0.56A 5hieB-3q4tA:
25.7		 5hieB-3q4tA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.78A 5hieB-4c02A:
24.2		 5hieB-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.37A 5hieB-4c02A:
24.2		 5hieB-4c02A:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 GLY A 201
VAL A 206
ALA A 217
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
 0.57A 5hieC-3q4tA:
25.9		 5hieC-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 GLY A 201
VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
 1.49A 5hieC-3q4tA:
25.9		 5hieC-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
 0.82A 5hieC-3q4tA:
25.9		 5hieC-3q4tA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 GLY A 215
PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.79A 5hieC-4c02A:
5.3		 5hieC-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.47A 5hieC-4c02A:
5.3		 5hieC-4c02A:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 GLY A 201
VAL A 206
ALA A 217
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
 0.59A 5hieD-3q4tA:
25.7		 5hieD-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
 0.55A 5hieD-3q4tA:
25.7		 5hieD-3q4tA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.77A 5hieD-4c02A:
24.3		 5hieD-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.36A 5hieD-4c02A:
24.3		 5hieD-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.51A 5i9xA-4c02A:
25.3		 5i9xA-4c02A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
GLU A 232
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.60A 5i9yA-3q4tA:
24.4		 5i9yA-3q4tA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.49A 5i9yA-4c02A:
25.3		 5i9yA-4c02A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.49A 5i9yA-4c02A:
25.3		 5i9yA-4c02A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 7 GLY A 215
GLY A 217
GLY A 220
VAL A 222
 None
None
None
TAK  A1507 (-4.7A)
 0.29A 5izjB-4c02A:
21.8		 5izjB-4c02A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		4 / 7 GLY A 215
GLY A 217
VAL A 222
LYS A 235
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
 0.34A 5izjA-4c02A:
16.8		 5izjA-4c02A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		5 / 7 GLY A 215
GLY A 217
VAL A 222
LYS A 235
ASP A 354
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.5A)
 0.82A 5j5xA-4c02A:
22.9		 5j5xA-4c02A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 GLU A 212
GLY A 215
ALA A 233
GLU A 248
TYR A 285
GLY A 289
ASP A 293
 EDO  A1515 (-3.8A)
None
TAK  A1507 (-3.3A)
None
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
None
 0.77A 5vc3A-4c02A:
24.8		 5vc3A-4c02A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.85A 5yu9A-4c02A:
24.7		 5yu9A-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		8 / 12 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
ASP A 293
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.87A 5yu9B-4c02A:
25.0		 5yu9B-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
LEU A 281
GLY A 289
ASP A 293
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.5A)
None
TAK  A1507 (-3.5A)
 0.88A 5yu9C-4c02A:
24.5		 5yu9C-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
GLY A 289
ASP A 293
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.51A 5yu9D-4c02A:
24.7		 5yu9D-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		6 / 12 VAL A 222
ALA A 233
LYS A 235
GLY A 289
ASP A 293
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-3.5A)
 0.77A 5yu9D-4c02A:
24.7		 5yu9D-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
LYS A 219
GLU A 232
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.76A 6fnmA-3q4tA:
25.5		 6fnmA-3q4tA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens) 		7 / 12 VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.80A 6fnmA-4c02A:
25.6		 6fnmA-4c02A:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
THR A 267
PHE A 269
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.88A 6hd6A-3q4tA:
23.7		 6hd6A-3q4tA:
15.41